Kazuhiko Koike

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Molecular mechanism of viral hepatocarcinogenesis
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Oncology 62:29-37. 2002
  2. ncbi Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
    Yoshizumi Shintani
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Gastroenterology 126:840-8. 2004
  3. ncbi Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:82-8. 2009
  4. ncbi LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL
    Makoto Kurano
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Lipids Health Dis 10:134. 2011
  5. ncbi Acquisition of methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a retrospective cohort study
    Masao Hashimoto
    Artificial Organ and Transplantation Division, Department of Surgery, University of Tokyo, Tokyo, Japan
    BMC Infect Dis 8:155. 2008
  6. ncbi Antiviral treatment of hepatitis C: present status and future prospects
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Infect Chemother 12:227-32. 2006
  7. ncbi Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis
    Kazuhiko Koike
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 23:S87-91. 2008
  8. ncbi Molecular basis of hepatitis C virus-associated hepatocarcinogenesis: lessons from animal model studies
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 3:S132-5. 2005
  9. ncbi Hepatitis C virus infection can present with metabolic disease by inducing insulin resistance
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Intervirology 49:51-7. 2006
  10. ncbi Hepatitis C virus contributes to hepatocarcinogenesis by modulating metabolic and intracellular signaling pathways
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:S108-11. 2007

Detail Information

Publications135 found, 100 shown here

  1. ncbi Molecular mechanism of viral hepatocarcinogenesis
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Oncology 62:29-37. 2002
    ..Such a scenario would explain an unusually high incidence and multicentric nature of HCC developing in chronic hepatitis B or C...
  2. ncbi Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
    Yoshizumi Shintani
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Gastroenterology 126:840-8. 2004
    ..These results provide a direct experimental evidence for the contribution of HCV in the development of insulin resistance in human HCV infection, which finally leads to the development of type 2 diabetes...
  3. ncbi Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:82-8. 2009
    ..These results would provide a clue for further understanding of the role of lipid metabolism in pathogenesis of HCV infection, including liver injury and hepatocarcinogenesis...
  4. ncbi LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL
    Makoto Kurano
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Lipids Health Dis 10:134. 2011
    ..The physiological regulation of hepatic apoE gene has not been clarified, although the expression of apoE in adipocytes and macrophages has been known to be regulated by LXR...
  5. ncbi Acquisition of methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a retrospective cohort study
    Masao Hashimoto
    Artificial Organ and Transplantation Division, Department of Surgery, University of Tokyo, Tokyo, Japan
    BMC Infect Dis 8:155. 2008
    ..The aim of the present study was to assess the incidence and to analyze the risk factors for the acquisition of MRSA after LDLT in adults by multivariate analysis...
  6. ncbi Antiviral treatment of hepatitis C: present status and future prospects
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Infect Chemother 12:227-32. 2006
    ..Thus, the treatment for HCV infection has progressed significantly, but therapies with new modalities, such as inhibitors of viral protease or RNA polymerase, are still being awaited...
  7. ncbi Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis
    Kazuhiko Koike
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 23:S87-91. 2008
    ..Such a synergy would reveal the molecular basis for the acceleration of HCC development by alcohol in HCV infection...
  8. ncbi Molecular basis of hepatitis C virus-associated hepatocarcinogenesis: lessons from animal model studies
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 3:S132-5. 2005
    ..Such a scenario, "non-Vogelstein type" carcinogenesis, may explain the unusually high incidence and multicentric nature of HCC development in HCV infection...
  9. ncbi Hepatitis C virus infection can present with metabolic disease by inducing insulin resistance
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Intervirology 49:51-7. 2006
    ..In conclusion, towards the future, HCV infection needs to be viewed not only as a liver disease but also as a metabolic disease...
  10. ncbi Hepatitis C virus contributes to hepatocarcinogenesis by modulating metabolic and intracellular signaling pathways
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:S108-11. 2007
    ..Such a scenario, 'non-Vogelstein-type' carcinogenesis, would explain the rare feature of hepatocarcinogenesis in HCV infection, the extraordinarily high incidence and the multicentric nature of HCC development...
