Research Topics
Genomes and GenesSpecies | S HirohataSummaryAffiliation: Teikyo University Country: Japan Publications
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Publications
Low-dose weekly methotrexate for progressive neuropsychiatric manifestations in Behcet's diseaseS Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
J Neurol Sci 159:181-5. 1998..These results suggest that low dose weekly MTX therapy might have a beneficial effect in the treatment of progressive NB, although a trial for a longer period would be necessary...- Behçet's diseaseShunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Arthritis Res Ther 5:139-46. 2003..As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required... - Enhanced generation of endothelial cells from CD34+ cells of the bone marrow in rheumatoid arthritis: possible role in synovial neovascularizationShunsei Hirohata
Teikyo University School of Medicine, Tokyo, Japan
Arthritis Rheum 50:3888-96. 2004..To examine the capacity of bone marrow CD34+ cells to generate endothelial cells, in order to assess the role of bone marrow in neovascularization in the synovium of rheumatoid arthritis (RA)... - Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritisShunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173 8605, Japan
Arthritis Res Ther 8:R54. 2006..These results indicate that the enhanced expression of NFkappaB1 mRNA in bone marrow CD34+ cells plays a pivotal role in their abnormal responses to TNF-alpha and, thus, in the pathogenesis of RA... - Association of cerebrospinal fluid anti-ribosomal p protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosusShunsei Hirohata
Department of Rheumatology and Infectious Disease, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
Arthritis Res Ther 9:R44. 2007.... - Bone marrow CD34+ progenitor cells stimulated with stem cell factor and GM-CSF have the capacity to activate IgD- B cells through direct cellular interactionShunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
J Leukoc Biol 71:987-95. 2002..Therefore, the data suggest that the accelerated recruitment of MLC from the bone marrow to the synovium might play a role in the local B cell activation in RA... - Regulation of human B cell function by sulfasalazine and its metabolitesShunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Int Immunopharmacol 2:631-40. 2002..The data therefore suggest that not only sulfasalazine, but its metabolites, might contribute to the beneficial effects of sulfasalazine... - Antiribosomal P protein antibody in human systemic lupus erythematosus reacts specifically with activated T cellsS Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Lupus 10:612-21. 2001.... - Systemic sclerosis complicated with nephrotic syndrome: relevance with antiribosomal P antibodyS Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Rheumatol Int 21:40-3. 2001..It is strongly suggested that antiribosomal P antibody might have been involved in the development of the nephrotic syndrome in our patient... - Inhibition of human B cell activation by a novel nonsteroidal anti-inflammatory drug, indometacin famesilS Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Immunopharmacology 44:245-54. 1999..These results indicate that INF preferentially suppresses the human B cell functions. Thus, the data suggest that INF may have more beneficial effects than IND in treatment of RA... - Bone marrow CD34+ progenitor cells from rheumatoid arthritis patients support spontaneous transformation of peripheral blood B cells from healthy individualsS Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Rheumatol Int 19:153-9. 2000..These results suggest that the capacity of BM CD34+ cells to support survival of B cells might contribute to the pathogenesis of RA by sustaining abnormal B cell responses... - Is the long-term use of systemic corticosteroids beneficial in the management of Behçet's syndrome?Shunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Nat Clin Pract Rheumatol 2:358-9. 2006 - Inhibition of cyclin A gene expression in human B cells by an immunosuppressant mizoribineS Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Clin Exp Immunol 120:448-53. 2000..The results indicate that mizoribine suppresses the expression of cyclin A mRNA in human B cells by down-regulating its stability, and thus down-regulates their responses... - Induction of fibroblast-like cells from CD34(+) progenitor cells of the bone marrow in rheumatoid arthritisS Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
J Leukoc Biol 70:413-21. 2001.... - Enhanced expression of mRNA for FK506-binding protein 5 in bone marrow CD34 positive cells in patients with rheumatoid arthritisR Matsushita
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan
Clin Exp Rheumatol 28:87-90. 2010..The current study therefore examined the expression of several representative genes, including amphiregulin (AREG), chemokine receptor 4 (CXCR4), and FK506-binding protein 5 (FKBP5) in RA BM CD34+ cells... - Differential influences of bucillamine and methotrexate on the generation of fibroblast-like cells from bone marrow CD34+ cells of rheumatoid arthritis patientsShunsei Hirohata
