Research Topics
Genomes and Genes
| Tomohiko OhtaSummaryAffiliation: St. Marianna University School of Medicine Country: Japan Publications
| Collaborators
|
Detail Information
Publications
[Breast and ovarian cancer susceptibility gene product BRCA1]Tomohiko Ohta
Tanpakushitsu Kakusan Koso 51:1395-400. 2006- HERC2 is an E3 ligase that targets BRCA1 for degradationWenWen Wu
Division of Breast and Endocrine Surgery, Department of Surgery, St Marianna University School of Medicine, Kawasaki, Japan
Cancer Res 70:6384-92. 2010..The HERC2 expression in breast epithelial cells and breast carcinomas suggests that this mechanism may play a role in breast carcinogenesis... - Perturbation of DNA repair pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agentsTakashi Takeshita
Division of Breast and Endocrine Surgery, St Marianna University School of Medicine, Kawasaki, Japan
Cancer Chemother Pharmacol 64:1039-46. 2009..We investigated the effect of proteasome inhibitors on the pathway after exposure to chemotherapeutic agents and examined its correlation with cytotoxicity... - The BRCA1 ubiquitin ligase and homologous recombination repairTomohiko Ohta
Department of Translational Oncology, St Marianna University Graduate School of Medicine, Kawasaki 216 8511, Japan
FEBS Lett 585:2836-44. 2011..Here, we review recent advances in our understanding of BRCA1 function in HR and discuss possible roles of the activity... - The ubiquitin E3 ligase activity of BRCA1 and its biological functionsWenWen Wu
Division of Breast and Endocrine Surgery, St, Marianna University School of Medicine, Kawasaki, 216 8511, Japan
Cell Div 3:1. 2008..Elucidation of this mechanism in relation to cell survival is now much anticipated because it could be a key to predict chemosensitivity of basal-like breast cancer... - Contemplating chemosensitivity of basal-like breast cancer based on BRCA1 dysfunctionTomohiko Ohta
Division of Breast and Endocrine Surgery, Department of Surgery, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
Breast Cancer 16:268-74. 2009..In individualized treatment of breast cancer, evaluation of the DNA repair capacity by the BRCA1 pathway may be an important issue when determining proper treatment of basal-like breast cancer... - Ubiquitin and breast cancerTomohiko Ohta
Division of Breast and Endocrine Surgery, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
Oncogene 23:2079-88. 2004..Understanding these pathways may provide some hints toward developing diagnostic tools and treatments for breast cancer patients... - Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2Ryosuke Hayami
Division of Breast and Endocrine Surgery, St Marianna University School of Medicine, Kawasaki, Japan
Cancer Res 65:6-10. 2005..Recognizing the importance of cyclin E1 overexpression in breast cancer development, these results suggest a CDK2-BRCA1-NPM pathway that coordinately functions in cell growth and tumor progression pathways... - BRCA1 ubiquitinates RPB8 in response to DNA damageWenWen Wu
Division of Breast and Endocrine Surgery, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
Cancer Res 67:951-8. 2007..Our findings suggest that ubiquitination of a common subunit of RNA polymerases is a mechanism underlying BRCA1-dependent cell survival after DNA damage... - Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteinsHideki Asakawa
Division of Breast and Endocrine Surgery, Department of Surgery, St, Marianna University School of Medicine, Kawasaki, Japan
Breast Cancer Res 12:R17. 2010..Proteins required for this pathway can be detected as nuclear foci at sites of DNA damage when the pathway is intact. Here we investigate whether focus formation of repair proteins can predict chemosensitivity of breast cancer... - Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligaseKo Sato
Division of Breast and Endocrine Surgery, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
J Biol Chem 279:30919-22. 2004..Given the many overlapped functions between NPM and BRCA1, we propose that NPM is a strong candidate as a substrate of the BRCA1-BARD1 ubiquitin ligase... - Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugatesAyaka Koike
Department of Translational Oncology, St Marianna University Graduate School of Medicine, Kawasaki, Japan
Cancer Res 70:6746-56. 2010..Collectively, our findings suggest that phosphorylated NPM1 is a novel component in DSB repair that is recruited by ubiquitin conjugates downstream of RNF8 and RNF168... - BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activityHiroyuki Nishikawa
Division of Breast and Endocrine Surgery, Institute of Advanced Medical Science, and Department of Radiology, St Marianna University School of Medicine, Kawasaki, Japan
Cancer Res 69:111-9. 2009..Together, these results suggest that BAP1 and BRCA1/BARD1 coordinately regulate ubiquitination during the DNA damage response and the cell cycle... - HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progressionNaoki Izawa
Department of Translational Oncology, Gastroenterology and Hepatology, Clinical Oncology, and Breast and Endocrine Surgery, Institute of Advanced Medical Science, St Marianna University Graduate School of Medicine, Kawasaki, Japan
Cancer Res 71:5621-5. 2011..These findings establish HERC2 as a critical function in DNA repair, checkpoint activation, and DNA replication... - A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeatsMakiko Tsuzuki
Division of Breast and Endocrine Surgery, Department of Surgery, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki 216 8511, Japan
Cancer Lett 233:108-16. 2006..DeltaRIN does not interact with BRCA1, whereas it interacts with and colocalizes with CstF-50 to cytoplasmic dots. Hence, a deletion variant of BARD1 occurs in cells and may play a distinct role with CstF-50... - Inhibition of caspase-9 activity and Apaf-1 expression in cisplatin-resistant head and neck squamous cell carcinoma cellsDaisuke Kuwahara
Department of Otolaryngology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan
Auris Nasus Larynx 30:S85-8. 2003..These results suggest that in a certain type of HNSCCs, the inhibition of Casp9 activity and Apaf-1 expression may represent a mechanism of acquired cisplatin resistance... - Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligaseHiroyuki Nishikawa
