T Yamasoba

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Ebselen prevents noise-induced excitotoxicity and temporary threshold shift
    Tatsuya Yamasoba
    Department of Otolaryngology Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 380:234-8. 2005
  2. ncbi Transgene expression in mature guinea pig cochlear cells in vitro
    Tatsuya Yamasoba
    Department of Otolaryngology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 335:13-6. 2002
  3. ncbi Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss
    Tatsuya Yamasoba
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Tokyo 113 8665, Japan
    Hear Res 226:185-93. 2007
  4. ncbi Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo
    Tatsuya Yamasoba
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Cell Tissue Res 325:23-31. 2006
  5. ncbi Cochlear damage due to germanium-induced mitochondrial dysfunction in guinea pigs
    Tatsuya Yamasoba
    Department of Otolaryngology, Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 395:18-22. 2006
  6. ncbi Deafness associated with vertebrobasilar insufficiency
    T Yamasoba
    Department of Otolaryngology, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    J Neurol Sci 187:69-75. 2001
  7. ncbi Ototoxicity after use of neomycin eardrops is unrelated to A1555G point mutation in mitochondrial DNA
    Tatsuya Yamasoba
    Department of Otolaryngology, Head and Neck Surgery, University of Tokyo, and the Third Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    J Laryngol Otol 118:546-50. 2004
  8. ncbi Vestibular evoked myogenic potentials of children with inner ear malformations before and after cochlear implantation
    Yulian Jin
    National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Acta Otolaryngol 129:1198-205. 2009
  9. ncbi Use of cartilage plate as tympanic membrane in total middle ear reconstructive surgery for infected radicalized ear
    Shin-Ichi Ishimoto
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Japan
    Otol Neurotol 24:2-5. 2003
  10. ncbi A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo
    Akinori Kashio
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan
    J Neurosci Res 85:1403-12. 2007

Collaborators

Detail Information

Publications83

  1. ncbi Ebselen prevents noise-induced excitotoxicity and temporary threshold shift
    Tatsuya Yamasoba
    Department of Otolaryngology Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 380:234-8. 2005
    ..These findings suggest that scavenging peroxynitrite can attenuate noise-induced excitotoxicity and, thereby, TTS...
  2. ncbi Transgene expression in mature guinea pig cochlear cells in vitro
    Tatsuya Yamasoba
    Department of Otolaryngology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 335:13-6. 2002
    ..These findings indicate that adenovirus vectors can be transfected into mature guinea pig hair cells and supporting cells in culture...
  3. ncbi Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss
    Tatsuya Yamasoba
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Tokyo 113 8665, Japan
    Hear Res 226:185-93. 2007
    ..Together these findings indicate that decreased energy metabolism due to accumulation of mtDNA mutations/deletions and decline of respiratory chain function play an important role in the manifestation of AHL...
  4. ncbi Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo
    Tatsuya Yamasoba
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Cell Tissue Res 325:23-31. 2006
    ..These findings indicate that Deiters cells in the mature mammalian cochlea maintain a limited competence to re-enter the cell cycle and proliferate after hair cell injury, and that they can survive at least for 1 month...
  5. ncbi Cochlear damage due to germanium-induced mitochondrial dysfunction in guinea pigs
    Tatsuya Yamasoba
    Department of Otolaryngology, Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 395:18-22. 2006
    ..5% GeO(2) induces mitochondrial dysfunction in the stria vascularis and supporting cells in the cochlea, as in the skeletal muscles and kidney, thereby causing hearing impairment in the guinea pigs...
  6. ncbi Deafness associated with vertebrobasilar insufficiency
    T Yamasoba
    Department of Otolaryngology, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    J Neurol Sci 187:69-75. 2001
    ..These findings indicate that hearing loss occurs in approximately one-fifth of VBI patients, much less frequently than vestibular disturbances, and that deafness associated with VBI mainly involves the cochlea...
  7. ncbi Ototoxicity after use of neomycin eardrops is unrelated to A1555G point mutation in mitochondrial DNA
    Tatsuya Yamasoba
    Department of Otolaryngology, Head and Neck Surgery, University of Tokyo, and the Third Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    J Laryngol Otol 118:546-50. 2004
    ..This finding indicates that application of low concentration neomycin to the middle ear can cause severe inner ear damage even in humans who are not hyper-susceptible to aminoglycosides...
