JianShe Wei

Summary

Affiliation: Tokyo Metropolitan Institute for Neuroscience
Country: Japan

Publications

  1. ncbi Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies
    JianShe Wei
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Am J Pathol 174:1891-909. 2009
  2. ncbi Gangliosides' protection against lysosomal pathology of synucleinopathies
    JianShe Wei
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Autophagy 5:860-1. 2009
  3. ncbi Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease
    Masaaki Waragai
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Neurosci Lett 425:18-22. 2007
  4. ncbi Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies
    JianShe Wei
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Biol Chem 282:28904-14. 2007
  5. ncbi Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage
    Masaaki Nakai
    Department of Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Biochem Biophys Res Commun 358:104-10. 2007
  6. ncbi A ?-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain
    Masayo Fujita
    Division of Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Nat Commun 1:110. 2010
  7. ncbi Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease
    Masaaki Waragai
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Biochem Biophys Res Commun 345:967-72. 2006
  8. ncbi Chaperone and anti-chaperone: two-faced synuclein as stimulator of synaptic evolution
    Masayo Fujita
    Department of Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Neuropathology 26:383-92. 2006
  9. ncbi alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity
    Masayo Fujita
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 282:5736-48. 2007

Collaborators

Detail Information

Publications9

  1. ncbi Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies
    JianShe Wei
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Am J Pathol 174:1891-909. 2009
    ..These data suggest that endogenous gangliosides may play protective roles against the lysosomal pathology of synucleinopathies...
  2. ncbi Gangliosides' protection against lysosomal pathology of synucleinopathies
    JianShe Wei
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Autophagy 5:860-1. 2009
    ..Finally, these phenotypes are reversed by ganglioside treatment. Taken together, our results suggest that endogenous gangliosides may play a protective role against the lysosomal pathology of synucleinopathies...
  3. ncbi Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease
    Masaaki Waragai
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Neurosci Lett 425:18-22. 2007
    ..01). Taken together, these results suggest that the plasma DJ-1 could be a useful biomarker for the evaluation of the disease severity in PD and possibly in other Lewy body diseases...
  4. ncbi Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies
    JianShe Wei
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Biol Chem 282:28904-14. 2007
    ..We suggest that these missense mutations of beta-syn might play a causative role in stimulating neurodegeneration...
  5. ncbi Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage
    Masaaki Nakai
    Department of Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Biochem Biophys Res Commun 358:104-10. 2007
    ..Together with previous reports showing the expression of alpha-syn in lymphocytes and platelets, the present finding supports a contention that alpha-syn might play some important functions in hematopoietic system...
  6. ncbi A ?-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain
    Masayo Fujita
    Division of Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Nat Commun 1:110. 2010
    ..Given the neuritic pathology of ?S in sporadic ?-synucleinopathies, it appears that alteration of ?S can contribute to the pathogenesis of a broad range of ?-synucleinopathies...
  7. ncbi Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease
    Masaaki Waragai
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    Biochem Biophys Res Commun 345:967-72. 2006
    ..001 by ANOVA with post hoc Bonferroni's test), suggesting a protective role of DJ-1 against oxidative stress during the early stage. Thus, we propose that CSF DJ-1 could be a possible biomarker for early sporadic PD...
  8. ncbi Chaperone and anti-chaperone: two-faced synuclein as stimulator of synaptic evolution
    Masayo Fujita
    Department of Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Neuropathology 26:383-92. 2006
    ..In this context, failure to regulate this process due to various causes, such as gene mutations and environmental risk factors, may result in imperfect adaptability against stresses, leading to neurodegenerative disorders...
  9. ncbi alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity
    Masayo Fujita
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 282:5736-48. 2007
    ..Thus, the mechanism of alpha-syn regulation of tumor differentiation and neuropathological effects of alpha-syn may considerably overlap with each other...