N Hotta

Summary

Affiliation: Tohoku Rosai Hospital
Country: Japan

Publications

  1. ncbi Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Diabetes Care 24:1776-82. 2001
  2. ncbi Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long-term treatment with an aldose reductase inhibitor, epalrestat
    N Hotta
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Diabet Med 25:818-25. 2008
  3. ncbi Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial
    Nigishi Hotta
    Chubu Rosai Hospital, 1 10 6 Komei, Nagoya 455 8530, Japan
    Diabetes Care 29:1538-44. 2006
  4. ncbi Nerve function and blood flow in Otsuka Long-Evans Tokushima Fatty rats with sucrose feeding: effect of an anticoagulant
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Eur J Pharmacol 313:201-9. 1996
  5. ncbi Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats
    J Nakamura
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Eur J Pharmacol 294:207-14. 1995
  6. ncbi Effect of an aldose reductase inhibitor on abnormalities of electroretinogram and vascular factors in diabetic rats
    N Hotta
    The Third Department of Internal Medicine, Nagoya University School of Medicine, Showa Ku, Japan
    Eur J Pharmacol 326:45-51. 1997
  7. ncbi A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats
    J Nakamura
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Diabetes 48:2090-5. 1999
  8. ncbi Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Diabetes 41:587-91. 1992
  9. ncbi Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivity
    J Nakamura
    Third Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
    Diabetologia 44:480-7. 2001
  10. ncbi Niceritrol prevents the decrease in red blood cell 2,3-diphosphoglycerate and neuropathy in streptozotocin-induced diabetic rats
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    J Diabetes Complications 9:133-9. 1995

