Toshiharu Hayashi

Summary

Affiliation: Yamaguchi University
Country: Japan

Publications

  1. ncbi Prevention of reovirus type 2-induced diabetes-like syndrome in DBA/1 suckling mice by treatment with antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Japan
    Int J Exp Pathol 76:403-9. 1995
  2. ncbi Destruction of salivary and lacrimal glands by Th1-polarized reaction in a model of secondary Sjögren's syndrome in lupus-prone female NZB?×?NZWF(1) mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Inflammation 35:638-46. 2012
  3. ncbi Enhanced contact hypersensitivity by delayed T-helper 2 response in BALB/c mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Allergy Asthma Proc 30:449-57. 2009
  4. ncbi Systemic administration of interleukin-4 expressing plasmid DNA delays the development of glomerulonephritis and prolongs survival in lupus-prone female NZB x NZW F1 mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1, Yoshida, Yamaguchi, 753 8515, Japan
    Nephrol Dial Transplant 22:3131-8. 2007
  5. ncbi Systemic treatment of anti-CD4CD25 T cell monoclonal antibody exacerbates sialoadenitis in submandibular glands during the early life in lupus-prone female NZB x NZWF mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Oral Pathol Med 38:234-40. 2009
  6. ncbi Acute urticaria[corrected]-like lesions in allergen-unexposed cutaneous tissues in a mouse model of late allergic rhinitis
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Int J Exp Pathol 89:188-200. 2008
  7. ncbi Ultrastructure of myoepithelial cells as a target cell in sialoadenitis of submandibular glands of lupus-prone female NZBxNZWF1 mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1, Yoshida, Yamaguchi, 753 8515, Japan
    Virchows Arch 453:177-88. 2008
  8. ncbi Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in BALB/c mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Inflammation 31:47-56. 2008
  9. ncbi Dysfunction of lacrimal and salivary glands in Sjögren's syndrome: nonimmunologic injury in preinflammatory phase and mouse model
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1, Yoshida, Yamaguchi 753 8515, Japan
    J Biomed Biotechnol 2011:407031. 2011
  10. ncbi Elimination of CD4+ CD25+ regulatory T cells breaks down reovirus type 2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Yoshida, Yamaguchi, Japan
    Scand J Immunol 63:116-24. 2006

Collaborators

Detail Information

Publications75

  1. ncbi Prevention of reovirus type 2-induced diabetes-like syndrome in DBA/1 suckling mice by treatment with antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Japan
    Int J Exp Pathol 76:403-9. 1995
    ..The role of ICAM-1 and LFA-1 molecules on the development of insulitis is discussed...
  2. ncbi Destruction of salivary and lacrimal glands by Th1-polarized reaction in a model of secondary Sjögren's syndrome in lupus-prone female NZB?×?NZWF(1) mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Inflammation 35:638-46. 2012
    ..The result suggests that the acini destruction in submandibular and lacrimal glands may be induced by systemic and local Th1 cell dominant reactions in lupus-prone B/WF(1) mice with sSjS...
  3. ncbi Enhanced contact hypersensitivity by delayed T-helper 2 response in BALB/c mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Allergy Asthma Proc 30:449-57. 2009
    ..Moreover, mast cell and IgE do not appear to be involved in delayed CHS...
  4. ncbi Systemic administration of interleukin-4 expressing plasmid DNA delays the development of glomerulonephritis and prolongs survival in lupus-prone female NZB x NZW F1 mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1, Yoshida, Yamaguchi, 753 8515, Japan
    Nephrol Dial Transplant 22:3131-8. 2007
    ..The present study examined the effects of administration of interleukin (IL)-4 (Th2 cytokine) expressing plasmid DNA (IL-4pDNA) on the development of glomerulonephritis and survival in lupus-prone female NZB x NZW (B/W)F1 mice...
  5. ncbi Systemic treatment of anti-CD4CD25 T cell monoclonal antibody exacerbates sialoadenitis in submandibular glands during the early life in lupus-prone female NZB x NZWF mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    J Oral Pathol Med 38:234-40. 2009
    ..The aim of the present study is to examine the effect of reduction of CD4(+)CD25(+) T cells on the development of sialoadenitis during the early life in female NZB x NZWF(1) (B/WF(1)) mice, a model for human sSS...
