Manabu Fujimoto

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy
    Yuki Ichimura
    Correspondence to Manabu Fujimoto, Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Ann Rheum Dis 71:710-3. 2012
  2. ncbi Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 64:513-22. 2012
  3. ncbi Autoantibodies to a collagen-specific molecular chaperone, heat-shock protein 47, in systemic sclerosis
    M Fujimoto
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Clin Exp Immunol 138:534-9. 2004
  4. ncbi Regulatory B cells in skin and connective tissue diseases
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Dermatol Sci 60:1-7. 2010
  5. ncbi A clue for telangiectasis in systemic sclerosis: elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease
    M Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    Dermatology 213:88-92. 2006
  6. ncbi B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation
    Manabu Fujimoto
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 176:873-9. 2006
  7. ncbi Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Immunol 185:2502-15. 2010
  8. ncbi CD19 expression in B cells is important for suppression of contact hypersensitivity
    Rei Watanabe
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 171:560-70. 2007
  9. ncbi Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction
    Toshihide Hara
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8501, Japan
    Am J Pathol 176:259-69. 2010
  10. ncbi Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007

Detail Information

Publications123 found, 100 shown here

  1. ncbi Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy
    Yuki Ichimura
    Correspondence to Manabu Fujimoto, Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Ann Rheum Dis 71:710-3. 2012
    ..Recent studies have shown that anti-NXP2 antibody (Ab) is a major MSA in juvenile dermatomyositis (JDM). In this study the frequencies and clinical associations of anti-NXP2 Ab were evaluated in adult patients with IIM...
  2. ncbi Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 64:513-22. 2012
    ....
  3. ncbi Autoantibodies to a collagen-specific molecular chaperone, heat-shock protein 47, in systemic sclerosis
    M Fujimoto
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Clin Exp Immunol 138:534-9. 2004
    ..Anti-HSP47 autoantibodies were also positive in 79% of TSK/+ mice. Thus, autoantibodies to HSP47 were present in the sera from SSc patients as well as those from TSK mice, and may be associated with the pathogenesis of SSc...
  4. ncbi Regulatory B cells in skin and connective tissue diseases
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Dermatol Sci 60:1-7. 2010
    ..Clarifying the molecular mechanisms by which regulatory B cells suppress immune responses will be of great benefit in the development of new B cell-targeted therapeutic strategies...
  5. ncbi A clue for telangiectasis in systemic sclerosis: elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease
    M Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    Dermatology 213:88-92. 2006
    ..The role of endoglin in SSc is potentially intriguing since limited cutaneous SSc (lcSSc) and HHT share several symptoms, including telangiectasia...
  6. ncbi B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation
    Manabu Fujimoto
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 176:873-9. 2006
    ..Thus, CD22 phosphorylation is not only quantitatively but also qualitatively regulated by different stimulations, which may determine the outcome of B cell signaling...
  7. ncbi Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Immunol 185:2502-15. 2010
    ....
  8. ncbi CD19 expression in B cells is important for suppression of contact hypersensitivity
    Rei Watanabe
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 171:560-70. 2007
    ..Thus, CD19 expression in B cells is critical for termination of CHS responses, possibly through the function of regulatory B cells...
  9. ncbi Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction
    Toshihide Hara
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8501, Japan
    Am J Pathol 176:259-69. 2010
    ....
  10. ncbi Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007
    ..Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts...
  11. ncbi Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction
    Takayuki Ishii
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 174:2225-33. 2009
    ..The IgE-mediated cutaneous reverse passive Arthus reaction may serve as an experimental model for cutaneous eosinophilic infiltration in vasculitis as well as in other diseases...
  12. ncbi Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation
    Kazuhiro Komura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Invest Dermatol 129:2661-7. 2009
    ..These results indicate that low-dose tolerization controls CHS by abrogating ICAM-1 upregulation during the elicitation phase...
