Tadashi Ohara

Summary

Affiliation: Tokyo Dental College
Country: Japan

Publications

  1. ncbi Eradication therapy of Helicobacter pylori directly induces apoptosis in inflammation-related immunocytes in the gastric mucosa--possible mechanism for cure of peptic ulcer disease and MALT lymphoma with a low-grade malignancy
    Tadashi Ohara
    Department of Internal Medicine, Chiba Hospital, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan
    Hepatogastroenterology 50:607-9. 2003
  2. ncbi Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Anticancer Res 24:3723-30. 2004
  3. ncbi Analysis of Toll-like receptor 2, 4, 6 and 9 genome DNA mutations in patients with tractable and intractable gastric mucosal diseases
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Int J Mol Med 17:53-8. 2006
  4. ncbi Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba 261 8502, Japan
    Int J Mol Med 18:59-63. 2006
  5. ncbi Pathophysiological role of human beta-defensins 2 in gastric mucosa
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Int J Mol Med 14:1023-7. 2004
  6. ncbi Analysis of the differences in structural chromosomal aberrations of the gastric mucosa between H. pylori positive and negative gastric cancer patients: involvement of H. pylori in the onset of gastric cancer and examination of the mechanism in gastric ca
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba 261 8502, Japan
    Oncol Rep 16:1333-42. 2006
  7. ncbi Regular hemodialysis reverses gastric mucosal atrophy of patients with chronic renal failure
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 51:679-83. 2004
  8. ncbi Usefulness of proton pump inhibitor (PPI) maintenance therapy for patients with H. pylori-negative recurrent peptic ulcer after eradication therapy for H. pylori: pathophysiological characteristics of H. pylori-negative recurrent ulcer scars and beyond ac
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 51:338-42. 2004
  9. ncbi Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Ichikawa General Hospital, Chiba, Japan
    Hepatogastroenterology 50:1774-9. 2003
  10. ncbi Investigation of the possibility of human-beta defensin 2 (hBD2) as a molecular marker of gastric mucosal inflammation
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 52:1320-4. 2005

