Research Topics
Genomes and Genes
| Hirotaka ChikudaSummaryAffiliation: University of Tokyo Country: Japan Publications
| Collaborators
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Detail Information
Publications
Mortality and morbidity in dialysis-dependent patients undergoing spinal surgery: analysis of a national administrative database in JapanHirotaka Chikuda
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Bone Joint Surg Am 94:433-8. 2012....- Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter studyHirotaka Chikuda
Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
Spine (Phila Pa 1976) 36:1453-8. 2011..Retrospective multicenter study... - Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumorsHirotaka Chikuda
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
Spine (Phila Pa 1976) 34:E110-4. 2009..A retrospective review of 10 consecutive patients with a noninflammatory retro-odontoid pseudotumor... - Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytesHirotaka Chikuda
Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
J Bone Miner Metab 23:200-4. 2005 - Correlation between pyramidal signs and the severity of cervical myelopathyHirotaka Chikuda
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Eur Spine J 19:1684-9. 2010..Considering their low sensitivity in patients with mild disability, the pyramidal signs may have limited utility in early diagnosis of cervical myelopathy... - Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytesYosuke Kawasaki
Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
J Clin Invest 118:2506-15. 2008..These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII... - Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formationFumitaka Kugimiya
Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, 113 8655, Japan
J Biol Chem 280:35704-12. 2005..We thus concluded that endogenous BMP2 and BMP6 cooperatively play pivotal roles in bone formation under both physiological and pathological conditions... - Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytesHirotaka Chikuda
Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
Genes Dev 18:2418-29. 2004.... - Aorta movement in patients with scoliosis after posterior surgeryKatsushi Takeshita
Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
Spine (Phila Pa 1976) 35:E1571-6. 2010..Retrospective analysis... - GSK-3beta controls osteogenesis through regulating Runx2 activityFumitaka Kugimiya
Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan
PLoS ONE 2:e837. 2007..These results establish GSK-3beta as a key attenuator of Runx2 activity in bone formation and as a potential molecular target for clinical treatment of bone catabolic disorders like cleidocranial dysplasia... - Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instabilitySatoru Kamekura
Faculty of Medicine, University of Tokyo, Tokyo, Japan
Arthritis Rheum 54:2462-70. 2006..CONCLUSION: RUNX-2 contributes to the pathogenesis of OA through chondrocyte hypertrophy and matrix breakdown after the induction of joint instability... - The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent mannerFumiko Yano
Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
Biochem Biophys Res Commun 333:1300-8. 2005..The response of Sox9-deficient cells was restored by the adenoviral expression of Sox9. Thus, the canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner... - Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5Toru Moro
Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Japan
J Cell Physiol 204:927-33. 2005..These results indicate that Cdk6 may be a regulator of chondrocyte differentiation and that its p38-mediated downregulation is involved in the efficient differentiation... - New parameters to represent the position of the aorta relative to the spine for pedicle screw placementKatsushi Takeshita
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
Eur Spine J 19:815-20. 2010..These new parameters enable surgeons to intuitively understand the position of the aorta in surgical planning or in placement of a pedicle screw... - Ossification of the posterior atlantoaxial membrane associated with an os odontoideum: a case reportJunichi Ohya
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
J Orthop Surg (Hong Kong) 19:392-4. 2011..Long-standing atlantoaxial instability might have played a role in ectopic ossification of the posterior atlantoaxial membrane... - Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic featuresNaoki Shoda
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
Eur Spine J 18:905-10. 2009..Small ADI and short neck, secondary to the vertical translocation by RA, may cause obstructive sleep apnea, probably through mechanical or neurological collapse of the upper airway... - Modified fenestration with restorative spinoplasty for lumbar spinal stenosisKo Matsudaira
Department of Orthopedics, Faculty of Medicine, Tokyo University, Bunkyo ku, Tokyo, Japan
J Neurosurg Spine 10:587-94. 2009..The MFRS technique produces an adequate and safe decompression of the spinal canal, even in patients with narrow and steep facet joints in whom conventional fenestration is technically demanding... - Diameter, length, and direction of pedicle screws for scoliotic spine: analysis by multiplanar reconstruction of computed tomographyKatsushi Takeshita
Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
Spine (Phila Pa 1976) 34:798-803. 2009..A morphometric study of thoracic and lumbar spine in scoliosis... - Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL sheddingAtsuhiko Hikita
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 280:41700-6. 2005..These results suggest that deltaCAPRI is a possible regulator of RANKL shedding by modulating MMP14 expression through Ras signaling cascades other than the Erk pathway... - Is a right pedicle screw always away from the aorta in scoliosis?Katsushi Takeshita
Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
Spine (Phila Pa 1976) 36:E1519-24. 2011..Retrospective analysis... - Use of Doppler ultrasonography to detect an elusive communication of a spinal extradural arachnoid cystMasakazu Kanetaka
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
J Clin Neurosci 18:863-4. 2011..Doppler ultrasonography may be a helpful adjunct for identifying the location of elusive communication in a spinal extradural arachnoid cyst... - Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblastsHiroaki Seto
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
J Clin Invest 113:718-26. 2004.... - Long-term follow-up of the progression of ossification of the posterior longitudinal ligamentMotoaki Murakami
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
J Neurosurg Spine 12:577-9. 2010..Segmental-type OPLL developed into mixed-type extensive OPLL. This case shows an accelerating maturation process of OPLL over the course of a few years. Segmental-type OPLL appears to represent an initial stage of extensive OPLL... - Postsurgical spinal magnetic resonance imaging with iterative decomposition of water and fat with echo asymmetry and least-squares estimationMizuho Murakami
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Comput Assist Tomogr 35:16-20. 2011..Here, we compared postsurgical spinal MRI with IDEAL versus chemical shift selective saturation (CHESS)... - Impairment of bone healing by insulin receptor substrate-1 deficiencyTakashi Shimoaka
Departments of Orthopaedic Surgery, Tissue Engineering, and Metabolic Diseases, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo 113 8655, Japan
J Biol Chem 279:15314-22. 2004....