Kitasato University School of Medicine, Kanagawa 228 8555, Japan
Int Immunopharmacol 9:86-90. 2009..Since MTX, but not BUC, has been previously shown to influence on type A synoviocytes, the data provide rationale of combination of BUC and MTX in the treatment of RA... - Association of transporter associated with antigen processing genes with Behçet's disease in JapaneseK Takizawa
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
Autoimmunity 36:161-5. 2003..5%) as compared to the control group (0.0%). [p = 0.03, RR = 15.4]. These results suggest the possibility that TAP molecule play some part in formation of skin lesion, such as erythema nodosum in BD in Japanese... - Anti-ribosomal P protein antibody in human systemic lupus erythematosus up-regulates the expression of proinflammatory cytokines by human peripheral blood monocytesTatsuo Nagai
Teikyo University School of Medicine, Tokyo, Japan
Arthritis Rheum 52:847-55. 2005.... - [Central nervous system involvement in Behçet's disease]S Hirohata
Department of Internal Medicine, Teikyo University School of Medicine
Rinsho Shinkeigaku 41:1147-9. 2001..Chronic progressive NB is resistant to conventional treatment with steroid, cyclophosphamide, or azathioprine. However, recent studies suggest the efficacy of low dose methotrexate in chronic progressive NB... - Myocardial infarction caused by rheumatoid vasculitis: histological evidence of the involvement of T lymphocytesM Takayanagi
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
Rheumatol Int 23:315-8. 2003..Moreover, our results suggest that infiltration of T lymphocytes might be involved in the development of rheumatoid vasculitis... - Efficacy of serum angiopoietin-1 measurement in the diagnosis of early rheumatoid arthritisA Ishikawa
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
Clin Exp Rheumatol 29:604-8. 2011..The present study was therefore designed to examine whether determination of serum Ang-1 might be effective in diagnosis of early RA... - Histopathology of the ruptured pulmonary artery aneurysm in a patient with Behçet's diseaseS Hirohata
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan
Clin Exp Rheumatol 27:S91-5. 2009..However, the mechanism of the development of PAA is unclear. In the present study, we carried out immunohistological examination of the ruptured pulmonary aneurysm in a patient with vasculo-Behçets disease... - Differential regulation of Th1 responses and CD154 expression in human CD4+ T cells by IFN-alphaH Shibuya
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
Clin Exp Immunol 132:216-24. 2003.... - [Central nervous system involvement in connective tissue diseases]Shunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine
Nihon Rinsho Meneki Gakkai Kaishi 27:109-17. 2004..As for ANCA-related vasculitis, pachymeningitis has been found to be associated with P-ANCA as well as C-ANCA... - Enhanced production of IgE anti-Japanese cedar pollen specific antibodies by peripheral blood B cells from patients with Japanese cedar pollinosisNobuharu Ohshima
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital, Tokyo, Japan
Allergol Int 57:147-55. 2008..We explored the capacity of peripheral blood B cells from pollinosis patients to produce anti-JCP specific IgE... - [Efficacy of leflunomide]Shunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine
Nippon Rinsho 60:2357-63. 2002..In addition, rheumatologists should be aware that leflunomide has a much longer half life than any other disease modifying antirheumatic drug... - [Systemic lupus erythematosus]Shunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine
Nippon Rinsho 62:429-34. 2004 - Possible physiological roles of proteolytic products of actin in neutrophils of patients with Behçet's diseaseS Yamashita
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
Biol Pharm Bull 24:733-7. 2001..These results suggest that the increase of 42-merP and truncated actin in patients with Behçet's disease changes functions of neutrophils.. - Effect of infliximab in progressive neuro-Behçet's syndromeHirotoshi Kikuchi
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173 8605, Japan
J Neurol Sci 272:99-105. 2008..Since infliximab has been shown to have cytotoxic effects on monocytes/macrophages, the rapid fall of CSF IL-6 after the infusion suggest that infliximab might directly act on such inflammatory cells producing IL-6... - Laser-mediated microdissection for analysis of gene expression in synovial tissueAtsushi Hashimoto
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara 228 8555, Japan
Mod Rheumatol 17:185-90. 2007..Combined with other new techniques such as real-time quantitative polymerase chain reaction or microarray analysis, LMM is becoming more important in the analysis of gene expression in rheumatology... - Immunohistological studies in neuro-Behçet's diseaseShunsei Hirohata
Department of Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan
Adv Exp Med Biol 528:385-7. 2003 - HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Behçet's diseaseKaori Aramaki
