Y Hosokawa

Summary

Affiliation: The University of Tokushima
Country: Japan

Publications

  1. ncbi Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1?-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Hum Immunol 73:26-30. 2012
  2. ncbi Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Clin Exp Immunol 144:494-502. 2006
  3. ncbi Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Clin Exp Immunol 146:540-9. 2006
  4. ncbi CXC chemokine ligand 16 in periodontal diseases: expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Immunol 149:146-54. 2007
  5. ncbi Adrenomedullin suppresses tumour necrosis factor alpha-induced CXC chemokine ligand 10 production by human gingival fibroblasts
    I Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Immunol 152:568-75. 2008
  6. ncbi CC chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Periodontal Res 43:471-7. 2008
  7. ncbi Human gingival fibroblasts express functional chemokine receptor CXCR6
    Y Hosokawa
    Departments of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Clin Exp Immunol 156:413-8. 2009
  8. ncbi Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima 770 8504, Japan
    J Nutr Biochem 21:659-64. 2010
  9. ncbi Catechins inhibit CCL20 production in IL-17A-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Cell Physiol Biochem 24:391-6. 2009
  10. ncbi TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Tokushima 770 8504, Japan
    Mol Immunol 47:666-70. 2010

Collaborators

Detail Information

Publications33

  1. ncbi Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1?-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Hum Immunol 73:26-30. 2012
    ..Therefore, IL-1? might be a therapeutic target for Th17-related diseases, such as periodontal disease and arthritis...
  2. ncbi Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Clin Exp Immunol 144:494-502. 2006
    ....
  3. ncbi Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Clin Exp Immunol 146:540-9. 2006
    ..Moreover, in combination with IL-1beta or TGF-beta1, TWEAK may be related to the exacerbation of periodontal disease to induce proinflammatory cytokines and adherent molecules by HGF...
  4. ncbi CXC chemokine ligand 16 in periodontal diseases: expression in diseased tissues and production by cytokine-stimulated human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Immunol 149:146-54. 2007
    ..These results suggest that the CXCL16 produced by HGFs may be involved in the migration of leucocytes into inflamed tissues, and provide evidence that CXCL16 production is controlled by cytokines in periodontal disease...
  5. ncbi Adrenomedullin suppresses tumour necrosis factor alpha-induced CXC chemokine ligand 10 production by human gingival fibroblasts
    I Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Immunol 152:568-75. 2008
    ..AM might be a therapeutic target of periodontal disease, because AM can inhibit CXCL10 production by HGFs...
  6. ncbi CC chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Periodontal Res 43:471-7. 2008
    ..Moreover, we investigated the effects of cytokines and toll-like receptor (TLR) ligands on the production of CCL17 by human gingival fibroblasts (HGFs)...
  7. ncbi Human gingival fibroblasts express functional chemokine receptor CXCR6
    Y Hosokawa
    Departments of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Clin Exp Immunol 156:413-8. 2009
    ..These results indicate that CXCL16 may play an important role in the pathogenesis and remodelling in periodontally diseased tissues...
  8. ncbi Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima 770 8504, Japan
    J Nutr Biochem 21:659-64. 2010
    ..In addition, EGCG and ECG attenuated OSMR beta expression on HGFs. These data provide a novel mechanism through which the green tea flavonoids, catechins, can provide direct benefits in periodontal disease...
  9. ncbi Catechins inhibit CCL20 production in IL-17A-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Cell Physiol Biochem 24:391-6. 2009
    ..In addition, EGCG and ECG attenuated IL-17 receptor expression on HGFs. These data provide a novel mechanism through which the green tea flavonoids catechins could be used to provide direct benefits in periodontal disease...
