Research Topics
Genomes and GenesSpecies | K W LeeSummaryAffiliation: College of Medicine Country: Korea Publications
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Publications
A novel HLA-B allele, B*40:123, carrying a nucleotide substitution at a conserved codonK W Lee
Hallym Institution for Genome Application, Hallym University, Anyang, Korea
Tissue Antigens 76:499-500. 2010..B*40:123 differs from the closest aligned sequence B*40: 01:01 by one nucleotide substitutions at conserved codon 20 (CCC -> TCC) resulting in an amino acid change at residue 20 (proline -> serine)...- Identification of three novel HLA class I alleles: HLA-A*0261, HLA-B*1585 and HLA-B*1587K W Lee
Hallym Institution for Genome Application, Hallym University, Sacred Heart Hospital, 896 Pyungchon Dong, Dongan Ku, Anyang, Kyungki Do 431 070, Korea
Tissue Antigens 65:493-6. 2005..These alleles seemed to be generated by either a point mutation or a gene conversion-like event from alleles existing in the population with high frequencies... - A novel hybrid allele (B*3563) originated from B*350101 and B*4001-like allelesK W Lee
Hallym Institution for Genome Application, College of Medicine, Hallym University, 896 Pyungchon Dong, Anyang, Kyungki Do 431 070, Korea
Tissue Antigens 70:260-2. 2007..The B*3563 showed a hybrid sequence carrying B*4001-like sequence (exon 2) on B*350101 background... - Two novel HLA class II alleles, DRB1*11:96 and DQB1*02:01:03, identified in KoreansK W Lee
Hallym Institution for Genome Application, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Dongan Gu, Anyang, Korea
Tissue Antigens 77:601-2. 2011..DRB1*11:96 and DQB1*02:01:03 differ from DRB1*11: 01:01 and DQB1*02:01:01 by one nucleotide in exon 2, respectively... - A new HLA-A*33 variant, HLA-A*3314, identified in a Korean individualK W Lee
Hallym Institute for Genome Application, Hallym University, Anyang, Korea
Tissue Antigens 71:570. 2008..The sequence of human leukocyte antigen (HLA)-A*3314 is identical to that of HLA-A*330301 except for a single-nucleotide substitution at codon 49 (GCG-->GGG) resulting in an amino acid change from Ala to Gly... - Description of a novel HLA-Cw*03 allele, HLA-Cw*0349, identified in a Korean individualK W Lee
Hallym Institute for Genome Application, College of Medicine, Hallym Universit, Anyang, Korea
Tissue Antigens 72:407-9. 2008..The sequence of human leukocyte antigen (HLA)-Cw*0349 is identical to that of HLA-Cw*030301 except for a single nucleotide substitution at codon 156 (CTG-->CGG) resulting in an amino acid change from Leu to Arg... - Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304K W Lee
Hallym Institute for Genome Application, Hallym University, Anyang, Korea
Tissue Antigens 71:575-7. 2008..DPA1*010304 was identical to DPA1*010301 except for a single silent substitution at codon 58 encoding Gly (GGC-->GGT)... - A novel HLA-B*40 allele, HLA-B*4083, identified in a Korean individualK W Lee
Hallym Institute for Genome Application, Hallym University, Anyang, Korea
Tissue Antigens 71:571-2. 2008.... - Description of three novel HLA-DRB3 alleles: DRB3*010105, DRB3*0112 and DRB3*0113K W Lee
Hallym Institution for Genome Application, College of Medicine, Hallym University Sacred Heart Hospital, Hallym University, Dongan Gu, Anyang, Korea
Tissue Antigens 73:83-4. 2009..Comparing with DRB3*010102, the sequence of DRB3*010105, DRB3*0112, and DRB3*0113 differ at codon 31 (TTC -> TTT), codon 84 (GGG -> CGG; Gly -> Arg), and codon 37 (TTC -> CTC; Phe -> Leu), respectively... - A novel HLA-B allele: HLA-B*5419K W Lee
Hallym Institution for Genome Application, Hallym University, Anyang, South Korea
Tissue Antigens 74:444-5. 2009..B*5419 differs from B*5401 by a single nucleotide substitution at codon 13 (TCC --> TTC)... - Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean populationK W Lee
Hallym Institution for Genome Application, Hallym University, Sacred Heart Hospital, 896 Pyungchon Dong, Dongan Ku, Anyang, Kyungki Do 431 070, Korea
Tissue Antigens 65:437-47. 2005..Information obtained in this study will be useful for medical and forensic applications as well as in anthropology... - Diversity of HLA-DQA1 gene in the Korean populationK W Lee
Hallym Institution for Genome Application, Hallym University Sacred Heart Hospital, Anyang, South Korea
Tissue Antigens 69:82-4. 2007..Information obtained in this study will be useful in medical and forensic areas as well as in anthropology... - Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver diseaseS G Kim
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, South Korea
Eur J Endocrinol 152:225-31. 2005..05). CONCLUSION: Serum adiponectin level and baPWV were significantly associated with NAFLD and various liver enzymes, especially in females... - Four novel human leukocyte antigen-DQA1 alleles identified in the Korean populationK W Lee
Hallym Institution for Genome Application, Hallym University Sacred Heart Hospital, Anyang, Kyungki do, Korea
Tissue Antigens 68:167-72. 2006..Putative haplotypes associated with the novel alleles were deduced based on the HLA types shared by the individuals carrying a novel allele or from previously reported population data... - Relationship between brachial-ankle pulse wave velocity and cardiovascular risk factors of the metabolic syndromeK M Choi
