T Shimizu

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice
    Yong Zheng Wu
    Unité de Défense Innée et Inflammation, Institut Pasteur, Paris, France
    Respir Res 11:49. 2010
  2. ncbi Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
    Takao Shimizu
    Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo 113 0033, Japan
    Annu Rev Pharmacol Toxicol 49:123-50. 2009
  3. ncbi Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3
    Andreas Koeberle
    Department of Biochemistry and Molecular Biology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    FASEB J 26:169-80. 2012
  4. ncbi Cytosolic phospholipase A2: biochemical properties and physiological roles
    Takao Shimizu
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
    IUBMB Life 58:328-33. 2006
  5. ncbi An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation
    Chisato Miyaura
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Exp Med 197:1303-10. 2003
  6. ncbi Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45
    Y Kawasawa
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113 0033, Japan
    Biochem Biophys Res Commun 276:952-6. 2000
  7. ncbi Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes
    K Kinugawa
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Circ Res 81:911-21. 1997
  8. ncbi Ets-1 is involved in transcriptional regulation of the chick inducible nitric oxide synthase gene in embryonic ventricular myocytes
    T Takahashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Mol Cell Biochem 226:57-65. 2001
  9. ncbi Impact of HLA-identity on results of ABO-incompatible living kidney transplantation
    H Shimmura
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 36:2172-4. 2004
  10. ncbi Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
    J Kamegai
    Department of Medicine, Nippon Medical School, Tokyo, Japan
    Endocrinology 141:4797-800. 2000

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. ncbi Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice
    Yong Zheng Wu
    Unité de Défense Innée et Inflammation, Institut Pasteur, Paris, France
    Respir Res 11:49. 2010
    ..Lungs of cystic fibrosis (CF) patients are chronically infected with Pseudomonas aeruginosa. Increased airway constriction has been reported in CF patients but underplaying mechanisms have not been elucidated...
  2. ncbi Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
    Takao Shimizu
    Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo 113 0033, Japan
    Annu Rev Pharmacol Toxicol 49:123-50. 2009
    ....
  3. ncbi Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3
    Andreas Koeberle
    Department of Biochemistry and Molecular Biology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    FASEB J 26:169-80. 2012
    ..We conclude that the induction of LPAAT3 during germ cell development critically contributes to the accumulation of PUFAs in testicular phospholipids, thereby possibly affecting sperm cell production...
  4. ncbi Cytosolic phospholipase A2: biochemical properties and physiological roles
    Takao Shimizu
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
    IUBMB Life 58:328-33. 2006
    ..Comprehensive analysis of lipid mediators using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is useful for understanding the roles of individual mediators in physiological and pathological processes...
  5. ncbi An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation
    Chisato Miyaura
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Exp Med 197:1303-10. 2003
    ..Here, we show that cPLA2alpha plays a key role in PGE production by osteoblasts and in osteoclastic bone resorption, and suggest a new approach to inflammatory bone disease by inhibiting cPLA2alpha...
  6. ncbi Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45
    Y Kawasawa
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, 113 0033, Japan
    Biochem Biophys Res Commun 276:952-6. 2000
    ..We suggest that mammalian PSP24 is a distinct GPCR family and plays a role in the brain function...
  7. ncbi Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes
    K Kinugawa
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Circ Res 81:911-21. 1997
    ..These data suggest that (1) iNOS induction simultaneously requires both NF-kappa B activation and IRF-1 induction, and (2) the heterodimer between C/EBP and CREB has synergistic effects on the iNOS induction via the CAAT box...
  8. ncbi Ets-1 is involved in transcriptional regulation of the chick inducible nitric oxide synthase gene in embryonic ventricular myocytes
    T Takahashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Mol Cell Biochem 226:57-65. 2001
    ..Ets-1 may be involved in the iNOS gene transcription in CEVM, presumably through interacting with the NF-kappaB...
  9. ncbi Impact of HLA-identity on results of ABO-incompatible living kidney transplantation
    H Shimmura
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 36:2172-4. 2004
    ..However, the impact on HLA-identity on the results of ABO-incompatible living donor kidney transplantation had not been investigated previously...
