Research Topics
| K TakuboSummaryAffiliation: Tokyo Metropolitan Institute of Gerontology Country: Japan Publications
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Detail Information
Publications
Telomere shortening with aging in human liverK Takubo
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
J Gerontol A Biol Sci Med Sci 55:B533-6. 2000..Despite the slow turnover of liver tissue, the overall reduction rate of telomere length decrease in 1 year was almost the same as that of digestive tract mucosa, with its very rapid renewal...- Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 yearsNaoko Honma
Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
Breast Cancer Res 11:R48. 2009..The aim of the present study is to elucidate whether there are any specific patterns in use of multiple exons 1 in elderly breast tissue... - The normal anatomy around the oesophagogastric junction: a histopathologic view and its correlation with endoscopyKaiyo Takubo
Research Team for Geriatric Diseases Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
Best Pract Res Clin Gastroenterol 22:569-83. 2008..The nature of the OGJ is clarified in detail through comparison between endoscopically evident and histological features... - Telomere lengths are characteristic in each human individualKaiyo Takubo
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015, Japan
Exp Gerontol 37:523-31. 2002..However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shortening with aging and telomere lengths in different organs are characteristic for human individuals... - Oncocytic adenocarcinoma of the stomach: parietal cell carcinomaKaiyo Takubo
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology and Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
Am J Surg Pathol 26:458-65. 2002..Previously reported cases of parietal cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma... - Ciliated surface in the esophagogastric junction zone: a precursor of Barrett's mucosa or ciliated pseudostratified metaplasia?Kaiyo Takubo
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Am J Surg Pathol 29:211-7. 2005..These findings may suggest that squamous metaplasia-like change at the EGJ is not a precursor of Barrett's mucosa but rather is a form of pseudostratified metaplasia... - Early squamous cell carcinoma of the oesophagus: the Japanese viewpointK Takubo
Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Histopathology 51:733-42. 2007..As a result of advances in the development of endoscopes, pathologists are now expected to diagnose very minute lesions, < 1 mm in size, in the oesophagus... - Barrett's adenocarcinoma of the esophagus with lymphoid stromaK Takubo
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
J Clin Gastroenterol 33:141-4. 2001..The data suggest that this tumor arose as a mucosal, well-differentiated adenocarcinoma without lymphoid stroma and that EBV had no relation to either its pathogenesis or progression... - Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteriKaiyo Takubo
Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
Digestion 80:248-57. 2009..Definitions and opinions in the field of gastroenterology vary widely in different countries... - Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situKaiyo Takubo
Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
J Pathol 221:201-9. 2010..We have demonstrated conclusively that oesophageal CIS arises from epithelium with short telomeres and chromosomal instability in the absence of histological inflammation... - Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescenceKaiyo Takubo
Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
Mech Ageing Dev 131:614-24. 2010..6%). Our results indicate that chromosomes having excessively shortened telomeres at late PDLs begin to show features of instability such as fusions and anaphase bridges... - Is there a set of histologic changes that are invariably reflux associated?Kaiyo Takubo
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
Arch Pathol Lab Med 129:159-63. 2005..To develop a set of characteristic reflux-associated features, endoscopists may perform targeted biopsies from several sites with various endoscopic features and at different stages of disease... - Detection of human papillomavirus infection of the cervix in very elderly women using PCRKaiyo Takubo
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Clin Cancer Res 11:2919-23. 2005.... - Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinomaKaiyo Takubo
Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Hum Pathol 40:65-74. 2009..Also, it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells, in accordance with histogenetic and practical standpoints... - Islands of squamous epithelium and their surrounding mucosa in columnar-lined esophagus: a pathognomonic feature of Barrett's esophagus?Kaiyo Takubo
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
Hum Pathol 36:269-74. 2005..From a practical point of view, biopsy specimens from columnar-lined mucosa of the esophagus do not always show intestinal metaplasia (specialized intestinal metaplasia)... - Changes of telomere length with agingKaiyo Takubo
