Research Topics
Genomes and Genes
| Seishi OgawaSummaryAffiliation: University of Tokyo Country: Japan Publications
| Collaborators
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Detail Information
Publications
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasmsSeishi Ogawa
Cancer Genomics Project, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
Clin Cancer Res 16:3825-31. 2010..The inhibition of mutant CBL protein or signaling pathways that it activates would have a role in therapeutics of myeloid neoplasms with CBL mutations...- Oncogenic mutations of ALK in neuroblastomaSeishi Ogawa
Cancer Genomics Project, The University of Tokyo, Tokyo, Japan
Cancer Sci 102:302-8. 2011.... - Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasmsSeishi Ogawa
Cancer Genomics Project, University of Tokyo, Bunkyo ku, Tokyo, Japan
Cell Cycle 9:1051-6. 2010..In this review, we summarize our current knowledge about c-CBL mutations and discuss the molecular mechanisms of their gain-of-function... - Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cellsSusumu Goyama
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, Tokyo 113 8655, Japan
Cell Stem Cell 3:207-20. 2008..Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells... - Pharmacokinetics of alemtuzumab after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab with or without CD52-positive malignanciesKumi Oshima
Department of Hematology, Cell Therapy and Transplantation Medicine, University of Tokyo Graduate School of Medicine and Hospital, Tokyo, Japan
Am J Hematol 81:875-9. 2006.... - Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarraysGo Yamamoto
Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Am J Hum Genet 81:114-26. 2007..In conclusion, AsCNAR should substantially improve our ability to dissect the complexity of cancer genomes and should contribute to our understanding of the genetic basis of human cancers... - Oncogenic mutations of ALK kinase in neuroblastomaYuyan Chen
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
Nature 455:971-4. 2008..We anticipate that our findings will provide new insights into the pathogenesis of advanced neuroblastoma and that ALK-specific kinase inhibitors might improve its clinical outcome... - Gain of GRHL2 is associated with early recurrence of hepatocellular carcinomaYasuo Tanaka
Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
J Hepatol 49:746-57. 2008..The aim of this study is to identify genomic changes that might be implicated in hepatocellular carcinoma (HCC) progression, and evaluate the associations with clinico-pathological features... - Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasmsMasashi Sanada
Cancer Genomics Project, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nature 460:904-8. 2009..Our findings provide a new insight into a role of gain-of-function mutations of a tumour suppressor associated with aUPD in the pathogenesis of some myeloid cancer subsets... - Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte developmentMasahito Kawazu
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Immunol 174:3526-33. 2005..These results suggest that the activation domain is essential for Runx1 to establish thymocyte development and that Runx1 has both TLE-dependent and TLE-independent functions in thymocyte development... - Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocationNoriko Hosoya
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Genes Chromosomes Cancer 42:269-79. 2005.... - Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/AblSachiko Seo
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Cancer Sci 102:2109-17. 2011..Thus, Cas-L seems to regulate the progression of CML in a negative way, presumably by attenuating extramedullary hyperplasia... - Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte developmentMasahito Kawazu
Department of Hematology and Oncology, University of Tokyo, Japan
J Immunol 179:5335-45. 2007.... - Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15Kyoko Haraguchi
Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
J Immunol 182:6168-78. 2009..Together, these results suggest that Notch signaling is important for the physiologic development of NK cells at differentiation stages beyond those previously postulated... - Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancerMotohisa Tada
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Cancer Sci 101:1261-9. 2010..Using high-density SNP arrays, we identified several novel and minute genomic alterations. LOH of four genes could be useful for prediction of lymph node metastasis and prognosis in early stage gastric cancers... - Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasisKeiki Kumano
Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
Pigment Cell Melanoma Res 21:70-8. 2008..Furthermore, Notch1 and Notch2 cooperates with c-kit signaling during embryogenesis, and they cooperate with each other to regulate melanocyte homeostasis after birth... - Derivation of functional mature neutrophils from human embryonic stem cellsYasuhisa Yokoyama
Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
