Research Topics
Genomes and Genes
| Osamu TsutsumiSummaryAffiliation: University of Tokyo Country: Japan Publications
| Collaborators
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Detail Information
Publications
Presence of dioxins in human follicular fluid: their possible stage-specific action on the development of preimplantation mouse embryosO Tsutsumi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
Biochem Biophys Res Commun 250:498-501. 1998..Findings suggest that PCDDs and PCDFs may be present in human reproductive fluid and may exert some stage-specific effects on early embryonic development...- Assessment of human contamination of estrogenic endocrine-disrupting chemicals and their risk for human reproductionOsamu Tsutsumi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Steroid Biochem Mol Biol 93:325-30. 2005..These findings may provide some insight into the metabolism of EDCs in human and the pathophysiology of endocrine disorders such as PCOS. Dioxin contamination in relationship to development of endometriosis is also discussed... - Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cellsYasushi Hirota
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
Hum Reprod 20:3547-53. 2005..We studied whether the protease-activated receptor 2 (PAR2), which is activated by enzymes from neutrophils and mast cells, in endometriotic stromal cells (ESC) has any implication in the development of the disease... - Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosisOsamu Yoshino
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo
Am J Reprod Immunol 52:306-11. 2004.... - Mechanical stretch stimulates interleukin-8 production in endometrial stromal cells: possible implications in endometrium-related eventsMiyuki Harada
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
J Clin Endocrinol Metab 90:1144-8. 2005..These findings imply that uterine movement has an impact on endometrium-related physiology and pathology by stimulating the production of a biochemical mediator(s) in the endometrium... - Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activityToru Takeuchi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
Endocr J 53:485-91. 2006..The clearance of BPA may be slowed in a TP dose-dependent manner, resulting in an increase of serum BPA concentration under hyperandrogenemic conditions... - Evidence for the presence of protease-activated receptor 2 and its possible implication in remodeling of human endometriumYasushi Hirota
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
J Clin Endocrinol Metab 90:1662-9. 2005..MAPKs may mediate PAR2 functions in these processes... - Evidence for the presence of toll-like receptor 4 system in the human endometriumTetsuya Hirata
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
J Clin Endocrinol Metab 90:548-56. 2005..Altogether, the results imply that the TLR4 system might represent local immunity in the human endometrium with differential modes of TLR4 actions between ESCs and EECs... - Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosisYasushi Hirota
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
J Clin Endocrinol Metab 90:3673-9. 2005..These findings imply that the thrombin system might be involved in the pathophysiology of endometriosis, stimulating inflammatory responses of endometriotic cells and their mitogenic activity... - Expression and regulation of periostin/OSF-2 gene in rat uterus and human endometriumHisahiko Hiroi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Japan
Endocr J 55:183-9. 2008..This study demonstrated that the expression of periostin/OSF-2 is regulated by ovarian steroid hormones in rat uterus and human endometrium... - The expression and possible roles of chemokine CXCL11 and its receptor CXCR3 in the human endometriumYasushi Hirota
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Immunol 177:8813-21. 2006..These findings suggest that IFN-gamma promotes implantation by stimulating EEC to produce CXCL11, which induces migration of trophoblast cells and T cells, proliferation of ESC, and apoptosis of EEC... - Upregulation of interleukin-8 by hypoxia in human ovariesOsamu Yoshino
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Am J Reprod Immunol 50:286-90. 2003..To evaluate the effect of hypoxia on interleukin (IL)-8 expression in human ovarian follicles... - The presence of midkine and its possible implication in human ovarian folliclesYasushi Hirota
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
Am J Reprod Immunol 58:367-73. 2007..Midkine (MK) is a heparin-binding growth factor that has angiogenic, mitogenic, and chemotactic activities. In the present study, we investigated the presence of MK and its possible role in human ovarian follicles... - Possible implication of midkine in the development of endometriosisYasushi Hirota
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
Hum Reprod 20:1084-9. 2005..The present study was conducted to assess whether midkine (MK), a multifunctional molecule known to stimulate tumor growth, may be involved in the development of endometriosis... - FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine modelOsamu Yoshino
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
J Reprod Immunol 72:85-93. 2006..These findings suggest that FR 167653 may inhibit the development of endometriosis possibly by suppressing peritoneal inflammatory status... - Akt as a possible intracellular mediator for decidualization in human endometrial stromal cellsOsamu Yoshino
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan
Mol Hum Reprod 9:265-9. 2003..We further suggest that Akt phosphorylation through the cAMP/PKA signal transduction pathway may regulate cellular functions coupled with decidualization... - Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosisMiyuki Harada