Collaborators

Detail Information

Publications34

  1. ncbi Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Diabetes Care 24:1776-82. 2001
    ..The purpose of this study was to evaluate the efficacy of fidarestat, a novel aldose reductase (AR) inhibitor, in a double-blind placebo controlled study in patients with type 1 and type 2 diabetes and associated peripheral neuropathy...
  2. ncbi Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long-term treatment with an aldose reductase inhibitor, epalrestat
    N Hotta
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
    Diabet Med 25:818-25. 2008
    ....
  3. ncbi Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial
    Nigishi Hotta
    Chubu Rosai Hospital, 1 10 6 Komei, Nagoya 455 8530, Japan
    Diabetes Care 29:1538-44. 2006
    ..We sought to evaluate the long-term efficacy and safety of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy...
  4. ncbi Nerve function and blood flow in Otsuka Long-Evans Tokushima Fatty rats with sucrose feeding: effect of an anticoagulant
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Eur J Pharmacol 313:201-9. 1996
    ....
  5. ncbi Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats
    J Nakamura
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Eur J Pharmacol 294:207-14. 1995
    ....
  6. ncbi Effect of an aldose reductase inhibitor on abnormalities of electroretinogram and vascular factors in diabetic rats
    N Hotta
    The Third Department of Internal Medicine, Nagoya University School of Medicine, Showa Ku, Japan
    Eur J Pharmacol 326:45-51. 1997
    ..These findings suggest that an aldose reductase inhibitor, TAT, has therapeutic value for diabetic retinopathy...
  7. ncbi A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats
    J Nakamura
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Diabetes 48:2090-5. 1999
    ....
  8. ncbi Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Diabetes 41:587-91. 1992
    ..These findings suggest that niceritrol has a clear inhibitory effect on the development of delayed MNCV in the diabetic rat, which may be due to reduced nerve blood flow and/or decreased nerve myo-inositol levels...
  9. ncbi Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivity
    J Nakamura
    Third Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan
    Diabetologia 44:480-7. 2001
    ....
  10. ncbi Niceritrol prevents the decrease in red blood cell 2,3-diphosphoglycerate and neuropathy in streptozotocin-induced diabetic rats
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    J Diabetes Complications 9:133-9. 1995
    ..These observations suggest that ischemia/hypoxia plays an important role in the development of diabetic neuropathy, and that niceritrol has a therapeutic effect on this condition by improving endoneurial ischemia/hypoxia...
  11. ncbi Common carotid intima-media thickness is predictive of all-cause and cardiovascular mortality in elderly community-dwelling people: Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study
    S Murakami
    Department of Medicine, Medical Center East, Tokyo Women's Medical University, Nishiogu 2-1-10, Arakawa, Tokyo 116-8567, Japan
    Biomed Pharmacother 59:S49-53. 2005
    ..351 (1.029-5.372) and 2.890 (1.059-7.891), respectively. Carotid IMT assessed by ultrasonography is positively associated with an increased risk of all-cause and cardiovascular death in elderly community-dwelling people...
  12. ncbi Fractal analysis of heart rate variability and mortality in elderly community-dwelling people -- Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study
    N Hotta
    Department of Medicine, Medical Center East, Tokyo Women's Medical University, Nishiogu 2-1-10, Arakawa, Tokyo 116-8567, Japan
    Biomed Pharmacother 59:S45-8. 2005
    ....
  13. ncbi Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy
    M Nakayama
    Third Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurama-cho, Showa-ku, Nagoya 466-8550, Japan
    Diabetes Care 24:1093-8. 2001
    ....
  14. ncbi Epalrestat, an aldose reductase ihibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients
    Y Hamada
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Diabetes Care 23:1539-44. 2000
    ..Plasma thiobarbituric acid-reactive substances (TBARS) were also determined as indicators of oxidative stress...
  15. ncbi Increased alanine uptake and lipid synthesis from alanine in isolated hepatocytes of Wistar-Kyoto fatty rats: an inhibitory effect of biguanides
    K Mori
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Can J Physiol Pharmacol 75:179-84. 1997
    ....
  16. ncbi The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Diabetes Res Clin Pract 19:49-58. 1993
    ....
  17. ncbi Physiological and morphometric analyses of neuropathy in sucrose-fed OLETF rats
    J Nakamura
    The Third Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma cho, Showa Ku, 466 8550, Nagoya, Japan
    Diabetes Res Clin Pract 51:9-20. 2001
    ....
  18. ncbi Biguanides may produce hypoglycemic action in isolated rat hepatocytes through their effects on L-alanine transport
    T Komori
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Diabetes Res Clin Pract 22:11-7. 1993
    ..Our results suggest that the inhibition of alanine uptake, related to a reduction in the Na+/L-alanine transport system, is a possible mechanism of biguanide-related inhibition of hepatic gluconeogenesis...
  19. ncbi Arterial stiffness independently predicts cardiovascular events in an elderly community -- Longitudinal Investigation for the Longevity and Aging in Hokkaido County (LILAC) study
    O Matsuoka
    Department of Medicine, Division of Neurocardiology and Chronoecology, Tokyo Women s Medical University, Medical Center East, Nishiogu 2 1 10, Arakawa, Tokyo 116 8567, Japan
    Biomed Pharmacother 59:S40-4. 2005