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Geriatr Gerontol Int 10:S197-206. 2010..Our Q-FISH method using our original software program "Tissue Telo" is excellent for measuring telomere lengths using tissue sections and PNA probes... - Effectiveness of preoperative chemotherapy using carboplatin (CBDCA) and surgery against an esophageal small cell carcinomaH Makino
Department of Surgery I, Nippon Medical School, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Dis Esophagus 15:237-41. 2002..5 x 0.5 cm. The lesion consisted mainly of small anaplastic cells, but included a small focus of squamous cell carcinoma. The patient has survived for more than 7 months with no further treatment and no evidence of recurrent disease... - Correlation of telomere lengths in normal and cancers tissue in the large bowelK Nakamura
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 32 5, Sakaecho Itabashi ku, 173 0015, Tokyo, Japan
Cancer Lett 158:179-84. 2000..Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level... - Combined modality therapy for basaloid squamous carcinoma of the esophagusY Tsuchiya
First Department of Surgery, Nippon Medical School, Tokyo, Japan
Hepatogastroenterology 46:2868-71. 1999..Chemotherapy and radiotherapy resulted in the disappearance of the metastasis. The patient has survived for more than 3 years since surgery with a good quality of life... - A case of bone metastasis from gastric carcinoma after a nine-year disease-free intervalM Kammori
Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan
Jpn J Clin Oncol 31:407-9. 2001..Remission was achieved and she survived for a further 13 months without major symptoms... - Telomerase activity in esophageal carcinomaK Takubo
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
J Surg Oncol 66:88-92. 1997..In patients with esophageal carcinoma, no data have been reported concerning the relationship between telomerase activity and clinicopathological findings... - Expression of oestrogen receptor-beta in apocrine carcinomas of the breastN Honma
Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Histopathology 50:425-33. 2007..The aim was to study ER-beta status in apocrine carcinoma... - Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breastN Honma
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo, Japan
Histopathology 47:195-201. 2005..Apocrine lesions reportedly exhibit an unusual immunohistochemical status, expressing androgen receptors (AR) instead of oestrogen receptors (ER), progesterone receptors (PR), or bcl-2. Their expression was also examined... - Wide-spread distribution of sentinel lymph nodes in esophageal cancerT Nomura
Department of Surgery I, Nippon Medical School, Tokyo, Japan
J Nihon Med Sch 68:393-6. 2001..The sentinel nodes were broadly distributed depending on the location of the tumor in esophageal cancer... - Telomere shortening in gastric carcinoma with aging despite telomerase activationE Furugori
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
J Cancer Res Clin Oncol 126:481-5. 2000.... - Primary malignant melanoma of the esophagus treated by esophagectomy and systemic chemotherapyT Matsutani
Department of Surgery I, Nippon Medical School, Tokyo, Japan
Dis Esophagus 14:241-4. 2001..Malignant melanoma of the esophagus has an extremely poor prognosis despite various therapeutic efforts... - Cyclin D1 overexpression as a prognostic factor in patients with esophageal carcinomaS Nagasawa
Department of Surgery I, Nippon Medical School, Tokyo, Japan
J Surg Oncol 78:208-14. 2001..We investigated the correlation between cyclin D1 overexpression and clinical characteristics to clarify its prognostic significance in patients with esophageal cancer... - Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasiaM Sawabe
Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
Arch Pathol Lab Med 125:1219-23. 2001..The 3-dimensional reconstruction study of hepatic microvasculature was successful in identifying the pathological changes responsible for the intrahepatic shunts in HHT... - Multiple primary malignant neoplasms in patients with esophageal cancerS Nagasawa
Department of Surgery I, Nippon Medical School, Tokyo, Japan
Dis Esophagus 13:226-30. 2000..Frequent examination in these cancer patients, using fiberoptic esophagogastric endoscopy for example, may be helpful in the early diagnosis of esophageal cancer... - Early carcinoma of the distal second part of the duodenum treated by wedge resectionY Tanaka
Department of Gastroenterology and Hepatology, Tokyo Metropolitan Geriatric Hospital, Japan
J Clin Gastroenterol 28:67-9. 1999..However, this requires careful observation of the entire duodenal mucosa, including that of the distal duodenum, at duodenoscopy... - Detailed comparison between endocytoscopy and horizontal histology of an esophageal intraepithelial squamous cell carcinomaM Fujishiro
Department of Gastroenterology, University of Tokyo, Tokyo, Japan