Division of Breast and Endocrine Surgery, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
J Biol Chem 279:3916-24. 2004..Hence, the results indicate that BRCA1-BARD1 mediates novel polyubiquitin chains that may be distinctly edited by 26 S proteasome from conventional Lys-48-linked polyubiquitin chains... - Clinical efficacy and value of redistributed subclavian arterial infusion chemotherapy for locally advanced breast cancerHiroshi Shimamoto
Department of Radiology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki 216 8511, Japan
Jpn J Radiol 29:236-43. 2011..We have focused on the local response, quality of life (QOL), and complications. We have also investigated factors that influence the local response of RESAIC... - Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'Satoshi Yamasaki
Department of Genome Science, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
EMBO J 26:113-22. 2007..Our results provide novel insights into p53 signaling mediated by Synoviolin... - The UPS: a promising target for breast cancer treatmentKo Sato
Division of Breast and Endocrine Surgery, St Marianna University School of Medicine, Kawasaki, 216 8511, Japan
BMC Biochem 9:S2. 2008..PUBLICATION HISTORY : Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)... - Putative tumor suppressor EDD interacts with and up-regulates APCRyuichi Ohshima
Division of Gastroenterological Surgery, Department of Surgery, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
Genes Cells 12:1339-45. 2007..Thus, through protein-protein interaction, EDD stabilizes APC and up-regulates APC's function to inhibit beta-catenin, suggesting that EDD could act as a colorectal tumor suppressor... - Sensitization of head and neck squamous cell carcinoma cells to Fas-mediated apoptosis by the inhibition of Bcl-X(L) expressionYoshihiro Otani
Department of Otolaryngology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan
Auris Nasus Larynx 30:S79-84. 2003..CONCLUSION: Our data suggest that Fas-signaling might be regulated by a Bcl-X(L)-inhibitable step in CH11-resistant HSC-2... - Radiologic-pathological correlation of punctate hyperechoic foci by ultrasound in stereotactic vacuum-assisted breast biopsy samplesHiroko Okazaki
Department of Radiology, St Marianna University School of Medicine, Miyamae ku, Kawasaki, Japan
Jpn J Radiol 27:438-43. 2009..To correlate punctate hyperechoic foci (PHF) on ultrasound (US) with microcalcifications detected by mammography (MMG) and at histopathology... - Targeted substrate degradation by an engineered double RING ubiquitin ligaseDaisuke Oyake
Department of Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawaski 216-8511, Japan
Biochem Biophys Res Commun 295:370-5. 2002..By redesigning the substrate recognition site, expression of engineered double RING ubiquitin ligases may provide a useful tool for removing many different gene products at the protein level... - [Breast-conserving surgery: quadrantectomy]Hisanori Kawamoto
Division of Breast and Endocrine Surgery, St. Marianna University School of Medicine, Kawasaki, Japan
Nippon Geka Gakkai Zasshi 103:811-5. 2002..It is important to determine the surgical technique that compromises between local curability and cosmetic results for each patient with breast cancer... - Essential role of synoviolin in embryogenesisNaoko Yagishita
Department of Genome Science, Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao Miyamae ku, Kawasaki, Kanagawa 216 8512, Japan
J Biol Chem 280:7909-16. 2005..Our findings emphasized the indispensable role of the Synoviolin in embryogenesis... - Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complexPeter S Brzovic
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:5646-51. 2003..Thus, binding alone is not sufficient for BRCA1-dependent Ub-ligase activity... - [Breast cancer]Mamoru Fukuda
Division of Breast and Endocrine Surgery, St. Marianna University School of Medicine
Gan To Kagaku Ryoho 29:1900-6. 2002..These controversies show the importance of assessment of screening mammography effectiveness in Japan... - Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cellsArata Shimo
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Cancer Sci 98:174-81. 2007..These findings suggest the involvement of a PRC1-KIF2C/MCAK complex in breast tumorigenesis, and this complex should be a promising target for the development of novel treatments for breast cancer... - Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damageJian Hu
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, NC 27599 7295, USA
Nat Cell Biol 6:1003-9. 2004..We suggest that DDB1 targets CDT1 for ubiquitination by a CUL4A-dependent ubiquitin ligase, CDL4A(DDB1), in response to UV irradiation... - [Genetic abnormalities in ovarian tumors]Kazushige Kiguchi
Division of Obstetrics and Gynecology, St. Marianna University School of Medicine
Nippon Rinsho 62:449-53. 2004 - A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repairNobuko Matsushita
Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701 0192, Japan
Mol Cell 19:841-7. 2005..These results define functional consequences of FancD2 monoubiquitination and reveal previously hidden functions for the FA protein core complex... - Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesisArata Shimo
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Cancer Sci 99:62-70. 2008..These findings suggest that overexpression of KIF2C/MCAK might be involved in breast carcinogenesis and is a promising therapeutic target for breast cancers... - [Predictive markers in breast cancer treatment--focusing on a recent topic "basal-like breast cancer"]Ayaka Koike
Division of Breast and Endocrine Surgery, St. Marianna University School of Medicine
Nippon Rinsho 65:285-90. 2007 - Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullinsManabu Furukawa
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
J Biol Chem 277:15758-65. 2002..We suggest that RING-E2, rather than cullin-RING, constitutes the catalytic core of the ubiquitin ligase and that one major function of the cullin subunit is to assemble the RING-E2 catalytic core and substrates together...