Research Topics
Genomes and Genes | Toshiya FunabashiSummaryAffiliation: Yokohama City University Country: Japan Publications
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Publications
Changes in neurotensin mRNA by estrogen in the female rat preoptic area during aging: an in situ hybridization histochemistry studyT Funabashi
Department of Physiology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
Gen Comp Endocrinol 112:364-71. 1998..Indeed, there is evidence of an increased responsiveness to estrogen with age...- Sex differences in the responses of orexin neurons in the lateral hypothalamic area and feeding behavior to fastingToshiya Funabashi
Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Neurosci Lett 463:31-4. 2009..We speculate that the demonstrated sex differences in the response of orexin neurons to fasting reflect the vulnerability of feeding mechanisms in females... - p-Nonylphenol, 4-tert-octylphenol and bisphenol A increase the expression of progesterone receptor mRNA in the frontal cortex of adult ovariectomized ratsT Funabashi
Neuroendocrinology, Yokohama City University Graduate School of Medicine, Fukuura, Yokohama, Japan
J Neuroendocrinol 16:99-104. 2004..These results suggest that, even in adult rats, endocrine disrupters alter the neocortical function by affecting the PR system, although the physiological significance of PR in the affected area is unknown... - Exposure to bisphenol A during gestation and lactation causes loss of sex difference in corticotropin-releasing hormone-immunoreactive neurons in the bed nucleus of the stria terminalis of ratsToshiya Funabashi
Department of Physiology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Psychoneuroendocrinology 29:475-85. 2004..We suggest that CRH neurons in the BST are more susceptible to endocrine disrupters than those in the POA, irrespective of the sex... - Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized ratsT Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
J Neuroendocrinol 15:134-40. 2003..The present study suggests that BPA influences reproductive functions, including sexual behaviour even in adulthood, by altering the PR system in the hypothalamus... - Gonadotropin-releasing hormone (GnRH) surge generator in female ratsToshiya Funabashi
Department of Physiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
Prog Brain Res 141:165-73. 2002 - Age- and sex-specific changes in naloxone-induced luteinizing hormone secretion and Fos expression in gonadotropin-releasing hormone neurons of gonadectomized ratsToahiya Funabashi
Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Neurosci Lett 471:157-61. 2010..These results suggest LH secretion is impaired with age, but the ability of GnRH neurons to be stimulated by naloxone is preserved. However, the opioid-controlling mechanism is more fragile in females than males during aging... - The endocrine disrupters butyl benzyl phthalate and bisphenol A increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized ratsT Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
Neuroendocrinology 74:77-81. 2001..No significant effect of E(2), BPA, or BBP on NT mRNA in the POA was detected. The present study demonstrates that the two endocrine disrupters BPA and BBP can increase the expression of PR mRNA in the POA of adult ovariectomized rats... - Intracerebroventricular injection of arginine-vasopressin V1 receptor antagonist attenuates the surge of luteinizing hormone and prolactin secretion in proestrous ratsT Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
Neurosci Lett 260:37-40. 1999..The present study provides evidence supporting our hypothesis that endogenous AVP plays a role in the induction of the surge of LH and PRL secretion as a stimulatory factor... - Changes in estrogenic regulation of estrogen receptor alpha mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization studyT Funabashi
Laboratory of Neurobiology and Behavior, Rockefeller University, New York, NY 10021, USA
Neurosci Res 38:85-92. 2000..The present study revealed that the induction of PR mRNA by estrogen in the hypothalamus was not impaired with age but ER alpha mRNA in the VMH and ARC was significantly impaired with age, but not in the POA... - Gonadotropin-releasing hormone exhibits circadian rhythm in phase with arginine-vasopressin in co-cultures of the female rat preoptic area and suprachiasmatic nucleusT Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
J Neuroendocrinol 12:521-8. 2000..We suggest that arginine-vasopressin neurones in the suprachiasmatic nucleus mediate the clock information to GnRH neurones in vivo as well... - Pulsatile gonadotropin-releasing hormone (GnRH) secretion is an inherent function of GnRH neurons, as revealed by the culture of medial olfactory placode obtained from embryonic ratsT Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
Neuroendocrinology 71:138-44. 2000..3 +/- 1.0 min for the NAP+forebrain vesicle culture and 36.0 +/- 6.3 min for the NAP+hypothalamus culture) as those in cultures without brain tissues. It is concluded that pulsatile GnRH release is an inherent function of GnRH neurons... - Estrogen increases arginine-vasopressin V1a receptor mRNA in the preoptic area of young but not of middle-aged female ratsT Funabashi
Department of Physiology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Japan
Neurosci Lett 285:205-8. 2000..However, this regulation by estrogen was lost in middle-aged rats, indicating an age-related impairment in the regulation of AVP V1a receptor mRNA by estrogen in the POA... - Sex difference in the response of melanin-concentrating hormone neurons in the lateral hypothalamic area to glucose, as revealed by the expression of phosphorylated cyclic adenosine 3',5'-monophosphate response element-binding proteinKazutaka Mogi
