K Mizoguchi

Summary

Affiliation: Tsumura and Co
Country: Japan

Publications

  1. ncbi Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Company, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    J Neurosci 20:1568-74. 2000
  2. ncbi Orbitofrontal dopaminergic dysfunction causes age-related impairment of reversal learning in rats
    K Mizoguchi
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 170:1110-9. 2010
  3. ncbi Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Company, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    J Neurosci 24:5492-9. 2004
  4. ncbi Saiko-ka-ryukotsu-borei-to, a herbal medicine, ameliorates chronic stress-induced depressive state in rotarod performance
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Pharmacol Biochem Behav 75:419-25. 2003
  5. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
  6. ncbi Saiko-ka-ryukotsu-borei-to, an herbal medicine, prevents chronic stress-induced disruption of glucocorticoid negative feedback in rats
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Life Sci 72:67-77. 2002
  7. ncbi Dopamine-receptor stimulation in the prefrontal cortex ameliorates stress-induced rotarod impairment
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Pharmacol Biochem Behav 72:723-8. 2002
  8. ncbi Chronic stress impairs rotarod performance in rats: implications for depressive state
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Pharmacol Biochem Behav 71:79-84. 2002
  9. ncbi Effect of chronic stress on cholinergic transmission in rat hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Brain Res 915:108-11. 2001
  10. ncbi Chronic stress differentially regulates glucocorticoid negative feedback response in rats
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, 300 1192, Ibaraki, Japan
    Psychoneuroendocrinology 26:443-59. 2001

Detail Information

Publications15

  1. ncbi Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Company, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    J Neurosci 20:1568-74. 2000
    ..These findings provide important information for understanding of the mechanisms underlying PFC dysfunction in stress-related neuropsychiatric disorders...
  2. ncbi Orbitofrontal dopaminergic dysfunction causes age-related impairment of reversal learning in rats
    K Mizoguchi
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 170:1110-9. 2010
    ..This finding provides direct evidence showing the involvement of OFC dopaminergic dysfunction in the development of cognitive inflexibility during the normal aging process...
  3. ncbi Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Company, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    J Neurosci 24:5492-9. 2004
    ..This finding indicates that endogenous glucocorticoids are essential for maintaining PFC cognitive function and suggests that HPA disruption contributes to PFC cognitive deficits...
  4. ncbi Saiko-ka-ryukotsu-borei-to, a herbal medicine, ameliorates chronic stress-induced depressive state in rotarod performance
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Pharmacol Biochem Behav 75:419-25. 2003
    ..These results suggest that saiko-ka-ryukotsu-borei-to ameliorates the chronic stress-induced depressive state based on the prevention of PFC dysfunction. These findings provide important information for treatment of depression...
  5. ncbi Chronic stress attenuates glucocorticoid negative feedback: involvement of the prefrontal cortex and hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki, 300 1192, Japan
    Neuroscience 119:887-97. 2003
    ....
  6. ncbi Saiko-ka-ryukotsu-borei-to, an herbal medicine, prevents chronic stress-induced disruption of glucocorticoid negative feedback in rats
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Life Sci 72:67-77. 2002
    ..Because some symptoms and symptomatic relapses in depressives are attributed to dysfunction of the hypothalamo-pituitary-adrenal axis, the present findings provide information important for prevention and treatment of depression...
  7. ncbi Dopamine-receptor stimulation in the prefrontal cortex ameliorates stress-induced rotarod impairment
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Pharmacol Biochem Behav 72:723-8. 2002
    ..These findings will further understanding of the mechanisms underlying the pathophysiology of depression...
  8. ncbi Chronic stress impairs rotarod performance in rats: implications for depressive state
    Kazushige Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Pharmacol Biochem Behav 71:79-84. 2002
    ..These findings provide insight into the underlying mechanisms of stress-induced neuropsychiatric disorders...
  9. ncbi Effect of chronic stress on cholinergic transmission in rat hippocampus
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Brain Res 915:108-11. 2001
    ..These results suggest that cholinergic transmission in the chronically stressed hippocampus does not contribute to working memory impairment, but it may be involved in maintenance of reference memory...
  10. ncbi Chronic stress differentially regulates glucocorticoid negative feedback response in rats
    K Mizoguchi
    Pharmacology Department, Central Research Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, 300 1192, Ibaraki, Japan
    Psychoneuroendocrinology 26:443-59. 2001
    ..These mechanisms may be involved in the stress-induced neural abnormalities observed in depression...
  11. ncbi Ameliorative effect of traditional Japanese medicine yokukansan on age-related impairments of working memory and reversal learning in rats
    K Mizoguchi
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 177:127-37. 2011
    ..These investigations provide information important for the treatment of brain dysfunctions in the elderly people...
  12. ncbi Aging attenuates glucocorticoid negative feedback in rat brain
    K Mizoguchi
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 159:259-70. 2009
    ..These mechanisms may underlie the vulnerable neuroendocrine systems associated with aging...
  13. ncbi Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats
    K Mizoguchi
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 162:1192-201. 2009
    ....
  14. ncbi Influence of aging on chondroitin sulfate proteoglycan expression and neural stem/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan
    Y Tanaka
    Section of Oriental Medicine, Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Neuroscience 164:1224-34. 2009
    ..These findings help to understand the physiology and pathology of the aged brain and provide an anti-aging strategy for the brain...
  15. ncbi Up-regulation of calcitonin gene-related peptide receptors underlying elevation of skin temperature in ovariectomized rats
    M Noguchi
    Kampo and Pharmacognosy Laboratories, Tsumura and Co, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    J Endocrinol 175:177-83. 2002
    ..The mechanism underlying the hot flashes observed in menopausal women may also involve, in part, the up-regulation of CGRP receptors following ovarian hormone deficiency...