  8. ncbi Vestibular evoked myogenic potentials of children with inner ear malformations before and after cochlear implantation
    Yulian Jin
    National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Acta Otolaryngol 129:1198-205. 2009
    ....
  9. ncbi Use of cartilage plate as tympanic membrane in total middle ear reconstructive surgery for infected radicalized ear
    Shin-Ichi Ishimoto
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Japan
    Otol Neurotol 24:2-5. 2003
    ..The use of cartilage plates seems to be clinically appropriate, particularly for patients with severe infection who expect a trouble-free ear rather than hearing gain after surgery...
  10. ncbi A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo
    Akinori Kashio
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan
    J Neurosci Res 85:1403-12. 2007
    ..These findings indicate that systemically administered TAT-FNK was successfully delivered to the guinea pig cochlea and effectively prevented apoptotic cell death of the cochlear HCs induced by KM and EA...
  11. ncbi Vestibular evoked myogenic potentials evoked by multichannel cochlear implant - influence of C levels
    Yulian Jin
    Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Japan
    Acta Otolaryngol 128:284-90. 2008
    ..This study showed that vestibular evoked myogenic potentials (VEMPs) evoked by cochlear implant (CI), could be related to the comfortable level (C level), particularly in the channels that are closer to the apical turn of the cochlea...
  12. ncbi Dislocation of stapes with footplate fracture caused by indirect trauma
    Ryoji Kagoya
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Japan
    Ann Otol Rhinol Laryngol 119:628-30. 2010
    ....
  13. ncbi Assessment of total middle ear reconstruction by patient survey correlated with clinical findings
    Anting Xu
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Auris Nasus Larynx 30:15-20. 2003
    ..The hearing satisfaction scale is a useful instrument for assessing patient satisfaction following this surgical procedure...
  14. ncbi Cochlear implantation in a patient with atypical Cogan's syndrome complicated with hypertrophic cranial pachymeningitis
    Sayaka Kawamura
    Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    Auris Nasus Larynx 37:737-41. 2010
    ..The patient did not have any postoperative complications and showed good speech perception...
  15. ncbi Cochlear histopathology associated with mitochondrial transfer RNA(Leu(UUR)) gene mutation
    T Yamasoba
    Department of Otolaryngology, University of Tokyo, Japan
    Neurology 52:1705-7. 1999
    ..These findings suggest that the mutation affects these inner ear structures preferentially and that deafness can occur even when the proportion of np 3243 mutation is low...
  16. ncbi Cochlear damage caused by continuous and intermittent noise exposure
    Akram Pourbakht
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655, Tokyo, Japan
    Hear Res 178:70-8. 2003
    ..This indicates that continuous noise causes greater damage to the cochlea than intermittent noise of the same intensity and that, at the intensities tested, damage to the cochlea is not proportional to the total noise energy...
  17. ncbi Influence of chronic middle ear diseases on gustatory function: an electrogustometric study
    Masaki Sano
    Department of Otorhinolaryngology Head and Neck Surgery, Graduate School of Medicine, Faculty of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Otol Neurotol 28:44-7. 2007
    ..We aimed to quantitatively determine whether middle ear inflammation associated with unilateral chronic otitis media (COM), cholesteatoma, or otosclerosis affects gustatory function...
  18. ncbi New method of using reconstructed images for assessment of patency of intracochlear spaces for cochlear implant candidates
    Shotaro Karino
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Laryngoscope 114:1253-8. 2004
    ....
  19. ncbi Atypical muscle pathology and a survey of cis-mutations in deaf patients harboring a 1555 A-to-G point mutation in the mitochondrial ribosomal RNA gene
    Tatsuya Yamasoba
    Department of Otolaryngology, University of Tokyo, Tokyo, Japan
    Neuromuscul Disord 12:506-12. 2002
    ....
  20. ncbi Vestibulo-ocular reflex (VOR) preserved in bilateral severe vestibular malformations with internal auditory canal stenosis
    Mitsuya Suzuki
    Department of Otolaryngology, Tokyo Metropolitan Police Hospital, Tokyo, Japan
    Acta Otolaryngol 127:1226-30. 2007
    ..These findings suggest that VOR can be acquired even with severe malformation of the inner ear whose labyrinthine functions markedly reduce bilaterally until nystagmus is slightly induced by rotation stimulation...
