Shusaku Uchida

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Neuron 69:359-72. 2011
  2. ncbi Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Proc Natl Acad Sci U S A 108:1681-6. 2011
  3. ncbi Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi 755 8505, Japan
    J Neurosci 30:15007-18. 2010
  4. ncbi Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Neurosci 27:2250-61. 2008
  5. ncbi Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Res 1316:43-50. 2010
  6. ncbi Altered sirtuin deacetylase gene expression in patients with a mood disorder
    Naoko Abe
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 45:1106-12. 2011
  7. ncbi Altered gene expression of histone deacetylases in mood disorder patients
    Teruyuki Hobara
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University, Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 44:263-70. 2010
  8. ncbi Reduced expression of glyoxalase-1 mRNA in mood disorder patients
    Michiko Fujimoto
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Neurosci Lett 438:196-9. 2008
  9. ncbi Altered expression of neurotrophic factors in patients with major depression
    Koji Otsuki
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 42:1145-53. 2008
  10. ncbi Aberrant REST-mediated transcriptional regulation in major depressive disorder
    Koji Otsuki
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University, Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 44:378-84. 2010

Collaborators

Detail Information

Publications13

  1. ncbi Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Neuron 69:359-72. 2011
    ..Our data provide insights into these mechanisms, suggesting that epigenetic modifications of Gdnf, along with genetic and environmental factors, contribute to behavioral responses to stress...
  2. ncbi Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    Proc Natl Acad Sci U S A 108:1681-6. 2011
    ....
  3. ncbi Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi 755 8505, Japan
    J Neurosci 30:15007-18. 2010
    ..These results suggest that the activation of REST4-mediated gene regulation in the mPFC during postnatal development is involved in stress vulnerability...
  4. ncbi Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Neurosci 27:2250-61. 2008
    ....
  5. ncbi Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Brain Res 1316:43-50. 2010
    ..These results suggest that while genetic differences between SD and F344 strains account for some of the variations in stress vulnerability, maternal factors also contribute...
  6. ncbi Altered sirtuin deacetylase gene expression in patients with a mood disorder
    Naoko Abe
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 45:1106-12. 2011
    ..Thus, our data suggest that altered SIRT1, 2 and 6 expression is state-dependent and might be associated with the pathogenesis and/or pathophysiology of mood disorders...
  7. ncbi Altered gene expression of histone deacetylases in mood disorder patients
    Teruyuki Hobara
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University, Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 44:263-70. 2010
    ..Our data suggest that aberrant transcriptional regulation caused by the altered expression of HDACs is associated with the pathophysiology of mood disorders...
  8. ncbi Reduced expression of glyoxalase-1 mRNA in mood disorder patients
    Michiko Fujimoto
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Neurosci Lett 438:196-9. 2008
    ..These results suggest that the aberrant expression of Glo1 might be involved in the pathophysiology of mood disorders...
  9. ncbi Altered expression of neurotrophic factors in patients with major depression
    Koji Otsuki
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 42:1145-53. 2008
    ..Our results suggest that the changes in the expression levels of GDNF, ARTN, and NT-3 mRNAs might be state-dependent and associated with the pathophysiology of major depression...
  10. ncbi Aberrant REST-mediated transcriptional regulation in major depressive disorder
    Koji Otsuki
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University, Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Psychiatr Res 44:378-84. 2010
    ....
  11. ncbi State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders
    Yusuke Wakabayashi
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1199-205. 2008
    ..Our results suggest that the reciprocal alteration in the expression of NCAM-140 and L1 mRNAs could be state-dependent and associated with the pathophysiology of bipolar disorder...
  12. ncbi State-dependent changes in the expression of DNA methyltransferases in mood disorder patients
    Fumihiro Higuchi
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Minami Kogushi, Ube, Yamaguchi, Japan
    J Psychiatr Res 45:1295-300. 2011
    ....
  13. ncbi Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients
    Toshio Watanuki
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi 755 8505, Japan
    J Affect Disord 110:62-9. 2008
    ....