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University Guro Hospital, Korea University, 80 Guro-dong, Guro-gu, Seoul 152-050, South Korea
Diabetes Res Clin Pract 66:57-61. 2004..548). The present study shows that baPWV is significantly associated with the features of the metabolic syndrome in Korean women... - Sequence of an HLA-B56 variant (B*5604) identified in the Korean populationK W Lee
Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
Tissue Antigens 51:210-2. 1998..The putative haplotype associated with the novel allele was A2-B*5604-Bw6-Cw7-DRB1*15-DRB5*02-DQA1*01-DQB 1*05... - Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver diseaseJ A Seo
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
Clin Endocrinol (Oxf) 68:555-60. 2008..We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults... - HLA-B22 diversity including a novel B54 variant (B*5507) in the Korean populationK W Lee
Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
Hum Immunol 60:731-7. 1999..Data obtained from this study will be useful in hematopoietic stem cell donor searches as well as in determination of a typing strategy for the HLA-B22 types in this population... - Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese womenK M Choi
Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine, Korea University, Seoul, Korea
Clin Endocrinol (Oxf) 70:569-74. 2009..We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers... - HLA-A*30 alleles and associated haplotypes in the Korean populationK W Lee
Department of Clinical Pathology, College of Medicine, Hallyn University, Seoul, Korea
Tissue Antigens 54:198-200. 1999..Conserved and distinct haplotypic associations of the two A*30 alleles imply that the two haplotypes may have evolved separately and are relatively new in this population... - HLA-B*4021: hybrid linking the B15 and B40 familiesK W Lee
Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
Tissue Antigens 54:625-7. 1999..This implies that the novel allele, B*4021, has evolved by a reciprocal gene recombination involving members of these two families. The haplotype associated with B*4021 is likely to be A11-Cw4-B*4021-DRB1*04-DRB4*01-DQA1*03-DQB1*0301 ... - DR6 in Koreans. DR11 frequently acts as a recipient gene to create DR13 allelesK W Lee
Department of Clinical Pathology, Hallym University, College of Medicine, Seoul, Korea
Hum Immunol 37:229-36. 1993..These data suggest that the DR11 allele has frequently acted as a recipient gene in the gene conversion events that created the subfamily of DR13 alleles, DRB1*1303, *1304, *1305, and the new allele described here... - HLA-B*15 diversity in the Korean populationK W Lee
Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
Tissue Antigens 56:428-35. 2000.... - Clarification of HLA-B serologically ambiguous types by automated DNA sequencingK W Lee
Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
Tissue Antigens 51:536-40. 1998..g. B*5106 encoded molecule) (9.5%). Overall, sequencing was helpful in clarifying ambiguous serologic reaction patterns improving the HLA typing for the Korean population... - Serologic heterogeneity of HLA-A24 correlates with allelic types in the Korean populationK W Lee
Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
J Korean Med Sci 15:623-6. 2000..This information will be helpful for accurately assigning HLA-A24 types by serology and for predicting serologic types of new alleles... - Characterization of an HLA-B62 variant (B*1538) exhibiting an additional B52 serologic reactivityK W Lee
Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Republic of Korea
Tissue Antigens 50:662-4. 1997..The novel B*1538 allele and its associated haplotype adds to the HLA diversity in this population... - Expression defect of an HLA-A*24 allele associated with DNA methylation in a normal individualK W Lee
Hallym Institution for Genome Application, Hallym University Sacred Heart Hospital, Anyang, Korea
Tissue Antigens 61:325-9. 2003..This result suggests that hypermethylation of the HLA-A gene may induce gene inactivation in the normal individuals... - Serum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly KoreansK M Choi
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
Clin Endocrinol (Oxf) 61:75-80. 2004..CONCLUSIONS: Reduced concentrations of adiponectin were found to be independently associated with increased risk of both type 2 diabetes and the metabolic syndrome in elderly Koreans... - The short-term changes of bone mineral metabolism following bone marrow transplantationM I Kang
Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea
Bone 26:275-9. 2000..In conclusion, the rapid impairment of bone formation and the increase in bone resorption, as shown by the biochemical markers in this study, might play a role in post-BMT bone loss... - Microsatellite typing for DRB1 alleles: application to the analysis of HLA associations with rheumatoid arthritisH S Lee
Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
