Research Topics
Genomes and Genes | Keisuke IshizawaSummaryAffiliation: The University of Tokushima Country: Japan Publications
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Publications
Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cellsKeisuke Ishizawa
Department of Pharmacology, Institute of Health Bioscience, University of Tokushima Graduate School, Kuramoto, Japan
J Pharmacol Sci 109:257-64. 2009..These findings suggest Q3GA would be an active metabolite of quercetin in plasma and may possess preventing effects for cardiovascular diseases relevant to vascular smooth muscle cell disorders...- Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent mannerKeisuke Ishizawa
Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
Nephrol Dial Transplant 25:364-72. 2010..We investigated the effects of an ARB, olmesartan, on the cell migration induced by platelet-derived growth factor (PDGF), a major mitogen involved in the pathogenesis of glomerulonephritis in rat mesangial cells (RMCs)... - Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migrationKeisuke Ishizawa
Departments of Pharmacology, Clinical Pharmacy Medical Pharmacology, The University of Tokushima Graduate School, The Institute of Health Bioscience, 3 18 15 Kuramoto, Tokushima, Japan
J Endocrinol 202:309-16. 2009..From these findings, it is implied that the elevated plasma adiponectin levels in patients with CKD might play a compensatory role aimed at counteracting renal dysfunction related to MC disorders... - Drug discovery for overcoming chronic kidney disease (CKD): development of drugs on endothelial cell protection for overcoming CKDKeisuke Ishizawa
Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
J Pharmacol Sci 109:14-9. 2009..Our preliminary data suggest that nitrosonifedipine is a new and useful drug for the treatment of CKD involving ameliorating effects on EC disorder... - Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migrationYuki Izawa
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan
Hypertens Res 30:1107-17. 2007..From these findings, it is suggested that BMK1 activation leads to VSMC migration induced by PDGF via Gab1-SHP-2 interaction, and that BMK1-mediated VSMC migration may play a role in the pathogenesis of vascular remodeling... - Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cellsYuki Motobayashi
Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
Hypertens Res 32:188-93. 2009..Furthermore, adiponectin selectively inhibited ERK1/2 pathway, not Akt-Bad pathway, stimulated by IGF-1. From these findings, it was implied that adiponectin suppressed IGF-1-induced VSMC migration and its signaling selectivity... - Protective effect of photodegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cellsYayoi Fukuhara
Department of Pharmacology, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan
J Med Invest 58:118-26. 2011..These data suggest that NO-NIF is a candidate for a new class of antioxidative drug that protect cells against oxidative stress in glomerular endothelial cells... - The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their associationNermin Ali
Department of Pharmacology, The University of Tokushima Graduate School, Institute of Health Biosciences, Japan
J Pharmacol Sci 102:112-20. 2006..Although the involvement of other signaling molecules cannot be ruled out, M475271 has potential as a drug for the inhibition of the angiogenesis needed for tumor growth and metastasis... - ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cellsYuki Izawa
Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto 770 8503, Japan
Exp Cell Res 308:291-9. 2005..It is shown that Ang II-induced ERK1/2 activation inhibits insulin-dependent glucose uptake through serine phophorylation of IRS-1 in RASMC... - Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy miceSoichiro Tajima
Dept of Pharmacology, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima, Japan
Am J Physiol Endocrinol Metab 302:E77-86. 2012..These findings suggest that reduction of iron levels ameliorates adipocyte hypertrophy via suppression of oxidative stress, inflammatory cytokines, and macrophage infiltration, thereby breaking a vicious cycle in obesity... - Effects of angiotensin II type 1 receptor blockade on the systemic blood nitric oxide dynamics in Nomega-nitro-L-arginine methyl ester-treated ratsYasuhisa Kanematsu
Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School of Medical Sciences, Japan
Hypertens Res 29:369-74. 2006..In conclusion, our findings suggested that chronic administration of olmesartan ameliorated the endothelial dysfunction in L-NAME-treated rats... - Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive ratsYasuhisa Kanematsu
Department of Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima City, Tokushima 770 8503, Japan
Am J Physiol Renal Physiol 295:F1457-62. 2008..We conclude that dietary nitrite-derived NO generation may serve as a backup system when the nitric oxide synthase/L-arginine-dependent NO generation system is compromised... - Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferationYoshiko Fujita
Department of Pharmacology, The University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Endocrinology 147:1377-85. 2006..These findings suggest that LPC-induced Flk-1/KDR transactivation via c-Src may have important implications for the progression of atherosclerosis... - Effect of angiotensin II on iron-transporting protein expression and subsequent intracellular labile iron concentration in human glomerular endothelial cellsSoichiro Tajima
Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
