Research Topics
Genomes and Genes | Kohsuke KataokaSummaryAffiliation: Tokyo Institute of Technology Country: Japan Publications
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Detail Information
Publications
A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activitiesK Kataoka
Department of Virology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku 108 8639, Tokyo, Japan
J Biol Chem 276:819-26. 2001..These results suggested that the interaction of a set of Hox proteins with Maf family members may interfere not only with their oncogenicity but also with their physiological roles...- MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin geneKohsuke Kataoka
Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
J Biol Chem 277:49903-10. 2002..Therefore, MafA is a beta-cell-specific and glucose-regulated transcriptional activator for insulin gene expression and thus may be involved in the function and development of beta-cells as well as in the pathogenesis of diabetes... - Maf and Jun nuclear oncoproteins share downstream target genes for inducing cell transformationK Kataoka
Department of Virology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Biol Chem 276:36849-56. 2001..This mutant repressed the cell transformation not only by Jun but also by Maf. Thus, Maf and Jun share downstream target gene(s) that are involved in cell transformation... - Induction of cellular antioxidative stress genes through heterodimeric transcription factor Nrf2/small Maf by antirheumatic gold(I) compoundsK Kataoka
Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, 226 8503 Yokohama, Japan
J Biol Chem 276:34074-81. 2001..Alternatively, activation of Nrf2/small Maf may be a protective response of cells against toxic effects of the drugs... - Presentation of functional foreign peptides on the surface of SV40 virus-like particlesRyou u Takahashi
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori ku, Yokohama 226 8501, Japan
J Biotechnol 135:385-92. 2008..This study demonstrates the potential usefulness of this strategy for the development of novel delivery vehicles with different cell tropisms... - Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with the minor capsid proteins VP2/3Takamasa Inoue
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuda, Midori ku, Kanagawa, Yokohama 226 8503, Japan
J Biotechnol 134:181-92. 2008..Therefore, proteins of interest can be encapsulated in VP1-VLPs by fusion to VP2/3 and successfully delivered to cells... - YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factorsChika Sawa
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
J Biol Chem 277:22484-90. 2002..These results provide a novel mechanism of transcriptional regulation by functionally distinct cofactor family members... - Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particlesHiroko Tsukamoto
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama, Kanagawa 226 8501, Japan
Genes Cells 12:1267-79. 2007..We propose that DNA may facilitate the formation of 40-nm spherical particles by acting as a scaffold that increases the local concentration of VP1 and/or by acting as an allosteric effector that alters the structure of VP1... - Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535Song-Iee Han
Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama 226-8501, Japan
Virology 320:144-55. 2004..These results suggest that phosphorylation of Rep68 and subsequent association with 14-3-3 proteins regulates Rep-mediated functions during the AAV life cycle... - The VP2/VP3 minor capsid protein of simian virus 40 promotes the in vitro assembly of the major capsid protein VP1 into particlesMasa-Aki Kawano
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan
J Biol Chem 281:10164-73. 2006..These results are relevant for controlling recombinant capsid formation in vitro, which is potentially useful for the in vitro development of SV40 virus vectors... - Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivoTakeyuki Nishi
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
J Biol Chem 277:44548-56. 2002..We propose that the Ref-1-dependent reduction of p50 in the nucleus is a necessary step for NF-kappaB activation. This study also provides the first example of a drug that inhibits the redox reaction between two specific proteins... - Selective ligand purification using high-performance affinity beadsYoshihiro Ohtsu
Frontier Collaborative Research Center, Tokyo Institute of Technology, Yokohama 226-8503, Japan
Anal Biochem 338:245-52. 2005..These data indicate that reverse affinity beads are powerful tools for identification of both specific ligands and proteins that interact with receptor/ligand complexes... - Simian virus 40 VP1 capsid protein forms polymorphic assemblies in vitroShin-Nosuke Kanesashi
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan
J Gen Virol 84:1899-905. 2003..VP1 is thus quite unique in that it can assemble into such diverse structures. These observations provide clues that will help elucidate the mechanisms underlying SV40 capsid formation... - Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testisChikanori Kuramori
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 226 8501 Yokohama, Japan
Toxicol Sci 109:143-51. 2009..We also show that DEHP administration affects glycogen metabolism in rat testis. Thus, inhibition of GDE by MEHP may play a role in germ cell apoptosis in the testis... - Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1Shinsaku Aramata
Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma 630 0192, Japan
Biochim Biophys Acta 1730:41-6. 2005..These results suggest that co-expression and functional synergism of these beta-cell enriched transactivators, MafA, Pdx1, and Beta2, are critical for establishing the beta-cell-specific and efficient expression of the insulin gene... - MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3Song Iee Han
Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan
Mol Cell Biol 27:6593-605. 2007..Our data suggest a new glucose-sensing signaling pathway in islet beta cells that regulates insulin gene expression through the regulation of MafA protein stability... - Roles and regulation of transcription factor MafA in islet beta-cellsShinsaku Aramata
Graduate School of Biological Science, Nara Institute of Science and Technology, Nara Japan
Endocr J 54:659-66. 2007..This review summarizes recent progress in determining the functions and roles of MafA in the regulation of insulin gene transcription in beta-cells... - Artificial oncoproteins: modified versions of the yeast bZip protein GCN4 induce cellular transformationMakoto Nishizawa
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Oncogene 22:7931-41. 2003..We have further constructed a regulatable GCN4-VP16 protein that will permit a kinetic characterization of target gene responses and will facilitate discrimination between direct and indirect targets... - MafA has strong cell transforming ability but is a weak transactivatorMakoto Nishizawa
Department of Molecular and Experimental Medicine, BCC239, The Scripps Research Institute, La Jolla, CA, 92037, USA
Oncogene 22:7882-90. 2003..These regulatable constructs permit a kinetic characterization of target gene responses and facilitate discrimination between direct and indirect targets... - Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genesKohsuke Kataoka
Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma, Nara 630 0192, Japan
J Biochem 141:775-81. 2007..This review summarizes the functions and roles of Maf in various biological processes and recent progress in elucidating the mechanisms whereby Maf proteins regulate transcription...