H Tanooka

Summary

Country: Japan

Publications

  1. ncbi Meta-analysis of non-tumour doses for radiation-induced cancer on the basis of dose-rate
    Hiroshi Tanooka
    Radiation Effects Association, Kaji cho, Chiyoda ku, Tokyo, Japan
    Int J Radiat Biol 87:645-52. 2011
  2. ncbi Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA
    H Tanooka
    Biological Effects Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Gene Ther 17:1-10. 2010
  3. ncbi Summary of entire Japanese thorotrast follow-up study: updated 1998
    T Mori
    National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba ken, Japan
    Radiat Res 152:S84-7. 1999
  4. ncbi Homologous recombination between p53 and its pseudogene in a radiation-induced mouse tumor
    H Tanooka
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 58:5649-51. 1998
  5. ncbi Application of a newly developed photoluminescence glass dosimeter for measuring the absorbed dose in individual mice exposed to low-dose rate 137Cs gamma-rays
    Y Hoshi
    Bio Science Department, Central Research Institute of Electric Power Industry, Tokyo, Japan
    J Radiat Res 41:129-37. 2000
  6. ncbi 1998 results of the first series of follow-up studies on Japanese thorotrast patients and their relationships to an autopsy series
    T Mori
    National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Radiat Res 152:S72-80. 1999
  7. ncbi Frequent p53 mutation in mouse tumors induced by repeated beta-irradiation
    A Ootsuyama
    Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 11:236-42. 1994
  8. ncbi New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B
    H Fujiki
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan
    Basic Life Sci 52:205-12. 1990
  9. ncbi X chromosome inactivation-mediated cellular mosaicism for the study of the monoclonal origin and recurrence of mouse tumors: a review
    H Tanooka
    National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Cytogenet Genome Res 104:320-4. 2004
  10. ncbi p53 Pseudogene dating: identification of the origin of laboratory mice
    H Tanooka
    Genetics Division, National Cancer Center Research Institute, Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Gene 270:153-9. 2001

Detail Information

Publications13

  1. ncbi Meta-analysis of non-tumour doses for radiation-induced cancer on the basis of dose-rate
    Hiroshi Tanooka
    Radiation Effects Association, Kaji cho, Chiyoda ku, Tokyo, Japan
    Int J Radiat Biol 87:645-52. 2011
    ..Conclusions: The cancer risk of ionising radiation varies 1000-fold depending on the dose-rate of radiation and exposure conditions. This analysis explains the discrepancy of cancer risk between A-bomb survivors and radium dial painters...
  2. ncbi Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA
    H Tanooka
    Biological Effects Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Gene Ther 17:1-10. 2010
    ..This suppressive effect involved the induction of apoptosis. These results indicate that mp53 activity causes tumors that can be suppressed by subsequent silencing of mp53 in the presence of wild-type p53 alleles...
  3. ncbi Summary of entire Japanese thorotrast follow-up study: updated 1998
    T Mori
    National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba ken, Japan
    Radiat Res 152:S84-7. 1999
    ..Rate ratios for liver cancer, liver cirrhosis, leukemia and lung cancer were 35.9, 6.9, 12.5 and 2.0 times higher, respectively, than those for controls...
  4. ncbi Homologous recombination between p53 and its pseudogene in a radiation-induced mouse tumor
    H Tanooka
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 58:5649-51. 1998
    ..A novel mechanism of cancer induction is suggested...
  5. ncbi Application of a newly developed photoluminescence glass dosimeter for measuring the absorbed dose in individual mice exposed to low-dose rate 137Cs gamma-rays
    Y Hoshi
    Bio Science Department, Central Research Institute of Electric Power Industry, Tokyo, Japan
    J Radiat Res 41:129-37. 2000
    ..The results clearly demonstrate the superiority of the glass dosimetry regarding simplicity of operation, stability of long-term dose accumulation and good detector uniformity, which allow accurate tissue dosimetry...
  6. ncbi 1998 results of the first series of follow-up studies on Japanese thorotrast patients and their relationships to an autopsy series
    T Mori
    National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Radiat Res 152:S72-80. 1999
    ..Results showed 523 liver malignancies per 10(4) person Gy and 150 blood diseases per 10(4) person Gy for Japanese male Thorotrast carriers (wasted dose 10 years)...
  7. ncbi Frequent p53 mutation in mouse tumors induced by repeated beta-irradiation
    A Ootsuyama
    Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 11:236-42. 1994
    ..Ha-ras mutation was absent in these tumors, indicating that repeated beta-irradiation created a cell-growth stimulating effect similar to that of ras mutation...
  8. ncbi New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B
    H Fujiki
    Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan
    Basic Life Sci 52:205-12. 1990
    ..EGCG and sarcophytols showed inhibition of tumor development by chemical carcinogenesis. A possibility of developing these compounds as cancer chemopreventives for human beings is discussed...
  9. ncbi X chromosome inactivation-mediated cellular mosaicism for the study of the monoclonal origin and recurrence of mouse tumors: a review
    H Tanooka
    National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Cytogenet Genome Res 104:320-4. 2004
    ..A series of experimental studies on this topic are reviewed...
  10. ncbi p53 Pseudogene dating: identification of the origin of laboratory mice
    H Tanooka
    Genetics Division, National Cancer Center Research Institute, Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Gene 270:153-9. 2001
    ..From comparison of the mutation spectrum, the origin of laboratory mice was identified to one of two M. m. domesticus groups...
  11. ncbi Induction of thioredoxin in human lymphocytes with low-dose ionizing radiation
    Y Hoshi
    Nuclear Energy Systems Department, Central Research Institute of Electric Power Industry, Komae shi, Tokyo, Japan
    Biochim Biophys Acta 1359:65-70. 1997
    ..The optimum radiation dose for enhancement of induction of the TRX mRNA was 0.25 Gy. The TRX protein also increased to a peak, a 3-fold increase at maximum, with the same timing as that for TRX mRNA...
  12. ncbi Residential randon exposure and lung cancer risk in Misasa, Japan: a case-control study
    T Sobue
    Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan
    J Radiat Res 41:81-92. 2000
    ..This study did not find that the risk pattern of lung cancer, possibly associated with residential radon exposure, in Misasa Town differed from patterns observed in other countries...
  13. ncbi Heterospecific expression of misrepair-enhancing activity of mucAB in Escherichia coli and Bacillus subtilis
    H Tanooka
    Radiobiology Division, National Cancer Center Research Institute, Tokyo, Japan
    J Bacteriol 173:2906-14. 1991
    ..coli cleavage was observed in Rec+ cells after treatment with either mitomycin C or an alkylating agent but was not detected in RecA- cells. Common activity of B. subtilis Rec and E. coli RecA in the induction of mutants is suggested...