  11. ncbi Role of hepatitis C virus in the development of hepatocellular carcinoma: transgenic approach to viral hepatocarcinogenesis
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol Hepatol 17:394-400. 2002
    ....
  12. ncbi Compensatory apoptosis in preneoplastic liver of a transgenic mouse model for viral hepatocarcinogenesis
    K Koike
    First Department of Internal Medicine, University of Tokyo, Japan
    Cancer Lett 134:181-6. 1998
    ..The disappearance or block of apoptotic signals, which may be the result of additional genetic or epigenetic aberrations, may result in the preneoplastic hepatocytes becoming neoplastic...
  13. ncbi Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells
    Kyoji Moriya
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Am J Pathol 175:1515-24. 2009
    ..These results may provide new therapeutic tools for chronic hepatitis C, in which oxidative stress and abnormalities in lipid and glucose metabolism contribute to liver pathogenesis...
  14. ncbi Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1570-5. 2011
    ..We aimed to elucidate the association between gastric cancer risk and the distribution of precancerous lesions in the stomach by histological analyses...
  15. ncbi Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Chemother Pharmacol 67:847-53. 2011
    ..Gallbladder cancer and intra-hepatic cholangiocarcinoma are previously reported prognostic factors of poor prognosis; however, tumor volume has not been analyzed in these previous reports...
  16. ncbi Specific increase in serum autotaxin activity in patients with pancreatic cancer
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Biochem 44:576-81. 2011
    ..To evaluate the potential clinical significance of serum autotaxin (ATX) level in patients with cancers of the digestive system...
  17. ncbi Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway
    Yotaro Kudo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 55:1400-8. 2011
    ....
  18. ncbi Duodenal invasion is a risk factor for the early dysfunction of biliary metal stents in unresectable pancreatic cancer
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Gastrointest Endosc 74:548-55. 2011
    ..Although the placement of self-expandable metal stents (SEMSs) has been widely accepted as palliation for distal malignant biliary obstruction, the risk factors for their early dysfunction remain unclear...
  19. ncbi Association between cigarette smoking and chronic kidney disease in Japanese men
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Hypertens Res 31:485-92. 2008
    ....
  20. ncbi Efficacy and safety of covered self-expandable metal stents for management of distal malignant biliary obstruction due to lymph node metastases
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Surg Endosc 25:3094-100. 2011
    ..However, the role of covered self-expandable metal stents (SEMS) in treating MBO has not been studied. The aim of this study was to evaluate the efficacy and safety of covered SEMS for the treatment of distal MBO due to LNM...
  21. ncbi Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer 117:4475-83. 2011
    ..The objective of this study was to further elucidate the clinical course and prognostic determinants of patients with this disease...
  22. ncbi Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Invest New Drugs 29:1488-93. 2011
    ..Two patients treated for approximately 1 year developed cisplatin-related toxicities. In conclusion, gemcitabine and cisplatin combination chemotherapy produces a limited tumor response in BTC, but may prolong patient's survival...
  23. ncbi Newly designed large cell Niti-S stent for malignant hilar biliary obstruction: a pilot study
    Hirofumi Kogure
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 25:463-7. 2011
    ..This study evaluated the feasibility and efficacy of the Niti-S large cell D-type biliary stent (LCD) with a uniform large cell for both uni- and bilateral drainage of malignant hilar biliary obstruction...
  24. ncbi Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression
    Hideyuki Miyoshi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 43:757-63. 2005
    ..We studied the effect of the core protein of hepatitis C virus (HCV) on the expression of SOCS-1 gene...
  25. ncbi Reduced expression of RAS protein activator like-1 in gastric cancer
    Motoko Seto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Cancer 128:1293-302. 2011
    ..Our findings demonstrate that reduced RASAL1 expression, partly due to genetic and epigenetic changes, contributes to gastric carcinogenesis, and also re-emphasize the importance of RAS signaling in gastric cancer development...
  26. ncbi Endoscopic bilateral metallic stenting for malignant hilar obstruction using newly designed stents
    Hirofumi Kogure
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatobiliary Pancreat Sci 18:653-7. 2011
    ..Whether unilateral or bilateral drainage should be performed for malignant hilar biliary obstruction is controversial. Moreover, endoscopic placement of bilateral metallic stents is difficult and complicated...