Detail Information

Publications15

  1. ncbi Eradication therapy of Helicobacter pylori directly induces apoptosis in inflammation-related immunocytes in the gastric mucosa--possible mechanism for cure of peptic ulcer disease and MALT lymphoma with a low-grade malignancy
    Tadashi Ohara
    Department of Internal Medicine, Chiba Hospital, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan
    Hepatogastroenterology 50:607-9. 2003
    ..We hypothesized and investigated that antibiotic treatment for elimination of H. pylori might directly affect inflammatory cells to induce apoptosis in them and protect against pathological changes of gastric mucosa...
  2. ncbi Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Anticancer Res 24:3723-30. 2004
    ..The present study was undertaken to examine the possibility and mechanism of direct induction of apoptosis of the tumor cells by the antibiotics used for bacterial eradication therapy...
  3. ncbi Analysis of Toll-like receptor 2, 4, 6 and 9 genome DNA mutations in patients with tractable and intractable gastric mucosal diseases
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Int J Mol Med 17:53-8. 2006
    ..These data suggest that mutations of the TLR 2, 4, 6 and 9 genome DNA may not be involved in the recurrence, delayed healing or intractability of gastritis and gastric ulcers...
  4. ncbi Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba 261 8502, Japan
    Int J Mol Med 18:59-63. 2006
    ..This suggests a disturbance in the protein phosphorylation reaction of TLR4, and that this disturbance is related to the development of poorly-differentiated gastric adenocarcinomas...
  5. ncbi Pathophysiological role of human beta-defensins 2 in gastric mucosa
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba 261 8502, Japan
    Int J Mol Med 14:1023-7. 2004
    ....
  6. ncbi Analysis of the differences in structural chromosomal aberrations of the gastric mucosa between H. pylori positive and negative gastric cancer patients: involvement of H. pylori in the onset of gastric cancer and examination of the mechanism in gastric ca
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba 261 8502, Japan
    Oncol Rep 16:1333-42. 2006
    ..These results suggest the possibility that Hp eradication does not affect chromosomal structures and Hp is involved in gastric carcinogenesis as an additive environmental factor rather than as a factor acting at the gene level...
  7. ncbi Regular hemodialysis reverses gastric mucosal atrophy of patients with chronic renal failure
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 51:679-83. 2004
    ..This study was performed to investigate endoscopically and histopathologically if hemodialysis to treat renal failure would regenerate the background gastric mucosa and to elucidate factors associated with the mucosal regeneration...
  8. ncbi Usefulness of proton pump inhibitor (PPI) maintenance therapy for patients with H. pylori-negative recurrent peptic ulcer after eradication therapy for H. pylori: pathophysiological characteristics of H. pylori-negative recurrent ulcer scars and beyond ac
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 51:338-42. 2004
    ....
  9. ncbi Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Ichikawa General Hospital, Chiba, Japan
    Hepatogastroenterology 50:1774-9. 2003
    ..We designed a clinical study to examine whether cytotoxic T lymphocyte-mediated apoptosis associated with peptic ulcer formation may occur via either or both of these two pathways...
  10. ncbi Investigation of the possibility of human-beta defensin 2 (hBD2) as a molecular marker of gastric mucosal inflammation
    Tadashi Ohara
    Department of Internal Medicine, Tokyo Dental College, Chiba Hospital, Chiba, Japan
    Hepatogastroenterology 52:1320-4. 2005
    ..The present study was conducted to evaluate the possibility of hBD2 as a molecular marker of gastric mucosal inflammation...
  11. ncbi Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication
    Tatsuhiro Masaoka
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hepatogastroenterology 52:1-4. 2005
    ..pylori eradication therapy, the observations suggesting that reduction of plasma ghrelin levels cannot be achieved merely by H. pylori eradication, without resolution of the gastric atrophy...
  12. ncbi Plasma ghrelin concentration correlates with the levels of serum pepsinogen I and pepsinogen I/II ratio--a possible novel and non-invasive marker for gastric atrophy
    Hidekazu Suzuki
    Department of Internal Medicine, School of Medicine Keio University, Tokyo, Japan
    Hepatogastroenterology 51:1249-54. 2004
    ..The present study was designed to investigate the correlation between the plasma ghrelin levels and the extent of gastric mucosal atrophy in patients with chronic gastritis caused by H. pylori infection...
  13. ncbi Confirmation of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the duodenal wall by direct spraying during endoscopic retrograde cholangiopancreatography
    Yuji Sakai
    Department of Medicine and Clinical Oncology K1, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba, Japan
    J Nat Med 63:200-3. 2009
    ..The spasm arrest duration was 7.2-21 min (mean 9.6 +/- 1.2 min). Direct spraying of TJ-68 on the duodenal mucosa suppressed duodenal spasm, and it may be useful during ERCP when anticholinergic agents are contraindicated...
  14. ncbi [Cisplatin schedule in combination with gemcitabine in unresectable non-small cell lung cancer]
    Tadashi Ohara
    Dept. of Respiratory Medicine, Shiga Medical Center for Adults
    Gan To Kagaku Ryoho 32:69-71. 2005
    ..Our data show less toxicity and no significant difference in response rates, so the administration of cisplatin on day 15 seemed to be a useful and safe regimen...
  15. ncbi Prognostic potential of a PSA complex in sera of prostate cancer patients with alpha2-macroglobulin deficiency
    Yuhsaku Kanoh
    Department of Laboratory Medicine, School of Medicine, Kitasato University, Kanagawa, Japan
    J Clin Lab Anal 22:302-6. 2008
    ..F/T ratios were significantly lower in PCa patients with alpha2M deficiency than in those PCa patients without alpha2M deficiency. PSA-ACT and F/T ratio may be useful for monitoring bone metastasis in PCa...