  13. ncbi The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity
    Asako Ogawa
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Japan
    J Invest Dermatol 130:1558-70. 2010
    ..These results suggest that ICAM-1 mediates Th1 cell recruitment irrespective of DNFB or FITC and that L-selectin recruits Th1 cells in Th1-type CHS, whereas it recruits Th2 cells in Th2-type CHS...
  14. ncbi B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
    Noriko Asano
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Am J Pathol 165:641-50. 2004
    ....
  15. ncbi P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand
    Hajime Tomita
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Invest Dermatol 129:2059-67. 2009
    ..These results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells...
  16. ncbi Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1
    Toru Yukami
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa 920 8641, Japan
    J Leukoc Biol 82:519-31. 2007
    ..These results indicate that skin wound healing is regulated cooperatively by all selectins and ICAM-1 and may provide critical information for the therapy of skin wounds...
  17. ncbi B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    Am J Pathol 169:954-66. 2006
    ..Thereby, B-cell depletion during disease onset suppressed skin fibrosis, indicating that B cells contribute to the initiation of systemic sclerosis pathogenesis in tight-skin mice but are not required for disease maintenance...
  18. ncbi BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Invest Dermatol 127:2772-80. 2007
    ..The results suggest that BAFF/BAFF receptor system is critical for the development of skin fibrosis in TSK/+ mice and could be a potent therapeutical target...
  19. ncbi CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Am J Pathol 172:1650-63. 2008
    ....
  20. ncbi Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid
    Nobuko Ishiura
    Department of Dermatology, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
    J Dermatol Sci 49:153-61. 2008
    ..Whereas IgG anti-BP180 autoantibodies play a primary role in the pathogenesis, there is a growing number of data regarding the potential pathogenic roles of IgE class autoantibodies in BP...
  21. ncbi Elevated serum concentrations of triggering receptor expressed on myeloid cells-1 in diffuse cutaneous systemic sclerosis: association with severity of pulmonary fibrosis
    Hajime Tomita
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Rheumatol 37:787-91. 2010
    ..To determine serum concentrations and clinical association of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with systemic sclerosis (SSc)...
  22. ncbi Clinical significance of serum hyaluronan levels in systemic sclerosis: association with disease severity
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:1825-9. 2008
    ..To determine any clinical association of serum levels of hyaluronan in patients with systemic sclerosis (SSc)...
  23. ncbi CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions
    Hiroko Nakashima
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    J Immunol 184:4637-45. 2010
    ..quot; CD22 deficiency results in disturbed CHS remission by impaired retention or survival of peritoneal B-1a cells that migrate into lymphoid organs...
  24. ncbi Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation
    Nobuko Ishiura
    Department of Dermatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 40:1192-204. 2010
    ..Thus, variations in phosphorylation patterns may contribute to the complexity of CD19-regulated signal transduction...
  25. ncbi Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies
    Takamasa Wayaku
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatol Int 28:113-9. 2007
    ..The antigenic stimulus in SLE may be different from other connective tissue diseases and is more likely to be native chromatin...
  26. ncbi Increased serum soluble CD40 levels in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Rheumatol 34:353-8. 2007
    ..To determine serum levels of soluble CD40 (sCD40) and clinical association in patients with systemic sclerosis (SSc)...
  27. ncbi Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway
    Chihiro Tanaka
    Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 62:1723-32. 2010
    ..Although the ICOS/ICOSL pathway is known to play various roles in adaptive immunity, its roles in innate immunity and tissue fibrosis remain unknown...
  28. ncbi Increased serum pentraxin 3 in patients with systemic sclerosis
    Yohei Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 36:976-83. 2009
    ..To determine serum concentrations of pentraxin 3 (PTX3) and its clinical associations in patients with systemic sclerosis (SSc)...
  29. ncbi A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 60:3465-75. 2009
    ....
  30. ncbi CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells
    Yoshihiro Kuwano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int Immunol 19:977-92. 2007
    ..These studies further emphasize a role for CD83 in lymphocyte development and immune regulation and reveal an unexpected role for CD83 expression in influencing cell-surface MHC class II turnover...
