Yukihiko Shirayama

Summary

Country: Japan

Publications

  1. ncbi Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor
    Hisahito Ishida
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    Hippocampus 17:271-80. 2007
  2. ncbi The psychological aspects of patients with delayed sleep phase syndrome (DSPS)
    Masako Shirayama
    Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Japan
    Sleep Med 4:427-33. 2003
  3. ncbi Pregnenolone and dehydroepiandrosterone administration in neonatal rats alters the immunoreactivity of hippocampal synapsin I, neuropeptide Y and glial fibrillary acidic protein at post-puberty
    Y Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 36 1 Nishi machi, Yonago, Tottori 683 8504, Japan
    Neuroscience 133:147-57. 2005
  4. ncbi [The problems of the current antidepressants and their future possibilities]
    Yukihiko Shirayama
    Nippon Yakurigaku Zasshi 127:209-12. 2006
  5. ncbi Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects
    Yukihiko Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurochem 90:1258-68. 2004
  6. ncbi In vivo 31P NMR spectroscopy shows an increase in glycerophosphorylcholine concentration without alterations in mitochondrial function in the prefrontal cortex of medicated schizophrenic patients at rest
    Yukihiko Shirayama
    Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, and Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Eur J Neurosci 20:749-56. 2004
  7. ncbi Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats
    Yukihiko Shirayama
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Hippocampus 21:1105-13. 2011
  8. ncbi Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study
    Yukihiko Shirayama
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuroimage 49:2783-90. 2010
  9. ncbi Subsequent exposure to the choline uptake enhancer MKC-231 antagonizes phencyclidine-induced behavioral deficits and reduction in septal cholinergic neurons in rats
    Yukihiko Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Tottori, Japan
    Eur Neuropsychopharmacol 17:616-26. 2007
  10. ncbi Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline
    Shiho Arakawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Pharmacol Biochem Behav 100:601-6. 2012