  10. ncbi Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
    J Kamegai
    Department of Medicine, Nippon Medical School, Tokyo, Japan
    Endocrinology 141:4797-800. 2000
    ..Thus, ghrelin has an alternative role in stimulating food intake via an increase of AGRP rather than the release of GH from the pituitary...
  11. ncbi Long-term effects of LTB4 antagonist on lipid induced renal injury
    A Nakao
    First Department of Internal Medicine, School of Medicine, University of Tokyo, Japan
    Kidney Int Suppl 63:S236-8. 1997
    ..1 mg/dl, P < 0.03) without statistical differences in serum total cholesterol, body weight and blood pressure between two groups. These results suggest that LTB4 plays an important role in progression of hyperlipidemic renal injury...
  12. ncbi Evaluation of immunosuppressive regimens in ABO-incompatible living kidney transplantation--single center analysis
    H Ishida
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Transplant 7:825-31. 2007
    ..001). We conclude that the FK/MMF combination regimen provides excellent graft survival results in ABO-ILKT...
  13. ncbi Cloning of hypoxia-inducible factor 1alpha cDNA from chick embryonic ventricular myocytes
    T Takahashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 281:1057-62. 2001
    ..These data suggest that HIF-1alpha may be involved in embryonic cardiovascular development. HIF-1alpha and EPAS1 may play distinct roles during developmental stages...
  14. ncbi A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages
    S Ishii
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan
    Biochem J 314:671-8. 1996
    ..These induction patterns were parallel to those of tumor necrosis factor-alpha mRNA. Thus the PAFR in macrophages is important in LPS-induced pathologies...
  15. ncbi Clinical and histological analysis of chronic tacrolimus nephrotoxicity in renal allografts
    T Shimizu
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 40:2370-2. 2008
    ..Since, the severity and influence of chronic TAC nephrotoxicity are not fully elucidated, we studied the clinicohistological characteristics of chronic TAC nephrotoxicity in kidney transplants...
  16. ncbi A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjects
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    J Biol Regul Homeost Agents 24:157-65. 2010
    ..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity...
  17. ncbi Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice
    T Nagase
    Department of Geriatric Medicine, and Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    J Clin Invest 104:1071-6. 1999
    ..Thus, inhibition of this pathway might provide a novel therapeutic approach to acute lung injury, for which no specific pharmaceutical agents are currently available...
  18. ncbi Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel
    Y Kurachi
    2nd Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 337:555-7. 1989
    ..These results indicate that arachidonic acid metabolites may stimulate the G-protein in a receptor-independent way...
  19. ncbi Role of cytosolic phospholipase A2 in allergic response and parturition
    N Uozumi
    Department of Biochemistry, University of Tokyo, Japan
    Nature 390:618-22. 1997
    ..Considered together with previous findings, our results indicate that cytosolic PLA2 plays a non-redundant role in allergic responses and reproductive physiology...
  20. ncbi Synthesis and structural identification of four dihydroxy acids and 11,12-leukotriene C4 derived from 11,12-leukotriene A4
    S Kitamura
    Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 176:725-31. 1988
    ..Upon incubation with rat liver glutathione S-transferase, 11,12-leukotriene A4 was converted to 11,12-leukotriene C4, a spasmogenic compound...
  21. ncbi A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Exp Med 192:421-32. 2000
    ..BLT2 provides a novel target for antiinflammatory therapy and promises to expand our knowledge of LTB(4) function. The location of the gene suggests shared transcriptional regulation of these two receptors...
  22. ncbi Analysis of renal transplant protocol biopsies in ABO-incompatible kidney transplantation
    K Setoguchi
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Transplant 8:86-94. 2008
    ..This deposition, however, was not linked to antibody-mediated rejection. We conclude that, in the ABO-I kidney transplantation setting, detection of C4d alone in protocol biopsies might not have any diagnostic or therapeutic relevance...
  23. ncbi Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor
    S Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113, Japan
    J Exp Med 187:1779-88. 1998
    ..These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock...