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Endocrinology 146:3325-33. 2005..The demonstrated sex differences in the response of MCH neurons to glucose correlated well with the gonadal steroid milieu; thus, MCH neurons may play an important role in sex differences in feeding behavior... - Nicotine inhibition of pulsatile GnRH secretion is mediated by GABAA receptor system in the cultured rat embryonic olfactory placodeFukuko Kimura
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Psychoneuroendocrinology 29:749-56. 2004..These results suggest that, in the cultured embryonic olfactory placode, nicotine stimulates GABA release, which then inhibits GnRH release through GABA(A) receptor system... - Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus: simultaneous measurements of the extracellular acetylcholine and serum corticosterone levels in the same subjectsDai Mitsushima
Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Endocrinology 149:802-11. 2008.... - Postpubertal feeding experience affects sex-specific spatial ability in ratsKenkichi Takase
Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura Kanazawa ku, Yokohama 236 0004, Japan
Physiol Behav 93:553-9. 2008..These results suggest that feeding conditions after 6 weeks of age may contribute to the sex difference in the spatial ability associated with the changes in the amount of ACh released in the dorsal hippocampus in rats... - Gonadal steroids maintain 24 h acetylcholine release in the hippocampus: organizational and activational effects in behaving ratsDai Mitsushima
Department of Physiology, Yokohama City University Graduate School of Medicine, 236 0004 Yokohama, Japan
J Neurosci 29:3808-15. 2009.... - The cAMP response element-binding protein in the bed nucleus of the stria terminalis modulates the formalin-induced pain behavior in the female ratHiroko Hagiwara
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
Eur J Neurosci 30:2379-86. 2009..These results suggest a novel role for CREB in the BSTLD as a modulator of the pain response in a female-specific, estrogen-dependent manner... - Food availability affects orexin a/ hypocretin-1-induced inhibition of pulsatile luteinizing hormone secretion in female ratsMiyako Furuta
Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Neuroendocrinology 91:41-7. 2010..Furthermore, glucose as well as food may act as a satiety factor in gonadotropin-releasing hormone pulse generation... - Effects of p-nonylphenol and 4-tert-octylphenol on the anterior pituitary functions in adult ovariectomized ratsMiyako Furuta
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Neuroendocrinology 84:14-20. 2006..The present study suggests that NP, even with a single injection, suppresses the pulsatile LH secretion in adult ovariectomized rats, probably by affecting the anterior pituitary level... - Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving ratsKenkichi Takase
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura Kanazawa ku, Yokohama 236 0004, Japan
Brain Res 1154:105-15. 2007..The present study is the first to report the sex difference in the 24-h profile of ACh release in the rFr2 in rats. The sex specific ACh release in the rFr2 may partly contribute to the sex difference in motor function in rats... - Bisphenol A induces transforming growth factor-beta3 mRNA in the preoptic area: a cDNA expression array and Northern blot studyAtsushi Fukushima
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
Neurosci Lett 411:81-5. 2007..The results suggest that, in the adult female rat, BPA acts on the MPOA by altering the expression of the TGF-beta3 gene in a manner distinct from that of estrogen... - Effects of GABA and bicuculline on the electrical activity of rat olfactory placode neurons derived at E13.5 and cultured for 1 week on multi-electrode dishesKumiko Suyama
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, Japan
Endocr J 51:171-6. 2004..1). These results suggest that cultured olfactory placode neurons, even in a probably immature stage, respond to GABA with inhibition, as generally observed at mature stages... - Formalin-induced nociceptive behavior and c-Fos expression in middle-aged female ratsHiroko Hagiwara
Department of Physiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Physiol Behav 100:101-4. 2010.... - Progesterone receptor immunoreactivity in the brains of ovariectomized aged ratsMiyako Furuta
Department of Physiology, St Marianna University School of Medicine, Miyamae ku, Kawasaki, Japan
Neuroreport 21:777-81. 2010..Therefore, the ability of estrogen to induce PR immunoreactivity in the hypothalamus in ovariectomized rats is attenuated in old rats compared with young rats... - Suppressive action of orexin A on pulsatile luteinizing hormone secretion is potentiated by a low dose of estrogen in ovariectomized ratsMiyako Furuta
Department of Physiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 Japan
Neuroendocrinology 75:151-7. 2002..In view of the finding that a much higher dose of orexin A suppresses pulsatile LH secretion in OVX rats not treated with E(2), we suggest that the suppressive action of orexin A on pulsatile LH secretion is potentiated by estrogen... - Sex differences in the basolateral amygdala: the extracellular levels of serotonin and dopamine, and their responses to restraint stress in ratsDai Mitsushima
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura Kanazawaku, Yokohama 236-0004, Japan
Eur J Neurosci 24:3245-54. 2006..We found sex differences in the extracellular levels of 5HT and DA in the BLA and their responses to restraint stress, which may be involved in the sex-specific emotional response to stress in rats... - Intracerebroventricular injection of corticotropin-releasing hormone receptor antagonist blocks the suppression of pulsatile luteinizing hormone secretion induced by neuromedin U in ovariectomized rats after 48 hours of fastingHong Quan
