Research Topics
| K OtsukaSummaryAffiliation: Tokyo Women's Medical University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Chronoecological health watch of arterial stiffness and neuro-cardio-pulmonary function in elderly community at high altitude (3524 m), compared with Japanese townK Otsuka
Department of Medicine, Medical Center East, Tokyo Women s Medical University, Nishiogu 2 1 10, Arakawa, Tokyo 116 8567, Japan
Biomed Pharmacother 59:S58-67. 2005....- Chronomics of heart rate variability on earth and in spaceK Otsuka
Tokyo Women s Medical University, Medical Center East, Department of Medicine, Arakawa ku, Japan
Respir Physiol Neurobiol 169:S69-72. 2009..Future work should focus on how phenomena in the cosmos, including helio- and geomagnetics, can affect physiological chronomes, those of the HRV in particular... - The change of hemodynamics and heart rate variability on bathing by the gap of water temperatureY Kataoka
Department of Internal Medicine, Showa University Toyosu Hospital, 4 1 18 Toyosu Koto Ku, Tokyo 135 8577, Japan
Biomed Pharmacother 59:S92-9. 2005..Based upon the results of this study we propose that the optimum period of time for bathing in water 41 degrees C in temperature is 5 min or less, and that for water 38 degrees C in temperature is 10 min or less... - Arterial stiffness independently predicts cardiovascular events in an elderly community -- Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) studyO Matsuoka
Department of Medicine, Division of Neurocardiology and Chronoecology, Tokyo Women s Medical University, Medical Center East, Nishiogu 2 1 10, Arakawa, Tokyo 116 8567, Japan
Biomed Pharmacother 59:S40-4. 2005..The early detection of risk by chronomics allows the timely institution of prophylactic measures, thereby shifting the focus from rehabilitation to prehabilitation medicine, as a public service to several Japanese towns... - Effect of aging on blood pressure in Leh, Ladakh, a high-altitude (3524 m) community, by comparison with a Japanese townK Otsuka
Department of Medicine, Medical Center East, Division of Neurocardiology and Chronoecology, Tokyo Women s Medical University, Nishiogu 2 1 10, Arakawa, Tokyo 116 8567, Japan
Biomed Pharmacother 59:S54-7. 2005..Longitudinal observations of effects of socio-ecologic factors on the cardiovascular system should help prevent strokes and other cardiovascular events, especially at high altitude... - Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people: Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) studyS Murakami
Department of Medicine, Medical Center East, Tokyo Women's Medical University, Nishiogu 2-1-10, Arakawa, Tokyo 116-8567, Japan
Biomed Pharmacother 59:S49-53. 2005..351 (1.029-5.372) and 2.890 (1.059-7.891), respectively. Carotid IMT assessed by ultrasonography is positively associated with an increased risk of all-cause and cardiovascular death in elderly community-dwelling people... - Depressive mood is independently related to stroke and cardiovascular events in a communityG Yamanaka
Department of Medicine, Tokyo Women's Medical University, Medical Center East, Nishiogu 2-1-10, Arakawa, Tokyo 116-8567, Japan
Biomed Pharmacother 59:S31-9. 2005..This recommendation stands at the basis of chronomics, focusing on prehabilitation in preference to rehabilitation, as a public service offered in several Japanese towns... - Fractal analysis of heart rate variability and mortality in elderly community-dwelling people -- Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) studyN Hotta
Department of Medicine, Medical Center East, Tokyo Women's Medical University, Nishiogu 2-1-10, Arakawa, Tokyo 116-8567, Japan
Biomed Pharmacother 59:S45-8. 2005.... - Positive impact of social intervention on disturbed neurobehavioral function in an elderly community-dwelling population: longitudinal investigation for longevity and aging in Hokkaido County (LILAC)S Murakami
Tokyo Women s Medical University, Daini Hospital, Department of Medicine, Division of Neurocardiology and Chronoecology, Nishiogu 2 1 10, Arakawa ku, Tokyo 116 8567, Japan