  6. ncbi Acute urticaria[corrected]-like lesions in allergen-unexposed cutaneous tissues in a mouse model of late allergic rhinitis
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Int J Exp Pathol 89:188-200. 2008
    ..This study suggests that acute urticaria[corrected]-like lesions in OVA-unexposed cutaneous tissues may be induced by immediate allergic reaction due to the systemic development of Th2-type response in a mouse model of LAR...
  7. ncbi Ultrastructure of myoepithelial cells as a target cell in sialoadenitis of submandibular glands of lupus-prone female NZBxNZWF1 mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1, Yoshida, Yamaguchi, 753 8515, Japan
    Virchows Arch 453:177-88. 2008
    ....
  8. ncbi Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in BALB/c mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Inflammation 31:47-56. 2008
    ..The present study suggests that the systemic administration of CpG ODN at the priming phase may reduce local OVA-specific Th2 responses, resulting in decreased nasal pathology in the late allergic eosinophilic rhinitis...
  9. ncbi Dysfunction of lacrimal and salivary glands in Sjögren's syndrome: nonimmunologic injury in preinflammatory phase and mouse model
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1, Yoshida, Yamaguchi 753 8515, Japan
    J Biomed Biotechnol 2011:407031. 2011
    ....
  10. ncbi Elimination of CD4+ CD25+ regulatory T cells breaks down reovirus type 2-triggered and CpG ODN-induced prolonged mild autoimmune insulitis in DBA/1 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Yoshida, Yamaguchi, Japan
    Scand J Immunol 63:116-24. 2006
    ..This system may give a novel model to elucidate the mechanisms of the development of overt diabetes from borderline subclinical diabetes in virus-triggered autoimmune type I diabetes in human...
  11. ncbi ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi 753 8515, Japan
    Histol Histopathol 20:45-52. 2005
    ....
  12. ncbi Elimination of CD4(+)CD25(+) T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB x NZW F mice
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    Int J Exp Pathol 86:289-96. 2005
    ..The present study results suggest that CD4(+)CD25+ T cells may, at least in part, downregulate the development of GN during the preactive phase in B/WF1 mice...
  13. ncbi Effect of antibodies to intercellular adhesion molecule (ICAM)-1 and lymphocyte function-associated antigen (LFA)-1 on cytokine mRNA expression in reovirus type-2-triggered autoimmune insulitis in suckling DBA/1 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Japan
    J Comp Pathol 128:283-8. 2003
    ..The present study suggests that ICAM-1/LFA-1 may be required for the differentiation of Th0 cells to Th1 cells, which mediate insulitis with IGT in Reo-2-infected suckling mice...
  14. ncbi Plasmid encoding interferon-gamma exacerbates reovirus type-2-induced diabetes in DBA/1 suckling mice
    K Hasegawa
    Laboratories of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, 753-8515, Japan
    J Comp Pathol 127:203-7. 2002
    ..These results suggested that the IFN-gamma-encoding plasmid promoted autoimmune insulitis in Reo-2-induced diabetes...
  15. ncbi Systemic administration of histamine reduces reovirus type 2-induced insulitis in suckling DBA/1 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Yamaguchi 753 8515, Japan
    J Comp Pathol 126:153-60. 2002
    ..In addition, histamine treatment increased cyclic adenosine monophosphate (cAMP) concentrations in the plasma. These results further suggest that the insulitis seen in Reo-2 infection in suckling mice is induced by an immune reaction...
  16. ncbi Interferon-gamma plays a role in pancreatic islet-cell destruction of reovirus type 2-induced diabetes-like syndrome in DBA/1 suckling mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Japan
    Int J Exp Pathol 79:313-20. 1998
    ..These results suggest that Reo-2-triggered autoimmune insulitis may be mediated by Th1 lymphocytes and IFN-gamma may play a role in islet inflammation leading to islet cell destruction...
  17. ncbi Effects of tacrolimus (FK506) on encephalomyocarditic virus-induced diabetes in mice
    Sachiko Yama
    Faculty of Agriculture, The University of Tokyo, Japan
    Microbiol Immunol 48:7-13. 2004
    ..The results suggest that tacrolimus suppresses expressions of TNF-alpha and IFN-gamma mRNAs to prevent the onset of D-EMCV-induced IDDM...
