Research Topics
Genomes and Genes | Akihiko WadaSummaryAffiliation: University of Miyazaki Country: Japan Publications
| Collaborators
|
Detail Information
Publications
New twist on neuronal insulin receptor signaling in health, disease, and therapeuticsAkihiko Wada
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
J Pharmacol Sci 99:128-43. 2005..More importantly, much remains unknown about the quality control mechanisms ensuring correct conformational maturation of the insulin receptor, and the cellular mechanisms regulating density of cell surface functional insulin receptors...- Roles of voltage-dependent sodium channels in neuronal development, pain, and neurodegenerationAkihiko Wada
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
J Pharmacol Sci 102:253-68. 2006..Na(v)1.7 proved to account for pain in human erythermalgia and inflammation, being the convincing molecular target of pain treatment... - Lithium and neuropsychiatric therapeutics: neuroplasticity via glycogen synthase kinase-3beta, beta-catenin, and neurotrophin cascadesAkihiko Wada
Department of Pharmacology, University of Miyazaki, Japan
J Pharmacol Sci 110:14-28. 2009..g., phosphoinositide 3-kinase / Akt / GSK-3beta pathway). This review will focus on the rapidly advancing new trends in the last five years about lithium, GSK-3beta/beta-catenin, and neurotrophin cascades... - Regulation of cell surface expression of voltage-dependent Nav1.7 sodium channels: mRNA stability and posttranscriptional control in adrenal chromaffin cellsAkihiko Wada
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
Front Biosci 9:1954-66. 2004..Neuroprotective, antiepiletic, antipsychotic, and local anesthetic drugs up-regulated Na+ channels via transcriptional/translational events... - Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseasesAkihiko Wada
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
J Pharmacol Sci 99:307-21. 2005..g., excitotoxicity, p53, Bax, caspase, cytochrome c release, beta-amyloid peptide production, and tau hyperphosphorylation), thus preventing or even reversing neuronal cell death and neurogenesis retardation... - Voltage-dependent Na(v)1.7 sodium channels: multiple roles in adrenal chromaffin cells and peripheral nervous systemA Wada
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Acta Physiol (Oxf) 192:221-31. 2008..7, and also cause up- and downregulation of Na(v)1.7. Na(v)1.7 seems to play an increasing number of crucial roles in health, disease and therapeutics... - Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38Takayuki Nemoto
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
Eur J Pharmacol 640:20-8. 2010..In veratridine-nontreated cells, basal constitutive activities of ERK1/ERK2 and p38 primed Nav1.7 to increase 22Na+ influx... - Lithium inhibits function of voltage-dependent sodium channels and catecholamine secretion independent of glycogen synthase kinase-3 in adrenal chromaffin cellsToshihiko Yanagita
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
Neuropharmacology 53:881-9. 2007..These results suggest that lithium selectively inhibits Na(+) influx thorough Na(+) channels and subsequent Ca(2+) influx and catecholamine secretion, independent of GSK-3 inhibition... - Destabilization of Na(v)1.7 sodium channel alpha-subunit mRNA by constitutive phosphorylation of extracellular signal-regulated kinase: negative regulation of steady-state level of cell surface functional sodium channels in adrenal chromaffin cellsToshihiko Yanagita
Department of Pharmacology, Miyazaki Medical College, Kiyotake, Japan
Mol Pharmacol 63:1125-36. 2003.... - Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawalToshihiko Yanagita
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
Neuropharmacology 57:311-21. 2009..Thus, GSK-3 inhibition by LiCl up-regulated cell surface Na(V)1.7 via acceleration of alpha-subunit gene transcription, enhancing veratridine-induced Na(+) influx, Ca(2+) influx and catecholamine secretion... - Lysophosphatidic acid-LPA1 receptor-Rho-Rho kinase-induced up-regulation of Nav1.7 sodium channel mRNA and protein in adrenal chromaffin cells: enhancement of 22Na+ influx, 45Ca2+ influx and catecholamine secretionToyoaki Maruta
Departments of Pharmacology, and Anesthesiology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
J Neurochem 105:401-12. 2008..LPA raised Nav1.7 mRNA level by approximately 37%. Thus, LPA-LPA(1) receptor-Rho/Rho kinase pathway up-regulated cell surface Nav1.7 and Nav1.7 mRNA levels, enhancing veratridine-induced Ca2+ influx and catecholamine secretion... - Nav1.7 sodium channel-induced Ca2+ influx decreases tau phosphorylation via glycogen synthase kinase-3beta in adrenal chromaffin cellsTasuku Kanai
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Neurochem Int 54:497-505. 2009.... - Glycogen synthase kinase-3beta: homologous regulation of cell surface insulin receptor level via controlling insulin receptor mRNA stability in adrenal chromaffin cellsHiroki Yokoo
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