  31. ncbi Serum CXCL16 concentrations correlate with the extent of skin sclerosis in patients with systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 36:1917-23. 2009
    ..To determine serum concentrations of soluble CXCL16 and its clinical associations in patients with systemic sclerosis (SSc)...
  32. ncbi CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling
    Yohei Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Am J Pathol 175:649-60. 2009
    ..Thus, this study is the first to reveal a critical role of B cells and novel mechanisms in wound healing...
  33. ncbi Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Ann Rheum Dis 70:194-200. 2011
    ..To determine serum levels of interleukin 27 (IL-27) in patients with systemic sclerosis (SSc) and relate the results to the clinical features of SSc...
  34. ncbi Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity
    Rei Watanabe
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    J Immunol 184:4801-9. 2010
    ..These results demonstrate an important protective role for regulatory B10 cells in this systemic autoimmune disease...
  35. ncbi The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
    Yuki Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Invest Dermatol 128:1838-51. 2008
    ..We propose that this is a useful model for investigating the mechanism of pressure ulcer formation using various transgenic mice...
  36. ncbi Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Clin Immunol 29:180-9. 2009
    ..However, the association of this system in systemic sclerosis (SSc) remains unknown...
  37. ncbi Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis
    Shihoko Okazaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Rheumatol Int 30:871-8. 2010
    ..These results suggest that autoantibody against caspase-3 is generated in SSc and that this Ab is related to the severity of pulmonary fibrosis, vascular damage, and inflammation...
  38. ncbi Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction
    Hidemitsu Orito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Leukoc Biol 81:1197-204. 2007
    ..Thus, VCAM-1 plays a complementary role to ICAM-1 in the cutaneous Arthus reaction by regulating leukocyte accumulation and proinflammatory cytokine production...
  39. ncbi Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis
    Yutaka Kuwatsuka
    Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Autoimmunity 42:120-5. 2009
    ..These results indicate the lack of anti-HDAC-3 autoantibody in SSc patients, which is produced in healthy individuals as well as DM and SLE patients, suggesting that this autoantibody might function as protective Ab...
  40. ncbi Anti-p53 autoantibody in systemic sclerosis: association with limited cutaneous systemic sclerosis
    Toshihide Hara
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:451-7. 2008
    ..To determine the prevalence and clinical significance of anti-p53 antibody in patients with systemic sclerosis (SSc)...
  41. ncbi Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production
    Shintaro Maeda
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Am J Pathol 179:2360-9. 2011
    ..Thus, our results indicate that ICOS-ICOSL costimulatory signaling has critical roles during wound healing, most likely by inducing IL-6 production...
  42. ncbi Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage
    Fumihide Ogawa
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Arch Dermatol Res 302:27-35. 2010
    ..These results suggest that elevated anti-MSRA autoantibody is associated with the disease severity of SSc and may enhance the oxidative stress by inhibiting MSRA enzymatic activity...
  43. ncbi CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes
    Norihito Yazawa
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo
    Blood 102:1374-80. 2003
    ..Thus, signaling through the B-cell-specific LPS receptor RP105 is uniquely regulated by the B-cell-specific signaling component, Lyn/CD19/Vav complex...
  44. ncbi Association between nail-fold capillary findings and disease activity in dermatomyositis
    Naoki Mugii
    Department of Rehabilitation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Rheumatology (Oxford) 50:1091-8. 2011
    ..Our objective was to assess the changes and red blood cell velocity in finger nail-fold capillaries using nail-fold video capillaroscopy (NVC) in patients with adult-onset DM...
  45. ncbi Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses
    Tomoyuki Fujita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 170:1649-58. 2007
    ..Collectively, P- and E-selectins cooperatively regulate CH response, although their roles may be different depending on the phase of the reaction...
  46. ncbi Increased serum soluble OX40 in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:2359-62. 2008
    ..To determine levels of serum soluble OX40 (also termed CD134, a member of the tumor necrosis factor receptor superfamily) and their clinical associations in patients with systemic sclerosis (SSc)...