Biomed Pharmacother 58:S45-7. 2004..Direct social intervention, including lifestyle modification can have a positive impact, notably on subjects with cardiovascular disorders... - Alternating light-darkness-influenced human electrocardiographic magnetoreception in association with geomagnetic pulsationsK Otsuka
Department of Medicine, Tokyo Women s Medical University, School of Medicine, Daini Hospital, Nishiogu, Japan
Biomed Pharmacother 55:63s-75s. 2001..Lastly, our study suggests the existence of a light-dark-influenced magnetoreception mechanism in humans involving mainly the Pc 6 band of the magnetic field... - Does Schumann resonance affect our blood pressure?G Mitsutake
Division of Neurocardiology and Chronoecology, Tokyo Women's Medical University, Medical Center East, Tokyo, Japan
Biomed Pharmacother 59:S10-4. 2005..004-0.016). Neither subjective health nor depression was significantly associated with BPR-SR. Future studies based on larger sample sizes are planned to see whether possible health effects can be generalized... - Geomagnetic disturbance associated with decrease in heart rate variability in a subarctic areaK Otsuka
Department of Medicine, Tokyo Women s Medical University, Daini Hospital, Nishiogu, Japan
Biomed Pharmacother 55:51s-56s. 2001..The effect of geomagnetic disturbances on heart rate variability (HRV) in healthy students in a subarctic area is studied herein... - Chronomics for chronoastrobiology with immediate spin-offs for life quality and longevityK Otsuka
Division of Neurocardiology and Chronoecology, Department of Medicine, Tokyo Women's Medical University, Daini Hospital, Nishiogu 2-1-10, Arakawa-ku, Tokyo, 116-8567, Japan
Biomed Pharmacother 57:1s-18s. 2003..Cognitive function was maintained or improved, especially for people suffering from hypertension, tachycardia, or a decreased HRV, suggesting that cardiovascular function is a major factor affecting cognitive function... - Impact of circadian amplitude and chronotherapy: relevance to prevention and treatment of strokeM Shinagawa
Department of Medicine, Tokyo Women's Medical University, Daini Hospital, Japan
Biomed Pharmacother 55:125s-132s. 2001..The fact that benidipine increases the day-night difference in HR may be another reason for the positive effects of this treatment... - Chronomic community screening reveals about 31% depression, elevated blood pressure and infradian vascular rhythm alterationK Otsuka
Department of Medicine, Tokyo Women s Medical University, Daini Hospital, Tokyo, Japan
Biomed Pharmacother 58:S48-55. 2004..e. anormal BP and HR chronome... - Intragastric acidity and circadian rhythmT Saitoh
Department of Internal Medicine, Tokyo Women s Medical University, School of Medicine, Daini Hospital, Japan
Biomed Pharmacother 55:138s-141s. 2001..pylori-negative group. Further, H. pylori-positive individuals were at a more advanced stage of the disease... - Salt-loading elevates blood pressure and aggravates insulin resistance in Wistar fatty rats: a possible role for enhanced Na+ -H+ exchanger activityT Hayashida
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
J Hypertens 19:1643-50. 2001..NHE activity was enhanced in WFR in correlation with the blood pressure. These results suggest that augmented NHE activity contributes to the development of salt-sensitive blood pressure elevation in WFR... - Administration of an angiotensin-converting enzyme inhibitor improves vascular function and urinary albumin excretion in low-risk essential hypertensive patients receiving anti-hypertensive treatment with calcium channel blockers. Organ-protecting effectsYoshihiko Watanabe
Department of Medicine, Tokyo Women s Medical University, Medical Center East, Tokyo, Japan
Clin Exp Hypertens 33:246-54. 2011..In low-risk hypertensive patients, perindopril improves renal and vascular function probably via its persistent anti-hypertensive effects and the concomitant effects of CCB... - Graded response of heart rate variability, associated with an alteration of geomagnetic activity in a subarctic areaS Oinuma
Department of Medicine, Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan
