Research Topics
| Takehisa IwaiSummaryAffiliation: Tokyo Medical and Dental University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Oral bacteria in the occluded arteries of patients with Buerger diseaseTakehisa Iwai
Department of Surgery, Division of Vascular Surgery, Periodontology, Tokyo Medical and Dental University, Japan
J Vasc Surg 42:107-15. 2005..In this study, to explore a possible link between oral infection and Buerger disease, we investigated whether oral (periodontal) bacteria were present in occluded arteries removed from patients with characteristic Buerger disease...- A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in JapaneseZhiyong Chen
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
J Hum Genet 56:545-7. 2011..It was suggested that MyD88 may confer resistance to BD in Japanese. Because this is the first report of the association between MyD88 and BD, replication studies in other cohorts are required... - Association between periodontitis and anti-cardiolipin antibodies in Buerger diseaseYi Wen Chen
Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Clin Periodontol 36:830-5. 2009..TLRVYK homologies are present in Porphyromonas gingivalis (TLRIYT) and Treponema denticola (TLALYK). This study investigated the association between periodontal infection and anti-CL antibodies in BD patients... - The periodontal anaerobe Porphyromonas gingivalis induced platelet activation and increased aggregation in whole blood by rat modelKang Min Yu
Department of Surgery, Division of Vascular Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
Thromb Res 127:418-25. 2011..However, in vivo effect on platelet activation and aggregation remains unclear. This study aimed to clarify its role on platelets activation on more physiological environment, that is, on whole blood and systemic circulation... - Increased expression of CEA and MHC class I in colorectal cancer cell lines exposed to chemotherapy drugsShunroh Ohtsukasa
Department of Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519 Tokyo, Japan
J Cancer Res Clin Oncol 129:719-26. 2003..CONCLUSION: These results suggest that chemotherapeutic agents trigger the immune system and cancer-specific immunotherapy may be effective when used in combination with systemic chemotherapy... - Arterial thrombosis after intravenous infusion of oral bacterium in a rat modelToshiya Kubota
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Tokyo, Japan
Ann Vasc Surg 22:412-6. 2008..3%). No control specimen had thrombosis or positive PCR results. Bacteremia due to the oral pathogen P. gingivalis may lead to thrombus formation in the peripheral arteries, especially in small-sized arteries... - Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCCYutaka Tokairin
Department of Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8510, Japan
Int J Exp Pathol 87:89-99. 2006..As X-ray exposure promoted carcinogenesis of GIT in adult Mlh1-/- mice, an increased risk of secondary cancers after radiotherapy for HNPCC patients should be taken into consideration... - Urinary protein analysis in pre- and postoperative cancer patientsKayo Yokomizo
Analytical Laboratory Chemistry, Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Japan
J Clin Lab Anal 19:253-9. 2005..G peaked within 1 day of operation, which was faster than for CRP. Conversely, other fractions decreased. These results suggest that urinary protein analysis is useful for monitoring the response to surgical stress... - Effects of cilostazol and k-134 on reconstructive surgery using prosthetic grafts in the abdominal aorta of beagle dogsYoshinori Inoue
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima Bukyo ku, Tokyo, 113 8519 Japan
Thromb Res 123:122-9. 2008..Neointimal thickening on the inner surface was slight even in control-group animals, and the effects of cilostazol and K-134 on such thickening were unclear... - Relationship between CDX2 gene methylation and dietary factors in gastric cancer patientsYasuhito Yuasa
Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
Carcinogenesis 26:193-200. 2005..Thus, diet could be an important factor determining the methylation status of genes such as CDX2 and the resultant aberrant expression of genes involved in carcinogenesis... - SOFA score predicts postoperative outcome of patients with colorectal perforationTakanori Ochiai
Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Hepatogastroenterology 51:1007-10. 2004..The present study was undertaken to identify factors and determine predictive scoring systems for the postoperative outcome of patients with colorectal perforation... - Surgical strategy for treating renal cell carcinoma with thrombus extending into the inferior vena cavaMasatoshi Jibiki
Department of Surgery, Tokyo Medical and Dental University Graduate School, Japan
J Vasc Surg 39:829-35. 2004..A surgical strategy for treating malignant renal tumors with thrombus extending into the inferior vena cava (IVC) was assessed... - Management for fistula-in-ano with Ginseng and Tang-kuei Ten CombinationToshiki Ohya
Department of Surgery and Pediatric Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Pediatr Int 46:72-6. 2004..Non-operative management for patients with fistula-in-ano in infancy using a traditional herbal medicine Ginseng and Tang-kuei Ten Combination (GTTC) is described... - Distributing pattern of the bile duct of the caudate lobe on computed tomography with drip infusion cholangiography and its surgical significanceSusumu Takamatsu
Department of Surgery, Kasukabe Shuwa Hospital, Kasukabe, Saitama, Japan
Hepatogastroenterology 51:29-32. 2004..To map the spatial relationship between the bile ducts and the liver parenchyma under physiological conditions, we performed an anatomical analysis of them using computed tomography combined with drip infusion cholangiography (DIC-CT)... - Investigation into the usefulness and adverse events of CDDP, 5-fU and dl-leucovorin (PFL-therapy) for advanced colorectal cancerSatoshi Okabe