  18. ncbi Lactic dehydrogenase virus infection enhances parasite egg production and inhibits eosinophil and mast cell responses in mice infected with the nematode Nippostrongylus brasiliensis
    M Morimoto
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan
    Immunology 93:540-5. 1998
    ..brasiliensis infection. These results suggest that LDV infection modulates protective immune responses against N. brasiliensis infection by the activation of T-helper type 1 cells...
  19. ncbi Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog
    Takuya Mizuno
    Laboratory of Veterinary Internal Medicine, Yamaguci University, Yamaguchi, Japan
    Vet Dermatol 20:72-9. 2009
    ..Immunohistochemical analysis of the neoplastic cells revealed that the tumour was a glucagonoma, consistent with earlier findings of persistent glucagonaemia and hypoaminoacidaemia...
  20. ncbi Role of interleukin-2 in pancreatic islet-cell destruction in reovirus type 2-infected DBA/1 suckling mice
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yoshida, Yamaguchi, 753 8515, Japan
    J Comp Pathol 120:313-20. 1999
    ..These results suggest that IL-2 may participate in pancreatic islet-cell destruction in Reo-2-induced diabetes-like syndrome...
  21. ncbi Dimethylthiourea reduces pancreatic islet-cell damage in DBA/1 sucking mice with reovirus type-2 infection
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Japan
    J Comp Pathol 117:329-38. 1997
    ..These results suggest that ROS play a role in the pathogenesis of Reo-2-induced diabetes-like syndrome...
  22. ncbi Lactate dehydrogenase-elevating virus infection at the sensitization and challenge phases reduces the development of delayed eosinophilic allergic rhinitis in BALB/c mice
    Y Sasaki
    Laboratory of Veterinary Pathology, Yamaguchi University, Yamaguchi, Japan
    Scand J Immunol 66:628-35. 2007
    ..These may be responsible for the reduction of the development of DAR by LDV infection...
  23. ncbi Bronchial lesions of the late asthmatic response in BALB/c and C57BL/6 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
    J Comp Pathol 125:208-13. 2001
    ....
  24. ncbi Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB x NZWF1 mice
    K Hasegawa
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    Lupus 12:838-45. 2003
    ..The present study suggests that CpG-ODN may enhance IL-6 production. The role of IL-6 in the development of GN will be discussed...
  25. ncbi Use of formalin-fixed paraffin-embedded tissue and single-strand conformation polymorphism analysis for polymerase chain reaction of antigen receptor rearrangements in dogs
    Naoki Kaneko
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 71:535-8. 2009
    ..These results show that PARR-FFPE is viable for tissues with an appropriate formalin fixation time and that application of FFPE and SSCP for PARR are useful for diagnosis and retrospective study of canine lymphoid neoplasia...
  26. ncbi Promotion of lupus in NZB x NZWF1 mice by plasmids encoding interferon (IFN)-gamma but not by those encoding interleukin (IL)-4
    K Hasegawa
    Laboratory of Veterinary Pathology, Yamaguchi University, Yoshida, Japan
    J Comp Pathol 127:1-6. 2002
    ..The findings clearly indicated that IFN-gamma but not IL-4 contributed to the development of lupus in the NZB x NZWF1 mice...
  27. ncbi Lactic dehydrogenase virus infection reduces the expulsion of the nematode Nippostrongylus brasiliensis
    M Morimoto
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1 1677 Yoshida, Yamaguchi 753 8515, Japan
    Parasitol Res 90:153-6. 2003
    ..These results suggest that LDV infection reduces the protective immune responses against N. brasiliensis infection by the suppression of IL-13 production...
  28. ncbi Lactic dehydrogenase virus infection inhibits allergic eosinophil reaction and IL-5 gene expression in vivo
    M Morimoto
    Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Int Arch Allergy Immunol 120:78-84. 1999
    ..The present results suggest, that suppression of IL-5 gene expression by LDV infection may not be mediated by a mutual inhibitory mechanism between Th1 and Th2 cells...
  29. ncbi Experimental infection of Japanese encephalitis virus in dogs
    Hiroshi Shimoda
    Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    J Vet Med Sci 73:1241-2. 2011
    ..Thus, since dogs live in close proximity to humans as companion animals, they are well suited for use as sentinels for surveying the human risk of JEV infection...