  10. ncbi TNFSF14 coordinately enhances CXCL10 and CXCL11 productions from IFN-gamma-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Tokushima 770 8504, Japan
    Mol Immunol 47:666-70. 2010
    ..These effects of TNFSF14 may promote the infiltration of Th1 cells into lesions with inflammatory diseases. TNFSF14 might act as a proinflammatory cytokine in some inflammatory diseases thus is a candidate therapeutic target...
  11. ncbi Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry, The University of Tokushima Graduate School, Tokushima, Japan
    Mol Nutr Food Res 54:S151-8. 2010
    ..In addition, EGCG, ECG, and TFDG attenuated TNFSF14 receptor expression on HGFs. These data provide a novel mechanism through which the green tea and black tea polyphenols could be used to provide direct benefits in periodontal disease...
  12. ncbi Proinflammatory effects of muramyldipeptide on human gingival fibroblasts
    I Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    J Periodontal Res 45:193-9. 2010
    ..In this study, we focused on expression and function of nucleotide binding oligomerization domain 2 (NOD2) in HGFs, which is a mammalian cytosolic pathogen recognition molecule...
  13. ncbi Oncostatin M synergistically induces CXCL10 and ICAM-1 expression in IL-1beta-stimulated-human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Cell Biochem 111:40-8. 2010
    ..These effects of OSM and IL-1beta may promote Th1 cells infiltration and retention in periodontally diseased tissues and be related to exacerbation of periodontal disease...
  14. ncbi Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts
    Yoshitaka Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Japan
    Int Immunopharmacol 11:670-4. 2011
    ..In addition, TFDG suppressed OSM receptor (OSMR) ? expression on HGFs. These data provide a novel mechanism where the black tea flavonoid, theaflavin, could provide direct benefits in periodontal disease...
  15. ncbi Increase of CCL20 expression by human gingival fibroblasts upon stimulation with cytokines and bacterial endotoxin
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Clin Exp Immunol 142:285-91. 2005
    ..Thus, CCL20 by HGF might be involved in inflammatory cells infiltration, and promote the progression of periodontal disease...
  16. ncbi CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Immunol 141:467-74. 2005
    ..This fact means that P. gingivalis may inhibit CXCR4+ cells infiltration and neovascularization in periodontal tissue and escape from the immune response...
  17. ncbi Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue
    Y Hosokawa
    Department of Conservative Dentistry, Tokushima University School of Dentistry, Tokushima, Japan
    Clin Exp Immunol 139:506-12. 2005
    ..Thus, these findings suggested that CX3CR1 and the corresponding chemokine, fractalkine may have an important regulatory role on specific leucocyte migration into inflamed periodontal tissue...
  18. ncbi Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue
    Y Hosokawa
    Department of Conservative Dentistry, Tokushima University School of Dentistry, Tokushima, Japan
    Clin Exp Immunol 128:548-54. 2002
    ..Thus, these findings suggested that CCR6 and the corresponding chemokine, MIP-3alpha may have an important regulatory role in specific lymphocyte migration into inflamed periodontal tissue...
  19. ncbi Cytokines differentially regulate CXCL10 production by interferon-gamma-stimulated or tumor necrosis factor-alpha-stimulated human gingival fibroblasts
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    J Periodontal Res 44:225-31. 2009
    ..CXC chemokine 10 (CXCL10) activates CXC chemokine receptor 3 (CXCR3) and attracts activated T-helper 1 cells. In this study we examined the effects of cytokines on CXCL10 production by human gingival fibroblasts...
  20. ncbi An immunohistological study on cyclooxygenase-2 in human dental pulp
    T Nakanishi
    Department of Conservative Dentistry, School of Dentistry, The University of Tokushima, Japan
    J Endod 27:385-8. 2001
    ....
  21. ncbi Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue
    I Hosokawa
    Department of Immunology, The Forsyth Institute, Boston, Massachusetts, USA
    Clin Exp Immunol 146:218-25. 2006
    ..These findings suggest that LL-37 displays distinct expression patterns from those of hBDs in gingival tissue...