Hypertens Res 33:713-21. 2010..Both of these events may participate in the progression of oxidative stress because of endothelial cell dysfunction through ferrous iron-mediated ROS generation... - Antioxidant effects of stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on angiotensin II-stimulated MAP kinase activation and vascular smooth muscle cell proliferationMoe Kyaw
Department of Pharmacology, The University of Tokushima Graduate School of Medicine, Tokushima 770-8503, Japan
J Pharmacol Sci 95:483-6. 2004..Our present study indicates the comparable effects of NAC stereoisomers in regulating intracellular GSH and the redox-dependent intracellular signaling mechanisms in VSMC... - Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosisKeisuke Ishizawa
Department of Medical Pharmacology, Institute of Health Bioscience, The University of Tokushima Graduate School, Japan
J Pharmacol Sci 115:466-70. 2011..These findings suggest Q3GA would be an active metabolite of quercetin in plasma and may have preventative effects on arteriosclerosis relevant to VSMC disorders... - A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migrationNermin Ali
Department of Pharmacology, The University of Tokushima Graduate School Institute of Health Biosciences, Japan
J Pharmacol Sci 98:130-41. 2005..Taken together, these data indicate that M475271 may be a useful candidate for inhibition of endothelial cell proliferation and migration relevant to angiogenesis... - Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activationKeisuke Ishizawa
Department of Pharmacology, University of Tokushima Graduate School of Medicine, Japan
Hypertension 46:1046-52. 2005..In addition to the classical steroid activity, rapid nongenomic effects induced by aldosterone may represent an alternative etiology for vascular diseases such as hypertension... - Basic fibroblast growth factor regulates glucose metabolism through glucose transporter 1 induced by hypoxia-inducible factor-1? in adipocytesYoshitaka Kihira
Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Int J Biochem Cell Biol 43:1602-11. 2011..Taken together, the findings suggest that bFGF has a harmful effect on the development of type 2 diabetes through metabolism reprogramming and attenuation of the insulin signal... - Dietary nitrite ameliorates renal injury in L-NAME-induced hypertensive ratsKoichiro Tsuchiya
Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 1 78 1 Sho machi, Tokushima 770 8505, Japan
Nitric Oxide 22:98-103. 2010..Further research is needed to investigate the interaction between nitrite-nitrate intakes and human health... - Effect of iron-quercetin complex on reduction of nitrite in in vitro and in vivo systemsHideki Ohnishi
Department of Pharmacology, The University of Tokushima Graduate School, 1 78 1 Sho machi, Tokushima 770 8505, Japan
J Agric Food Chem 56:10092-8. 2008..These results may indicate that iron(II) is critical to the generation of NO gas from nitrite, whereas quercetin contributed little under the in vivo experimental conditions... - Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell functionYasumasa Ikeda
Department of Pharmacology, University of Tokushima Graduate School of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Atherosclerosis 215:339-47. 2011..Herein, we clarify the effect and mechanism of action of DFO on angiogenesis... - Antioxidant effects of photodegradation product of nifedipineYuya Horinouchi
Department of Pharmacology, The Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
Chem Pharm Bull (Tokyo) 59:208-14. 2011..Our findings suggest that NO-NIF is a candidate for a new class of antioxidative drugs that protect cells against oxidative stress... - Dual effects of endothelin-1 (1-31): induction of mesangial cell migration and facilitation of monocyte recruitment through monocyte chemoattractant protein-1 production by mesangial cellsKeisuke Ishizawa
Department of Pharmacology, University of Tokushima School of Medicine, Japan
Hypertens Res 27:433-40. 2004..Since human chymase has been reported to be involved in glomerular disease, ET-1 (1-31) may be among the mediators... - Drug discovery for improvement of chronic kidney disease and cardiovascular diseaseKeisuke Ishizawa
Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Yakugaku Zasshi 131:1347-52. 2011..Also we review the data on a possible new class drug against oxidative stress to improve CKD and CVD... - Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery:inflammatory responses of hypoxia-inducible factor 1? (HIF-1?) in T cells observed in development of vascular remodelingShuhei Tomita
Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
J Pharmacol Sci 115:433-9. 2011.... - Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cellsMasanori Yoshizumi
Department of Pharmacology, The University of Tokushima School of Medicine, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
Br J Pharmacol 136:1023-32. 2002..Thus, inhibition of JNK by ebselen may imply its usefulness for treatment of ischaemic cerebral diseases relevant to neuronal cell death... - Inhibitory action of novel arginine derivative on catecholamine secretion evoked by acetylcholine from cultured bovine adrenal chromaffin cellsMami Azuma
Department of Pharmacy, Tokushima University Hospital, Tokushima, Japan
J Cardiovasc Pharmacol 42:S15-8. 2003.... - Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodelingHirotsugu Kurobe
epartment of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Arterioscler Thromb Vasc Biol 30:210-7. 2010..We show that hypoxia-inducible factor 1 (Hif-1) (specifically expressed in T cells) is involved in the immune response to vascular remodeling that accompanies arteriosclerosis...