  27. ncbi Alteration of intrahepatic cytokine expression and AP-1 activation in transgenic mice expressing hepatitis C virus core protein
    Takeya Tsutsumi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Virology 304:415-24. 2002
    ..Thus, the altered in vivo expression of cytokines with AP-1 activation in consequence to the core protein expression may contribute to hepatocarcinogenesis in persistent HCV infection...
  28. ncbi Plant sterols increased IL-6 and TNF-? secretion from macrophages, but to a lesser extent than cholesterol
    Makoto Kurano
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
    J Atheroscler Thromb 18:373-83. 2011
    ..In this study, we investigated whether phytosterols would affect inflammatory reactions in macrophages and macrophage cell lines...
  29. ncbi Lower incidence of biliary carcinoma in patients with primary sclerosing cholangitis and high serum levels of immunoglobulin E
    Kenji Hirano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 10:79-83. 2012
    ..High serum levels of immunoglobulin (Ig)E often are detected in patients with primary sclerosing cholangitis (PSC), but the clinical significance is not known...
  30. ncbi A large volume of visceral adipose tissue leads to severe acute pancreatitis
    Yoko Yashima
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 46:1213-8. 2011
    ..Obesity plays an important role in acute pancreatitis. Assuming that the volume of visceral adipose tissue (VAT) directly influences the severity of acute pancreatitis, we investigated the relationship between VAT and acute pancreatitis...
  31. ncbi Living donor liver transplantations in HIV- and hepatitis C virus-coinfected hemophiliacs: experience in a single center
    Kunihisa Tsukada
    Department of Infectious Diseases, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Transplantation 91:1261-4. 2011
    ....
  32. ncbi Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    J Rheumatol 37:410-6. 2010
    ..We investigated the relationship among percentage changes in waist circumference (%dWC), body mass index (%dBMI), and serum uric acid (%dUA)...
  33. ncbi Relationship between the initial dose of micafungin and its efficacy in patients with candidemia
    Yasuo Ota
    Department of Infectious Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    J Infect Chemother 13:208-12. 2007
    ..Considering these results, we recommend the administration of 2.25 mg/kg/day or more of micafungin in the initial treatment of patients with candidemia...
  34. ncbi Association between changes in obesity parameters and incidence of chronic kidney disease in Japanese individuals
    Yuko Ishizaka
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Kidney Blood Press Res 32:141-9. 2009
    ....
  35. ncbi Gemcitabine and oxaliplatin combination chemotherapy for patients with refractory pancreatic cancer
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Oncology 80:97-101. 2011
    ..The aim of this study was to investigate the effect of gemcitabine and oxaliplatin combination chemotherapy on refractory pancreatic cancer...
  36. ncbi Association between chronic kidney disease and carotid intima-media thickening in individuals with hypertension and impaired glucose metabolism
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 30:1035-41. 2007
    ....
  37. ncbi Impact of introduction of wire-guided cannulation in therapeutic biliary endoscopic retrograde cholangiopancreatography
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1552-8. 2011
    ..We assessed the learning curve for WGC in therapeutic biliary ERCP (study 1) and compared WGC and conventional contrast-assisted cannulation (CC) by a matched case-control study (study 2)...
  38. ncbi Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species
    Hidetake Fujinaga
    Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Oncology 81:11-7. 2011
    ..e. very frequent and multicentric development of HCC, in persistent HCV infection...
  39. ncbi Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 20:2204-11. 2011
    ....
  40. ncbi Analysis of plasmid-mediated multidrug resistance in Escherichia coli and Klebsiella oxytoca isolates from clinical specimens in Japan
    Takashi Ode
    Department of Microbiology and Immunology, Graduate School of Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Int J Antimicrob Agents 34:347-50. 2009
    ..oxytoca isolates. We describe the identification of qnrB6 and aac(6')-Ib-cr and the close association of qnr with aac(6')-Ib and aac(6')-IIc for the first time in clinical isolates producing ESBL or MBL in Japan...