  21. ncbi Results of hearing tests after total middle ear reconstruction
    Toru Sasaki
    Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655 Japan
    Acta Otolaryngol 127:474-9. 2007
    ..Total middle ear reconstruction (TMER) improves the hearing of these patients by correcting cavity problems and resolution of ear discharge, which facilitates ossicular chain reconstruction such as type III or type IV tympanoplasty...
  22. ncbi Time course of apoptotic cell death in guinea pig cochlea following intratympanic gentamicin application
    Mitsuya Suzuki
    Department of Otolaryngology Head and Neck Surgery, University of Tokyo, Tokyo, Japan
    Acta Otolaryngol 128:724-31. 2008
    ..The present study showed that the molecular signal that promotes the death of cochlear hair cells (HCs) induced by intratympanic gentamicin application is significant before the manifestation of morphological and functional changes...
  23. ncbi Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa: age-related progression
    Kenji Kondo
    Department of Otolaryngology, Head and Neck Surgery, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cell Tissue Res 335:489-503. 2009
    ..This information should prove useful in improving the understanding of the pathogenetic mechanisms underlying age-related changes in the peripheral olfactory system...
  24. ncbi Ocular vestibular-evoked myogenic potentials (oVEMPs) require extraocular muscles but not facial or cochlear nerve activity
    Yasuhiro Chihara
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, 113 8655 Tokyo, Japan
    Clin Neurophysiol 120:581-7. 2009
    ..The purpose of the present study was to clarify the origin of oVEMPs by examining these possibilities using clinical findings...
  25. ncbi Novel subtype of idiopathic bilateral vestibulopathy: bilateral absence of vestibular evoked myogenic potentials in the presence of normal caloric responses
    Chisato Fujimoto
    Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Neurol 256:1488-92. 2009
    ....
  26. ncbi Rotating computed tomographic movie for evaluating partially ossified cochlea
    Ken Ito
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Otol Neurotol 29:124-30. 2008
    ..To describe our newly devised method of viewing intracochlear ossification for the purpose of minimizing bone drilling during cochlear implantation for partially ossified cochleas and to evaluate its usefulness...
  27. ncbi Assessment of diagnostic accuracy of foam posturography for peripheral vestibular disorders: analysis of parameters related to visual and somatosensory dependence
    Chisato Fujimoto
    Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    Clin Neurophysiol 120:1408-14. 2009
    ..The purpose of this study was to assess the diagnostic accuracy of foam posturography for peripheral vestibulopathy, with emphasis on visual and somatosensory dependence...
  28. ncbi Endocytosis of microperoxidase in marginal cells is mainly regulated by RhoA signaling cascade, but not by Rho-associated protein kinase, myosin light-chain kinase and myosin phosphatase
    Akinobu Kakigi
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 73:1-8. 2011
    ..The main endocytotic pathway of MPO did not depend on the Rho-associated protein kinase molecular switch or actin/myosin motor system, but was mainly regulated by the RhoA signaling cascade...
  29. ncbi Endocytosis of MPO in marginal cells is regulated by PKC, protein phosphatase, ERK and PI3-K signaling cascades, but not by PKA and MEK signaling cascades
    Akinobu Kakigi
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 72:188-95. 2010
    ..MPO endocytosis was strongly dependent on PKC, ERK, PTP, PP1/2A and PI3-K signaling networks, but not on PKA and MEK signaling networks. The MPO endocytic pathways are clathrin-, GPI-AP-, and caveolae-independent...
  30. ncbi A spontaneous true aneurysm of the superficial temporal artery treated by surgical resection
    Takashi Sakamoto
    Department of Otolaryngology and Head and Neck Surgery, The University of Tokyo, Japan
    Auris Nasus Larynx 38:119-22. 2011
    ..Pathological examination showed that the mass was a true aneurysm. The literature is reviewed and the management of the STA aneurysm is discussed...