  24. ncbi Acute antibody-mediated rejection in living ABO-incompatible kidney transplantation: long-term impact and risk factors
    D Toki
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Transplant 9:567-77. 2009
    ....
  25. ncbi Hepatitis G virus coinfection influences the liver histology of patients with chronic hepatitis C
    M Moriyama
    Third Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Liver 20:397-404. 2000
    ....
  26. ncbi Cloning and characterization of rat leukotriene B(4) receptor
    A Toda
    Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Biochem Biophys Res Commun 262:806-12. 1999
    ..The present results suggest important roles of LTB(4) in macrophage recruitment and activation...
  27. ncbi Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after experimental subarachnoidal hemorrhage
    T Shimizu
    Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan
    J Neurochem 51:1126-31. 1988
    ..1 nmol 5-HETE/5 min/mg of protein) after subarachnoidal hemorrhage. The observation that fatty acid hydroperoxides stimulated the 5-lipoxygenase activity indicates a possible role of lipid peroxides in the development of vasospasm...
  28. ncbi Characterization of the guinea pig lung membrane leukotriene D4 receptor solubilized in an active form. Association and dissociation with an islet-activating protein-sensitive guanine nucleotide-binding protein
    T Watanabe
    First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 265:21237-41. 1990
    ..These data provide an insight into the molecular mechanism of regulation of the LTD4 receptor signaling process by association and dissociation with an IAP-sensitive GTP-binding protein...
  29. ncbi Efficacy of IgM anti-blood type antibody monitoring by enzyme-linked immunosorbent assay after renal transplantation across the blood barrier: high-dose immunoglobulin administration blocks IgM rather than IgG anti-blood type antibodies
    H Ishida
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 36:2178-81. 2004
    ..Blocking of IgM seems to play an important role in improving ABO-incompatible grafts...
  30. ncbi Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems
    Y Kawasawa
    Department of Biochemistry and Molecular Biology, University of Tokyo, Bunkyo ku, Tokyo, 113 0033, Japan
    Biochem Biophys Res Commun 276:957-64. 2000
    ..Thus, unlike xPSP24, we conclude that PSP24s are not functional LPA receptors in mammalian systems...
  31. ncbi Expression of genes encoding vascular endothelial growth factor and its Flk-1 receptor in the chick embryonic heart
    Y Sugishita
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Mol Cell Cardiol 32:1039-51. 2000
    ..VEGF produced by the chick embryonic heart may play important roles in embryonic cardiovascular development by acting on surrounding endothelial cells and, possibly, on ventricular myocytes themselves...
  32. ncbi Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
    S Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Prog Lipid Res 39:41-82. 2000
    ..This review also describes the phenotypes of these mutant mice and discusses them by referring to previously reported pharmacological and genetical data...
  33. ncbi Isolation and properties of platelet-activating factor receptor cDNAs
    M Nakamura
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Lipid Mediat 6:163-8. 1993
    ....
  34. ncbi IGF-I, leptin and active ghrelin levels in very low birth weight infants during the first 8 weeks of life
    N Ohkawa
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Acta Paediatr 99:37-41. 2010
    ..We investigated the relationship between plasma insulin-like growth factor I (IGF-I), leptin, active ghrelin levels, and postnatal growth in very low birth weight (VLBW) infants...
  35. ncbi Effect of phytoncide from trees on human natural killer cell function
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Int J Immunopathol Pharmacol 22:951-9. 2009
    ..Phytoncides, such as alpha-pinene and beta-pinene, were detected in the hotel room air. These findings indicate that phytoncide exposure and decreased stress hormone levels may partially contribute to increased NK activity...
  36. ncbi Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene
    K Kato
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Exp Med 192:413-20. 2000
    ..K. Kato, K. Terawaki, T. Izumi, and T. Shimizu. 2000. J. Exp. Med. 192:421-431). To our knowledge, this is the first example of "promoter in ORF" in higher eukaryotes...