J Neurochem 103:1883-96. 2007..Thus, GSK-3beta regulates IR level via controlling IR mRNA stability... - Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylationTakayuki Nemoto
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Neuropharmacology 58:1097-108. 2010..Thus, IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells... - Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763Takayuki Nemoto
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
Eur J Pharmacol 586:82-9. 2008.... - Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cellsNorie Yoshikawa
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Neurochem Int 56:42-50. 2010..Hsp90 inhibitors oppositely altered insulin receptor substrate-1 and -2 levels via proteasomal degradation and gene transcription... - Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of ?(2)-adrenoceptor in adrenal chromaffin cellsToyoaki Maruta
Department of Anesthesiology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
J Anesth 25:549-57. 2011..In the present study, we examined whether dexmedetomidine and clonidine could inhibit the function of tetrodotoxin-sensitive Na(+) channels, which play important roles in the generation of pain... - Proteasomal degradation of IRS-2, but not IRS-1 by calcineurin inhibition: attenuation of insulin-like growth factor-I-induced GSK-3beta and ERK pathways in adrenal chromaffin cellsShinya Satoh
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
Neuropharmacology 55:71-9. 2008..Thus, calcineurin inhibition decreased IRS-2 level via proteasomal IRS-2 degradation, attenuating IGF-I-induced GSK-3beta and ERK pathways... - Distinct effects of ketone bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cellsHiroki Yokoo
Department of Pharmacology, Miyazaki Medical College, Miyazaki, Japan
J Pharmacol Exp Ther 304:994-1002. 2003..These results suggest that chronic treatment with acetoacetate selectively down-regulated the density of cell surface functional IR via lowering IR mRNA levels and IR synthesis, thereby retarding insulin-induced activation of IRS-1... - Enhancement of insulin-induced PI3K/Akt/GSK-3beta and ERK signaling by neuronal nicotinic receptor/PKC-alpha/ERK pathway: up-regulation of IRS-1/-2 mRNA and protein in adrenal chromaffin cellsTakashi Sugano
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
J Neurochem 98:20-33. 2006..Thus, stimulation of nAChRs up-regulated expression of IRS-1/IRS-2 via Ca(2+)-dependent sequential activation of cPKC-alpha and ERK, and enhanced insulin-induced PI3K/Akt/GSK-3beta and ERK signaling pathways... - Constitutive activity of glycogen synthase kinase-3beta: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cellsTakayuki Nemoto
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Brain Res 1110:1-12. 2006..These results suggest that constitutive activity of GSK-3beta in quiescent cells positively maintains steady-state levels of IRS-1 and IRS-2 via regulating proteasomal degradation and/or synthesis of IRS-1 and IRS-2 proteins... - Serum deprivation-induced upregulation of voltage-dependent sodium channels in adrenal chromaffin cells: selective involvement of extracellular signal-regulated kinase pathwayToshihiko Yanagita
Department of Pharmacology, Miyazaki Medical College, Miyazaki 889 1692, Japan
Ann N Y Acad Sci 971:153-5. 2002.... - Regulation of voltage-dependent sodium channel expression in adrenal chromaffin cells: involvement of multiple calcium signaling pathwaysHideyuki Kobayashi
Department of Pharmacology, Miyazaki Medical College, Miyazaki 889 1692, Japan
Ann N Y Acad Sci 971:127-34. 2002.... - Differential effects of bupivacaine enantiomers, ropivacaine and lidocaine on up-regulation of cell surface voltage-dependent sodium channels in adrenal chromaffin cellsSeiji Shiraishi
Department of Pharmacology, Miyazaki Medical College, Miyazaki 889-1692, Kiyotake, Japan
Brain Res 966:175-84. 2003.... - Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: the role of GSK-3beta in the maintenance of steady-state levels of insulin receptor signaling molecules and Na(v)1.7 sodium channel in adrenal Takayuki Nemoto
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Japan
J Pharmacol Sci 109:157-61. 2009..g., lithium) up-regulated the voltage-dependent Na(v)1.7 sodium channel... - Inhibition by selenium compounds of catecholamine secretion due to inhibition of Ca2+ influx in cultured bovine adrenal chromaffin cellsYasuhito Uezono
Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Japan
J Pharmacol Sci 101:223-9. 2006..Thus, sodium selenite may specifically exert adverse effects, such as inhibition of physiological stimulus-induced catecholamine secretion from adrenal chromaffin cells due to inhibition of Ca2+ influx... - GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeuticsAkihiko Wada
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Front Biosci 14:1558-70. 2009..Chemical structures of GSK-3 inhibitors are listed in the review articles (2, 4)... - Down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation by inhibitor of 90-kDa heat-shock protein family: endoplasmic reticulum retention of monomeric insulin receptor precursor with calnexin in adrenal chromaffinTomokazu Saitoh
