APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremiaXia Jin
Department of Medicine, University of Rochester, NY 14682, USA
J Virol 79:11513-6. 2005
..00012) in these patients. Furthermore, we discovered that the order of hA3G mRNA levels is LTNPs > HIV-uninfected subjects > progressors...
- APOBEC3G levels predict rates of progression to AIDS
Xia Jin
Departments of Medicine, University of Rochester, Rochester, New York 14642, USA
Retrovirology 4:20. 2007
..These conflicting results indicate that a more comprehensive, conclusive investigation of hA3G expression levels in various patient cohorts is urgently needed...
- Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
Jie Yu
Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
J Med Virol 78:1147-57. 2006
..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
- Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells
Zhihua Kou
Department of Medicine, Infectious Diseases Division, University of Rochester, Rochester, New York 14642, USA
J Med Virol 80:134-46. 2008
..They also demonstrate that using modern experimental technology, DV infection, and neutralization and enhancement of DV infection can be easily assessed simultaneously in multiple cell types...
- Dengue virus neutralization is modulated by IgG antibody subclass and Fcgamma receptor subtype
W W Shanaka I Rodrigo
Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA
Virology 394:175-82. 2009
..Thus, the IgG antibody subclass profile generated by DENV infection or vaccination may independently influence the magnitude of the neutralizing response...
- Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro
Shanley Blackley
Department of Biology, University of Rochester, Rochester, New York 14642, USA
J Virol 81:13325-34. 2007
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- Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection
Maria T Arévalo
Department of Microbiology and Immunology, University of Rochester, New York 14642, USA
J Med Virol 81:519-28. 2009
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- An automated Dengue virus microneutralization plaque assay performed in human Fc{gamma} receptor-expressing CV-1 cells
W W Shanaka I Rodrigo
Departments of Pathology and Laboratory Medicine, Microbiology and Immunology, and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Trop Med Hyg 80:61-5. 2009
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- Statistical determination of threshold for cellular division in the CFSE-labeling assay
Dacheng Liu
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, NY 14642, USA
J Immunol Methods 312:126-36. 2006
..071% (95% confidence) and 0.114% (99% confidence) of total CFSE-labeled cells under our laboratory conditions. We offer our methods presented here for other investigators to calculate a threshold in their own CFSE-labeling experiments...
- A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in mice
Olivia K T Block
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Vaccine 28:8085-94. 2010
..Vaccine strategies directed to DENV-dIII-targeted neutralizing antibody production remain attractive but will likely require further modifications to induce safe, protective immunity...
- Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes
Zhihua Kou
Department of Medicine, University of Rochester, Rochester, NY 14642, USA
Virology 410:240-7. 2011
..These results demonstrate that the regulation of virus production in ADE infection of primary human monocytes is more complex than previously appreciated...
- Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture
Carrie Dykes
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Clin Microbiol 44:1930-43. 2006
..This flow cytometry-based growth competition assay offers advantages over current assays for HIV replication efficiency and should prove useful for the evaluation of patient samples in clinical trials...
- Dengue vaccine development and dengue viral neutralization and enhancement assays
Xia Jin
Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Antivir Ther 14:739-49. 2009
..We conclude that modification of current neutralization assays is required to improve the correlation between neutralization end point determinations and protection against secondary heterotypic dengue infections...
- The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children
Mary T Caserta
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Brain Behav Immun 22:933-40. 2008
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- HIV vaccine could use a little help
Jiong Wang
Department of Medicine, University of Rochester, Rochester, NY, USA
Hum Vaccin 6:476-81. 2010
..In the paper, we focus on reviewing the importance of CD4+ T helper cells and past experience of HIV vaccine clinical trials, as well as making some projections on the future development in HIV vaccine research field...
- Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32)
W W Shanaka I Rodrigo
Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Crittenden Avenue, Rochester, NY 14642, USA
J Virol 80:10128-38. 2006
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- Human immunodeficiency virus type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypes
Xia Jin
Infectious Disease Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
J Virol 76:12603-10. 2002
..05). The data are consistent with the hypothesis that higher levels of virus-specific CTL contribute to protection against HIV disease progression in infected individuals with B*35-PY, but not in those with B*35-Px...
- Establishment of an alternative intracellular cytokine staining assay for HIV/AIDS clinical studies
Huiyuan Chen
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, NY 14642, USA
J Virol Methods 123:131-40. 2005
..The results suggest that this ICS assay format is sensitive and specific, and is amenable to standardization for screening for HIV-specific CD8+ T cells in clinical trials...
- Virological and immunological outcomes in HIV-1-infected Chinese patients treated with a combination of Efavirenz and Indinavir for 48 weeks
Li Li
National Center for AIDS Prevention and Control, Beijing 100050, China
Chin Med J (Engl) 117:347-52. 2004
..CONCLUSIONS: The combination of Efavirenz and Indinavir was generally well tolerated and efficient at reducing HIV-1 RNA. Furthermore, the treatment improved the immunological function...
- Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination
Martin Markowitz
Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York 10016, USA
J Infect Dis 186:634-43. 2002
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- HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses
Jennifer E Snyder-Cappione
David H. Smith Center for Vaccine Biology and Immunology, and Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
J Immunol 176:2662-8. 2006
..Analysis of the frequency of directly cytotoxic HIV-specific T cells may be of considerable value in the assessment of disease progression and the potential efficacy of HIV vaccines...
- Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
Rongzhen Zhang
University of California, San Francisco, San Francisco General Hospital, 995 Potrero Avenue, Building 80, Ward 84, Box 0874, San Francisco, CA 94110, USA
J Neuroimmunol 159:215-24. 2005
..These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS...
- Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapy
Xia Jin
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 1st Avenue, 7th Floor, New York, NY 10016, USA
J Virol 76:2206-16. 2002
..In summary, vaccination with vCP1452 and recombinant gp160 appears safe and immunogenic in newly HIV-1-infected patients on HAART...