  37. ncbi Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2
    T Nagase
    Department of Geriatric Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113, Japan
    Nat Immunol 1:42-6. 2000
    ..Thus, the inhibition of cPLA2-initiated pathways may provide a therapeutic approach to acute lung injury, for which no pharmaceutical agents are currently effective...
  38. ncbi cDNA cloning and characterization of guinea-pig leukotriene B4 receptor
    K Masuda
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem J 342:79-85. 1999
    ..The present study demonstrated that although LTB(4) and 20-hydroxy-LTB(4) bind to the receptor with similar affinities, they do differ in activating intracellular signalling...
  39. ncbi Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat
    N Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    FEBS Lett 463:155-9. 1999
    ..These data suggest that the cardiac LTA(4) hydrolase-LTB(4) system plays a positive role in the promotion of cardiac inflammation in hypertension...
  40. ncbi Impact of positive PRA on the results of ABO-incompatible kidney transplantation
    H Shimmura
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 36:2169-71. 2004
    ..It is well known that highly sensitized patients with positive panel reactive antibodies (PRA) often present with acute rejection. Therefore, we examined the impact of a positive PRA on the results of ABO-incompatible LKT...
  41. ncbi c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis
    T Shimizu
    Division of Gene Regulation, Institute for Advanced Medical Research, Keio University, Tokyo, Japan
    Oncogene 29:5687-99. 2010
    ..Our findings indicate that differentiation potential has a key role in OS tumorigenic activity, and that the suppression of adipogenic ability is a critical factor for the development of OS...
  42. ncbi Selectivity of felodipine for depolarized ventricular myocytes: a study at the single-cell level
    O Kohmoto
    Internal Medicine II, Faculty of Medicine, University of Tokyo, Japan
    Eur J Pharmacol 319:355-63. 1997
    ..Thus, therapeutic concentrations (1-10 nM) of felodipine could inhibit E-C coupling in depolarized ventricular myocytes, which might simulate an ischemic or failing heart...
  43. ncbi Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade
    H Bito
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 269:12722-30. 1994
    ..SSTR4, in addition, provides a useful system to study the Ca(2+)-independent, Gi-dependent (pertussis toxin-sensitive) pathway of MAP kinase activation...
  44. ncbi Localization and regulation of cytosolic phospholipase A(2)
    T Hirabayashi
    Department of Biochemistry and Molecular Biology, The University of Tokyo, Japan
    Biochim Biophys Acta 1488:124-38. 2000
    ..The regional distribution and cellular localization of cPLA(2) may help to better understand its function as an arachidonic acid supplier to downstream enzymes and as a regulator of specific cellular processes...
  45. ncbi Isolation and characterization of murine orthologue of PTP-BK
    T Tomemori
    Department of Molecular Genetics, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo, 173 0015, Japan
    Biochem Biophys Res Commun 276:974-81. 2000
    ..02cR distal to from the marker D6Mit339 on chromosome 6. Mouse PTP-BK was classified in PTPRO family in novel nomenclature. We discuss here the diversity and physiological functions of PTPRO family of PTP...
  46. ncbi Alpha-adrenergic activation of the muscarinic K+ channel is mediated by arachidonic acid metabolites
    Y Kurachi
    2nd Department of Internal Medicine, University of Tokyo, Japan
    Pflugers Arch 414:102-4. 1989
    ..These observations suggest that 5-lipoxygenase metabolites of arachidonic acid may be involved in the alpha-adrenergic activation of IK.ACh...
  47. ncbi Co-expression of two LTB4 receptors in human mononuclear cells
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan
    Life Sci 68:2207-12. 2001
    ..These findings suggest novel roles of LTB4 in immune system, and the biological significance of high- and low- affinity LTB4 receptors in chemotaxis...
  48. ncbi Continent orthotopic ileal neobladder after kidney transplantation in a patient with urothelial cell carcinoma associated with Chinese herb nephropathy
    H Shirakawa
    Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 40:1741-3. 2008
    ..We suggest that an orthotopic ileal neobladder is a safe method of urinary diversion after cystectomy in kidney transplant recipients...