  31. ncbi Carhart notch 2-kHz bone conduction threshold dip: a nondefinitive predictor of stapes fixation in conductive hearing loss with normal tympanic membrane
    Akinori Kashio
    Department of Otolaryngology, Teikyo University School of Medicine, 2 11 1 Kaga Itabashi ku, Tokyo, Japan
    Arch Otolaryngol Head Neck Surg 137:236-40. 2011
    ..To evaluate the significance of the Carhart notch (a 2-kHz bone conduction threshold dip [2KBD]) in the diagnosis of stapes fixation by comparing its incidence among ears with various ossicular chain abnormalities...
  32. ncbi Age-related changes in cell dynamics of the postnatal mouse olfactory neuroepithelium: cell proliferation, neuronal differentiation, and cell death
    Kenji Kondo
    Department of Otolaryngology Head and Neck Surgery, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    J Comp Neurol 518:1962-75. 2010
    ..This observation suggests that the turnover of mature ORNs is slower in the older neuroepithelium compared to the younger neuroepithelium...
  33. ncbi Effects of unilateral dysfunction of the inferior vestibular nerve system on postural stability
    Chisato Fujimoto
    Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, Japan
    Clin Neurophysiol 121:1279-84. 2010
    ..To investigate whether disorders of the inferior vestibular nerve (IVN) system affect postural stability...
  34. ncbi Comparison of hearing improvement and complications after stapes surgery with and without potassium titanyl phosphate laser for manipulation of the foot plate
    Takashi Sakamoto
    Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan tsakamoto tky umin ac jp
    ORL J Otorhinolaryngol Relat Spec 72:16-21. 2010
    ....
  35. ncbi Metastases to the lingual nodes in tongue cancer: a pitfall in a conventional neck dissection
    Mizuo Ando
    Department of Otorhinolaryngology, School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Auris Nasus Larynx 37:386-9. 2010
    ....
  36. ncbi Ocular vestibular evoked myogenic potentials to bone-conducted vibration in vestibular schwannomas
    Shinichi Iwasaki
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Otol Neurotol 31:147-52. 2010
    ..Because it is unclear whether the oVEMPs to BCV primarily originate from activation of the superior or the inferior vestibular nerve, the results in patients with VS might enlighten us concerning the origin of oVEMPs to BCV...
  37. ncbi Frequency tuning properties of ocular vestibular evoked myogenic potentials
    Yasuhiro Chihara
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Neuroreport 20:1491-5. 2009
    ..The difference in the best frequencies between the two stimuli may originate from the difference in the end organs (saccule or utricle), preferentially activated by each stimulus...
  38. ncbi Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice
    Akinori Kashio
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 390:394-8. 2009
    ..These findings suggest that VC depletion can accelerate AHL but that supplementing VC may not increase VC level in the inner ear or slow AHL in mice...
  39. ncbi The firing properties of vestibular ganglion cells in heterozygous BDNF null mice
    Yasuhiro Chihara
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Neuroreport 20:1167-71. 2009
    ..These results suggest that brain-derived neurotrophic factor not only contributes to the survival of the VGCs but also affects their firing properties...
  40. ncbi Cortical activation shortly after cochlear implantation
    Ken Ito
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Audiol Neurootol 9:282-93. 2004
    ..The activation in the immediate association cortices near the primary area was lower in early CI users, while the periphery of the association cortex seemed to be more mobilized...
  41. ncbi Changes in cell proliferation in rat and guinea pig cochlea after aminoglycoside-induced damage
    Tatsuya Yamasoba
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, 113 8665, Tokyo, Japan
    Neurosci Lett 347:171-4. 2003
    ..These findings suggest that in the mature mammalian cochlea cell proliferation increases in nonsensory regions after ototoxic damage but may not occur in the auditory sensory epithelium...
  42. ncbi Traumatic luxation of the stapes into the vestibule
    Tatsuya Yamasoba
    Department of Otolaryngology, University of Tokyo, Tokyo, Japan
    Otolaryngol Head Neck Surg 129:287-90. 2003
  43. ncbi The role of the external auditory canal in the development of the malleal manubrium in humans
    Shin Ichi Ishimoto
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arch Otolaryngol Head Neck Surg 130:913-6. 2004
    ..To determine if the external auditory canal (EAC) plays a role in the induction and proper positioning of the malleal manubrium in humans...