Collaborators

Detail Information

Publications45

  1. ncbi Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor
    Hisahito Ishida
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    Hippocampus 17:271-80. 2007
    ..These results suggest that infusion of NPY into the CA3 region of hippocampus of LH rats produces antidepressant-like activity through Y1 receptors and attenuating effects through Y2 receptors...
  2. ncbi The psychological aspects of patients with delayed sleep phase syndrome (DSPS)
    Masako Shirayama
    Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Japan
    Sleep Med 4:427-33. 2003
    ..The current study attempts to define the psychological features of patients with delayed sleep-phase syndrome (DSPS)...
  3. ncbi Pregnenolone and dehydroepiandrosterone administration in neonatal rats alters the immunoreactivity of hippocampal synapsin I, neuropeptide Y and glial fibrillary acidic protein at post-puberty
    Y Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 36 1 Nishi machi, Yonago, Tottori 683 8504, Japan
    Neuroscience 133:147-57. 2005
    ..No differences were detected in dynorphin A immunoreactivity among the experimental groups. These results of this study suggest that pregnenolone and DHEA play an important role in the development of hippocampus...
  4. ncbi [The problems of the current antidepressants and their future possibilities]
    Yukihiko Shirayama
    Nippon Yakurigaku Zasshi 127:209-12. 2006
  5. ncbi Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects
    Yukihiko Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurochem 90:1258-68. 2004
    ..These results indicate that both dynorphin A and dynorphin B contribute to the effects of stress, and suggest that blockade of kappa-opioid receptors may have therapeutic potential for the treatment of depression...
  6. ncbi In vivo 31P NMR spectroscopy shows an increase in glycerophosphorylcholine concentration without alterations in mitochondrial function in the prefrontal cortex of medicated schizophrenic patients at rest
    Yukihiko Shirayama
    Department of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, and Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Eur J Neurosci 20:749-56. 2004
    ..Thus, an increase in GPC concentration in the prefrontal cortex could be characteristic of the pathophysiology of schizophrenia with mild negative symptoms...
  7. ncbi Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats
    Yukihiko Shirayama
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Hippocampus 21:1105-13. 2011
    ..These results suggest that ALLO exerts antidepressant-like effects in the CA3 region of hippocampus through the GABA system and in the central region of amygdala, dependently on the activation of the glutamatergic mechanisms...
  8. ncbi Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study
    Yukihiko Shirayama
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Neuroimage 49:2783-90. 2010
    ..These data suggest that specific metabolites of the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia...
  9. ncbi Subsequent exposure to the choline uptake enhancer MKC-231 antagonizes phencyclidine-induced behavioral deficits and reduction in septal cholinergic neurons in rats
    Yukihiko Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Tottori, Japan
    Eur Neuropsychopharmacol 17:616-26. 2007
    ..These results suggest that MKC-231 could be a therapeutic drug for the treatment of schizophrenia...
  10. ncbi Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline
    Shiho Arakawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Pharmacol Biochem Behav 100:601-6. 2012
    ..Taken together, minocycline may be a therapeutic drug for the treatment of depression...
  11. ncbi Altered levels of synapsin I, dopamine transporter, dynorphin A, and neuropeptide Y in the nucleus accumbens and striatum at post-puberty in rats treated neonatally with pregnenolone or DHEA
    Katsumasa Muneoka
    Department of Anatomy I, Showa University School of Medicine, Tokyo, Japan
    Int J Dev Neurosci 27:575-81. 2009
    ..The results suggest that neurosteroid levels during the neonatal period have larger impact on synaptic formation, development of DA and NPY systems in the nigrostriatal rather than the mesolimbic pathway...
  12. ncbi Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors
    Shinsui Kunitachi
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Brain Res 1279:189-96. 2009
    ..Therefore, it is likely that donepezil would be potential therapeutic drugs for the treatment of the cognitive deficits in schizophrenia...
  13. ncbi Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou ku, Chiba 260 8670, Japan
    Psychopharmacology (Berl) 198:363-74. 2008
    ..However, differences in efficacy have also been reported, and further comparative pharmacological studies are still needed...
  14. ncbi Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    PLoS ONE 3:e1944. 2008
    ..In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex of schizophrenic patients. Furthermore, we examined correlations between GSH levels and clinical variables in patients...
  15. ncbi A study of a dendritic marker, microtubule-associated protein 2 (MAP-2), in rats neonatally treated neurosteroids, pregnenolone and dehydroepiandrosterone (DHEA)
    Masaaki Iwata
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Tottori 683 8504, Japan