  30. ncbi Eosinophilic venulitis in the small intestines in a mouse model of late asthma
    Linh Kan Bui
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi, 753 8515, Japan
    Inflammation 34:499-508. 2011
    ..In addition, eosinophilic venulitis in small intestines may be subclinical enteric lesions...
  31. ncbi Ultrastructure of goblet-cell metaplasia from Clara cell in the allergic asthmatic airway inflammation in a mouse model of asthma in vivo
    Toshiharu Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, 753 8515 Yamaguchi, Japan
    Virchows Arch 444:66-73. 2004
    ..In addition, mucus was found in neither ciliated nor basal epithelium. The present study suggests that goblet-cell metaplasia in the bronchus and bronchiole of inflamed mucosa may be derived, at least in part, from Clara cells...
  32. ncbi Less sensitivity for late airway inflammation in males than females in BALB/c mice
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan
    Scand J Immunol 57:562-7. 2003
    ..Moreover the testosterone, at least in part, may be responsible for the decreased Th2 cell responses in males in vivo...
  33. ncbi Interleukin-4-expressing plasmid DNA inhibits reovirus type-2-triggered autoimmune insulitis in DBA/1 J suckling mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Yamaguchi, Japan
    Int J Exp Pathol 84:101-6. 2003
    ..The inhibitory effects of IL-4 on the development of insulitis with IGT and the advantages of pIL-4 as compared to rIL-4 in this model are discussed...
  34. ncbi CpG oligodeoxynucleotides accelerate reovirus type 2-triggered insulitis in DBA/1 suckling mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Yoshida, Yamaguchi 753 8515, Japan
    Int J Exp Pathol 83:217-23. 2002
    ..This evidence suggests that CpG ODN may contribute to accelerate Reo-2-induced autoimmune reaction against pancreatic islet cells via additional effects of Th1 cytokines especially IFN-gamma...
  35. ncbi Reduced streptozotocin-induced insulitis in CD-1 mice by treatment with anti-intercellular adhesion molecule-1 and anti-lymphocyte function associated antigen-1 monoclonal antibodies together with lactic dehydrogenase virus infection
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Japan
    Int J Exp Pathol 75:117-21. 1994
    ..The suppressive effect of LDV infection on the development of insulitis is discussed...
  36. ncbi Nematode infection in Alymphoplasia (aly) mice: worm species-dependent differential effect of defects of the gut-associated lymphatic tissue system
    M Morimoto
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Scand J Immunol 63:365-70. 2006
    ..These results suggested that the dependency of GALT in activation of Th2 responses against gastrointestinal nematodes was different depending on the species of nematode...
  37. ncbi Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Japan
    Brain Res 857:246-51. 2000
    ..Our results suggest that VPA can modulate immune responses in vitro. These findings raise the possibility that such modulation might occur with clinical use of VPA...
  38. ncbi Cerebrospinal fluid concentrations of alpha-melanocyte-stimulating hormone in bacterial and aseptic meningitis
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Japan
    Acta Paediatr 89:803-5. 2000
    ..CONCLUSION: CSF alpha-MSH is elevated in children with severe bacterial meningitis who had neurological sequelae...
  39. ncbi Elevated cerebrospinal fluid level of ciliary neurotrophic factor in acute disseminated encephalomyelitis
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, 755 8505, Yamaguchi, Japan
    J Neurol Sci 177:146-9. 2000
    ..Our results suggest that CNTF is part of the regulatory system for oligodendrocyte functions, such as remyelination, in ADEM...
  40. ncbi Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Antimicrob Agents Chemother 45:44-7. 2001
    ..These findings are consistent with the idea that clarithromycin suppresses the production of proinflammatory cytokines via inhibition of NF-kappaB activation...
  41. ncbi Possible involvement of IL-12 in reovirus type-2-induced diabetes in newborn DBA/1 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Yoshida, Yamaguchi 753 8515, Japan
    Scand J Immunol 53:572-8. 2001
    ..The present study suggested that Th1-dominant systemic immune responses, being responsible for the development of autoimmune insulitis, might be induced by IL-12-induced and IL-18-activated mechanisms...