  47. ncbi Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis
    Toshihide Hara
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Rheumatol 36:99-105. 2009
    ..To determine the serum concentrations and clinical association of polymorphonuclear neutrophilic leukocyte (PMN) elastase in patients with systemic sclerosis (SSc)...
  48. ncbi Elevated serum levels of APRIL, but not BAFF, in patients with atopic dermatitis
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Exp Dermatol 17:197-202. 2008
    ..These results suggest that elevated serum levels of APRIL are associated with disease severity and activity in AD, and APRIL may have an important role in the pathogenesis of AD...
  49. ncbi The involvement of Gab1 and PI 3-kinase in beta1 integrin signaling in keratinocytes
    Yoshihiro Kuwano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 361:224-9. 2007
    ..These observations suggest that Gab1 and phosphatidylinositol 3-kinase play pivotal roles in the beta1 integrin-mediated regulation of the epidermal stem cell compartment...
  50. ncbi Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma
    Saori Tomimura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Japan
    J Dermatol Sci 52:47-54. 2008
    ..Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies...
  51. ncbi E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis
    Mayuka Horikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 169:740-9. 2006
    ..These results suggest that E- and P-selectins synergistically inhibit lung fibrosis by promoting the recruitment of NKT cells...
  52. ncbi Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 168:812-21. 2006
    ..Thus, CD19 modulates the Th1/Th2 cytokine balance in B cells and plays a critical role as a suppressive molecule in the development of EAE...
  53. ncbi Elevated circulating TWEAK levels in systemic sclerosis: association with lower frequency of pulmonary fibrosis
    Koichi Yanaba
    Department of Dermatology, Nagasaki University GraduateSchool of Biomedical Sciences, Nagasaki and Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 36:1657-62. 2009
    ..To determine serum levels of tumor necrosis factor-related weak inducer of apoptosis (TWEAK) and its clinical associations in patients with systemic sclerosis (SSc)...
  54. ncbi Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata
    Yoshihiro Kuwano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arch Dermatol Res 298:493-8. 2007
    ....
  55. ncbi The roles of P- and E-selectins and P-selectin glycoprotein ligand-1 in primary and metastatic mouse melanomas
    Toshifumi Yamaoka
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Dermatol Sci 64:99-107. 2011
    ..Malignant melanoma is often accompanied by a host response of inflammatory cell infiltration that is highly regulated by multiple adhesion molecules...
  56. ncbi Activation of Akt by mechanical stretching in human epidermal keratinocytes
    Shoichiro Yano
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    Exp Dermatol 15:356-61. 2006
    ..In summary, our results demonstrate the activation of the Akt signaling pathway by mechanical stretching, generating not only proliferative but also antiapoptotic signals in human keratinocytes...
  57. ncbi Elevation of serum lymphotactin levels in patients with systemic sclerosis
    Eiji Muroi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:834-8. 2008
    ..To determine serum concentrations of lymphotactin, a Th1 chemokine, and their clinical association in patients with systemic sclerosis (SSc)...
  58. ncbi Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis
    Takashi Matsushita
    Department of Dermatology and Division of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 34:1012-8. 2007
    ..To investigate the distribution of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies among patients with autoimmune diseases, and to analyze the clinical features of patients with dermatomyositis (DM) with anti-ARS antibodies...
  59. ncbi Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor-beta-induced mouse fibrosis
    Yuka Ikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Cell Physiol 216:680-7. 2008
    ....
  60. ncbi Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes
    Shoichiro Yano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 122:783-90. 2004
    ..These mechanisms may contribute to the hyperproliferative nature of the epidermis, which is mechanically stretched by various stimuli...
