Research Topics
| P C BullSummaryAffiliation: Kenya Medical Research Institute Country: Kenya Publications
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Detail Information
Publications
Plasmodium falciparum variant surface antigen expression patterns during malariaPeter C Bull
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
PLoS Pathog 1:e26. 2005....- Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host ageP C Bull
Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi Unit, Kilifi, Kenya
J Infect Dis 182:252-9. 2000..We propose that parasites causing severe disease tend to express a subset of VSA variants that are preferentially associated with infections of children with low immunity... - Plasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severityPeter C Bull
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
J Infect Dis 192:1119-26. 2005..Here, we assessed, in 115 Kenyan children, the potential role played by in vivo selection pressures in either favoring or selecting against VSA(FoRH) among parasites that cause malaria... - Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variantsP C Bull
Kenya Medical Research Institute CGMRC, Kilifi Unit, Kilifi, Kenya
Infect Immun 67:733-9. 1999..These results support the idea that preexisting anti-PfEMP1 antibodies can select the variants that are expressed during a new infection and may suggest the existence of a dominant subset of PfEMP1 variants... - Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan childrenPeter C Bull
Kenya Medical Research Insitute KEMRI Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
J Infect Dis 185:1688-91. 2002.... - Allele-specific antibodies to Plasmodium falciparum merozoite surface protein-2 and protection against clinical malariaF H A Osier
KEMRI Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
Parasite Immunol 32:193-201. 2010..Thus, even for this well-studied antigen, the importance of an allele-specific component of naturally acquired protective immunity to malaria remains to be confirmed... - Protection against clinical malaria by heterologous immunoglobulin G antibodies against malaria-infected erythrocyte variant surface antigens requires interaction with asymptomatic infectionsSamson M Kinyanjui
Kenya Medical Research Institute Centre for Geographic Medicine Research Coast, Kilifi, Kenya
J Infect Dis 190:1527-33. 2004..These results support previous findings and underline the importance of considering the parasitological status of study participants when examining the role that immune responses to VSAs and other malaria antigens play... - The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malariaBritta C Urban
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, United Kingdom
Infect Immun 74:6700-6. 2006.... - Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocksPeter C Bull
Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
Mol Microbiol 68:1519-34. 2008.... - The use of cryopreserved mature trophozoites in assessing antibody recognition of variant surface antigens of Plasmodium falciparum-infected erythrocytesSamson M Kinyanjui
Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, P.O. Box 230, Kilifi, Kenya
J Immunol Methods 288:9-18. 2004..The use of cryopreserved mature trophozoites could help to circumvent the problems associated with recovery of cryopreserved ring trophozoites... - Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2Francis M Ndungu
Kenya Medical Research Institute Centre for Geographical Medicine Research Coast, Kilifi, Kenya
Parasite Immunol 24:77-82. 2002..02). Conversely, elevated levels of IgG2 in relation to IgG1 and IgG3 antibodies were associated with a higher risk of developing severe malaria (P = 0.006)... - Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malariaFaith H A Osier
KEMRI Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya
Infect Immun 76:2240-8. 2008.... - An approach to classifying sequence tags sampled from Plasmodium falciparum var genesPeter C Bull
Kenya Medical Research Institute Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
Mol Biochem Parasitol 154:98-102. 2007 - What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunitySamson M Kinyanjui
Kenyan Medical Research Institute KEMRI, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi 80108, Kenya
Malar J 8:242. 2009..This approach has identified a number of important responses against malaria, but their protective efficacies vary considerably between studies... - Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malariaFederica Verra
Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, University of Rome La Sapienza, Rome, Italy
PLoS ONE 2:e978. 2007..The enhanced immune reactivity in both HbC and HbS carriers supports the hypothesis that the protection against malaria of these adaptive genotypes might be at least partially mediated by acquired immunity against malaria... - Transient cross-reactive immune responses can orchestrate antigenic variation in malariaMario Recker
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Nature 429:555-8. 2004..Antigenic variation has always been seen as an adaptation of the parasite to evade host defence: we show that the coordination necessary for the success of this strategy might be provided by the host... - The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malariaPeter C Bull
Trends Microbiol 10:55-8. 2002.... - In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfateHelen M Kyriacou
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
Antimicrob Agents Chemother 51:1321-6. 2007..The strong ability to inhibit rosetting suggests that CRDS has the potential to reduce the severe complications and mortality rates from P. falciparum malaria among African children. Our data support further clinical trials of CRDS...