  42. ncbi Involvement of CPI-17 downregulation in the dysmotility of the colon from dextran sodium sulphate-induced experimental colitis in a mouse model
    K Sato
    Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Neurogastroenterol Motil 19:504-14. 2007
    ..These results suggest that the suppression of carbachol-induced contraction in mice with colitis is attributable at least partially to the increased activity of myosin phosphatase following the downregulation of CPI-17...
  43. ncbi Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Naunyn Schmiedebergs Arch Pharmacol 364:558-61. 2001
    ..These findings are consistent with the idea that theophylline suppresses the production of proinflammatory cytokines via inhibition of NF-kappaB activation through protection of the IkappaBalpha protein...
  44. ncbi Lactic dehydrogenase virus (LDV) infection inhibits allergic eosinophil reaction in the airway
    M Morimoto
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Res Vet Sci 72:131-6. 2002
    ....
  45. ncbi Systemic administration of interferon-gamma-expressing plasmid reduces late allergic bronchitis in a mouse model of asthma
    T Hayashi
    Laboratories of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan
    Int J Exp Pathol 83:81-6. 2002
    ....
  46. ncbi Intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) contribute to the elimination of equine herpesvirus type 1 (EHV-1) from the lungs of intranasally infected BALB/c mice
    K Maeda
    Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi-city, Yamaguchi 753-8515, Japan
    J Comp Pathol 130:162-70. 2004
    ..It was concluded that ICAM-1 and LFA-1 contributed to the elimination of EHV-1 from the lung, and to recovery. These findings may be relevant to EHV-1 infection in the horse...
  47. ncbi Calreticulin expression in neoplastic versus normal dog mammary glands: a cDNA subtraction-based study
    Takumi Okawa
    Department of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan
    Res Vet Sci 92:80-91. 2012
    ..Furthermore, cCRT was molecularly cloned, and the amino acid sequence of cCRT was found to be very similar to those of other species. Further studies are required to elucidate additional roles of cCRT in canine MGT...
  48. ncbi Maxillofacial rhabdomyosarcoma in the canine maxillofacial area
    Munekazu Nakaichi
    Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 69:65-7. 2007
    ..All dogs died within two months of the first admission...
  49. ncbi Eimeria vermiformis infection reduces goblet cells by multiplication in the crypt cells of the small intestine of C57BL/6 mice
    Bui Khanh Linh
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi 753 8515, Japan
    Parasitol Res 104:789-94. 2009
    ..vermiformis was noted, and there was recovery of the villous epithelium along with regeneration of the crypt and goblet cells. The current study examined the reduction of goblet cells and their possible importance in eimerian infections...
  50. ncbi Relationship between sialoadenitis and periductal laminin expression in the submandibular salivary gland of NZBxNZWF(1) mice
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
    J Comp Pathol 125:110-6. 2001
    ..These results suggest that laminin expression is associated with the cellular infiltration of the submandibular salivary gland of NZBxNZWF(1) mice...
  51. ncbi Suppression of development of anti-nuclear antibody and glomerulonephritis in NZB x NZWF1 mice by persistent infection with lactic dehydrogenase virus: possible involvement of superoxide anion as a progressive effector
    T Hayashi
    Laboratory of Veterinary Pathology, University of Yamaguchi, Japan
    Int J Exp Pathol 74:553-60. 1993
    ....
  52. ncbi Effect of infection by lactic dehydrogenase virus on expression of intercellular adhesion molecule-1 on vascular endothelial cells of pancreatic islets in streptozotocin-induced insulitis of CD-1 mice
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Japan
    Int J Exp Pathol 75:211-7. 1994
    ..Also, decreased expression of ICAM-1 in the islets may be responsible for the inhibition of the development of insulitis seen in SZ-treated mice with LDV infection...
  53. ncbi Lactic dehydrogenase virus inhibits allergic immunoglobulin E production: in vivo molecular analysis of cytokines
    M Morimoto
    Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Scand J Immunol 50:211-4. 1999
    ....
  54. ncbi Reduction of serum interferon (IFN)-gamma concentration and lupus development in NZBxNZWF(1)mice by lactic dehydrogenase virus infection
    T Hayashi
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677 1 Yoshida, Yamaguchi, 753 8515, Japan
    J Comp Pathol 125:285-91. 2001
    ..These changes were inhibited in LDV-infected NZBxNZWF(1)mice. Our findings suggest that increase in serum IFN-gamma may be associated with the active disease in NZBxNZWF(1)mice...