Blood 113:6584-92. 2009..Thus, this is the first description of a detailed functional analysis of mature hESC-derived neutrophils... - AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesisMasahiro Nakagawa
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
Blood 108:3329-34. 2006..Our findings also suggest that Notch signaling may modulate both expression and transcriptional activity of Runx1... - Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric proteinTakahiro Suzuki
Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Stem Cells 24:2456-65. 2006..Interestingly, the CD133-sorted cells contained approximately 4.5 times more SRCs than the CD34-sorted cells. The present study provides a promising method to expand HSCs and encourages future trials on clinical transplantation... - AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesisMotoshi Ichikawa
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Immunol 180:4402-8. 2008..We also found an increase in HSC number within the AML1-deficient bone marrow using limiting dilution bone marrow transplantation assays. These results indicate that the number of quiescent HSCs is negatively regulated by AML1... - CD1d expression level in tumor cells is an important determinant for anti-tumor immunity by natural killer T cellsKyoko Haraguchi
Department of Hematology Oncology, University of Tokyo Graduate School of Medicine and Hospital, Hongo, Tokyo, Japan
Leuk Lymphoma 47:2218-23. 2006..These observations possibly suggest that direct cytotoxicity of tumor cells by iNKT cells is common to both humans and mice, and that the high expression level of CD1d may be a predictor whether the tumor is a good target of iNKT cells... - Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fateMamiko Sakata-Yanagimoto
Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Proc Natl Acad Sci U S A 105:7839-44. 2008..Taken together, signaling through Notch2 determines the fate of myeloid progenitors toward mast cell-producing progenitors, via coordinately up-regulating Hes-1 and GATA3... - Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBPEriko Nitta
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
Oncogene 24:6165-73. 2005..These results suggest that oligomerization may contribute to the oncogenic potential of Evi-1-containing proteins... - Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300Shigeo Masuda
Department of Hematology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
Cancer Sci 96:274-82. 2005..Taken together, we propose that Notch oncoproteins promote cell growth and cancer development partly by suppressing the growth inhibitory effects of TGF-beta through sequestrating p300 from Smad3... - In vivo alemtuzumab enables haploidentical human leukocyte antigen-mismatched hematopoietic stem-cell transplantation without ex vivo graft manipulationYoshinobu Kanda
Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Hongo, Tokyo, Japan
Transplantation 79:1351-7. 2005..This study evaluates the safety of unmanipulated peripheral blood stem-cell transplantation from two or three loci-mismatched related donors using alemtuzumab in vivo... - Host-residual invariant NK T cells attenuate graft-versus-host immunityKyoko Haraguchi
Departments of Hematology Oncology, Cell Therapy Transplantation Medicine, University of Tokyo Graduate School of Medicine and Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Immunol 175:1320-8. 2005..These results indicate that host-residual iNKT cells attenuate graft-vs-host immunity rather than host-vs-graft immunity... - A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arraysYasuhito Nannya
Department of Hematology/Oncology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
Cancer Res 65:6071-9. 2005.... - Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene deliveryAleksandra Crcareva
Department of Hematology Oncology, University of Tokyo, Japan
Exp Hematol 33:1459-69. 2005..The objective of this study is to examine whether the use of fibroblast growth factor-1 (FGF-1)-expanded bone marrow cells provide an improved source for retroviral gene delivery to HSCs... - Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemiaFumio Nakahara
Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
Blood 115:2872-81. 2010..These results suggest that Hes1 is a key molecule in blast crisis transition in CML... - Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantatioToshio Yabe
Japanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan
Biol Blood Marrow Transplant 14:75-87. 2008.... - Long-term sustained mixed chimerism after allogeneic stem cell transplantation in a patient with severe aplastic anemiaAkiko M Saito
Department of Hematology Oncology, Graduate School of Medicine and Department of Cell Therapy Transplantation Medicine, University of Tokyo Hospital, University of Tokyo, Tokyo
Intern Med 46:1923-6. 2007..This report describes the most comprehensive case study known to date... - The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) regionSusumu Goyama
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Blood 104:3558-64. 2004..Thus, this experimental system will become a valuable tool to analyze the physiologic function and domain contribution of Runx proteins in hematopoiesis... - Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastomaKan Takahashi