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
Neurosci Lett 369:33-8. 2004..The present study suggests that synergistic inhibitory effect of NMU and fasting on the pulsatile LH secretion is at least in part mediated via CRH neurons... - Nicotine inhibits pulsatile luteinizing hormone secretion in human males but not in human females, and tolerance to this nicotine effect is lost within one week of quitting smokingToshiya Funabashi
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawaku, Yokohama 236-0004, Japan
J Clin Endocrinol Metab 90:3908-13. 2005..However, we cannot deny the possibility that nicotine effect would have been detected in females if more subjects had been studied... - Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in ratsHiroko Hagiwara
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Japan
Neurosci Lett 412:264-7. 2007..Alternatively, sexual differentiation of the brain response to formalin-induced nociceptive behavior may be different from ordinary sexual differentiation... - Role of gamma-aminobutyric acid neurons in the release of gonadotropin-releasing hormone in cultured rat embryonic olfactory placodesToshiya Funabashi
Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan
Neuroendocrinology 76:193-202. 2002..Although it is speculative, these latter GnRH neurons may be responsible for the surge of GnRH release... - Estrogen increases messenger RNA and immunoreactivity of aryl-hydrocarbon receptor nuclear translocator 2 in the rat mediobasal hypothalamusDai Mitsushima
Department of Neuroendocrinology, Yokohama City University, Graduate School of Medical Sciences, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
Biochem Biophys Res Commun 307:248-53. 2003..These observations suggest that estrogen regulates Arnt2 expression in the mediobasal hypothalamus and modulates the toxic action of dioxins in rats... - Feeding with powdered diet after weaning increases visuospatial ability in association with increases in the expression of N-methyl-D-aspartate receptors in the hippocampus of female ratsKenkichi Takase
Department of Neuroendocrinology, Yokohama City University, Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
Neurosci Res 53:169-75. 2005..We suggest that the sex difference in visuospatial ability is at least in part due to feeding conditions... - Effects of neuromedin U on the pulsatile LH secretion in ovariectomized rats in association with feeding conditionsHong Quan
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
Biochem Biophys Res Commun 311:721-7. 2003..We suggest that NMU and fasting synergistically inhibit the pulsatile LH secretion, even though NMU has been said to act as a satiety factor... - GnRH antagonist-induced down-regulation of the mRNA expression of pituitary receptors: comparisons with GnRH agonist effectsMariko Murase
Department of Obstetrics and Gynecology, Yokohama City University Graduate School of Medicine, Fukuura, Yokohama, Japan
Endocr J 52:131-7. 2005..The findings in the present study support the hypothesis that the mechanism by which GnRHant leads to down-regulation of the mRNA expression of pituitary receptors is similar to that of GnRHa... - Role of corticotropin-releasing hormone in ovarian steroidogenesisMariko Murase
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Japan
Endocrine 18:255-60. 2002..These effects are attributed to cellular events downstream of cyclic adenosine monophosphate generation. CRH seems to modulate steroidogenesis via autocrine or paracrine actions in the ovary... - Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine releaseDai Mitsushima
Department of Physiology, Yokohama City University School of Medicine, 3 9 Fukuura Kanazawaku, Yokohama 236 0004, Japan
Psychoneuroendocrinology 28:574-83. 2003..Although cage size does not influence stress-induced secretion of corticosterone, rats housed in a small cage exhibit lower levels of stress-induced ACh release than rats living in a large cage... - [Mechanism for controlling gonadotropin secretion by the central nervous system]Toshiya Funabashi
ment of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
No To Shinkei 58:381-9. 2006 - Specific preservation of biosynthetic responses to insulin in adipose tissue may contribute to hyperleptinemia in insulin-resistant obese miceTooru M Mizuno
Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories and Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
J Nutr 134:1045-50. 2004..These studies demonstrate the utility of immediate-early gene expression in the analysis of biosynthetic mechanisms of insulin resistance... - [Strategies and methods for research on sex- and gender-differences in the rat and human brain]Fukuko Kimura-Tanaka
School of Nursing and Rehabilitation Sciences at Odawara, International University of Health and Welfare
Nihon Rinsho 65:1135-45. 2007.... - [Signals that regulate GnRH secretion]Toshiya Funabashi
Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine
Nippon Rinsho 64:18-23. 2006 - Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure- Tin-Tin-Win-Shwe
National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Appl Pharmacol 226:192-8. 2008..These findings suggest that nanoparticle CB may modulate the extracellular amino acid neurotransmitter levels and proinflammatory cytokine IL-1 beta mRNA expressions synergistically with LTA in the mice olfactory bulb... - Effects of tributyltin on the emotional behavior of C57BL/6 mice and the development of atopic dermatitis-like lesions in DS-Nh miceKaoru Ohtaki
Department of Environmental Immuno Dermatology, Yokohama City University, Graduate School of Medicine, Kanagawa, Japan
J Dermatol Sci 47:209-16. 2007..Tributyltin (TBT) compounds have been widely used as antifouling biocides on ships and are known to be endocrine disrupters. However, little is known about the influence of TBT on emotion and atopic dermatitis...