Department of Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Med Dent Sci 49:77-84. 2002..We will be able to demonstrate the usefulness of this regimen for Japanese patients with advanced colorectal cancers after adding new cases to the present report... - Evaluation of an indicator for lymph node metastasis of esophageal squamous cell carcinoma invading the submucosal layerYasuaki Nakajima
Department of Surgery, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
Jpn J Cancer Res 93:305-12. 2002..In addition, P53 accumulation could be helpful to identify the patients who need additional treatment after EMR... - Effect of dai-kenchu-to on obstructive bowel disease in childrenToshiki Ohya
Department of Surgery, Tokyo Medical and Dental University, School of Medicine 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
Am J Chin Med 31:129-35. 2003..If DKT is effective, the regimen is continued. However, in cases where DKT is not effective, we will consider laparotomy or will further investigate the illness... - An ultrastructural study of Porphyromonas gingivalis-induced platelet aggregationXiangfeng Li
Department of Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
Thromb Res 122:810-9. 2008..gingivalis were identified in the activated platelets. Thus, this observation suggests that P. gingivalis residing in the RR-negative vacuoles is incorporated into the platelet cytoplasm by phagocytosis... - Preoperative imaging of surrounding arteries by three-dimensional CT: is it useful for laparoscopic gastrectomy?Shinsuke Usui
Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Surg Laparosc Endosc Percutan Tech 15:61-5. 2005..All laparoscopic gastrectomy procedures were performed successfully without conversion to open surgery. Preoperative 3-dimensional computed tomographic angiography was considered to be useful for laparoscopic gastrectomy... - Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger diseaseZhiyong Chen
Department of Vascular and Applied Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
Hum Genet 122:367-72. 2007..Odds ratios ranged from 4.72 to 12.57 in individuals carrying any two of these three markers. These findings suggested that the susceptibility to BD was in part controlled by genes involved in the innate and adaptive immunity... - Tumor thrombectomy without bypass for low-grade malignant tumors extending into the inferior vena cava: report of two casesMasatoshi Jibiki
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Graduate School, 1-5-45 Yushima, Tokyo, 113-8519, Japan
Surg Today 36:465-9. 2006..Aggressive surgical treatment is thus recommended to excise a tumor thrombus with or without an IVC resection in patients with ESS of low-grade malignancy extending into the IVC to prevent sudden death due to PE... - Long-term results of aorta-superior mesenteric artery bypass using a new routeYoshinori Inoue
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Surg Today 34:658-61. 2004..CONCLUSION: Infrarenal aorta-SMA bypass relieved mesenteric ischemia and achieved good long-term graft patency. Thus, we consider it to be an effective and durable vascular procedure to reduce postoperative mortality and morbidity... - Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomachYun-Qing Bai
Department of Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
Cancer Lett 176:47-55. 2002..Our results thus suggest that CDX2 and CDX1 may play a role during IM formation and gastric carcinogenesis... - Is drip infusion cholecystocholangiography (DIC) an acceptable modality at cholecystectomy for cholecystolithiasis, considering the frequency of bile duct maljunction and intraoperative bile duct injury?Takanori Ochiai
Department of Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510 Japan
J Hepatobiliary Pancreat Surg 11:135-9. 2004.... - Microbiological evaluation after gastrectomy and reconstruction for gastric cancerYoshihisa Sekita
Department of Surgery, Graduate School of Health Science, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
Int Surg 92:355-60. 2007..Some patients after jejunal pouch reconstruction worried about their halitosis. Therefore, elimination of anaerobes may relieve it and improve postoperative quality of life... - Infected abdominal aortic aneurysm caused by nontyphoid Salmonella in an immunocompromised patient with rheumatoid arthritisKayoko Kaneko
Department of Medicine and Rheumatology, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Infect Chemother 15:312-5. 2009.... - Enhanced adhesion of early endothelial progenitor cells to radiation-induced senescence-like vascular endothelial cells in vitroNuttawut Sermsathanasawadi
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Tokyo, Japan
J Radiat Res 50:469-75. 2009..Our findings are first to implicate the complex effects of this phenotype on tumor neovascularization following irradiation... - Percutaneous transhepatic lymphography method to image and treat intra-abdominal lymph node metastasis in patients with unresectable hepatobiliary pancreatic cancerKenichi Teramoto
Division of Hepatobiliary Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Surgery 131:529-33. 2002..CONCLUSIONS: The present study showed that PTL can be used as a drug delivery system specific for intra-abdominal lymph nodes as well as for identification of the lymph tracts... - Hand-assisted laparoscopic esophagojejunostomy using newly developed purse-string suture instrument "Endo-PSI"Shinsuke Usui
Department of Surgery, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo, Japan
Surg Laparosc Endosc Percutan Tech 17:107-10. 2007..This newly developed Endo-PSI was useful for laparoscopic purse-string suture... - Local injection of interferon beta in malignant melanoma of the esophagus as adjuvant of systemic pre- and postoperative DAV chemotherapy: case report with 7 years of long-term survivalKenro Kawada
Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Gastrointest Endosc 66:408-10. 2007 - CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 geneYun Qing Bai
Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
Oncogene 22:7942-9. 2003..These data suggest that p21 is a transcriptional target of CDX2. Our results may thus provide a new mechanism underlying the functions of CDX2... - Hand-assisted laparoscopic total gastrectomy for early gastric cancerShinsuke Usui
Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Surg Laparosc Endosc Percutan Tech 13:304-7. 2003..We successfully performed this procedure in 5 patients. The mean operating time and blood loss were 275 minutes and 177.5 mL, respectively. Hand-assisted laparoscopic total gastrectomy is suitable and feasible for early gastric cancer... - Transanal laser Doppler flowmetry to assess microcirculation in the upper rectum during abdominal aortic aneurysmectomyIchiro Matsukura
Department of Surgery, Division of Vascular Surgery, Tokyo Medical and Dental University, School of Medicine, 1-5-45 Yushima, Bunkyo-ku, 113-8519 Tokyo, Japan
Surg Today 33:812-6. 2003.... - Laparoscopy-assisted total gastrectomy for early gastric cancer: comparison with conventional open total gastrectomyShinsuke Usui
Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Surg Laparosc Endosc Percutan Tech 15:309-14. 2005..This study demonstrated that laparoscopy-assisted total gastrectomy is suitable and feasible for early gastric cancer and has the advantage of a shorter recovery time compared with open total gastrectomy... - Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysisHideaki Tanami
Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
Lab Invest 85:1118-29. 2005..Our experiments also confirmed the power of subtractive CGH and CGH-array analysis for identifying cancer-related genes... - Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transductionTao Yu
Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
Hypertension 42:329-34. 2003..These findings suggest a potential role for amlodipine in monocyte-endothelial interactions by modulation of protein kinase C- and RhoA-dependent mechanisms, which might account for its vascular protective effects... - Atheroembolic signals detected by Doppler ultrasound scan monitoring in a patient with blue toe syndrome: report of a caseToshifumi Kudo
Department of Surgery, Division of Vascular Surgery, Tokyo Medical and Dental University School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Surg Today 32:938-41. 2002..Microscopically, cholesterin crystals were seen in the arterioles of the amputated digits. Thus, Doppler ultrasound could be a valuable test to determine the appropriate treatment for patients at risk of atheroembolic BTS... - An animal model study to clarify and investigate endoscopic tissue coagulation by using a new monopolar deviceFadi Salameh
Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan
Gastrointest Endosc 59:107-12. 2004..CONCLUSIONS: The ablative procedure with the new overtube device is minimally invasive, clearly feasible, and easy to apply. This new device potentially can be used in patients for tissue ablation... - Vascular closure system type of nonpenetrating arcuate-legged titanium clips for graft-artery and graft-graft anastomoses: review of our clinical experienceYoshinori Inoue
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Surg Today 34:231-6. 2004..Thus, VCS clips could be durable enough for graft-artery anastomoses in the iliac or popliteal region... - Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instabilityToshiaki Ishikawa
Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
Cancer Res 63:5564-72. 2003..Therefore, tumor-specific peptides generated by MSI may be involved in antitumor immune responses and may be useful for the development of diagnostic and therapeutic methods for patients with MSI+ CRC... - [Perioperaive evaluation and management in vascular surgery especially for arteriosclerosis obliterans]Yoshinori Inoue
Department of Vascular and Applied Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
Nippon Geka Gakkai Zasshi 106:344-8. 2005..Beta-blockers or alpha-agonists were effective to reduce incidence of perioperative IHD. Although even optimal preoperative assessment and perioperative management, some patients will have perioperative MI... - IFN-gamma production from liver mononuclear cells of mice in burn injury as well as in postburn bacterial infection models and the therapeutic effect of IL-18Katsunori Ami
Division of Basic Traumatology, National Defense Medical College Research Institute, Namiki 3 2, Tokorozawa 359 8513, Japan
J Immunol 169:4437-42. 2002..Thus, IL-18 therapy restores the Th1 response and may decrease the susceptibility to bacterial infection in mice with burn injury... - Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancerYoko Oishi
Department of Molecular Diagnosis, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
J Hum Genet 52:271-9. 2007..We also determined that immunohistostaining for the Stathmin1 gene product is a potential tool for predicting the outcome of breast cancer patients with supraclavicular lymph node metastasis... - Elevated IgG titers to periodontal pathogens related to Buerger diseaseYi-Wen Chen
Int J Cardiol 122:79-81. 2007..denticola, P. gingivalis and A. actinomycetemcomitans (P=0.002, P=0.039, and P=0.011, respectively). CONCLUSIONS: This study provides evidence for possible implications of periodontitis in Buerger disease... - Enhancement of immunologic tumor regression by intratumoral administration of dendritic cells in combination with cryoablative tumor pretreatment and Bacillus Calmette-Guerin cell wall skeleton stimulationMasaru Udagawa
Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
Clin Cancer Res 12:7465-75. 2006..We developed an effective immunotherapy, which could induce antitumor immune responses against shared and unique tumor antigens expressed in autologous tumors...