Noriyuki Tsumaki

..These findings may contribute not only to understanding of bone biology and pathology, but also to improvement of the clinical efficacy of BMPs...

..The aim of this study was to determine if low-intensity pulsed ultrasound would accelerate callus maturation when applied after distraction to limbs treated with opening-wedge high tibial osteotomy by hemicallotasis...

..BMP signaling plays important roles in normal bone development and regulation of bone resorption...

..These results demonstrate an essential role for SIK3 in facilitating chondrocyte hypertrophy during skeletogenesis and growth plate maintenance...

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..Mating Smad6 and Smurf1 transgenic mice produced double-transgenic pups with more delayed endochondral ossification than Smad6 transgenic mice. These results provided evidence that Smurf1 supports Smad6 function in vivo...

..BMPs promote chondrocyte proliferation and hypertrophy, whereas Smad signaling regulates chondrocyte hypertrophy. Proper regulation of these signals is necessary for normal bone formation...

..Thus, continued expression of Sox9 in differentiated chondrocytes is essential for subsequent hypertrophy and sustains chondrocyte-specific survival mechanisms by binding to the Pik3ca promoter, inducing Akt phosphorylation...

..Our results showed that the intergenic sequence including 11P insulates Rxrb promoter from Col11a2 enhancer, possibly associating with unknown factors that recognize a motif similar to CTCF...

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..These hypoxia-induced phenomena may act on chondrocytes to enhance and preserve their phenotype and function during chondrocyte differentiation and endochondral ossification...

..Use of porous HA ceramic combined with LIPUS may be a promising treatment for filling large bone defects in a clinical setting...

..These phenotypic differences suggest that the signaling through TGF-? receptors is complex in cartilage...

..These conclusions may account for the reason why multiple BMPs are coexpressed in cartilage...

..Transgenic and conditional knockout mice have been generated and analyzed to clarify function of these molecules in skeletal tissues by using bone- or cartilage-specific promoter sequences...

..These results indicate that cells do not undergo a pluripotent state during direct induction of chondrogenic cells from fibroblast culture by transduction of c-Myc, Klf4 and SOX9...

..It is possible that Cre-mediated recombination occurs at loxP sites in osteoblasts of chondrocyte-specific conditional knockout mice, suggesting that bone phenotype should be carefully analyzed and discussed...

..Thus, this approach could lead to the preparation of hyaline cartilage directly from skin, without generating iPS cells...

..Comparison of phenotypes between these mice have elucidated general roles of BMP signals as well as individual effect of each molecule during endochondral bone formation...

..Each corresponds to a subdomain, epidermal growth factor 1(EGF1), EGF2, and a short complement repeat (SCR)...

..Early intervention to prevent secondary osteoporosis is recommended to maintain the quality of life in patients with rheumatoid arthritis, especially those with functional impairment or undergoing glucocorticoid therapy...

..These results demonstrate that KRAB-zinc finger protein NT2 inhibits transcription of its physiological target gene, suggesting a novel regulatory mechanism of cartilage-specific expression of Col11a2...

..We here show that these two cell lines exhibit the unique characteristics of hyaline cartilage formation and enchondral ossification in vitro and in vivo...