  41. ncbi Comorbidity, not age, is prognostic in patients with advanced pancreatic cancer receiving gemcitabine-based chemotherapy
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
    Crit Rev Oncol Hematol 78:252-9. 2011
    ..To evaluate the impact of age and comorbidity on clinical outcomes in advanced pancreatic cancer...
  42. ncbi Anti-tumor activity of the proteasome inhibitor bortezomib in gastric cancer
    Wachiko Nakata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 39:1529-36. 2011
    ..We also observed anti?tumor effects of bortezomib in vivo. Bortezomib is a potential novel molecular targeting drug for the treatment of unresectable advanced gastric cancer...
  43. ncbi Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperon, prohibitin, in cells expressing hepatitis C virus core protein
    Takeya Tsutsumi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Hepatology 50:378-86. 2009
    ....
  44. ncbi Fatal liver failure caused by reactivation of lamivudine-resistant hepatitis B virus: a case report
    Yuka Suzuki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan
    World J Gastroenterol 13:964-9. 2007
    ..Antiviral therapy for patients with breakthrough hepatitis in advanced liver disease should be carefully performed...
  45. ncbi Molecular characterizations of carbapenem and ciprofloxacin resistance in clinical isolates of Pseudomonas putida
    Wakako Kumita
    Department of Microbiology and Immunology, Graduate School of Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Infect Chemother 15:6-12. 2009
    ..putida...
  46. ncbi Impact of S-1 in patients with gemcitabine-refractory pancreatic cancer in Japan
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Clin Oncol 40:774-80. 2010
    ..We investigated the impact of S-1 on the prognosis of patients with gemcitabine-refractory pancreatic cancer...
  47. ncbi Covered metallic stenting for malignant distal biliary obstruction: clinical results according to stent type
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatobiliary Pancreat Sci 18:673-7. 2011
    ..However, there are very few reports on factors influencing the results of inserting CMSs. We evaluated differences in clinical results according to stent type...
  48. ncbi Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 54:185-95. 2011
    ..This study provides new insight into the regulation of stress- activated MAPK signaling in hepatocarcinogenesis...
  49. ncbi Impacts of changes in obesity parameters for the prediction of blood pressure change in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 32:421-7. 2009
    ..The %dWC, %dBMI, and %dBPs was defined as (WC2 - WC1)/WC1 x 100, (BMI2 - BMI1)/BMI1 x 100, and (BPs2 - BPs1)/BPs1 x 100, respectively...
  50. ncbi Autotaxin as a novel serum marker of liver fibrosis
    Hayato Nakagawa
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Chim Acta 412:1201-6. 2011
    ..Serum ATX enzymatic activity reportedly increases in parallel with liver fibrosis and exhibits a gender difference...
  51. ncbi Association between metabolic syndrome and carotid atherosclerosis in individuals without diabetes based on the oral glucose tolerance test
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Atherosclerosis 204:619-23. 2009
    ..We investigated whether metabolic syndrome is associated with carotid atherosclerosis in individuals who were shown not to have diabetes mellitus based on results of the 75-g oral glucose tolerance test (OGTT)...
  52. ncbi Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells
    Kyoji Moriya
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Med Virol 82:776-92. 2010
    ..Thus, HCV infection not only induces oxidative stress but also hampers the iron-induced antioxidant activation in the liver, thereby exacerbating oxidative stress that would facilitate hepatocarcinogenesis...
  53. ncbi Association between obesity and chronic kidney disease in Japanese: differences in gender and hypertensive status?
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 30:1059-64. 2007
    ....
  54. ncbi Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein
    Hideyuki Miyoshi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 54:432-8. 2011
    ..Experimental studies have revealed that the core protein of hepatitis C virus (HCV) induces steatosis...
  55. ncbi MicroRNA-22 and microRNA-140 suppress NF-?B activity by regulating the expression of NF-?B coactivators
    Akemi Takata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
    Biochem Biophys Res Commun 411:826-31. 2011
    ..Our results provide new information about the roles of miRNAs in the regulation of NF-?B activity...
  56. ncbi Drug resistance in antiviral treatment for infections with hepatitis B and C viruses
    Hiroshi Yotsuyanagi
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    J Gastroenterol 42:329-35. 2007
    ..In this review, we outline pathological conditions associated with hepatitis B and C viruses and their treatments, and discuss the current situation and mechanisms underlying the emergence of antiviral drug-resistant strains...