  55. ncbi Expression of T helper 1 and T helper 2 cytokine mRNAs in freshly isolated peripheral blood mononuclear cells from dogs with atopic dermatitis
    S Hayashiya
    Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Yoshida, Japan
    J Vet Med A Physiol Pathol Clin Med 49:27-31. 2002
    ..These results suggest that there is a tendency for the PBMCs of atopic dogs to express a type 2 cytokine pattern that is similar to the pattern observed in human AD patients...
  56. ncbi Co-localization of chondromodulin-I (ChM-I) and bone morphogenetic protein-6 (BMP-6) in myoepithelial cells of canine mammary tumors
    Atsushi Kawabata
    Department of Pathogenetic and Preventive Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Japan
    J Vet Med Sci 67:1097-102. 2005
    ..Our results support the hypothesis that proliferating myoepithelial cells with ChM-I and BMP-6 expression play important roles in mesenchymal metaplasia in canine mammary tumors...
  57. ncbi Evaluation of cytokine messenger RNA expression in peripheral blood mononuclear cells from dogs with canine demodicosis
    Kenji Tani
    Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Japan
    J Vet Med Sci 64:513-8. 2002
    ..Also, increased TGF-beta mRNA expression might be a key factor for revealing the difference in the mechanism of onset between LD and GD...
  58. ncbi Clearance of LDH-5 from the circulation of inbred mice correlates with binding to macrophages
    T Hayashi
    Laboratory of Veterinary Pathology, Yamaguchi University, Japan
    Int J Exp Pathol 75:165-8. 1994
    ..The rate at which LDH-5 is cleared from the circulation correlates with the degree of binding to macrophages. These findings suggest that the binding of LDH-5 to macrophages may serve as an in-vitro index of enzyme clearance...
  59. ncbi Suppression of development of glomerulonephritis in NZB x NZWF1 mice by persistent infection with lactic dehydrogenase virus: relations between intercellular adhesion molecule-1 expression on endothelial cells and leucocyte accumulation in glomeruli
    Y Kameyama
    Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan
    Int J Exp Pathol 75:295-304. 1994
    ..Thus there may be a pathogenetic role for ICAM-1 expression and for intraglomerular accumulation of leucocytes, especially PMNs, which express LFA-1 in the development of GN...
  60. ncbi Decreased serum paraoxonase-1 activity during intestinal nematode (Nippostrongylus brasiliensis) infection in rats
    Ayman Samir Farid
    Veterinary Teaching Hospital and Parasitology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
    Am J Trop Med Hyg 78:770-6. 2008
    ..i. These cytokines are known to inhibit the synthesis of hepatic PON1 mRNA. Thus, the observed reduction in PON1 activity during N. brasiliensis infection is likely associated with inflammatory reactions mounted against the parasites...
  61. ncbi Detection of the anti-P53 antibodies in dogs with tumors
    Noriko Kanaya
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Japan
    J Vet Med Sci 64:973-9. 2002
    ..These results suggest that the anti-P53 antibodies are also produced in tumor dogs with p53 gene mutations...
  62. ncbi Interleukin-6 production by macrophages from BALB/c mice with a chronic infection of lactic dehydrogenase virus
    H Iwata
    Laboratory of Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University, Japan
    Jikken Dobutsu 43:559-62. 1994
    ....
  63. ncbi NF-kappaB activation in peripheral blood monocytes/macrophages and T cells during acute Kawasaki disease
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan
    Clin Immunol 99:373-7. 2001
    ..05). The present findings suggest that CD14+ monocytes/macrophages play an important role in cytokine production during acute KD...
  64. ncbi Enhanced clearance of lactic dehydrogenase-5 in severe combined immunodeficiency (SCID) mice: effect of lactic dehydrogenase virus on enzyme clearance
    T Hayashi
    Laboratory of Veterinary Pathology, University of Yamaguchi, Japan
    Int J Exp Pathol 73:173-81. 1992
    ..These results suggest that the smaller increase of plasma LDH after infection might be due, at least in part, to the enhanced LDH-5 clearance function by macrophages in SCID mice...