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Hum Reprod 19:2188-91. 2004..In the present study, we addressed the possibility that the TRAIL/OPG system is involved in the pathogenesis of endometriosis... - Concentrations of interferon-gamma-induced protein-10 (IP-10), an antiangiogenic substance, are decreased in peritoneal fluid of women with advanced endometriosisOsamu Yoshino
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
Am J Reprod Immunol 50:60-5. 2003.... - Inhibitory effects of cholesterol sulfate on progesterone production in human granulosa-like tumor cell line, KGNRyo Tsutsumi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Endocr J 55:575-81. 2008..The expression of ferredoxin and ferredoxin reductase mRNA was not affected by CS treatment. These data implied that CS has an inhibitory effect on progesterone production by regulating the expression of StAR and P450scc gene expression... - Development of an experimental model of endometriosis using mice that ubiquitously express green fluorescent proteinTetsuya Hirata
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Hum Reprod 20:2092-6. 2005..0062). CONCLUSION: The present endometriosis model using 'green mice' would be useful for expeditious identification and quantitative evaluation of endometriotic lesions... - Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunctionToru Takeuchi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
Endocr J 51:165-9. 2004..514, p<0.001) concentrations in all subjects. These findings show that there is a strong relationship between serum BPA and androgen concentrations, speculatively due to the effect of androgen on the metabolism of BPA... - Elevated interleukin-16 levels in the peritoneal fluid of women with endometriosis may be a mechanism for inflammatory reactions associated with endometriosisKaori Koga
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
Fertil Steril 83:878-82. 2005..To investigate the role of interleukin (IL)-16 in peritoneal fluid in the pathogenesis of endometriosis... - Interleukin (IL)-1beta stimulates migration and survival of first-trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8Yasushi Hirota
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Tokyo 113 8655, Japan
Endocrinology 150:350-6. 2009..These findings suggest that IL-1 promotes implantation by stimulating EECs to produce IL-8, which subsequently induces migration of vCTs and contributes to survival of vCTs... - Induction of early decidualization by cadmium, a major contaminant of cigarette smokeRyo Tsutsumi
Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan
Fertil Steril 91:1614-7. 2009.... - Evidence for the expression of alcohol dehydrogenase class I gene in rat uterus and its up-regulation by progesteroneTomoko Ohno
Department of Obstetrics and Gynecology, University of Tokyo, Japan
Endocr J 55:83-90. 2008..This study demonstrated that ADH class I gene is progesterone-responsive in the uterus. This implies that progesterone might be involved with retinoic acid synthesis in the uterus, since ADH is the key enzyme for retinoic acid synthesis... - Gender difference in serum bisphenol A levels may be caused by liver UDP-glucuronosyltransferase activity in ratsToru Takeuchi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Biochem Biophys Res Commun 325:549-54. 2004..001) in female than in male rat livers. The gender difference in serum BPA concentrations may be explained by the difference in clearance based on the UGT activities... - Possible roles of thrombin-induced activation of protease-activated receptor 1 in human luteinized granulosa cellsYasushi Hirota
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan
J Clin Endocrinol Metab 88:3952-7. 2003..These findings suggest that thrombin plays physiological roles in ovulation by enhancing the production of chemoattractive and gelatinolytic substances by granulosa cells by a mechanism involving PAR 1... - Human chorionic gonadotropin combined with progesterone for luteal support improves pregnancy rate in patients with low late-midluteal estradiol levels in IVF cyclesAkihisa Fujimoto
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Assist Reprod Genet 19:550-4. 2002.... - Characteristic images of deeply infiltrating rectosigmoid endometriosis on transvaginal and transrectal ultrasonographyKaori Koga
Department of Obstetrics and Gynecology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Japan
Hum Reprod 18:1328-33. 2003..The procedures would be useful in the management of rectosigmoid endometriosis... - Differences in serum bisphenol a concentrations in premenopausal normal women and women with endometrial hyperplasiaHisahiko Hiroi
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan
Endocr J 51:595-600. 2004..The mode of action of BPA may be more complex than expected and the contradictory results may serve as a clue to addressing the mechanisms of linkage between occurrence of estrogen-dependent diseases and endocrine disruption... - Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndromeToru Takeuchi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Gynecol Endocrinol 24:385-91. 2008..To investigate the insulin response to glucose loading and to determine which method is best in order to evaluate insulin resistance in women with polycystic ovary syndrome (PCOS)... - Evidence for the presence of angiogenin in human testisKaori Koga
Department of Obstetrics and Gynecology, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
