Research Topics
Genomes and Genes | Satoshi NishimuraSummaryAffiliation: University of Tokyo Country: Japan Publications
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Publications
[In vivo imaging reveals adipose tissue inflammation in obesity and multi-cellular processes of developing thrombus]Satoshi Nishimura
Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
Yakugaku Zasshi 132:425-31. 2012....- In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signalingSatoshi Nishimura
Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
Blood 119:e45-56. 2012.... - CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesitySatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Nat Med 15:914-20. 2009..These results support the notion that CD8(+) T cells have an essential role in the initiation and propagation of adipose inflammation... - Follow-up study of aortic-valve replacement surgery in patients with Takayasu's disease complicated by aortic regurgitationSatoshi Nishimura
Department of Cardiovascular Medicine, The Sakakibara Heart Institute, Tokyo, Japan
Circ J 66:564-6. 2002.... - In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissueSatoshi Nishimura
Department of Cardiovascular Medicine and Nano Bioengineering Education Program, University of Tokyo, Tokyo, Japan
J Clin Invest 118:710-21. 2008..In addition, this technique may prove to be a valuable tool to evaluate potential therapeutic interventions... - Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vesselsSatoshi Nishimura
Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
Diabetes 56:1517-26. 2007..However, little is known about how adipocytes, adipocyte precursors, blood vessels, and stromal cells interact with one another to achieve adipogenesis... - Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditionsSatoshi Nishimura
The Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
J Mol Cell Cardiol 39:231-9. 2005..These results clearly indicate the importance of the loading conditions in evaluating the contractile function of CMP hamster myocytes, and may provide insights into the mechanism of contractile dysfunction in this disease... - Responses of single-ventricular myocytes to dynamic axial stretchingSatoshi Nishimura
Department of Cardiovascular Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
Prog Biophys Mol Biol 97:282-97. 2008..The amplitude may also modulate the ion selectivity of stretch-activated channels. This combination of the carbon fiber technique with fluorescence measurement could represent a powerful tool for clarifying MEF at the cellular level... - Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed-dependent mannersSatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan
Cardiovasc Res 72:403-11. 2006..CONCLUSIONS: Application of axial stretching to rat ventricular myocytes changed the membrane potential in phase-, amplitude- and speed-dependent manners. Amplitude may also modulate the ion selectivity of stretch-activated channels... - Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytesSatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Tokyo 113-0033, Japan
Mol Cell Biochem 286:59-65. 2006..Adv-GFP expression may not be an ideal control for specific gene expression experiments in myocardial tissue... - Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditionsSatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Am J Physiol Heart Circ Physiol 287:H196-202. 2004..In conclusion, the present results confirmed the fact that each myocyte forms the functional basis for ventricular function and that single cell mechanics can be a link between subcellular events and ventricular mechanics... - Microtubules modulate the stiffness of cardiomyocytes against shear stressSatoshi Nishimura
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan
Circ Res 98:81-7. 2006..In the complex strain field that living myocytes experience in the body, observed changes in shear stiffness may have a significant influence on the diastolic property of the diseased heart... - Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistanceNozomu Kamei
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Biol Chem 281:26602-14. 2006..We concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-MCP-1 mice... - Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cellsNaoya Takayama
Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, Tokyo, Japan
J Exp Med 207:2817-30. 2010..These findings suggest that the pattern of c-MYC expression, particularly its later decline, is key to producing functional platelets from selected iPSC clones... - Involvement of CaV3.1 T-type calcium channels in cell proliferation in mouse preadipocytesAtsushi Oguri
Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
Am J Physiol Cell Physiol 298:C1414-23. 2010..1 T-type Ca(2+) channel encoded by alpha(1G) subtype is the dominant Ca(V) in mouse preadipocytes and may play a role in regulating preadipocyte proliferation, a key step in adipose tissue development... - Adipose tissue inflammation in obesity and metabolic syndromeSatoshi Nishimura
Department of Cardiovascular Medicine, and Translational Systems Biology and Medicine Initiative, The University of Tokyo Graduate School of Medicine, Tokyo 112 0033, Japan
Discov Med 8:55-60. 2009..Thus clarification of the inflammatory processes ongoing in obese adipose tissue would seem essential for the understanding of metabolic syndrome and for developing novel therapeutic strategies to treat it... - IFATS collection: Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanismHirotaka Suga
Department of Plastic Surgery, University of Tokyo, Japan
Stem Cells 27:238-49. 2009..This study revealed a functional role for ASCs in the response to injury and provides new insight into the therapeutic potential of ASCs... - Structural heterogeneity in the ventricular wall plays a significant role in the initiation of stretch-induced arrhythmias in perfused rabbit right ventricular tissues and whole heart preparationsKinya Seo
Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
Circ Res 106:176-84. 2010..Mechanical stress is known to alter the electrophysiological properties of the myocardium and may trigger fatal arrhythmias when an abnormal load is applied to the heart... - Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overloadNorifumi Takeda
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, Japan
J Clin Invest 120:254-65. 2010..Modulation of cardiac fibroblast function may provide a novel strategy for treating heart failure, with KLF5 serving as an attractive target... - Carbon fiber technique for the investigation of single-cell mechanics in intact cardiac myocytesSeiryo Sugiura
Computational Biomechanics Laboratory, Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
Nat Protoc 1:1453-7. 2006..In combination with other experimental procedures, this technique can also be applied to the study of mechano-transduction. This protocol can be completed in 3.5 h... - Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscleTetsuya Kubota
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
Cell Metab 13:294-307. 2011..Furthermore, improving endothelial insulin signaling may serve as a therapeutic strategy for ameliorating skeletal muscle insulin resistance... - Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivoHitoshi Takizawa
Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo, Japan
J Clin Invest 120:179-90. 2010..Outside-in signaling modulators could represent new therapeutic targets for the prevention of cardiovascular events... - A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivoNobuhiro Yagi
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
Cancer Res 69:6531-8. 2009..Our findings support the idea that siRNA/WS can be used to knock down specific genes within tumors and thereby exert therapeutic effects against cancers... - Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytesSo-ichiro Yasuda
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Am J Physiol Heart Circ Physiol 285:H470-5. 2003..Our results suggest that Ca2+ transients reflect the affinity of troponin C for Ca2+, which is influenced by the change in strain on the thin filament but not by the length change per se... - Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasisYoshikazu Hirose
Laboratory of Cell Growth and Differentiation and Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
Proc Natl Acad Sci U S A 109:4263-8. 2012..These results suggest that blocking Stab2 function prevents tumor metastasis by elevating circulating HA levels. Stab2 may be a potential target in antitumor therapy... - Three-dimensional simulation of calcium waves and contraction in cardiomyocytes using the finite element methodJun Ichi Okada
Core Research for Evolutional Science and Technology of the Japan Science and Technology Agency, Saitama, Japan
Am J Physiol Cell Physiol 288:C510-22. 2005..The present 3-D simulator, with its ability to study the interaction between Ca(2+) waves and contraction, will serve as a useful tool for studying the mechanism of this complex phenomenon... - Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epitheliumSatoshi Nishimura
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto City, 602 8566, Japan
Dig Dis Sci 48:1523-9. 2003..This is the first report outlining expression of Musashi-1 in human colon crypt cells...