  61. ncbi Elevated serum insulin-like growth factor (IGF-1) and IGF binding protein-3 levels in patients with systemic sclerosis: possible role in development of fibrosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 35:2363-71. 2008
    ..To examine serum concentrations of insulin-like growth factor (IGF-1) and IGF binding protein (IGFBP-3), a major carrier protein for IGF-1, in patients with systemic sclerosis (SSc); and to relate the results to clinical features in SSc...
  62. ncbi Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Dermatol 147:391-8. 2011
    ..To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific autoantibodies (Abs) in adult Japanese patients with DM...
  63. ncbi Herpetiform pemphigus without anti-desmoglein 1/3 autoantibodies
    Hiroko Nakashima
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Dermatol 37:264-8. 2010
    ..This case suggests that non-desmoglein antigen on keratinocyte cell surface can be targeted in some patients with this unusual variant of pemphigus...
  64. ncbi Bullous pemphigoid positive for anti-BP180 and anti-laminin 5 antibodies in a patient with graft-vs-host disease
    Rieko Izumi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Am Acad Dermatol 56:S94-7. 2007
    ..Immune disturbance as well as destruction of basal epidermal cells and base membrane by GVHD may result in the induction of autoimmune blistering diseases with unusual clinical and laboratory manifestations...
  65. ncbi Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Dermatol Sci 39:1-7. 2005
    ..Thus, altered B cell function may result in tissue fibrosis, as well as autoimmunity, in SSc...
  66. ncbi Re-emergence of anti-topoisomerase I antibody with exacerbated development of skin sclerosis in a patient with systemic sclerosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Am Acad Dermatol 62:142-4. 2010
    ..This case suggests a role for anti-topo I in the pathogenesis of systemic sclerosis and an effect of corticosteroids on skin sclerosis and autoantibody production...
  67. ncbi CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    Eriko Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Clin Invest 109:1453-62. 2002
    ..CD19 deficiency also inhibited IL-6 production by TSK/+ B cells. Thus, chronic B cell activation resulting from augmented CD19 signaling in TSK/+ mice leads to skin sclerosis possibly through IL-6 overproduction as well as autoimmunity...
  68. ncbi Autoantibody against a protease domain of caspase-8 in patients with systemic sclerosis
    T Yamaoka
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Exp Rheumatol 26:998-1004. 2008
    ..Systemic sclerosis (SSc) is characterized by autoantibodies against various cellular components...
  69. ncbi Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis
    S Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 43:1261-6. 2004
    ..To determine serum levels of soluble cytotoxic T-lymphocyte associated molecule-4 (sCTLA-4) and clinical association in patients with systemic sclerosis (SSc)...
  70. ncbi CCL13 is a promising diagnostic marker for systemic sclerosis
    K Yanaba
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Br J Dermatol 162:332-6. 2010
    ..Previous studies suggest that CCL13 may have some role in the pathogenesis of systemic sclerosis (SSc)...
  71. ncbi Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome
    Hiroko Nakashima
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol 33:557-62. 2006
    ..The findings with these immunostainings support the characteristics of HE-staining, and suggest hyponutrition may induce changing differentiation/proliferation of keratinocytes...
  72. ncbi Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 50:1918-27. 2004
    ..To determine phenotypic and functional abnormalities of blood B cell subsets in patients with systemic sclerosis (SSc)...
  73. ncbi Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis
    Naoyuki Tsuchiya
    Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Arthritis Rheum 50:4002-7. 2004
    ..In this study, we examined whether CD19 polymorphisms are associated with genetic susceptibility to SSc...
  74. ncbi Antinucleosome antibody is a major autoantibody in localized scleroderma
    S Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Br J Dermatol 151:1182-8. 2004
    ..Therefore, it has been hypothesized that antihistone antibody is induced by nucleosome or native chromatin as immunogens in LSc...
  75. ncbi Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress
    Y Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Rheumatology (Oxford) 46:790-5. 2007
    ..To determine the prevalence and clinical correlation of autoantibody to peroxiredoxin (Prx) I, an antioxidant enzyme, in patients with systemic sclerosis (SSc)...