Department of Pharmacology, Miyazaki Medical College, Miyazaki, Japan
Mol Pharmacol 62:847-55. 2002.... - Pathophysiological function of adrenomedullin and proadrenomedullin N-terminal peptides in adrenal chromaffin cellsHideyuki Kobayashi
Department of Pharmacology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Hypertens Res 26:S71-8. 2003..PAMP20 and PAMP12 are endogenous peptides that modulate chromaffin cell function in an autocrine manner, whereas AM may mainly regulate vascular cell function in a paracrine manner... - Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cellsHideyuki Kobayashi
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Brain Res 1123:12-9. 2006..Since glucocorticoid therapy has well known beneficial effects in the treatment of brain edema, the induction of AQP1 by dexamethasone raises a possibility that AQP1 plays a role in ameliorating brain edema... - Insulin-induced neurite-like process outgrowth: Acceleration of tau protein synthesis via a phosphoinositide 3-kinase?mammalian target of rapamycin pathwayTakayuki Nemoto
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Neurochem Int 59:880-8. 2011..Taken together, these results suggest that insulin-induced activation of PI3K?mTOR pathway up-regulated tau protein via acceleration of protein synthesis, on which insulin promoted neurite-like process outgrowth... - [The adrenomedullin family and sympathoadrenal system]Akihiko Wada
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki
Nippon Rinsho 62:252-5. 2004 - Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporins in the brainHideyuki Kobayashi
Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Japan
J Pharmacol Sci 96:264-70. 2004..Changes in AQP expression may be correlated with edema formation of the brain. In this review, we describe the physiological function of AQPs and the regulatory mechanism of their expression in the brain... - Beyond vasodilation: the antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aortaYuan-Ning Cao
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
Biochem Biophys Res Commun 332:866-72. 2005..AM possesses significant antioxidant properties that improve endothelial function... - [Expression of insulin receptor and its signaling molecules: regulatory mechanisms in neuronal cells]Hiroki Yokoo
Nippon Yakurigaku Zasshi 125:141-6. 2005 - [Regulation of brain microvessel function]Hideyuki Kobayashi
Department of Pharmacology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Nihon Yakurigaku Zasshi 119:281-6, 309. 2002.... - Differential expression of Kir4.1 and aquaporin 4 in the retina from endotoxin-induced uveitis ratXiao Qiang Liu
Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
Mol Vis 13:309-17. 2007..In this study, we investigated the expression of Kir4.1 and AQP4 in the retina during endotoxin-induced uveitis (EIU) in rats... - Insulin induces internalization of the 5-HT2A receptor expressed in HEK293 cellsMasamichi Ohkura
First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Yoshino, Nobeoka 882-8508, Japan
Eur J Pharmacol 518:18-21. 2005.... - Differential effects of short and prolonged exposure to carvedilol on voltage-dependent Na(+) channels in cultured bovine adrenal medullary cellsKoji Kajiwara
Second Department of Internal Medicine, School of Medicine, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu 807-8555, Japan
J Pharmacol Exp Ther 302:212-8. 2002..This may add new pharmacological effects of carvedilol to our understanding in the treatment of heart failure and hypertension... - Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosisKiyoko Kawamura
Division of Pathology, Chiba Cancer Center, 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan
Anticancer Res 26:4647-51. 2006..These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU... - [Cell surface expression and localization mechanisms of voltage-dependent Na+ channels and Na+ channelopathy]Akihiko Wada
Tanpakushitsu Kakusan Koso 47:779-86. 2002 - Acute encephalopathy associated with intravenous immunoglobulin therapyAkihiko Wada
Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
AJNR Am J Neuroradiol 26:2311-5. 2005.... - Expression of CD40 ligand in CD40-positive murine tumors activates transcription of the interleukin-23 subunit genes and produces antitumor responsesAkihiko Wada
Division of Pathology, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuo-ku, Chiba, Japan
Anticancer Res 24:2713-6. 2004..Since expression of IL-23 in tumors can produce antitumor effects, the present data suggest that the CD40/CD40L interaction can activate cytokine transcripts in certain tumors and consequently contribute to antitumor responses... - DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancersKiyoko Kawamura
Division of Pathology, Chiba Cancer Center Research Institute, Chiba, Japan
Int J Cancer 109:9-16. 2004..These results implicate that Pol theta may have a specialized function in lymphocytes and that its overexpression may contribute to tumor progression...