Changes in adipocytokines and insulin sensitivity during and after antiviral therapy for hepatitis C genotype 4Mahmoud Aboelneen Khattab
Department of Internal Medicine, Minia University, Minia, Egypt
J Gastrointestin Liver Dis 21:59-65. 2012
..Hepatitis C virus (HCV) infection, especially genotypes 1 and 4, is associated with wide metabolic disarrangements...
Targeting host factors: a novel rationale for the management of hepatitis C virusMahmoud Aboelneen Khattab
Department of Internal Medicine, El Minia University, El Minia 61111, Egypt
World J Gastroenterol 15:3472-9. 2009
..However the principle drawback of this strategy is the greater potential for cellular toxicity...
Pioglitazone improves virological response to peginterferon alpha-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistanceMahmoud Khattab
Department of Internal Medicine, Minya University, Minya, Egypt
Liver Int 30:447-54. 2010
..The safety and efficacy of pioglitazone on insulin sensitivity and SVR in treatment-naïve patients with chronic hepatitis C (CHC) genotype 4 with IR receiving standard antiviral therapy were evaluated in a randomized-controlled study...
Hepatic steatosis in genotype 4 chronic hepatitis C patients: implication for therapyMahmoud Aboelneen Khattab
Department of Internal Medicine, Faculty of Medicine, Minya University Hospital, Egypt
J Clin Gastroenterol 44:707-12. 2010
..We aimed to determine the parameters associated with steatosis among HCV-4 patients and to assess the effect of steatosis on treatment with peginterferon and ribavirin...
Insulin resistance predicts rapid virologic response to peginterferon/ribavirin combination therapy in hepatitis C genotype 4 patientsMahmoud Khattab
Department of Internal Medicine, Minya University, Minya, Egypt
Am J Gastroenterol 105:1970-7. 2010
..We aimed to assess which pretreatment variables might predict an RVR and a sustained virologic response (SVR)...
Seroprevalence of hepatitis C and B among blood donors in Egypt: Minya Governorate, 2000-2008Mahmoud Aboelneen Khattab
Department of Internal Medicine, Minya University, Minya, Egypt
Am J Infect Control 38:640-1. 2010
..65% and 9.02%, respectively. Antibody to hepatitis C virus and hepatitis B surface antigen prevalence estimates dropped from 11.06% to 6.3% (P = .001) and 1.24% to 1.17% (P = .2), respectively...
Management of hepatitis C virus genotype 4: recommendations of an international expert panelMahmoud A Khattab
Department of Internal Medicine, University of Minia, Egypt
J Hepatol 54:1250-62. 2011
..Therefore, this document, drafted by a panel of international experts, aimed to review current knowledge on the epidemiology, natural history, clinical, histological features, and treatment of HCV-4 infections...
Serum lipids and chronic hepatitis C genotype 4: interaction and significanceMahmoud A Khattab
Department of Internal Medicine, Minia University, Minia, Egypt
Ann Hepatol 11:37-46. 2012
..However, the genotypic differences of these disarrangements in patients infected with CHC genotype 4 (HCV-4) and its association with liver histology and viral loads remain unknown...