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Tokyo 173-8605, Japan
Mod Rheumatol 17:81-2. 2007 - [Neuromuscular involvement in rheumatoid arthritis]Shunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine
Nippon Rinsho 63:266-9. 2005 - Low dose MTX for progressive neuro-Behçet's disease. A follow-up study for 4 yearsHirotoshi Kikuchi
Rheumatic Disease Division, Department of Internal Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan
Adv Exp Med Biol 528:575-8. 2003 - Elevated levels of soluble fractalkine in active systemic lupus erythematosus: potential involvement in neuropsychiatric manifestationsNobuyuki Yajima
Showa University School of Medicine, Tokyo, Japan
Arthritis Rheum 52:1670-5. 2005..Soluble Fkn is also a serologic marker of disease activity and organ damage in patients with SLE, and its measurement in CSF may be useful for the diagnosis of NPSLE and followup of patients with NPSLE... - Reversible focal neurological deficits in systemic lupus erythematosus: report of 2 cases and review of the literatureMiho Kimura
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
J Neurol Sci 272:71-6. 2008..Therefore, we propose that reversible focal neurological deficits should be added to the 1999 nomenclature and classification and case definitions... - Accuracy of cerebrospinal fluid IL-6 testing for diagnosis of lupus psychosis. A multicenter retrospective studyShunsei Hirohata
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
Clin Rheumatol 28:1319-23. 2009..3%, respectively, at the cut-off value of 4.3 pg/ml. These results indicate that CSF IL-6 might be an effective measure in diagnosing LP, although exclusion of infectious meningoencephalitis and cerebrovascular accident is necessary... - Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J miceFumihito Suzuki
Department of Medicine and Rheumatology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
J Immunol 175:6987-96. 2005..The results also point to the potential therapeutic usefulness of CX3CL1 inhibition and/or blockade of CX3CL1-CX3CR1 interaction in idiopathic inflammatory myopathy... - Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosusYoshiyuki Arinuma
Teikyo University School of Medicine, Tokyo, Japan
Arthritis Rheum 58:1130-5. 2008..To explore the association of antibodies directed against N-methyl-D-aspartate receptor subunit NR2 (anti-NR2) in cerebrospinal fluid (CSF) with neuropsychiatric manifestations in systemic lupus erythematosus (NPSLE)... - Histopathology of central nervous system lesions in Behçet's diseaseShunsei Hirohata
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
J Neurol Sci 267:41-7. 2008..More importantly, it is suggested that soluble factors produced by infiltrating cells, including IL-6, might play a role in the induction of apoptosis of neurons in NB... - Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritisAtsushi Hashimoto
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa, Japan
J Rheumatol 34:2144-53. 2007.... - High diagnostic value of anticalpastatin autoantibodies in rheumatoid arthritis detected by ELISA using human erythrocyte calpastatin as antigenSachiko Iwaki-Egawa
Department of Pathological Biochemistry, Hokkaido College of Pharmacy, Otaru, Japan
J Rheumatol 31:17-22. 2004..To develop a quantitative method of measuring autoantibodies against human calpastatin in rheumatoid arthritis (RA) and to determine their diagnostic value compared with other autoimmune and articular diseases... - [Diagnosis and therapy for Behcet disease]Shunsei Hirohata
Nippon Naika Gakkai Zasshi 96:2220-5. 2007 - [Laboratory tests for collagen disease: recent progress]Shunsei Hirohata
Internal Medicine, Teikyo University School of Medicine
Rinsho Byori . 2003 - Specificity of enzyme-linked immunosorbent assay for IgG anti-NR2 glutamate receptor antibodies: comment on the concise communication by Yoshio et alShunsei Hirohata
Arthritis Rheum 56:386-7. 2007 - Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta-analysisFotini B Karassa
Dept. of Hygiene and Epidemiology, University of Ioannina School of Medicine, 45110 Ioannina, Greece
Arthritis Rheum 54:312-24. 2006..CONCLUSION: Anti-P antibody testing has limited diagnostic value for NPSLE, and it is not helpful in differentiating among various disease phenotypes... - Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet's disease: a randomised, double-blind, placebo-controlled studyTakahide Matsuda
Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
Drugs R D 4:19-28. 2003..We prospectively investigated the efficacy of rebamipide, a gastroprotective drug, against oral aphthous ulcers in BD patients... - [Fully human anti TNF-alpha monoclonal antibodies (adalimumab, golimumab)]Shunsei Hirohata
Department of Rheumatology and Infectious Diseases, Kitasato University, School of Medicine
Nihon Rinsho 65:1202-8. 2007..Thus, adalimumab has already been approved for treatment of RA in the United States and European Union. The clinical trials of another fully human anti-TNF-alpha monoclonal antibody golimumab are now under way...