  57. ncbi Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma
    Ryota Masuzaki
    Graduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:759-64. 2011
    ..The utility of Sonazoid in radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) was investigated in this study...
  58. ncbi A single amino acid of toll-like receptor 4 that is pivotal for its signal transduction and subcellular localization
    Shintaro Yanagimoto
    Center for Structuring Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153 8903, Japan
    J Biol Chem 284:3513-20. 2009
    ..These results suggest that the leucine at position 815 is required for the normal maturation of TLR4 and for formation of the TLR4.MD-2 complex...
  59. ncbi Liver lipid content is reduced in rat given 7-day administration of angiotensin II
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Renin Angiotensin Aldosterone Syst 12:462-8. 2011
    ..Angiotensin II reduced triglyceride content in the liver, unlike in the kidney or heart, via an AT1 receptor-dependent mechanism...
  60. ncbi New method of covered wallstents for distal malignant biliary obstruction to reduce early stent-related complications based on characteristics
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
    Dig Endosc 23:49-55. 2011
    ..A modified covered Wallstent insertion method based on stent characteristics was evaluated to reduce stent-related complications...
  61. ncbi Impact of changes in obesity parameters on glucose metabolism and insulin resistance over a one-year period
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:1246-55. 2010
    ..We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-year period...
  62. ncbi Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 60:1249-53. 2011
    ..In this study, the frequency of patients with IPMNs developing extrapancreatic cancers during follow-up was examined...
  63. ncbi Effects of the AT(1) receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo, Tokyo, Japan
    Hypertens Res 33:263-8. 2010
    ....
  64. ncbi Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase
    Takatoshi Kitazawa
    Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Microbes Infect 9:1410-4. 2007
    ..These results collectively indicated that chlamydophilal antigens induce foam cell formation mainly via Toll-like receptor 2 and c-Jun NH2 terminal kinase...
  65. ncbi [Mechanisms of drug resistance in hepatitis viruses B and C]
    Hiroshi Yotsuyanagi
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine and Faculty of Medicine, University of Tokyo
    Nippon Rinsho 65:493-6. 2007
  66. ncbi Clinical significance of bile cytology via an endoscopic nasobiliary drainage tube for pathological diagnosis of malignant biliary strictures
    Hiroshi Yagioka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatobiliary Pancreat Sci 18:211-5. 2011
    ..We aimed to reveal the significance of ENBD cytology for the pathological diagnosis of malignant biliary strictures...
  67. ncbi Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression
    Dai Mohri
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:203-13. 2012
    ..However, the molecular mechanisms of cancer progression from IPMN remain largely unknown. In this study we examined the differences in genetic alteration(s) among the IPMN subtypes...
  68. ncbi Bacterial flagellin inhibits T cell receptor-mediated activation of T cells by inducing suppressor of cytokine signalling-1 (SOCS-1)
    Shu Okugawa
    Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cell Microbiol 8:1571-80. 2006
    ..These results collectively indicate that bacterial flagellin inhibits TCR-mediated activation of T cells by inducing SOCS-1...
  69. ncbi Bezafibrate for the treatment of primary sclerosing cholangitis
    Suguru Mizuno
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 45:758-62. 2010
    ..However, there has been little evidence of its efficacy for the treatment of primary sclerosing cholangitis (PSC)...
  70. ncbi Relationship between albuminuria, low eGFR, and carotid atherosclerosis in Japanese women
    Yuko Ishizaka
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Kidney Blood Press Res 31:164-70. 2008
    ..In conclusion, in Japanese women who underwent general health screening, albuminuria, but not low eGFR, was positively associated with carotid plaque...
  71. ncbi Impact of S-1 on the survival of patients with advanced pancreatic cancer
    Yousuke Nakai
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Pancreas 39:989-93. 2010
    ..The aim of this study was to investigate the effect of S-1 on the prognosis of advanced pancreatic cancer...