J Androl 25:369-74. 2004..The specific localization of angiogenin in PTMCs suggests that angiogenin plays physiologic roles in the human testis... - Impaired growth hormone secretion after glucose loading in non-obese women with polycystic ovary syndrome, possibly related to androgen but not insulin and free fatty acidsToru Takeuchi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Gynecol Endocrinol 23:468-73. 2007..Secretion of growth hormone (GH) is known to be suppressed in women with polycystic ovary syndrome (PCOS). The suppression may be implicated in the pathogenesis of PCOS... - Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsiaKaori Koga
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Clin Endocrinol Metab 88:2348-51. 2003..130, p = 0.476). These findings may point to an involvement of sVEGFR-1 in the pathophysiology of preeclampsia possibly by antagonizing of VEGF effects on the formation of placental vasculature and maternal endothelial cell function... - Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cellsJiping Xu
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Biochem Biophys Res Commun 292:456-62. 2002..Up-regulation of Bax and down-regulation of Bcl2 were suggested to be involved in this apoptotic effect... - Cellular mechanisms of growth inhibition of human epithelial ovarian cancer cell line by LH-releasing hormone antagonist CetrorelixXiaohui Tang
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
J Clin Endocrinol Metab 87:3721-7. 2002.... - The activity of bisphenol A depends on both the estrogen receptor subtype and the cell typeTakako Kurosawa
Department of Obstetrics and Gynecology, University of Tokyo, Japan
Endocr J 49:465-71. 2002..Thus, the activity of BPA may depend on the ER subtype and the tissue involved... - Endometrial stromal cells undergoing decidualization down-regulate their properties to produce proinflammatory cytokines in response to interleukin-1 beta via reduced p38 mitogen-activated protein kinase phosphorylationOsamu Yoshino
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Clin Endocrinol Metab 88:2236-41. 2003..The altered property of decidualized cells is thought to be caused by attenuation of IL-1 beta-induced p38 MAPK phosphorylation in a way that involves the activation of the cAMP/protein kinase A pathway... - Is endometriosis really associated with pain?Mikio Momoeda
Department of Obstetrics and Gynecology, University of Tokyo, Japan
Gynecol Obstet Invest 54:18-21; discussion 21-3. 2002.... - Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposureYumiko Ikezuki
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Hum Reprod 17:2839-41. 2002..CONCLUSION: These results suggest accumulation of BPA in early fetuses and significant exposure during the prenatal period, which must be considered in evaluating the potential for human exposure to endocrine-disrupting chemicals... - [Rokitansky syndrome]Osamu Tsutsumi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
Nippon Rinsho . 2006 - Estrogen activates cyclin-dependent kinases 4 and 6 through induction of cyclin D in rat primary osteoblastsMasayo Fujita
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
Biochem Biophys Res Commun 299:222-8. 2002..Our findings indicate that estrogen and its receptors enhance Cdk4/6 activities through the induction of D-type cyclins, leading to the growth promotion of osteoblasts... - Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid microsatellite analysisAkira Namba
Department of Obstetrics and Gynecology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Obstet Gynecol 102:991-4. 2003..CONCLUSION: This is the first description of an ovarian pregnancy of a partial hydatidiform mole-derived ovarian choriocarcinoma... - [XY female]Osamu Tsutsumi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
Nippon Rinsho . 2006 - Safety and immunogenicity of a peptide containing the cross-neutralization epitope of HPV16 L2 administered nasally in healthy volunteersKei Kawana
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo 113 8655, Japan
Vaccine 21:4256-60. 2003..1mg group and the placebo group recipients. This study suggests the L2-108/120 peptide is tolerable in humans and has the potential as a broad-spectrum prophylactic vaccine against genital HPV... - The evaluation of the sentinel node successfully conducted in a case of malignant melanoma of the vaginaShunsuke Nakagawa
Department of Obstetrics and Gynecology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
Gynecol Oncol 86:387-9. 2002..To date, only one case was reported for successful detection of the sentinel node using a radiopharmaceutical-directed mapping technique in malignant melanoma of the vagina... - [DES syndrome]Osamu Tsutsumi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
Nippon Rinsho . 2006 - Differential clinical manifestations of congenital cytomegalovirus infection between dizygotic twins: a case reportKei Kawana
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Japan
Am J Perinatol 21:383-6. 2004..These data suggest the severity of CMV manifestations of dizygotic twins may be in accord with the number of CMV-positive cells in the placenta... - Role of laparoscopy in the treatment of endometriosis-associated infertilityYutaka Osuga
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Gynecol Obstet Invest 53:33-9. 2002..On the other hand, IVF-ET outcome of patients who previously underwent laparoscopy was not influenced by preexisiting tubal adhesions and endometriosis... - Serum bisphenol a concentrations showed gender differences, possibly linked to androgen levelsToru Takeuchi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
Biochem Biophys Res Commun 291:76-8. 2002..These findings showed that there are gender differences in serum BPA concentrations, possibly due to differences in the androgen-related metabolism of BPA...