  76. ncbi Intra-arterial steroid-injection therapy for steroid-refractory acute graft-versus-host disease with the evaluation of angiography
    K Nakai
    First Department of Internal Medicine, Kansai Medical University, Moriguchi Shi, Osaka, Japan
    Bone Marrow Transplant 33:1231-3. 2004
    ..IAST might be an earlier option for steroid-refractory aGVHD...
  77. ncbi Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    J Invest Dermatol 120:542-7. 2003
    ....
  78. ncbi Antiphospholipid antibody in localised scleroderma
    S Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Ann Rheum Dis 62:771-4. 2003
    ..To investigate the prevalence and clinical correlation of antiphospholipid antibodies in localised scleroderma...
  79. ncbi Clinical significance of serum surfactant protein D (SP-D) in patients with polymyositis/dermatomyositis: correlation with interstitial lung disease
    H Ihn
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Rheumatology (Oxford) 41:1268-72. 2002
    ..01). Moreover, the serum SP-D level was inversely correlated with %VC (r=-0.452, P < 0.01) and %DLCO (r=-0.349, P < 0.05). CONCLUSION: The serum SP-D level may be a useful marker for ILD in patients with PM/DM...
  80. ncbi Longitudinal analysis of serum KL-6 levels in patients with systemic sclerosis: association with the activity of pulmonary fibrosis
    K Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Rheumatol 21:429-36. 2003
    ..CONCLUSION: Rapidly increased serum KL-6 levels during disease course were associated with new onset or deterioration of PF...
  81. ncbi Anti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma
    M Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Rheumatol 24:19-24. 2006
    ..We investigated anti-PS/PT Ab levels in patients with LSc...
  82. ncbi Autoantibody-mediated regulation of B cell responses by functional anti-CD22 autoantibodies in patients with systemic sclerosis
    M Odaka
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Immunol 159:176-84. 2010
    ..This unique regulation may contribute to the autoimmune aspect of SSc...
  83. ncbi Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy
    K Kaji
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 46:25-8. 2007
    ..In this study, we identified a novel MSA reactive with 155 and 140 kDa nuclear proteins [anti-155/140 antibody (Ab)] and determined the clinical feature of DM patients positive for this autoantibody (autoAb)...
  84. ncbi Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Mol Immunol 41:1123-33. 2004
    ..Thus, chronic B cell activation resulting from augmented CD19 signaling leads to skin fibrosis possibly through IL-6 overproduction, as well as autoantibody production, in tight-skin mice and SSc patients...
  85. ncbi RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells
    Hiroyo Oda
    Department of Pathology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Immunol 182:957-62. 2009
    ..We also found RhoH-Syk association that was greatly enhanced by active Fyn. Our results indicate that RhoH regulates FcepsilonRI signaling in mast cells by facilitating Syk activation, possibly as an adaptor molecule for Syk...
  86. ncbi B lymphocytes and systemic sclerosis
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Curr Opin Rheumatol 17:746-51. 2005
    ..Collectively, B cells and B-cell-specific response regulators such as CD19/CD22 appear to be potential therapeutic targets of the disease...
  87. ncbi Elevated levels of circulating CD44 in patients with systemic sclerosis: association with a milder subset
    K Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Rheumatology (Oxford) 41:1149-54. 2002
    ..CONCLUSION: Elevated sCD44 levels were associated with a relatively mild subset of SSc. These results suggest that CD44 could be a potential therapeutic target in SSc...
  88. ncbi Clinical significance of surfactant protein D as a serum marker for evaluating pulmonary fibrosis in patients with systemic sclerosis
    Y Asano
    University of Tokyo, Japan
    Arthritis Rheum 44:1363-9. 2001
    ..These two markers also predicted PF to almost the same degree (31% versus 33%, respectively). CONCLUSION: These results suggest that SP-D, as well as KL-6, may be a useful serum marker for evaluating PF in patients with SSc...