  44. ncbi Are vestibular sensory cells preserved after destruction of Scarpa's ganglion? A study based on metastatic tumors of temporal bone
    Keigo Suzukawa
    Department of Otolaryngology, Hitachi General Hospital, Hitachi, Japan
    Otol Neurotol 26:1191-5. 2005
    ..The authors investigated this issue by observing vestibular end organs in the temporal bone of three patients in whom the internal auditory canal was infiltrated with tumor cells, and Scarpa's ganglion cells showed complete degeneration...
  45. ncbi Ebselen attenuates cochlear damage caused by acoustic trauma
    Akram Pourbakht
    Department of Otolaryngology, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8655 Tokyo, Japan
    Hear Res 181:100-8. 2003
    ..These findings indicate that ebselen attenuates noise-induced cochlear damage. The concentration that provides optimal protection against such damage has now to be determined...
  46. ncbi Aplasia of zygomatic arch and dislocation of temporomandibular joint capsule in Treacher-Collins syndrome: three-dimensional reconstruction of computed tomographic scans
    Kimitaka Kaga
    Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Pediatr Otorhinolaryngol 67:1189-94. 2003
    ....
  47. ncbi Surgical treatment of medial meatal fibrosis. Report of four cases
    Keigo Suzukawa
    Department of Otolaryngology Head and Neck Surgery, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8665, Japan
    Auris Nasus Larynx 34:365-8. 2007
    ..We describe four cases of medial meatal fibrosis, a rare condition of the external auditory canal, in which hearing improved following surgery...
  48. ncbi Correlation between microtia and temporal bone malformation evaluated using grading systems
    Shin Ichi Ishimoto
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arch Otolaryngol Head Neck Surg 131:326-9. 2005
    ..To evaluate the relationships between temporal bone abnormalities and the severity of microtia in Japanese patients using objective grading systems...
  49. ncbi Effect of noise exposure on blood-labyrinth barrier in guinea pigs
    Mitsuya Suzuki
    Department of Otolaryngology, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, 113 8655, Japan
    Hear Res 164:12-8. 2002
    ....
  50. ncbi Hearing levels in patients with microtia: correlation with temporal bone malformation
    Shin Ichi Ishimoto
    Department of Otolaryngology, Social Insurance Central General Hospital, Tokyo, Japan
    Laryngoscope 117:461-5. 2007
    ..To evaluate the relationship between hearing level and temporal bone abnormalities in patients with microtia...
  51. ncbi Adenoviral vector gene delivery via the round window membrane in guinea pigs
    Mitsuya Suzuki
    Department of Otolaryngology, Tokyo Metropolitan Police Hospital, Tokyo, Japan
    Neuroreport 14:1951-5. 2003
    ..In the vestibular labyrinth, expression was seen in the sensory and supporting cells, transitional cells, and the dark-cell area. Thus, adenovirus can transfect a variety of inner ear cells in the guinea pig through a damaged RWM...
  52. ncbi Comparison of Electroaudiometry with cochlear implant in children with inner ear anomaly
    T Takanami
    Department of Otolaryngology, University of Tokyo, Tokyo 113 8655, Japan
    Int J Pediatr Otorhinolaryngol 73:153-8. 2009
    ..It can provide useful information for a successful cochlear implant and evaluation of postoperative performances...
  53. ncbi Transfection of young guinea pig vestibular cells in vitro with an adenovirus vector
    M Suzuki
    Department of Otolaryngology, Tokyo Metropolitan Police Hospital, 2-10-41, Fujimi, Chiyoda-ku, Tokyo 102-0071, Japan
    Neuroreport 12:4013-7. 2001
    ..These findings suggest that adenovirus vectors can transform a variety of vestibular epithelial cells, but that it is difficult for adenovirus vectors to pass through the otoconial membrane...
  54. ncbi Latency variation of auditory N1m responses to vocal and nonvocal sounds
    Tomomi Mizuochi
    Department of aSensory and Motor Neuroscience, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neuroreport 18:1945-9. 2007
    ..This latency independence may be attributed to the relatively high power in the higher frequency spectrum...
  55. ncbi Involvement of CaV3.1 T-type calcium channels in cell proliferation in mouse preadipocytes
    Atsushi Oguri
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Am J Physiol Cell Physiol 298:C1414-23. 2010
    ..1 T-type Ca(2+) channel encoded by alpha(1G) subtype is the dominant Ca(V) in mouse preadipocytes and may play a role in regulating preadipocyte proliferation, a key step in adipose tissue development...