Biomed Pharmacother 56:284s-288s. 2002..This graded response of HRV to geomagnetic activity should encourage us to search for human magnetoreceptors and for a better understanding of putative mechanisms of magnetoreception... - Selective genotyping with epistasis can be utilized for a major quantitative trait locus mapping in hypertension in ratsY Ohno
Department of Internal Medicine, TEPCO Hospital, Tokyo 160, Japan
Genetics 155:785-92. 2000..0001, by chi-square analysis). In conclusion, selective genotyping with epistasis can be utilized for a major QTL mapping near Sa on chromosome 1 in SHR... - Experimental and clinical chronocardiologyK Otsuka
Department of Medicine, Tokyo Women s Medical College, Daini Hospital, Japan
Chronobiologia 17:135-63. 1990..Lastly, a reference has been made to the recent development of ambulatory BP monitoring. A chronobiologic approach to the analysis of time-series data in cardiology will lead to many advantages in clinical practice... - Seasonal variation in 1/f fluctuations of heart rate in asthmatic childrenN Kazuma
Department of Pediatrics, Tokyo Women s Medical College, Daini Hospital, Japan
Biomed Pharmacother 55:102s-105s. 2001..In the children with asthma, although their HR varied by season, the l/f fluctuations of HR did not... - Nifekalant versus lidocaine for in-hospital shock-resistant ventricular fibrillation or tachycardiaTsuyoshi Shiga
Department of Cardiology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Resuscitation 81:47-52. 2010..To compare the efficacy and safety of nifekalant, a pure class III anti-arrhythmic drug, and lidocaine in patients with shock-resistant in-hospital ventricular fibrillation (VF) or ventricular tachycardia (VT)... - Changes in ultra-low and very low frequency heart rate variability after coronary artery bypass graftingY Suda
Department of Cardiovascular Surgery, Daini Hospital, Tokyo Women s Medical University, Japan
Biomed Pharmacother 55:110s-114s. 2001..However, improvement of the ULF/TF ratio, one of the prognostic indicators for patients with cardiac disease, should be related to the relief of myocardial ischemia by CABG... - Effect of H2 blockers on the circadian rhythm of intragastric acidityT Saitoh
Department of Internal Medicine, Tokyo Women s Medical University, School of Medicine, Daini Hospital, Tokyo, Japan
Biomed Pharmacother 56:349s-352s. 2002..54; and for acrophase, 324.0. 312.3, and 274.5 (p < 0.001). The H2 blockers suppressed the normal circadian rhythm of intragastric acidity, which rises in the evening until the middle of the night and then drops in the morning... - Influence of interleukin-10 on the interleukin-1 receptor antagonist/interleukin-1 beta ratio in the colonic mucosa of ulcerative colitisK Ishizuka
3rd Division, Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
Digestion 63:22-7. 2001..In Japanese patients with UC, the IL-1ra allele gene 2 phenotype had no effect on the IL-1ra/IL-1 beta ratio. Our findings suggest that a relative deficiency of IL-10 in patients with UC may contribute to persistent inflammatory changes... - Ovariectomy aggravated sodium induced hypertension associated with altered platelet intracellular Ca2+ in Dahl ratsK Otsuka
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
Am J Hypertens 10:1396-403. 1997..We concluded that ovariectomy enhanced sodium induced hypertension associated with the decreased internal Ca2+ discharge capacity and increased platelet aggregation in Dahl-Iwai salt-sensitive rats... - Depression, quality of life, and lifestyle: chronoecological health watch in a communityK Otsuka
Tokyo Women Medical University, School of Medicine, Daini Hospital, Division of Neurocardiology and Chronoecology, Nishiogu 2 1 10, Arakawa ku, Tokyo 116 856, Japan
Biomed Pharmacother 56:231s-242s. 2002..Depression was also found to be a useful indicator of DRI, HLS, and QOL... - Does sodium sensitivity affect nocturnal blood pressure variation in outpatients with hypertension?Y Watanabe
Department of Medicine, Daini Hospital, Tokyo Women's Medical University, Japan
Clin Exp Hypertens 24:99-107. 2002..In conclusion, the results of this study show that patients with high sodium sensitivity index have strong sodium sensitivity and non-dipper is not always changed by sodium restriction...