Research Topics
Species | K YasuiSummaryAffiliation: Shinshu University Country: Japan Publications
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Detail Information
Publications
Roles of phosphatidylinositol 3-kinase and phospholipase D in temporal activation of superoxide production in FMLP-stimulated human neutrophilsK Yasui
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto 390, Japan
Cell Biochem Funct 19:43-50. 2001..NADPH oxidase is activated in a PI3-kinase-dependent manner at the early phase, and PLD activity follows it and is related to superoxide production at the late phase in human neutrophils by stimulation with FMLP...
Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonismK Yasui
Department of Pediatrics, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
Clin Exp Allergy 39:1857-65. 2009..Dendritic cells (DCs) are professional antigen-presenting cells, capable of priming naïve T cells, and play key roles in the activation of immune responses in asthma...
Thalidomide prevents formation of multinucleated giant cells (Langhans-type cells) from cultured monocytes: possible pharmaceutical applications for granulomatous disordersK Yasui
Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Int J Immunopathol Pharmacol 22:707-14. 2009..Our results support thalidomides clinical efficacy in the treatment of chronic granulomatous disorders (granulomatosis)...
Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonismK Yasui
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
J Leukoc Biol 67:529-35. 2000..These findings suggest that theophylline has an immunomodulatory action on neutrophil apoptosis via a mechanism of A2A antagonism...
Presenility of granulocytes in Down syndrome individualsK Yasui
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Am J Med Genet 84:406-12. 1999....
Effects of theophylline on human eosinophil functions: comparative study with neutrophil functionsK Yasui
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
J Leukoc Biol 68:194-200. 2000..Theophylline thus modulates granulocyte functions in association with specific adenosine receptor antagonism and cAMP-PDE inhibition...
The effect of ascorbate on minor recurrent aphthous stomatitisK Yasui
Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Acta Paediatr 99:442-5. 2010..The purpose of this study was to evaluate the potential of ascorbate (vitamin C) to reduce the frequency of MRAS and severity of pain...
Absence of IgD-CD27(+) memory B cell population in X-linked hyper-IgM syndromeK Agematsu
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto 390, Japan
J Clin Invest 102:853-60. 1998..However, the IgG production can be induced by stimulation of immunoglobulin receptors and CD40 in cooperation with such cytokines as IL-2 and IL-10 in vitro...
Therapeutic potential of superoxide dismutase (SOD) for resolution of inflammationK Yasui
Department of Pediatrics, Shinshu University School of Medicine, Asahi 3 1 1, Matsumoto 390 8621, Japan
Inflamm Res 55:359-63. 2006..If the drug can be delivered efficiently to the inflammatory site, SOD may be useful as an inhibitory mediator of neutrophil-mediated inflammation...
Multi-nucleated giant cell formation from human cord blood monocytes in vitro, in comparison with adult peripheral blood monocytesY Kondo
Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 5 1 Shikata cho, Okayama, Japan
Clin Exp Immunol 158:84-90. 2009..0001). These results suggest the possibility that the susceptibility of newborns to mycobacterium infection is due partly to impaired MGC formation...
New clinical applications of xanthine derivatives: modulatory actions on leukocyte survival and functionK Yasui
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Int J Hematol 73:87-92. 2001..Here, we review some recent advances in the understanding of pharmacological actions and new applications of xanthine derivatives...
Increased serum concentration of urinary trypsin inhibitor with asthma exacerbationK Yasui
Dept of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Eur Respir J 22:739-42. 2003..The monitoring of urinary trypsin inhibitor concentrations might be useful for evaluating the neutrophil-mediated inflammation in childhood asthma attack...
Neutrophilic inflammation in childhood bronchial asthmaK Yasui
Thorax 60:704-5. 2005