  56. ncbi Alteration of frequency range for binaural beats in acute low-tone hearing loss
    Shotaro Karino
    Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
    Audiol Neurootol 10:201-8. 2005
    ..The significant correlation between the hearing level at 250 Hz and FRNBs suggests that FRNBs represent the degree of cochlear damage caused by ALHL...
  57. ncbi Musashi-1 expression in postnatal mouse olfactory epithelium
    Kenta Watanabe
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Neuroreport 18:641-4. 2007
    ..These findings are consistent with the fact that globose basal cells are proliferating olfactory precursor cells and that their ability to generate new neurons decreases with aging...
  58. ncbi [Molecular mechanism of age-related hearing loss: toward its prevention]
    Tatsuya Yamasoba
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo
    Nihon Jibiinkoka Gakkai Kaiho 112:414-21. 2009
    ..Taken together, these findings suggest that accumulation of mtDNA mutations during aging leads to mitochondrial dysfunction and induces an apoptotic program, thereby causing AHL...
  59. ncbi Histopathological differences in bony destruction of malleus and incus following mastoidectomy
    T Sasaki
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    J Laryngol Otol 124:1162-6. 2010
    ..This study aimed to investigate this impression...
  60. ncbi The diagnostic value of vestibular-evoked myogenic potential in patients with vestibular schwannoma
    Munetaka Ushio
    Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Neurophysiol 120:1149-53. 2009
    ..This study examined the diagnostic value of the vestibular-evoked myogenic potential (VEMP) in comparison with the caloric test in patients with vestibular schwannoma (VS)...
  61. ncbi [Development of hearing, speech and language in congenitally deaf infants and children after cochlear implantation]
    Kimitaka Kaga
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Tokyo
    No To Hattatsu 39:335-45. 2007
    ..At the age of elementary school enrollment, most of their verbal IQ was considered to be the same as age-matched normal children. Cochlear implant is the most important treatment at present...
  62. ncbi Indication of the side of delayed endolymphatic hydrops by vestibular evoked myogenic potential and caloric test
    Naoya Egami
    Department of Otolaryngology, University of Tokyo, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 72:242-6. 2010
    ..This study aims to investigate the relationship between the results of vestibular evoked myogenic potential (VEMP) and caloric testing and the clinical type of DEH...
  63. ncbi Vestibular disturbance after myelography. Contrast media in the internal auditory canal
    M Mizuno
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 54:113-5. 1992
    ..Nystagmus towards the affected side and normal caloric responses were observed; therefore, contrast media are considered to act as irritants to the vestibular nerve...
  64. ncbi Recovery of facial movement and facial synkinesis in Bell's palsy patients
    Kaori Kanaya
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Otol Neurotol 30:640-4. 2009
    ..We examined the relationship between the time course of development of facial synkinesis in patients with Bell's palsy and the severity of facial nerve damage...
  65. ncbi Methimazole-induced cell death in rat olfactory receptor neurons occurs via apoptosis triggered through mitochondrial cytochrome c-mediated caspase-3 activation pathway
    Takashi Sakamoto
    Department of Otolaryngology, Mutual Aid Association for Tokyo Metropolitan Teachers and Officials, Sanraku Hospital, Tokyo, Japan
    J Neurosci Res 85:548-57. 2007
    ....
  66. ncbi Aberrant internal carotid artery protruding through a tympanic membrane perforation
    Masafumi Yoshida
    Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan
    Otolaryngol Head Neck Surg 136:679-80. 2007
  67. ncbi Effect of Burow's solution on the guinea pig inner ear
    Mitsuya Suzuki
    Department of Otolaryngology, University of Tokyo, Tokyo, Japan
    Ann Otol Rhinol Laryngol 119:495-500. 2010
    ..We examined the changes in the inner ear hair cells following intratympanic injection of Burow's solution...
  68. ncbi Etiology and one-year follow-up results of hearing loss identified by screening of newborn hearing in Japan
    Nodoka Adachi
    Division of Otolaryngology, Saitama Children s Medical Center, Tokyo, Japan
    Otolaryngol Head Neck Surg 143:97-100. 2010
    ..To evaluate the incidence of newborn hearing loss in a Japanese population and to elucidate etiological factors and one-year prognosis...