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
Brain Dev 33:353-6. 2011..13 to 13q32.3 and involving the RB1 gene. This patient is the first case of Arima syndrome, or a Joubert syndrome-related disorder, that showed linkage to chromosome 13q... - Immunotherapy against metastatic renal cell carcinoma with mature dendritic cellsAkihiko Matsumoto
Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Int J Urol 14:277-83. 2007..We performed a clinical trial of immunotherapy using autologous mature dendritic cells (DC) pulsed with autologous tumor lysate, for patients with metastatic renal cell carcinoma (RCC)... - Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenanceSachiko Seo
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Immunol 175:3492-501. 2005..Thus, Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion... - Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft modelShigeo Masuda
Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
Cancer Sci 100:2444-50. 2009.... - Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridizationNoriko Hosoya
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
Genes Chromosomes Cancer 45:482-94. 2006..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat... - Hepatoblastoma in a patient with sotos syndromeMotohiro Kato
Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Pediatr 155:937-9. 2009..Genome-wide analysis of copy number alterations showed a gain of chromosome 2, uniparental disomy of 18q, and microdeletion of 5q35... - Clinical significance of peripheral blood erythroblastosis after hematopoietic stem cell transplantationSusumu Goyama
Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Japan
Leuk Lymphoma 45:2439-43. 2004..As for post-transplant events, a high EBL concentration was frequently preceded by graft-vs.-host disease, thrombotic microangiopathy, hypoxia, and hematological relapse... - Integrated analysis of copy number alterations and loss of heterozygosity in human pancreatic cancer using a high-resolution, single nucleotide polymorphism arrayLian jie Lin
Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Oncology 75:102-12. 2008..To chart molecular genetic events in pancreatic cancer... - Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastomaJunko Takita
Department of Cell Therapy and Transplantation, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Cancer Sci 102:1645-50. 2011..In addition, the findings suggest a possible prognostic value for NEGR1 in neuroblastoma... - MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysisReika Iwakawa
Biology Division, National Cancer Center Research Institute Cancer Genomics Project, The University of Tokyo, Tokyo, Japan
Clin Cancer Res 17:1481-9. 2011..The purpose of this study was to identify genetic alterations that define prognosis of patients with early-stage lung ADC... - Assessment of the international prognostic scoring system for determining chemotherapeutic indications in myelodysplastic syndrome: Japanese retrospective multicenter studyYoshikazu Ito
First Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, Japan
Int J Hematol 82:236-42. 2005..Our proposition may be useful for developing a chemotherapeutic strategy for patients with MDS in Japan... - Molecular cytogenetic analyses of HIG, a novel human cell line carrying t(1;3)(p36.3;q25.3) established from a patient with chronic myelogenous leukemia in blastic crisisNoriko Hosoya
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Int J Hematol 78:432-8. 2003..Further analyses of the deregulated genes in the HIG cell line should provide important insight into the mechanisms involved in these types of leukemias... - A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host diseaseAkiko Hori
Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
Transplantation 79:372-4. 2005..A randomized controlled trial is warranted to evaluate the efficacy of pravastatin against chronic GVHD... - Single-nucleotide polymorphism array karyotyping in clinical practice: where, when, and how?Aiko Sato-Otsubo
Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
Semin Oncol 39:13-25. 2012..Here, we review the current status of SNP-A karyotyping and its application to hematopoietic neoplasms... - Frequent pathway mutations of splicing machinery in myelodysplasiaKenichi Yoshida
Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nature 478:64-9. 2011..Our results provide the first evidence indicating that genetic alterations of the major splicing components could be involved in human pathogenesis, also implicating a novel therapeutic possibility for myelodysplasia... - Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap projectYasuhito Nannya
Department of Hematology Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
Hum Mol Genet 16:2494-505. 2007..7], we can expect satisfactory power with currently available large-scale genotyping platforms using realistic sample size ( approximately 1000 per arm)... - Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletionYoshinari Asaoka