Dis Esophagus 21:181-5. 2008..Further horizontal histological investigations of this case also showed the variety of endocytoscopic images in non-cancerous and cancerous epithelia... - Multiple colorectal cancers in the elderly: a retrospective study of both surgical and autopsy casesT Arai
Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
J Gastroenterol 36:748-52. 2001..CONCLUSIONS: These results indicate that the incidence of multiple CRCs in elderly patients with CRC is approximately 8%-10%, with no age-related difference, while extracolorectal malignancies increase with advancing age... - Fulminant hepatic failure in the elderly: a clinicopathological study of autopsy cases aged over 65 yearsM Sawabe
Departments of Pathology and Internal Medicine, Tokyo Metropolitan Geriatric Hospital, Tokyo
Pathol Int 50:98-105. 2000..However, impaired hepatic regeneration is occasionally observed in the elderly cases and AH-BHN is often lethal because of frequent underlying diseases and severe complications... - Ex-vivo study of high-magnification chromoendoscopy in the gastrointestinal tract to determine the optimal staining conditions for endocytoscopyS Kodashima
Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
Endoscopy 38:1115-21. 2006..CONCLUSIONS: This study provides important information on appropriate staining conditions for endocytoscopy. Further ex-vivo and in-vivo studies are necessary before this technique comes into standard use, however... - Hepatocellular carcinoma arising in an elderly male with primary biliary cirrhosisY Tanaka
Department of Gastroenterology, Tokyo Metropolitan Geriatric Hospital, Japan
Eur J Gastroenterol Hepatol 12:239-41. 2000..We believe that, to date, this is the oldest reported patient to have had interventional radiology for the management of HCC... - Liver abscesses associated with stromal tumour of the stomach in a young womanT Matsutani
Department of Surgery I, Nippon Medical School, Tokyo, Japan
Eur J Gastroenterol Hepatol 13:1485-9. 2001..This is a rare case of a liver abscess associated with a stromal tumour of the stomach in a young patient. The bacteriological examinations suggested a possible association between these diseases... - Effects of preoperative chemotherapy on metastatic lymph nodes in esophageal squamous cell carcinomaY Tsuchiya
Department of Surgery I, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
Dis Esophagus 15:226-31. 2002..07). Preoperative chemotherapy reduced the number of metastatic lymph nodes and may contribute to improving the outcome of the patients who have undergone esophagectomy for squamous cell carcinoma of the esophagus... - Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor statusN Honma
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Breast Pathology, Cancer Institute, Tokyo, Japan
Histopathology 42:120-7. 2003..In an effort to understand the pathogenesis of breast carcinoma in these women, this study was undertaken to compare the histological patterns and hormone receptor status of breast carcinomas arising in very elderly and younger women... - Primary adenocarcinoma of the duodenum in the elderly: clinicopathological and immunohistochemical study of 17 casesT Arai
Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
Pathol Int 49:23-9. 1999..Furthermore, it is concluded that invasive duodenal adenocarcinomas with high PR should be considered as potentially aggressive tumors, although their histology may indicate a high degree of differentiation... - Reconstruction of the portal vein using a peritoneal patch-graftM Yoshioka
First Department of Surgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8603, Tokyo, Japan
Am J Surg 181:247-50. 2001..Prosthetic material is associated with an increased risk of infection. We therefore created an animal model of portal vein reconstruction using the peritoneum... - Clinicopathological characteristics of left ventricular myocardium with transient asynergy: report of three casesK Chida
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital, Japan
Jpn Heart J 42:235-48. 2001..In conclusion, left ventricular myocardium with transient asynergy. detected clinically during acute ischemic attack, consists of normal myocardium or small ischemic lesions primarily in the subendocardium... - Immunohistochemical prognostic indicators of gastrointestinal carcinoid tumoursM Kawahara
Department of Gastroenterological Surgery, University of Tokyo, Tokyo, Japan
Eur J Surg Oncol 28:140-6. 2002..The aim of this study was to determine whether expression of the oncoproteins p21, p53, E-cadherin (EC), cyclin D1, bcl-2 and Rb and the proliferation marker Ki-67 is predictive of malignant behaviour in gastrointestinal carcinoid tumours... - Ex vivo pilot study using computed analysis of endo-cytoscopic images to differentiate normal and malignant squamous cell epithelia in the oesophagusS Kodashima
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
Dig Liver Dis 39:762-6. 2007..To simplify discrimination between normal and malignant tissue in the oesophagus using endo-cytoscopy system, we analysed the nuclear (dark staining) area in the obtained images with the goal of an accurate, automatic diagnosis...