  89. ncbi Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse
    K Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Ann Rheum Dis 67:867-72. 2008
    ..To assess the association of CD40/CD40 ligand (CD40L) interactions with the development of skin fibrosis and autoimmunity in tight-skin (TSK/+) mouse, which is a mouse model for human systemic sclerosis...
  90. ncbi Autoantibody against activating transcription factor-2 in patients with systemic sclerosis
    Y Akiyama
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Clin Exp Rheumatol 27:751-7. 2009
    ..To determine the prevalence and clinical correlation of autoantibody to activating transcription factor (ATF)-2, a transcription factor of ATF/CREB family, in patients with systemic sclerosis (SSc)...
  91. ncbi Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus vulgaris
    N Asashima
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan
    Br J Dermatol 155:330-6. 2006
    ..CONCLUSIONS: BAFF may be a useful marker for early activation of an autoimmune diathesis and may play a critical role in triggering activation of self-antigen-driven autoreactive B cells in BP...
  92. ncbi Characterization of multipotent adult stem cells from the skin: transforming growth factor-beta (TGF-beta) facilitates cell growth
    Yoko Kawase
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan
    Exp Cell Res 295:194-203. 2004
    ..These results suggest that SKPs maintained in the presence of TGF-beta during culture are of potential use in cell-replacement therapies employing adult tissue sources...
  93. ncbi Interleukin 15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line, HaCaT
    Shoichiro Yano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Biochem Biophys Res Commun 301:841-7. 2003
    ..These results suggest a therapeutic approach to inflammatory skin diseases by controlling these signals...
  94. ncbi [B cell signal transduction and autoimmunity]
    Manabu Fujimoto
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan
    Nihon Rinsho Meneki Gakkai Kaishi 25:244-54. 2002
  95. ncbi [A female case of hyper-IgM immunodeficiency syndrome with uncommon skin manifestations]
    Nobuko Asashima
    Department of Dermatology, Faculty of Medicine, University of Tokyo
    Nihon Rinsho Meneki Gakkai Kaishi 27:350-5. 2004
    ..Her skin manifestations improved transiently by the intravenous immunogrobulin and corticosteroids therapy...
  96. ncbi B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Dermatol Sci 46:1-9. 2007
    ..Importantly, this "CD19/CD22 loop" is significantly related to an autoimmune phenotype in mice. Thus, the CD19/CD22 loop may be a potential therapeutic target in autoimmune disease for modulating B cell signaling...
  97. ncbi Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage
    Senji Shirasawa
    Department of Pathology, Research Institute, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Proc Natl Acad Sci U S A 101:13921-6. 2004
    ....
  98. ncbi Clinical significance of soluble CD31 in patients with systemic sclerosis (SSc): association with limited cutaneous SSc
    S Sato
    Department of Dermatology, Kanazawa University School of Medicine, Ishikawa, Japan
    J Rheumatol 28:2460-5. 2001
    ..To determine serum levels of soluble CD31 (sCD31) and its clinical associations in patients with systemic sclerosis (SSc)...
  99. ncbi Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid
    R Watanabe
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    J Dermatol Sci 46:53-60. 2007
    ..Although the functions of APRIL have not been fully evaluated, recent studies suggest that circulating levels of APRIL are increased in various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis...
  100. ncbi Reduced red blood cell velocity in nail-fold capillaries as a sensitive and specific indicator of microcirculation injury in systemic sclerosis
    Naoki Mugii
    Department of Rehabilitation, Kanazawa University Hospital, Kanazawa, Japan
    Rheumatology (Oxford) 48:696-703. 2009
    ..To assess red blood cell velocity in finger nail-fold capillaries using video capillaroscopy in patients with SSc and other collagen diseases...
  101. ncbi Elevated serum APRIL levels in patients with systemic sclerosis: distinct profiles of systemic sclerosis categorized by APRIL and BAFF
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 34:2056-62. 2007
    ..We investigated serum levels of a proliferation-inducing ligand (APRIL), a close homolog to BAFF, and its clinical association in patients with SSc as well as its correlation with BAFF...