Research Topics
| T W MwangiSummaryAffiliation: Kenya Medical Research Institute Country: Kenya Publications
| Collaborators
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Detail Information
Publications
The effects of untreated bednets on malaria infection and morbidity on the Kenyan coastTabitha W Mwangi
Kenya Medical Research Institute, CGMRC Wellcome Trust Collaborative Programme, PO Box 230, Kilifi, Kenya
Trans R Soc Trop Med Hyg 97:369-72. 2003..In the face of persistent failure of communities to take up net retreatment, there is hope that untreated nets will offer some protection against malaria infection and disease compared with not using nets at all...- Malaria and helminth interactions in humans: an epidemiological viewpointT W Mwangi
Kenya Medical Research Institute, Centre for Geographic Medicine and Research, P O Box 230, 80108 Kilifi, Kenya
Ann Trop Med Parasitol 100:551-70. 2006..Future studies that might be considered, in order to address the gaps in knowledge, are also considered... - Case definitions of clinical malaria under different transmission conditions in Kilifi District, KenyaTabitha W Mwangi
Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast Wellcome Trust Collaborative Program, Kenya
J Infect Dis 191:1932-9. 2005..We defined and quantified cases of malaria in people of different age groups from 2 areas with different rates of transmission of malaria... - Clinical algorithms for malaria diagnosis lack utility among people of different age groupsTabitha W Mwangi
Kenya Medical Research Institute, CGMRC Wellcome Trust Collaborative Program, Kilifi, Kenya
Trop Med Int Health 10:530-6. 2005.... - The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of KenyaSammy Wambua
Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, Kilifi District Hospital, Kilifi, Kenya
PLoS Med 3:e158. 2006.... - An immune basis for malaria protection by the sickle cell traitThomas N Williams
Kenya Medical Research Institute, Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
PLoS Med 2:e128. 2005.... - Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell traitThomas N Williams
Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya
Nat Genet 37:1253-7. 2005..Negative epistasis could explain the failure of alpha(+)-thalassemia to reach fixation in any population in sub-Saharan Africa... - Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseasesThomas N Williams
Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
J Infect Dis 192:178-86. 2005..Nevertheless, >50 years after this hypothesis was first proposed, the epidemiological description of the relationships between HbAS, malaria, and other common causes of child mortality remains incomplete... - Helminth infection and eosinophilia and the risk of Plasmodium falciparum malaria in 1- to 6-year-old children in a malaria endemic areaPhilip Bejon
Kenya Medical Research Institute, Centre for Geographical Medicine Research Coast, Kilifi, Kenya
PLoS Negl Trop Dis 2:e164. 2008..Animal models suggest that helminth infections may increase susceptibility to malaria, but epidemiological data has been limited and contradictory... - The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of KenyaSarah H Atkinson
KEMRI Wellcome Trust Programme, Centre of Geographic Medicine Research, Kilifi District Hospital, Kilifi, Kenya
Clin Infect Dis 44:802-9. 2007..The Hp2 allele is thought to have spread under strong selection pressure, but it is unclear whether this is due to protection from malaria or other diseases... - Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1Claire L Mackintosh
Kenya Medical Research Institute Centre for Geographic Medicine Research Coast, Kilifi District Hospital, Kilifi, Kenya
Malar J 7:155. 2008..The precise target for these antibodies is unknown. The best characterized and most likely target is the erythrocyte surface-expressed variant protein family Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)... - A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan childrenNeil E Jenkins
Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
Clin Infect Dis 41:1817-9. 2005..We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis... - Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, KenyaWendy P O'Meara
Kenya Medical Research Institute, Centre for Geographic Medicine Research Wellcome Trust Collaborative Program, Kilifi, Kenya Fogarty International Center, National Institutes of Health, Bethesda, MD, USA
Lancet 372:1555-62. 2008..We aimed to assess the epidemiological characteristics of malaria in Kilifi, Kenya, during a period of decreasing transmission intensity... - The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparumPhilip Bejon
Kenya Medical Research Institute, Centre for Geographical Medicine Research Coast Kilifi, Kenya
J Immunol 179:4193-201. 2007..Malaria may reduce the efficacy vaccinations such as bacillus Calmette-Guérin and investigational T cell-inducing vaccines, and may delay the acquisition of immunity following natural exposure to malaria and other pathogens... - B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic areaJeffrey R Dorfman
Kenya Medical Research Institute, Wellcome Trust Research Laboratories, Kilifi, Kenya
J Infect Dis 191:1623-30. 2005.... - Contrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene familyFederica Verra
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Mol Biochem Parasitol 149:182-90. 2006..Population expansion simulations were performed under a neutral model, further supporting the departures from neutrality of these genes... - Heritability of malaria in AfricaMargaret J Mackinnon
School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS Med 2:e340. 2005..While many individual genes have been identified that confer protection against malaria, the overall impact of host genetics on malarial risk remains unknown... - High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal KenyaSpencer D Polley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Vaccine 24:4233-46. 2006..falciparum populations and that MSP2 could be combined with other P. falciparum antigens to form a multi-component malaria vaccine... - Relationship between exposure, clinical malaria, and age in an area of changing transmission intensityWendy P O'Meara
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
Am J Trop Med Hyg 79:185-91. 2008..However, the age group experiencing the clinical attacks of malaria increased steadily as exposure declined and may precede changes in the number of episodes in an area with declining transmission...