  22. ncbi Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography
    Y Nakase
    Department of Surgery and Physiology of Digestive System, Graduate School of Medical Science, Surgery and Regenerative Medicine, Kyoto, Japan
    Br J Cancer 92:562-9. 2005
    ..Measurement of RUNX3 expression and detection of RUNX3 methylation in remnant gastric mucosa may estimate the forward risk of carcinogenesis in the remnant stomach...
  23. ncbi Cloning and sequence analysis of a cDNA encoding the Rieske iron-sulfur protein of rat mitochondrial cytochrome bc1 complex
    M Nishikimi
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Biophys Res Commun 159:19-25. 1989
    ..Northern blot analysis indicated that rat liver possibly contains different sizes of mRNAs for the Rieske iron-sulfur protein, and Southern blot analysis demonstrated that rats and mice possess a single gene for this protein...
  24. ncbi Cloning and sequencing of a cDNA for human mitochondrial ubiquinone-binding protein of complex III
    H Suzuki
    Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan
    Biochem Biophys Res Commun 156:987-94. 1988
    ..This implies that the human QP-C is synthesized without a presequence which is required for import of most nuclear-encoded mitochondrial proteins into mitochondria...
  25. ncbi Induction of D2 and D3 cyclin-encoding genes during promotion of the G1/S transition by prolactin in rat Nb2 cells
    Y Hosokawa
    Department of Biochemistry, Mie University Faculty of Medicine, Japan
    Gene 147:249-52. 1994
    ..cDNA clones encoding these rat cyclins D2 and D3 were isolated and analyzed...
  26. ncbi Structural organization and tissue-specific expression of the gene encoding rat cysteine dioxygenase
    N Tsuboyama
    Department of Chemistry, Kochi Medical School, Japan
    Gene 181:161-5. 1996
    ..Northern blots of RNA from rat tissues revealed the highest CDO mRNA level in the liver. Significant levels were observed in the kidney, lung and brain, implying tissue-specific differences in CDO promoter function...
  27. ncbi Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus
    K Yasojima
    Department of Biochemistry and Molecular Genetics, Kyoto Prefectural University of Medicine, Japan
    Biochem Biophys Res Commun 231:481-7. 1997
    ..We propose that KF-1 is involved in membranous protein-sorting apparatus similarly to RAPsyn. We mapped the human kf-1 gene to 2p11.2...
  28. ncbi Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons
    Y Hosokawa
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan
    Neurosci Res 35:281-90. 1999
    ....
  29. ncbi API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products
    M Motegi
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Pathol 156:807-12. 2000
    ..Thus, the RT-PCR assay used here should serve as an effective molecular tool for understanding molecular pathogenesis and the clinical significance of API2-MALT1 for MALT lymphomas...
  30. ncbi Anti-apoptotic action of API2-MALT1 fusion protein involved in t(11;18)(q21;q21) MALT lymphoma
    Y Hosokawa
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, 464 8681, Japan
    Apoptosis 10:25-34. 2005
    ....
  31. ncbi Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer
    K Inoue
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan
    Anticancer Res 21:2471-6. 2001
    ..Our results suggest that PPAR-gamma may play an important role in the pathogenesis and/or progression of lung cancer, and may be a novel therapeutical target for therapy of lung cancer...
  32. ncbi Detection of AP12-MALT1 chimaeric gene in extranodal and nodal marginal zone B-cell lymphoma by reverse transcription polymerase chain reaction (PCR) and genomic long and accurate PCR analyses
    M Yonezumi
    Division of Molecular Medicine, Aichi Cancer Centre Research Institute, Chikusa-ku, Nagoya, Japan
    Br J Haematol 115:588-94. 2001
    ....
  33. ncbi Decrease of rat liver cysteine dioxygenase (cysteine oxidase) activity mediated by glucagon
    Y Hosokawa
    J Biochem 84:419-24. 1978
    ..The evidence obtained here suggests that enhancement of degradation or inactivation of cysteine dioxygenase is responsible for the glucagon-mediated decrease of the enzyme activity in rat liver...