  49. ncbi Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo and the Japan Science and Technology Corporation CREST, Tokyo 113 0033, Japan
    J Biol Chem 276:12454-9. 2001
    ..These findings suggest that BLT2 functions as a low affinity receptor, with broader ligand specificity for various eicosanoids, and mediates distinct biological and pathophysiological roles from BLT1...
  50. ncbi Risk factors for deterioration of renal function after donor nephrectomy
    T Nozaki
    Department of Urology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Transplant Proc 42:1476-8. 2010
    ..The aim of this study was to identify factors that protect renal function among actual live kidney donors...
  51. ncbi Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor
    H Mutoh
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 322:129-34. 1993
    ..Existence of distinct promoters was thus suggested to play a role in the regulatory control of PAF receptor gene expression in different human tissues and cells...
  52. ncbi Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats
    T Hirohashi
    Graduate School of Pharmaceutical Sciences, Hongo, Bunkyo ku, Tokyo 113, Japan
    Mol Pharmacol 53:1068-75. 1998
    ..These findings suggest that MLP-1 and MLP-2 might be novel members of the MRP family responsible for the excretion of organic anions from these epithelial cells, and that MLP-2 is an inducible one...
  53. ncbi Localization of platelet-activating factor receptor messenger RNA in the rat eye
    M Mori
    Department of Ophthalmology, Faculty of Medicine, University of Tokyo, Japan
    Invest Ophthalmol Vis Sci 38:2672-8. 1997
    ..To determine the distribution of platelet-activating factor (PAF) receptor in the rat eye...
  54. ncbi Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region
    K Kobayashi
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Japan
    Eur J Neurosci 11:1313-6. 1999
    ..Furthermore, the application of PAF itself caused no detectable changes in excitatory synaptic transmission. Thus, we conclude that the PAF receptor is not required for LTP in the CA1 region. Introduction..
  55. ncbi Splenic artery embolization before laparoscopic splenectomy in children
    T Takahashi
    First Department of Surgery, Nippon Medical School, 1 1 5 Sendagi, Tokyo, 113 8605, Japan
    Surg Endosc 19:1345-8. 2005
    ..This study assessed the safety and utility of preoperative splenic artery embolization before laparoscopic splenectomy in children...
  56. ncbi Differential expression of the parkin gene in the human brain and peripheral leukocytes
    Y Sunada
    Department of Neurology and Neuroscience, Teikyo University School of Medicine, Tokyo, Japan
    Neurosci Lett 254:180-2. 1998
    ..Moreover, physiological splicing of deletion-prone exons may provide an important clue to understanding the pathogenesis of AR-JP...
  57. ncbi Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta
    W L Jin
    Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Diabetologia 54:1921-9. 2011
    ..As a first step towards elucidating the above, we investigated the effect of hypoglycaemia on monocyte-endothelial interaction...
  58. ncbi Safety and efficacy of high-dose ranimustine, cytarabine, etoposide and CY (MCVAC) regimen followed by autologous peripheral blood stem cell transplantation for high-risk diffuse large B-cell lymphoma
    J Kato
    Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Bone Marrow Transplant 46:923-8. 2011
    ..In conclusion, the MCVAC regimen would be an effective and tolerable conditioning regimen without TBI for autologous PBSCT for high-risk or relapsed DLBCL. However, late-onset pulmonary toxicity and MDS/AML should be monitored...
  59. ncbi Cytokines in the gastric mucosa of children with Helicobacter pylori infection
    T Shimizu
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Acta Paediatr 93:322-6. 2004
    ..This study investigated cytokines and their effects on histological abnormalities in the gastric mucosa of children with H. pylori infection...
  60. ncbi Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA
    H Bito
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 221:211-8. 1994
    ..Isolation of rat PAF-receptor cDNA should facilitate further analysis of PAF-receptor function and pharmacology in diverse pathophysiological processes...