Genes Immun 7:533-43. 2006..In addition, these two alleles are both associated with rheumatoid arthritis, making the elucidation of these haplotype relationships potentially important for understanding disease susceptibility... - Sequence-based typing of HLA-DQA1: comprehensive approach showed molecular heterogeneityC E M Voorter
Tissue Typing Laboratory, University Hospital Maastricht, Maastricht, The Netherlands
Tissue Antigens 69:76-81. 2007..A tight association between DQA1 and DRB1/DQB1 alleles was observed in all three populations... - Identification of a novel HLA-B*55 variant (B*5513) from a Korean familyH S Park
Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, South Korea
Tissue Antigens 64:96-8. 2004..This substitution altered serologic reactivity of the B55 molecule to B22-specific alloantisera... - Light, carbon dioxide, and octenol-baited mosquito trap and host-seeking activity evaluations for mosquitoes in a malarious area of the Republic of KoreaD A Burkett
Detachment 3, U.S. Air Force Institute for Environment, Safety, and Occupational Health Risk Analysis, Okinawa, Japan, APO AP 96368
J Am Mosq Control Assoc 17:196-205. 2001..Additionally, field evaluations demonstrate that various traps can be utilized for isolation and detection of arboviruses and other pathogens... - Identification of a novel DRB1*04 allele: DRB1*0445S-C Bae
Department of Internal Medicine, Division of Rheumatology, Hanyang University College of Medicine, Seoul, Korea
Tissue Antigens 62:270-2. 2003..The haplotype associated with the novel allele is A*2402-B*5401-Cw*0102-DRB1*0445-DRB4*01-DQB1*0302... - Diphyllobothrium latum infection after eating domestic salmon fleshK W Lee
Department of Pediatrics, Ajou University School of Medicine, Suwon 442 721, Korea
Korean J Parasitol 39:319-21. 2001..It is our expectation that the salmon associated tapeworm infections would be enlisted as one of the major parasitic problems with the growing consumption of salmon in Korea... - Study on size distribution of total aerosol and water-soluble ions during an Asian dust storm event at Jeju Island, KoreaS H Park
University of British Columbia, Mechanical Engineering, 2324 Main Mall, Vancouver, British Columbia, Canada
Environ Monit Assess 93:157-83. 2004..Asian dust aerosols, arriving at Jeju Island, contained considerable amounts of sea-salt particles as they passed over the Yellow Sea. Ca2+ was shown to be the most abundant species in Asian dust particles... - Two divergent routes of evolution gave rise to the DRw13 haplotypesK W Lee
Department of Microbiology, Georgetown University School of Medicine, Washington, DC 20007
J Immunol 145:3119-25. 1990.... - Seroprevalence of leptospirosis in animals in KoreaB Y Jung
Animal Disease Diagnosis Division, National Veterinary Research and Quarantine Service, Kyunggi Do 430-824, Republic of Korea
Vet Rec 163:28-9. 2008 - Comparison of serum concentrations of C-reactive protein, TNF-alpha, and interleukin 6 between elderly Korean women with normal and impaired glucose toleranceK M Choi
Department of Internal Medicine, Korea University Guro Hospital, 80 Guro dong, Guro Gu, Seoul 152 050, South Korea
Diabetes Res Clin Pract 64:99-106. 2004..However, the hypothesis that pro-inflammatory cytokine-induced systemic inflammation is an early metabolic defect prior to onset of type 2 diabetes, is not supported in our study of elderly Korean women... - Structural basis of SNT PTB domain interactions with distinct neurotrophic receptorsC Dhalluin
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York 10029, USA
Mol Cell 6:921-9. 2000..Our results suggest mechanisms by which SNTs serve as molecular switches to mediate the essential interplay between FGFR and TRK signaling during neuronal differentiation... - Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal womenK M Choi
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Seoul 152-050, Korea
Metabolism 54:1510-4. 2005..147). Elevated iron stores were positively associated with serum ALT levels and metabolic syndrome in Korean postmenopausal women... - Effects of pore mutations and permeant ion concentration on the spontaneous gating activity of OmpC porinN Liu
Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5513, USA
Protein Eng 13:491-500. 2000..These results suggest that the ionic interactions that exist between charged residues at the constriction zone of porin may play a role in the transitions between the channel's closed and open states... - Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndromeK M Choi
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea
Diabetes Res Clin Pract 75:235-40. 2007..Furthermore, serum adiponectin levels are associated with serum hsCRP, IL-6 and IL-10 levels. These results suggest that adiponectin might be associated with the metabolic syndrome through regulation of pro-/anti-inflammatory cytokines... - Safety of donors with fatty liver in liver transplantationC H D Kwon
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-gu, Seoul, Korea 135-710
Transplant Proc 38:2106-7. 2006..In conclusion, fatty livers with less than 30% macrovesicular steatosis may be good donor candidates without significant complications as long as sufficient residual liver volume is left for the donor...