    ..The early detection of risk by chronomics allows the timely institution of prophylactic measures, thereby shifting the focus from rehabilitation to prehabilitation medicine, as a public service to several Japanese towns...
  20. ncbi Use of the C64 quantitative tuning fork and the effect of niceritrol in diabetic neuropathy
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Clin Ther 16:1007-15. 1994
    ..01 to 0.001). Our results suggest that the C64 quantitative tuning fork is a convenient and objective tool for assessing the severity of diabetic neuropathy and that niceritrol is useful for the treatment of this disease...
  21. ncbi The role of C5a in the development of thrombotic glomerulonephritis in rats
    C Kondo
    The Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Clin Exp Immunol 124:323-9. 2001
    ..These findings indicated that glomerular thrombosis is dependent on the leucocytes, and mediated in part by the anaphylatoxin C5a but not MAC in the present model...
  22. ncbi Insulin modulation of intracellular free magnesium in heart: involvement of protein kinase C
    T Amano
    The Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, 466 8550, Japan
    Br J Pharmacol 130:731-8. 2000
    ..Insulin modulates [Mg(2+)](i) and haemodynamics, presumably via activation of PKC, thereby antagonizing the reduction of [Mg(2+)](i) induced by beta-adrenoceptor stimulation...
  23. ncbi Risk factors for IgA nephropathy: a case-control study in Japan
    K Wakai
    Department of Preventive Medicine and the Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Am J Kidney Dis 33:738-45. 1999
    ..Episodes of tonsillitis and exposure to organic solvents were found not to be associated with the risk in the present study. Our findings may provide some clues to the cause of IgAN...
  24. ncbi Acute renal failure after a sea anemone sting
    M Mizuno
    The Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Am J Kidney Dis 36:E10. 2000
    ..This is the first time that a marine envenomation case has been reported in which the sting of a sea anemone has caused ATN without the failure of any other organs...
  25. ncbi Characteristic patterns of circadian variation in plasma catecholamine levels, blood pressure and heart rate variability in Type 2 diabetic patients
    K Kondo
    Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Diabet Med 19:359-65. 2002
    ..CONCLUSIONS: The present study demonstrated distinctive patterns of circadian variation in plasma noradrenaline level, BP and HRV in Type 2 diabetic patients, associated with an abnormal circadian pattern of sympathovagal modulation...
  26. ncbi Depressive mood is independently related to stroke and cardiovascular events in a community
    G Yamanaka
    Department of Medicine, Tokyo Women's Medical University, Medical Center East, Nishiogu 2-1-10, Arakawa, Tokyo 116-8567, Japan
    Biomed Pharmacother 59:S31-9. 2005
    ..This recommendation stands at the basis of chronomics, focusing on prehabilitation in preference to rehabilitation, as a public service offered in several Japanese towns...
  27. ncbi The effect of cigarette smoking on soluble adhesion molecules in middle-aged patients with Type 2 diabetes mellitus
    N Takeuchi
    Department of Metabolism and Endocrine Internal Medicine, Chubu Rosai Hospital, Nagoya University School of Medicine, Nagoya, Japan
    Diabet Med 19:57-64. 2002
    ..These data suggest a possible mechanism for accelerated atherosclerosis induced by smoking in patients with diabetes...
  28. ncbi Lipid peroxidation may predict restenosis after coronary balloon angioplasty
    K Imai
    Third Department of Internal Medicine, Nagoya University, School of Medicine, Japan
    Jpn Circ J 65:495-9. 2001
    ..57, p<0.01). Our results suggest that oxidative stress contributes to restenosis and indicate that an elevated plasma level of TBARS may be a reliable predictor of restenosis...
  29. ncbi Endothelial and inflammatory markers in relation to progression of ischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus
    T Umemura
    Department of Neurology, Chubu Rosai Hospital, 1 10 6 Komei, Minato ku, Nagoya City, Aichi 455 8530, Japan
    J Neurol Neurosurg Psychiatry 82:1186-94. 2011
    ....
  30. ncbi Efficacy of glucose, ouabain and an aldose reductase inhibitor on 2-[3H] myo-inositol uptake by human, rat and rabbit erythrocytes
    N Hotta
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Horm Metab Res 20:387-90. 1988
    ....
  31. ncbi Effects of a new synthetic selectin blocker in an acute rat thrombotic glomerulonephritis
    I Ito
    Third Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan
    Am J Kidney Dis 38:265-73. 2001
    ..The superior effects and more favorable characteristics of SKK60037 to sLe(x) suggest the potential of SKK60037 for clinical application...
  32. ncbi Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells
    Y Yasuda
    Third Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 281:71-7. 2001
    ....
  33. ncbi Characterization of a newly found stretch-activated KCa,ATP channel in cultured chick ventricular myocytes
    T Kawakubo
    Department of Internal Medicine III, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Am J Physiol 276:H1827-38. 1999
    ..From these data taken together, we concluded that the channel is a new type of KCa channel that could be designated as an "SA KCa,ATP channel." To our knowledge, this is the first report of KCa channel in heart cells...
  34. ncbi [Clinical difference between thiazolidinediones and biguanides]
    N Hotta
    Chubu Rosai Hospital
    Nippon Rinsho 59:2219-27. 2001
    ..Therefore, combination therapy with these two drugs results in further improvement in glucose control. Combination therapy including these two drugs is attractive prospects in future treatment for patients with type 2 diabetes...