  61. ncbi Left ventricular relaxation abnormality is detectable by analysis of the relaxation time constant in patients with atrial fibrillation
    K Harada
    Department of Cardiovascular Medicine, University of Tokyo, Japan
    Jpn Circ J 65:610-6. 2001
    ..R was significantly different between the 2 groups. Thus, a beat-to-beat analysis of tau may be a practical and feasible way for detecting LV relaxation abnormality in patients with AF...
  62. ncbi Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor
    K Kume
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo, Tokyo 113, Japan
    J Biol Chem 272:22898-904. 1997
    ....
  63. ncbi Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor
    S Ishii
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan
    EMBO J 16:133-42. 1997
    ..Furthermore, our findings provide new insights regarding the role of PAF in the morphogenesis of dermal tissues as well as the mitogenic activity of PAF and PAFR in vivo...
  64. ncbi Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase
    T Yamamoto
    The Department of Biochemistry and Molecular Biology, CREST of Japan Science and Technology Corporation, Tokyo, Japan
    Eur J Biochem 268:6105-13. 2001
    ..These findings will lead to the identification of the unrevealed roles of PGs and LTs in these tissues...
  65. ncbi Molecular cloning and expression of inducible nitric oxide synthase in chick embryonic ventricular myocytes
    T Shimizu
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Cardiovasc Res 38:405-13. 1998
    ..The aim of this study was to elucidate evolutional changes in myocardial iNOS expression and function...
  66. ncbi Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation
    T Izumi
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Biochem J 305:829-35. 1995
    ..These systems may provide a useful experimental model with which to investigate the relationship between eosinophilic differentiation and PAF receptor induction, and the role of eosinophils in allergic responses...
  67. ncbi Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase
    T Yokomizo
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 268:18128-35. 1993
    ..These results suggest that the enzyme acts specifically on the 12(R)-hydroxy group of leukotriene B4 and is involved in the metabolic inactivation of LTB4 in the porcine kidney...
  68. ncbi Hypertrophic cardiomyopathy with midventricular obstruction and apical aneurysm: a case report
    K Harada
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Jpn Circ J 65:915-9. 2001
    ..Myocardial ischemia may have played an important role in the genesis of the apical aneurysm...
  69. ncbi Microplate chromatography assay for acetyl-CoA: lysoplatelet-activating factor acetyltransferase
    K Kume
    Faculty of Medicine, University of Tokyo, Bunkyo, Tokyo, 113, Japan
    Anal Biochem 246:118-22. 1997
    ..This tailor-made microplate chromatography separation step is readily applicable for other kinds of enzyme assays...
  70. ncbi Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling
    Z I Honda
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 272:25753-60. 1997
    ....
  71. ncbi Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver
    K Ito
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    J Biol Chem 273:1684-8. 1998
    ....
  72. ncbi cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase
    T Yokomizo
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 271:2844-50. 1996
    ..We found that three glycines at 152, 155, and 166 have crucial roles in the enzyme activity, possibly by producing an NADP+ binding pocket...
  73. ncbi Energy-dependent export of leukotriene B4 in Xenopus oocytes
    M Mori
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Biochim Biophys Acta 1168:23-9. 1993
    ..It was thus shown that the two potent lipid mediators are exported from cells in a different manner and that oocytes are a good model for analyzing export systems for bioactive mediators...
  74. ncbi A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan
    Nature 387:620-4. 1997
    ..Our findings, together with previous reports, show that LTB4 is a unique lipid mediator that interacts with both cell-surface and nuclear receptors...
  75. ncbi Renal amyloidosis in recessive dystrophic epidermolysis bullosa
    K Kaneko
    Department of Pediatrics Juntendo University School of Medicine, Tokyo, Japan
    Dermatology 200:209-12. 2000
    ..We, however, had seen a young adult with RDEB who died of renal failure due to systemic amyloidosis...
  76. ncbi Leukotriene B4: metabolism and signal transduction
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, CREST of Japan, Science and Technology Corporation
    Arch Biochem Biophys 385:231-41. 2001
    ..In this article recent findings on the metabolism of and the receptors for LTB4 are reviewed. We also discuss briefly a coreceptor role of BLT in HIV infection, and ion channel modification by LTB4...