  72. ncbi Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage
    Hirofumi Kogure
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 46:1411-7. 2011
    ..We aimed to evaluate whether discontinuing antibiotic therapy for acute cholangitis immediately after the resolution of clinical symptoms, achieved by endoscopic biliary drainage, was safe and effective...
  73. ncbi Application of loop-mediated isothermal amplification technique to rapid and direct detection of methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures
    Yoshiki Misawa
    Department of Infection Control and Prevention, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Infect Chemother 13:134-40. 2007
    ..Therefore, the LAMP assay appears to be a sensitive and reliable new method to diagnose MRSA bloodstream infection for appropriate antibiotic therapy...
  74. ncbi [Molecular dissection of hepatocarcinogenesis in HCV infection using transgenic animal models]
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo
    Nippon Rinsho 62:131-4. 2004
  75. ncbi Risk factors for retinopathy associated with interferon alpha-2b and ribavirin combination therapy in patients with chronic hepatitis C
    Chiaki Okuse
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
    World J Gastroenterol 12:3756-9. 2006
    ..004, OR = 245.918, 95% CI = 5.6-10786.2). CONCLUSION: Retinopathy associated with combination therapy of interferon alpha-2b and ribavirin tends to develop in patients with hypertension...
  76. ncbi Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart
    Makiko Hongo
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Pharmacol 604:87-92. 2009
    ....
  77. ncbi New targeted therapies for gastric cancer
    Yoshinari Asaoka
    The University of Tokyo, Graduate School of Medicine, Department of Gastroenterology, Japan
    Expert Opin Investig Drugs 20:595-604. 2011
    ..The appropriate design for clinical trials of molecularly targeted therapeutic agents is also important. Targeted therapies tailored to individual genomic profiles would provide a more personalized treatment for advanced gastric cancer...
  78. ncbi Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Chim Acta 411:765-70. 2010
    ..Because our previous evidence suggests that S1P is involved in liver pathophysiology, we examined plasma S1P concentration in chronic hepatitis C patients...
  79. ncbi Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion
    Yoshinari Asaoka
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 394:1042-6. 2010
    ..This information will be useful for screening of inhibitors targeting gastric cancer with c-Met aberration...
  80. ncbi Clinical analysis of high serum IgE in autoimmune pancreatitis
    Kenji Hirano
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Gastroenterol 16:5241-6. 2010
    ..To clarify the clinical significance of high serum IgE in autoimmune pancreatitis (AIP)...
  81. ncbi Lipid metabolism and liver disease in hepatitis C viral infection
    Kazuhiko Koike
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan kkoike tky umin ac jp
    Oncology 78:24-30. 2010
    ..These results would provide a clue for further understanding of the role of lipid metabolism in pathogenesis of hepatitis C including liver injury and hepatocarcinogenesis...
  82. ncbi Therapeutic significance of a D-dimer cut-off level of >3 µg/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab
    Satoshi Mochizuki
    Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, 6 5 1 Kashiwanoha, Kashiwa 277 8577 Japan
    Jpn J Clin Oncol 40:933-7. 2010
    ..It is not clear what D-dimer level might indicate an increased risk of venous thromboembolism in the colorectal cancer patients treated with bevacizumab-containing chemotherapy...
  83. ncbi Endoscopic transgastric pure NOTES cholecystectomy with naso-gallbladder drainage tube placement and injection of a hyaluronic acid mixture (with Video)
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatobiliary Pancreat Sci 18:106-11. 2011
    ..We tried a transgastric pure NOTES procedure without laparoscopic procedure in an animal study after placing an endoscopic naso-gallbladder drainage (ENGBD) tube and injecting a hyaluronic acid (HA) mixture...
  84. ncbi RNA-dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand
    Hiroshi Kanamori
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gen Virol 91:1207-12. 2010
    ..2N, indicating the importance of the RNA element in the polymerization by RdRp. These results suggest the involvement of the RNA stem-loop structure of the negative strand in the replication process...
  85. ncbi Impact of changes in waist circumference and BMI over one-year period on serum lipid data in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    J Atheroscler Thromb 16:764-71. 2009
    ..We therefore analyzed the impact of changes in WC and BMI over a one-year period on serum levels of LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides (TG)...