    Neurosci Lett 386:145-9. 2005
    ..Neonatal treatment with pregnenolone and DHEA increased the expression of MAP-2 in the hippocampus and nucleus accumbens but not in the prefrontal cortex, striatum or amygdala in adulthood...
  16. ncbi Biphasic effects of neonatal allopregnanolone on striatal dopamine metabolism
    Katsumasa Muneoka
    Department of Anatomy I, Showa University School of Medicine, Tokyo, Japan
    Neuroreport 20:860-3. 2009
    ..Allopregnanolone did not significantly affect cortical DA metabolism, or cortical or striatal serotonin metabolism. Data indicate that neonatal allopregnanolone treatment has a biphasic effect on striatal DA metabolism...
  17. ncbi In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats
    Yukihiko Shirayama
    Department of Biochemistry and Cellular Biology, National Institute of Neuroscience NCNP, Kodaira, Tokyo, Japan
    J Neurochem 92:1317-26. 2005
    ..Our results suggest that amygdala kindling may affects amino acid metabolism, but not energy metabolism...
  18. ncbi Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors
    Hiroko Hagiwara
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Eur Neuropsychopharmacol 18:448-54. 2008
    ..Therefore, perospirone could be a potential therapy for the cognitive deficits observed in schizophrenic patients...
  19. ncbi Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  20. ncbi Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia
    Tomihisa Niitsu
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1836-40. 2011
    ..Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia...
  21. ncbi Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats
    Masaaki Iwata
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    Hippocampus 21:877-84. 2011
    ..These results indicate that astrocytes are responsive to the antidepressant-like effect of imipramine in the dentate gyrus and CA3 region of the hippocampus...
  22. ncbi Deficits in auditory P50 inhibition in obsessive-compulsive disorder
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:288-96. 2008
    ..Our findings suggest that sensory gating deficits may be involved in the pathophysiology of OCD in a different way from clinical symptoms and executive attention dysfunction...
  23. ncbi Plasma levels of homovanillic acid, 5-hydroxyindoleacetic acid and cortisol, and serotonin turnover in depressed patients
    Hideaki Mitani
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 36-1 Nishi-machi, Yonago, Tottori, 683-8504, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:531-4. 2006
    ..Taken together, plasma levels of HVA and 5-HIAA, and 5-HT turnover (5-HIAA/5-HT) could be good markers for evaluating depression...
  24. ncbi Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats
    Hisahito Ishida
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Japan
    Brain Res 1046:239-43. 2005
    ..Subchronic treatment of learned helplessness rats, but not naive rats, with imipramine ameliorated the decrease in the number of NPY-positive cells. Therefore, NPY-positive cells in the hippocampus may contribute to depression...
  25. ncbi Effects of acute administration of methamphetamine on Narp mRNA in rat brain
    Makoto Fukumoto
    Department of Neuropsychiatry, Faculty of Medicine, Tottori Unversity, Tottori, Japan
    Addict Biol 10:257-9. 2005
    ..6 mg/kg, intraperitoneally (i.p.)] increased Narp mRNA in the prefrontal cortex, whereas the same treatment with MAP decreased Narp mRNA in the hippocampus. Therefore, Narp gene could be involved in the MAP-induced effects...
  26. ncbi Correlation between plasma levels of glutamate, alanine and serine with severity of depression
    Hideaki Mitani
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 36-1 Nishi-machi, Yonago, Tottori 683-8504, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1155-8. 2006
    ..The results indicate that plasma level of glutamate, alanine and L-serine could reflect the severity of depression rather than glutamine, glycine and taurine...
  27. ncbi Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects
    Goro Fukami
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Ann Gen Psychiatry 9:37. 2010
    ..The object of the present study was to examine the effects of etizolam and ethyl loflazepate, with EHs of 6 h and 122 h, respectively, on information processing in healthy subjects...
  28. ncbi Dopamine transporter density and behavioral response to methylphenidate in a hyperlocomotor rat model
    Katsumasa Muneoka
    Department of Anatomy I, Showa University School of Medicine, Tokyo, Japan
    Congenit Anom (Kyoto) 46:155-9. 2006
    ....
  29. ncbi Does hypofrontality expand to global brain area in progression of schizophrenia?: a cross-sectional study between first-episode and chronic schizophrenia
    Nobuhisa Kanahara
    Department of Psychiatry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:410-5. 2009
    ..The present study suggested that the reduction in rCBF occurs in the posterior brain area in addition to the frontal lobe across all clinical stages of schizophrenia...
  30. ncbi Effects of cyclohexanonic long-chain fatty alcohol, tCFA15 on amino acids in diabetic rat brain: a preliminary study
    Chiko Shinbori
    Department of Neuropsychiatry, Tottori University Faculty of Medicine, Yonago, Japan
    Neurochem Res 33:1189-95. 2008