  77. ncbi Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release
    T Shimizu
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Lipid Mediat Cell Signal 14:103-8. 1996
    ..Arachidonic acid or its derivatives, thus produced by the activation of these receptors may play some roles in synaptic transmission and synaptic plasticity...
  78. ncbi Dystroglycan is a binding protein of laminin and merosin in peripheral nerve
    H Yamada
    Department of Neurology and Neuroscience, Teikyo University School of Medicine, Tokyo, Japan
    FEBS Lett 352:49-53. 1994
    ..The interaction between alpha-dystroglycan and merosin may play a role in the regulation of Schwann cell myelination and/or maintenance of myelin sheath...
  79. ncbi Amino-acid sequence and tissue distribution of guinea-pig leukotriene A4 hydrolase
    M Minami
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Gene 161:249-51. 1995
    ..The previously characterized zinc-binding motif and a putative active site were highly conserved, supporting the aminopeptidase activity described for this enzyme. RNA blot analysis demonstrated ubiquitous expression of the LTA4H mRNA...
  80. ncbi Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary structure of an enzyme involved in eicosanoid synthesis
    M Minami
    Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 262:13873-6. 1987
    ..The complete primary structure of the enzyme composed of 610 amino acid residues (molecular weight, 69,153) was deduced from the cDNA...
  81. ncbi cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase
    K Kume
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 237:663-6. 1997
    ..The enzyme utilized both saturated and unsaturated acyl-CoA as an acyl-donor, while it utilized LPA but not other lysophospholipids as an acceptor...
  82. ncbi Glutamyl-tRNA synthetase from Thermus thermophilus HB8. Molecular cloning of the gltX gene and crystallization of the overproduced protein
    O Nureki
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    Eur J Biochem 204:465-72. 1992
    ..The crystals diffract X-rays beyond 0.35 nm. The crystal belongs to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters of a = 8.64 nm, b = 8.86 nm and c = 8.49 nm...
  83. ncbi Calbindin-D28k in cerebrovascular extrinsic innervation system of the rat
    T Shimizu
    Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    Auton Neurosci 84:130-9. 2000
    ..These findings are significant in understanding the calcium-mediated mechanism of the neural control of the cerebral blood vessels...
  84. ncbi Architectures of class-defining and specific domains of glutamyl-tRNA synthetase
    O Nureki
    Department of Biophysics and Biochemistry, School of Science, University of Tokyo, Japan
    Science 267:1958-65. 1995
    ....
  85. ncbi Human leukocyte antigen (HLA) phenotypes in siblings with osteosarcoma
    T Shinozaki
    Department of Orthopedic Surgery, Gunma University, Faculty of Medicine, Maebashi, Japan
    Arch Orthop Trauma Surg 120:343-5. 2000
    ..These cases suggest that genetic similarity may influence the development of osteosarcoma. Ascertainment of the HLA phenotypes in siblings with osteosarcoma might be a useful strategy to facilitate the early diagnosis of this tumor...
  86. ncbi Role of the platelet-activating factor (PAF) receptor during pulmonary infection with gram negative bacteria
    A C Soares
    Immunopharmacology Laboratory, , ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Br J Pharmacol 137:621-8. 2002
    ..Our results suggest that PAF, acting on its receptor, plays a protective role during infection with K. pneumoniae in mice...
  87. ncbi Mice deficient in cytosolic phospholipase A2 are less susceptible to cerebral ischemia/reperfusion injury
    S Tabuchi
    Department of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Japan
    Acta Neurochir Suppl 86:169-72. 2003
    ..These data indicate a critical role for cPLA2 in the pathogenesis of cerebral ischemia/ reperfusion injury...
  88. ncbi Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue
    Y Boie
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Eur J Pharmacol 380:203-13. 1999
    ..The recombinant guinea pig BLT receptor will permit the comparison of the intrinsic potencies of leukotriene B4 receptor antagonists used in guinea pig in vivo models of allergic and inflammatory disorders...