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Biochem Biophys Res Commun 394:1042-6. 2010..This information will be useful for screening of inhibitors targeting gastric cancer with c-Met aberration... - Frequent inactivation of A20 in B-cell lymphomasMotohiro Kato
Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nature 459:712-6. 2009.... - Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinomaReika Iwakawa
Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Tokyo, Japan
Genes Chromosomes Cancer 51:462-72. 2012..These results strongly indicate that somatic PARK2 mutations occur rarely (or do not occur) in LADC development and that germline PARK2 mutations could contribute to LADC progression but not to LADC development... - Polycomb-mediated loss of miR-31 activates NIK-dependent NF-?B pathway in adult T cell leukemia and other cancersMakoto Yamagishi
Graduate School of Frontier Sciences, The University of Tokyo, Japan
Cancer Cell 21:121-35. 2012..Furthermore, this emerging circuit operates in other cancers and receptor-initiated NF-?B cascade. Our findings provide a perspective involving the epigenetic program, inflammatory responses, and oncogenic signaling... - Graft-versus-tumor effect against advanced pancreatic cancer after allogeneic reduced-intensity stem cell transplantationYoshinobu Kanda
Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Transplantation 79:821-7. 2005.... - Immature granulocyte fraction in the peripheral blood is a practical indicator for mobilization of CD34(+) cellsMari Endo-Matsubara
Departments of Cell Therapy/Transplantation Medicine and Hematology/Oncology, University of Tokyo Hospital and Graduate School of Medicine, Tokyo, Japan
Am J Hematol 77:223-8. 2004..These findings indicate that LSI is a useful and simple method for predicting the yield of CD34(+) cells before the start of PBSC collection and avoiding unnecessary apheresis... - Prospective comparison of the diagnostic potential of real-time PCR, double-sandwich enzyme-linked immunosorbent assay for galactomannan, and a (1-->3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disordMasahito Kawazu
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
J Clin Microbiol 42:2733-41. 2004..In conclusion, among these weekly screening tests for IA, the double-sandwich ELISA test was the most sensitive at predicting the diagnosis of IA in high-risk patients with hematological disorders, using a reduced cutoff of 0.6 O.D.I... - Runx1/AML-1 ranks as a master regulator of adult hematopoiesisMotoshi Ichikawa
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Cell Cycle 3:722-4. 2004.... - AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesisMotoshi Ichikawa
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
Nat Med 10:299-304. 2004..AML-1 is thus required for maturation of megakaryocytes and differentiation of T and B cells, but not for maintenance of hematopoietic stem cells (HSCs) in adult hematopoiesis... - Rapid diagnosis of invasive pulmonary aspergillosis by quantitative polymerase chain reaction using bronchial lavage fluidMasahito Kawazu
Department of Hematology and Oncology, University of Tokyo, Tokyo, Japan
Am J Hematol 72:27-30. 2003..This novel tool will provide rapid, sensitive, and specific diagnosis of pulmonary aspergillosis... - KIF5B-RET fusions in lung adenocarcinomaTakashi Kohno
Division of Genome Biology, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
Nat Med 18:375-7. 2012.... - Molecular characterization of the recurrent unbalanced translocation der(1;7)(q10;p10)Lili Wang
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
Blood 102:2597-604. 2003..Our results provide a novel insight into the structural basis for generation of this translocation as well as its leukemogenic roles... - Influence of glutathione S-transferase A1 polymorphism on the pharmacokinetics of busulfanMakiko Kusama
Department of Pharmacy, University of Tokyo Hospital University of Tokyo, 7 3 1 Hongo, Bunkyo ku Tokyo, 113 8655, Japan
Clin Chim Acta 368:93-8. 2006..Glutathione S-transferase (GST) A1, whose genetic polymorphism in its promoter region has been reported, is responsible for busulfan metabolism. We investigated the polymorphism of GSTA1 on busulfan pharmacokinetics... - Mutational analyses of the AML1 gene in patients with myelodysplastic syndromeOich Imai
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
Leuk Lymphoma 43:617-21. 2002..In this review, we summarize mutational changes of the AML1 gene in hematological malignancies, especially in MDS and discuss the mechanism whereby the mutant acts as a dominant negative inhibitor of wild-type AML1... - Generation of Fas-independent CD4+ cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptideYuji Tanaka
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan
Leuk Res 26:317-21. 2002..Success in establishment of the p190 bcr-abl fusion peptide-specific T-cell clone encourages us to develop a new approach to an effective immunotherapy for Ph+ALL... - Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cellsKeiki Kumano
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
Immunity 18:699-711. 2003..In contrast, Notch2(-/-) embryos showed no hematopoietic deficiency. These data indicate that Notch1, but not Notch2, is essential for generating hematopoietic stem cells from endothelial cells...