  69. ncbi From the Cover: Neurons in the anterior olfactory nucleus pars externa detect right or left localization of odor sources
    Shu Kikuta
    Departments of Otolaryngology and Physiology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 107:12363-8. 2010
    ..These results indicate that individual AONpE neurons can distinguish the right or left position of an odor source by referencing signals from the two nostrils...
  70. ncbi Modified nasal specula and flexible holder for endoscopic nasal surgery
    Munetaka Ushio
    Department of Otolaryngology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Laryngoscope 118:1293-4. 2008
    ..Our modified nasal specula are readily applicable to resolve the problems such as unstable endoscope and narrow working space in septal surgery under endoscopic view...
  71. ncbi Acquired atrophy of the long process of the incus
    Yutaka Imauchi
    Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Otolaryngol Head Neck Surg 132:156-8. 2005
    ....
  72. ncbi Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys
    Shinichi Someya
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    Curr Aging Sci 3:20-5. 2010
    ..Here, we review studies on CR's ability to prevent cochlear pathology and AHL in laboratory animals and discuss potential molecular mechanisms of CR's actions...
  73. ncbi The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma
    Shinichi Someya
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Neurobiol Aging 29:1080-92. 2008
    ....
  74. ncbi [Amynoglycoside-induced hearing loss]
    Tatsuya Yamasoba
    Department of Otolaryngology, Tokyo University Graduate School of Medicine
    Nippon Rinsho 60:332-6. 2002
  75. ncbi [Hearing loss]
    Tatsuya Yamasoba
    Department of Otolaryngology, Tokyo University Graduate School of Medicine
    Nippon Rinsho 60:530-4. 2002
  76. ncbi A glucocorticoid reduces adverse effects of adenovirus vectors in the cochlea
    Shin Ichi Ishimoto
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Mich 48109 0506, USA
    Audiol Neurootol 8:70-9. 2003
    ..These data demonstrate that immunosuppressive treatment can reduce the negative consequences of repeated adenovirus-mediated gene therapy...
  77. ncbi Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice
    Shinichi Someya
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA
    Brain Res 1182:26-33. 2007
    ..Thus, these observations provide evidence that AHL is associated with profound down-regulation of genes involved in the mitochondrial respiratory chain complexes in the cochlea of aged DBA/2J mice...
  78. ncbi Mechanisms of noise-induced hearing loss indicate multiple methods of prevention
    Colleen G Le Prell
    Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109 0506, USA
    Hear Res 226:22-43. 2007
    ..Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss...
  79. ncbi Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis
    Shinichi Someya
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Neurobiol Aging 28:1613-22. 2007
    ..Taken together, our findings suggest that loss of critical cells through apoptosis is an important mechanism of presbycusis in mammals, and that CR can retard this process by suppressing apoptosis in the inner ear tissue...
  80. ncbi Fibrous dysplasia of the temporal bone: assessment by three-dimensional helical CT imaging
    Shotaro Karino
    Otolaryngol Head Neck Surg 133:643. 2005
  81. ncbi A case of middle-ear myoepithelioma
    Miho Hagisawa
    Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Otolaryngol Head Neck Surg 135:967-8. 2006
  82. ncbi Cholesteatoma of the petrous bone: the crucial role of diffusion-weighted MRI
    Tsuyoshi Yoshida
    Eur Arch Otorhinolaryngol 262:440-1. 2005
  83. ncbi Cyclooxygenase-2 regulates the degree of apoptosis by modulating bcl-2 protein in pleomorphic adenoma and mucoepidermoid carcinoma of the parotid gland
    Takashi Sakamoto
    Department of Otorhinolaryngology, Mutual Aid Association for Tokyo Metropolitan Teachers and Officials, Sanraku Hospital, Tokyo, Japan
    Acta Otolaryngol 125:191-5. 2005
    ..These results suggest that COX-2 and bcl-2 protein were overexpressed and that apoptosis was reduced in MEC compared to PMA, and that COX-2 may regulate the degree of apoptosis by modulating bcl-2 protein in PMA and MEC...