  86. ncbi Relationship between smoking, white blood cell count and metabolic syndrome in Japanese women
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Tokyo, Japan
    Diabetes Res Clin Pract 78:72-6. 2007
    ..These data collectively suggested that the association between current smoking and metabolic syndrome is heavily confounded by certain factors that increase the circulating white blood cell count in Japanese women, as in men...
  87. ncbi Angiotensin II-induced regulation of the expression and localization of iron metabolism-related genes in the rat kidney
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Hypertens Res 30:195-202. 2007
    ..The relative contribution, if any, of these genes to renal and/or whole-body iron homeostasis in various disorders in which the renin angiotensin system is activated should be investigated in future studies...
  88. ncbi A proteomics method revealing disease-related proteins in livers of hepatitis-infected mouse model
    Tomoko Ichibangase
    Research Institute of Pharmaceutical Sciences, Musashino University, 1 1 20 Shinmachi, Nishitokyo shi, Tokyo, Japan
    J Proteome Res 6:2841-9. 2007
    ..This fluctuating expression of proteins could explain the progression of hepatocarcinogenesis. The method would be useful for clinical proteomics analysis because of its high resolution, sensitivity, and reproducibility...
  89. ncbi Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic mouse studies
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Gastroenterol 37:55-64. 2002
    ..This may explain the very high frequency of HCC in patients with HCV or HBV infection...
  90. ncbi Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men?
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 28:160-5. 2008
    ..We have investigated whether serum CEA levels are associated with early carotid atherosclerosis...
  91. ncbi Evaluation of a chromogenic agar medium for the detection of extended-spectrum ß-lactamase-producing Enterobacteriaceae
    R Saito
    Department of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan
    Lett Appl Microbiol 51:704-6. 2010
    ....
  92. ncbi Hepatitis C as a systemic disease: virus and host immunologic responses underlie hepatic and extrahepatic manifestations
    Chiaki Okuse
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University, Kawasaki, Japan
    J Gastroenterol 42:857-65. 2007
  93. ncbi Dengue hemorrhagic shock and disseminated candidiasis
    Satoshi Suzuki
    Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo
    Intern Med 46:1043-6. 2007
    ..The patient developed a disseminated Candida tropicalis infection, which may have been due to translocation of the fungus from the intestine damaged by the dengue virus...
  94. ncbi Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly
    Kazuaki Tejima
    Department of Clinical Laboratory Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 45:876-84. 2010
    ..We have examined the potential difference in thrombocytopenia between patients with CLD-B and those with CLD-C in terms of liver fibrosis adjustment and splenomegaly...
  95. ncbi Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma
    Hideyuki Miyoshi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    J Gastroenterol 39:563-9. 2004
    ..However, principally, it is methylation in the 5'-noncoding region but not that in the coding region which determines the regulation of gene expression...
  96. ncbi Subsegmental transcatheter arterial embolization for small hepatocellular carcinoma
    Mariko Itsubo
    Department of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8, Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan
    Hepatogastroenterology 49:735-9. 2002
    ....
  97. ncbi [Aberration in HBV genome and hepatocellular carcinoma]
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo
    Nippon Rinsho 62:372-6. 2004
  98. ncbi Novel dengue virus type 1 from travelers to Yap State, Micronesia
    Yoko Nukui
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 12:343-6. 2006
    ..Genome sequencing demonstrated that this virus belonged to genotype IV and had a 29-nucleotide deletion in the 3 noncoding region...
  99. ncbi Successful vancomycin desensitization with a combination of rapid and slow infusion methods
    Takatoshi Kitazawa
    Department of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Hongo
    Intern Med 45:317-21. 2006
    ....
  100. ncbi Molecular epidemiology of hepatitis A virus in metropolitan areas in Japan
    Hideaki Takahashi
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Institute of Medical Science, St Marianna University, Kawasaki, Japan
    J Gastroenterol 41:981-6. 2006
    ....
  101. ncbi Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity
    Takeya Tsutsumi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatology 35:937-46. 2002
    ..In conclusion, these results suggest that modulation of RXRalpha-controlled gene expression via interaction with the core protein contributes to the pathogenesis of HCV infection...