    ..The alteration in glutamate/glutamine ratio may indicate that experimental models of type 1 diabetes have abnormalities of neuron-gria interaction in brain...
  31. ncbi A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression
    Yuji Ozeki
    Department of Psychiatry, Dokkyo Medical University, Japan
    Neurosci Res 69:154-60. 2011
    ..In summary, we propose an idea that PSAT1 may be implicated in altered serine metabolism and schizophrenia spectrum conditions...
  32. ncbi A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia
    Akihiro Shiina
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Ann Gen Psychiatry 9:27. 2010
    ..Therefore, it is of particular interest to investigate the effects of tropisetron on the cognitive deficits in patients with schizophrenia...
  33. ncbi Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese...
  34. ncbi Correlation of plasma neurosteroid levels to the severity of negative symptoms in male patients with schizophrenia
    Yukihiko Shirayama
    Department of Neuropsychiatry, Showa University Fujigaoka Hospital, Yokohama, Japan
    Schizophr Res 58:69-74. 2002
    ..The measurements of plasma neurosteroid levels could be a useful biological marker for the severity of negative symptoms in schizophrenic patients...
  35. ncbi [A case of Addison's disease presented with depression as a first symptom]
    Masaaki Iwata
    Division of Neuropsychiatry, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University
    Seishin Shinkeigaku Zasshi 106:1110-6. 2004
    ..In addition, Addison's disease presenting with psychiatric features in the early stage has the tendency to be overlooked and misdiagnosed. Thus, we suggest the necessity of blood work for ACTH and cortisol in the field of psychiatry...
  36. ncbi Effects of a neurosteroid, pregnenolone, during the neonatal period on adenosine A1 receptor, dopamine metabolites in the fronto-parietal cortex and behavioral response in the open field
    Katsumasa T Muneoka
    Department of Neuropsychiatry, Kagoshima University Faculty of Medicine, Kagoshima, Japan
    Brain Res 956:332-8. 2002
    ..The present results indicate that pregnenolone treatment during the neonatal period influences the cortical dopaminergic and adenosinergic systems as well as behavioral responses in the open field...
  37. ncbi Delayed-onset obsessive-compulsive symptoms after brain infarctions treated with paroxetine
    Katsumasa Muneoka
    Gakuji kai Kimura Hospital, Chiba, Japan Department of Anatomy I, Showa University School of Medicine, Tokyo, Japan and Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
    Clin Neuropharmacol 34:260-1. 2011
    ..Her scores on the Yale-Brown Obsessive Compulsive Scale reduced from 31 to 8 points after this treatment. This case may suggest therapeutic modulation of language-related cortical activity elicited by paroxetine...
  38. ncbi High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503
    Masatomo Ishikawa
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Biol Psychiatry 62:878-83. 2007
    ..The present study was undertaken to examine whether fluvoxamine binds to sigma-1 receptors in living human brain...
  39. ncbi Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Neuropsychopharmacology 32:2004-10. 2007
    ..Therefore, it is possible that minocycline would be a potential therapeutic drug for schizophrenia...
  40. ncbi Effect of acute and chronic administration of the selective 5-HT2C receptor antagonist SB-243213 on midbrain dopamine neurons in the rat: an in vivo extracellular single cell study
    Thomas P Blackburn
    GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, CM19 5AW, UK
    Synapse 46:129-39. 2002
    ..Overall, our results indicate that antagonism of the 5-HT2C receptor alters the activity of midbrain DA neurons in anesthetized rats and suggest that SB-243213 has an atypical antipsychotic profile following chronic administration...
  41. ncbi Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
    Yukihiko Shirayama
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3251-61. 2002
    ..Infusions of BDNF and NT-3 did not influence locomotor activity or passive avoidance. The results provide further support for the hypothesis that BDNF contributes to the therapeutic action of antidepressant treatment...
  42. ncbi Effect of the acute and chronic administration of the putative atypical antipsychotic drug Y-931 (8-fluoro-12- (4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3b][1,5] benzodiazepine maleate) on spontaneously active rat midbrain dopamine neurons: an in vivo
    Yoshio Minabe
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, 431-3192 Japan
    Synapse 51:19-26. 2004
    ....
  43. ncbi Charles Bonnet syndrome with visual hallucinations of childhood experience: successful treatment of 1 patient with risperidone
    Kazuhisa Maeda
    J Clin Psychiatry 64:1131-2. 2003
  44. ncbi Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study
    Yoshio Minabe
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, 431-3192 Shizuoka, Japan
    Synapse 52:20-8. 2004
    ..Clinical studies are required to understand what role 5-HT(6) receptor blockade might eventually play in the treatment of schizophrenia...
  45. ncbi Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan
    Eur J Pharmacol 544:1-9. 2006
    ..Our findings suggest that minocycline protects the neurotoxicity of the 5-HT and dopamine systems in the mouse brain after the administration of MDMA...