Engineered heart tissue: a novel tool to study the ischemic changes of the heart in vitroRajesh G Katare
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan
PLoS ONE 5:e9275. 2010
..Here, we demonstrate a novel function for the spontaneously contracting EHT as an experimental model in studying the acute ischemia-induced changes in vitro...
- Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway
Rajesh G Katare
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
J Mol Cell Cardiol 46:405-12. 2009
..Chronic intermittent fasting markedly improves the long-term survival after CHF by activation through its pro-angiogenic, anti-apoptotic and anti-remodeling effects...
- Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes
Yanan Zhang
Department of Clinical Laboratory, Kochi Medical School, Japan
J Pharmacol Sci 101:214-22. 2006
..These results suggest that ACh is responsible for restoring the decrease in the Cx43 protein level, resulting in functional activation of gap junctions...
- New device for intraoperative graft assessment: HyperEye charge-coupled device camera system
Takemi Handa
Department of Surgery 2, Kochi Medical School, Nankoku, Kochi, 783 8505, Japan
Gen Thorac Cardiovasc Surg 58:68-77. 2010
..e., HyperEye technology), which can detect simultaneously color and near-infrared (NIR) rays from 380 to 1200 nm. Here, we demonstrate intraoperative graft assessment using the HyperEye system...
- Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury
Rajesh G Katare
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan
J Mol Cell Cardiol 49:234-44. 2010
..VS and ACh protects the heart against acute ischemia or hypoxic injury by differentially regulating the TNF receptor subtypes...
- Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin
Masanori Kuwabara
Department of Medicine and Geriatrics, Kochi Medical School, Nankoku, Japan
FEBS Lett 581:4821-30. 2007
..Consequently, G-CSF suppressed ventricular arrhythmia induced by myocardial infarction. As a result, G-CSF could be used as a therapeutic tool for arrhythmia...
- Nitric oxide stimulates vascular endothelial growth factor production in cardiomyocytes involved in angiogenesis
Masanori Kuwabara
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan
J Physiol Sci 56:95-101. 2006
..001, n = 5) and accelerated angiogenesis. CONCLUSION: Our results suggest that cardiomyocytes produce VEGF through a nonhypoxic HIF-1alpha induction pathway activated by NO, resulting in angiogenesis...
- Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice
Takemi Handa
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan
J Card Fail 15:805-11. 2009
....
- Efferent vagal nerve stimulation protects heart against ischemia-induced arrhythmias by preserving connexin43 protein
Motonori Ando
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
Circulation 112:164-70. 2005
..Vagal nerve stimulation has been postulated to contribute to the antifibrillatory effect. Here, we suggest a novel mechanism for the antiarrhythmogenic properties of vagal stimulation during acute MI...
- Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect
Rajesh G Katare
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi, Japan
J Thorac Cardiovasc Surg 137:223-31. 2009
..Here we demonstrate a novel therapeutic strategy against ischemia-reperfusion injury: vagally mediated prevention of reperfusion-induced opening of mitochondrial permeability transition pore...
- Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model
Yoshihiko Kakinuma
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
J Mol Cell Cardiol 48:680-93. 2010
..The present study concludes that donepezil can act as a therapeutic tool to accelerate angiogenesis in cardiovascular disease patients...
- A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function
Yoshihiko Kakinuma
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan
FEBS Lett 582:332-40. 2008
..These findings suggest that AI is involved in suppressing mitochondrial function, thereby leading to cellular stress eradication and consequently to protection during hypoxia...
- Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha
Yoshihiko Kakinuma
Department of Cardiovascular Control, Kochi Medical School, Nankoku 783 8505, Japan
FEBS Lett 579:2111-8. 2005
..In acute myocardial ischemia, vagal nerve stimulation increased HIF-1alpha expression and reduced the infarct size. These results suggest that ACh and vagal stimulation protect cardiomyocytes through the PI3K/Akt/HIF-1alpha pathway...
- Preliminary experience for the evaluation of the intraoperative graft patency with real color charge-coupled device camera system: an advanced device for simultaneous capturing of color and near-infrared images during coronary artery bypass graft
Takemi Handa
Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
Interact Cardiovasc Thorac Surg 9:150-4. 2009
..Our findings show that this device may become a standard intraoperative graft and perfusion assessment tool in coronary artery bypass graft (CABG)...