  65. ncbi Immunofluorescent antibody response to lactic dehydrogenase virus in different strains of mice
    T Hayashi
    Laboratory of Veterinary Pathology, University of Yamaguchi, Japan
    J Comp Pathol 107:179-83. 1992
    ..B-17 and ICR mice). SCID mice did not develop antibody. These results suggest that IIF may be applicable for detecting LDV infection in many other ordinary strains of mice...
  66. ncbi Detection of the binding of IgG2a and IgG2b on the surface of macrophages from mice chronically infected with lactic dehydrogenase virus
    T Hayashi
    Laboratory of Veterinary Pathology, University of Yamaguchi, Japan
    J Comp Pathol 107:35-40. 1992
    ..These results suggest that IC in the circulation may bind to Fc receptors for IgG2a and IgG2b on the surface of macrophages and lead to the modulation of macrophage function seen in chronically LDV-infected mice...
  67. ncbi Lactic dehydrogenase virus infection prevents development of anti-nuclear antibody in (NZB x NZW)F1 mice; role of prostaglandin E2 and macrophage Ia antigen expression
    T Hayashi
    Laboratory of Veterinary Pathology, University of Yamaguchi, Japan
    Int J Exp Pathol 73:593-601. 1992
    ....
  68. ncbi Effect of prostaglandin E2 on plasma lactic dehydrogenase activity in (NZB x NZW)F1 mice with a chronic infection of lactic dehydrogenase virus
    T Hayashi
    Laboratory of Veterinary Pathology, University of Yamaguchi, Japan
    J Comp Pathol 107:41-8. 1992
    ..The results suggest that enhanced clearance of LDH-5 in mice treated with PGE2 may account for the fall in plasma LDH in LDV-infected mice...
  69. ncbi Binding of asparaginase to mouse monocytes
    I Mori
    Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Yamaguchi, Japan
    Int J Exp Pathol 73:585-92. 1992
    ..Neither strain nor age differences affected the binding to monocytes. The results suggest that the ability of asparaginase to bind to monocytes in vitro may reflect clearance function in vivo...
  70. ncbi Antimicrobial susceptibility of Staphylococcus intermedius isolated from healthy and diseased dogs
    A Shimizu
    Department of Microbiology and Immunology, Faculty of Agriculture, Kobe University, Hyogo, Japan
    J Vet Med Sci 63:357-60. 2001
    ..intermedius. Thirty-three strains (36.7%) were resistant to one or more anitmicrobial agents such as OTC (n=32), KM (n=9), EM (n=7), AIV-TS (n=7), and LCM (n=7)...
  71. ncbi Immunohistochemical expression of Mdm2 and p53 in canine cutaneous mast cell tumours
    H Wu
    United Graduate School of Veterinary Sciences, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
    J Vet Med A Physiol Pathol Clin Med 53:65-8. 2006
    ..The results suggest that Mdm2 overexpression plays a crucial role in canine mast cell tumorigenesis and is consistent with the histologic grade, and its expression may be induced without p53 overexpression...
  72. ncbi Bovine posterior pituitary extract stimulates prolactin release from the anterior pituitary gland in vitro and in vivo in cattle
    T Hashizume
    Faculty of Agriculture, Iwate University, Ueda, Morioka, Japan
    Reprod Domest Anim 40:184-9. 2005
    ..The intra-hypothalamic infusion (arcuate nucleus) of 0.0625 eq./head of bPP extract strongly stimulated PRL release in calves (p < 0.05). The present results show that PP contains a physiologically potent PRF in cattle...
  73. ncbi Immunohistochemical expression of p27 and p21 in canine cutaneous mast cell tumors and histiocytomas
    H Wu
    Department of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
    Vet Pathol 41:296-9. 2004
    ....
  74. ncbi Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies
    Tomiko Kawakami
    Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Int J Mol Med 20:177-85. 2007
    ..Taken together, these results suggest that IA-2 beta undergoes at least three distinct proteolytic cleavages...
  75. ncbi Analysis of T-cell receptor Vbeta gene from infiltrating T cells in insulitis and myocarditis in encephalomyocarditis virus-infected BALB/C mice
    Aki Kawagishi
    Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Japan
    Biochem Biophys Res Commun 310:791-5. 2003
    ..This study suggests that mice infected with EMC virus are a useful animal model for autoimmune diseases such as insulin-dependent diabetes...