Anti-TNF-alpha treatment for deep endometriosis-associated pain: a randomized placebo-controlled trialP R Koninckx
Department of Obstetrics and Gynaecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, B3000 Leuven, Belgium
Hum Reprod 23:2017-23. 2008
..Endometriosis is associated with an inflammatory response. Hence infliximab, an anti-TNF-alpha monoclonal antibody, might relieve pain...
The elephant in the room: quality control of endometriosis dataPhilippe R Koninckx
Katholieke Universiteit, Leuven, Belgium
J Minim Invasive Gynecol 17:637-40. 2010
..To support the secondary peer-review process, we urge open-access journals to welcome letters to the editor and publish them instead of quietly "burying" them on the Internet...
Videoregistration of surgery should be used as a quality controlPhilippe R Koninckx
Department of Obstetrics and Gynecology, Leuven, Belgium
J Minim Invasive Gynecol 15:248-53. 2008
..In conclusion, we need to reflect and organize quality control in surgery. Systematic videotaping of entire procedures seems to be an inexpensive and easy way to organize this control...
Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse modelM M Binda
Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49 Bus 611, B3000, Leuven, Belgium
Surg Endosc 21:1826-34. 2007
..Specifically, this first study aimed to investigate the effects of reactive oxygen species (ROS) scavengers, antiinflammatory agents, and a calcium-channel blocker on pneumoperitoneum-enhanced adhesions...
Hyperoxia and prevention of adhesion formation: a laparoscopic mouse model for open surgeryM M Binda
Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
BJOG 117:331-9. 2010
....
Prevention of adhesion formation in a laparoscopic mouse model should combine local treatment with peritoneal cavity conditioningM M Binda
Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
Hum Reprod 24:1473-9. 2009
..Adhesion prevention, therefore, should combine local treatment while minimizing adverse peritoneal factors through conditioning of the pneumoperitoneum...
Accident analysis: factors contributing to a ureteric injury during deep endometriosis surgeryR Schonman
Department of Obstetrics and Gynaecology, University Hospital, Leuven, Belgium
BJOG 115:1611-5; discussion 1615. 2008
..To analyse factors associated with a ureteric injury...
The impact of the learning curve on adhesion formation in a laparoscopic mouse modelRoberta Corona
Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
Fertil Steril 96:193-7. 2011
..To evaluate the impact of surgeon training on adhesion formation in a laparoscopic mouse model. Laparoscopic surgery and bowel manipulation was demonstrated to enhance postoperative adhesion formation...
Intraperitoneal temperature and desiccation during endoscopic surgery Intraoperative humidification and cooling of the peritoneal cavity can reduce adhesionsRoberta Corona
Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, Leuven, Belgium
Am J Obstet Gynecol 205:392.e1-7. 2011
..With a modified humidifier, desiccation could be eliminated while maintaining the intraperitoneal temperature between 31 to 32°C...
Effect of temperature upon adhesion formation in a laparoscopic mouse modelM M Binda
Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, B3000 Leuven, Belgium
Hum Reprod 19:2626-32. 2004
..The effect of desiccation upon adhesion formation is widely accepted. The specific effect of the associated cooling upon adhesion formation remains unexplored, and was addressed specifically in our laparoscopic mouse model...
Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse modelC R Molinas
Center for Surgical Technologies, Katholieke Universiteit Leuven, Belgium
Fertil Steril 76:560-7. 2001
..To develop a laparoscopic mouse model to evaluate the hypothesis that mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation...
Hypoxaemia induced by CO(2) or helium pneumoperitoneum is a co-factor in adhesion formation in rabbitsC R Molinas
Centre for Surgical Technologies, University Hospital Gasthuisberg, Leuven, Belgium
Hum Reprod 15:1758-63. 2000
....
Wilms' tumor gene 1 (WT1) overexpression in neurons in deep endometriosis: a pilot studyAn Coosemans
Department of Obstetrics and Gynaecology, Experimental Laboratory of Gynaecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
Fertil Steril 91:1441-4. 2009
..Innervation of deep endometriosis has recently been linked to its severe pain symptoms. We demonstrated for the first time that the Wilms' tumor gene 1 is overexpressed in part of these nerves...
Tension-free Vaginal Tapes and Pelvic Nerve NeuropathyRoberta Corona
Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
J Minim Invasive Gynecol 15:262-7. 2008
....
Endometrium protection and acceptability of nasally administered continuously combined hormone therapy: a multicentre, multinational, double-blind trial in post-menopausal women evaluating three regimens of 17beta-estradiol and norethisterone when compareSerge Rozenberg
Department of Obstetrics and Gynaecology, CHU St Pierre, Rue Haute 290, Brussels 1000, Belgium
Hum Reprod 24:1739-47. 2009
..To determine the optimal daily dose of intranasal hormone therapy (HT) in order to achieve adequate endometrial protection...
Reactive oxygen species and adhesion formation: clinical implications in adhesion preventionM M Binda
Department of Obstetrics and Gynaecology and Centre for Surgical Technologies, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
Hum Reprod 18:2503-7. 2003
..This can explain the increase in ROS activity. The aim of this debate is to open a discussion about the importance of ROS activity, besides the known players and mechanisms involved, in adhesion formation and in adhesion prevention...
Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacityPetra A B Klemmt
Nuffield Department of Obstetrics and Gynaecology, The Women's Centre, John Radcliffe Hospital, Oxford, United Kingdom
Fertil Steril 85:564-72. 2006
..Loss of differentiation capacity of the endometriotic cell lines and endometrial cells from women with endometriosis may influence the capacity for proliferation and survival of these cells in the ectopic environment...
Asymmetric distribution of sciatic nerve endometriosisRonald E Batt
Obstet Gynecol 103:400-1; author reply 401. 2004