  89. ncbi Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart
    T Sugimoto
    Department of Internal Medicine, Mayo Clinic, Mayo Foundation, Rochester, MN 55905
    Biochem Biophys Res Commun 189:617-24. 1992
    ..These results suggest a tissue-specific translational mechanism responsible for regulation of the expression of the PAF receptor mRNA in these tissues...
  90. ncbi Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils
    S Kishimoto
    Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    J Immunol 157:4126-32. 1996
    ..These findings will be of value for understanding the mechanisms of selective infiltration and activation of eosinophils in allergic diseases in which PAF and IL-5 are crucially involved...
  91. ncbi Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis
    D Nakai
    Department of Molecular Genetics, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Biochem Biophys Res Commun 289:463-71. 2001
    ..The result implied the essential role of coq7 in CoQ synthesis, maintenance of mitochondrial integrity, and neurogenesis in mice...
  92. ncbi Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene
    K Takaku
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Biol Chem 275:34013-6. 2000
    ..These results suggest that in the colon, group X sPLA(2) supplies arachidonic acid in both the normal epithelium and the polyps even in the absence of cPLA(2)...
  93. ncbi Evidence for the autocrine induction of capacitation of mammalian spermatozoa
    C Wu
    Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    J Biol Chem 276:26962-8. 2001
    ..7%). The study shows for the first time the operation of an autocrine loop that induces capacitation in sperm in vitro and shows that this loop acts in concert with other mediators of capacitation to promote efficient fertilization...
  94. ncbi The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain
    K Ohnishi
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland and the Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    J Biol Chem 275:31134-44. 2000
    ..We call this B lineage-, intestine-, liver- and leukocyte-expressed gene BILL-cadherin. The possible functions of BILL-cadherin in B cell development are discussed...
  95. ncbi Role of cytosolic phospholipase A2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells
    N Nakatani
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Biochem J 352:311-7. 2000
    ..While the overall effect is still a decrease in the release of mast cell mediators, explaining the in vivo findings, the present study proposes a novel link between cPLA(2) and the degranulation machinery...
  96. ncbi Processing of beta-dystroglycan by matrix metalloproteinase disrupts the link between the extracellular matrix and cell membrane via the dystroglycan complex
    H Yamada
    Department of Neurology and Neuroscience, Teikyo University School of Medicine, Tokyo 173-8605, Japan
    Hum Mol Genet 10:1563-9. 2001
    ..Based on these and previously reported findings, we propose a hypothesis that this processing may play a crucial role in the molecular pathogenesis of sarcoglycanopathy...
  97. ncbi Single nucleotide polymorphism of human platelet-activating factor receptor impairs G-protein activation
    K Fukunaga
    Department of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
    J Biol Chem 276:43025-30. 2001
    ....
  98. ncbi Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice
    Y Oikawa
    Division of Stem Cell Regulation Research, G6, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    FEBS Lett 579:3975-8. 2005
    ..These results suggested that cPLA(2)alpha plays a protective role in progression of insulitis and development of autoimmune diabetes by suppression of TNF-alpha production from macrophages...
  99. ncbi Analysis of a suppressor mutation ssb (kinC) of sur0B20 (spo0A) mutation in Bacillus subtilis reveals that kinC encodes a histidine protein kinase
    K Kobayashi
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan
    J Bacteriol 177:176-82. 1995
    ..DNase I protection experiments showed that the Spo0A protein binds to two adjoining sites in the kinC promoter region with different affinities. These results suggest that kinC expression might be regulated by Spo0A...
  100. ncbi Nerve injury induces the expression of EXT2, a glycosyltransferase required for heparan sulfate synthesis
    K Murakami
    Department of Anatomy and Neurobiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, Osaka 545-8585, Japan
    Neuroscience 141:1961-9. 2006
    ....
  101. ncbi Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cells
    D Hirano
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
    Biochem J 316:81-6. 1996
    ..These results suggest that cyclic AMP production through Ado A2a receptor inhibits thrombin-elicited MAPK activation by a Ca(2+)-independent/wortmannin-sensitive pathway in CHO cells...