Research Topics
Genomes and GenesSpecies | Michio HashimotoSummaryAffiliation: Shimane University Country: Japan Publications
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Publications
Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model ratsMichio Hashimoto
Department of Physiology, Shimane Medical University, Izumo, Japan
J Neurochem 81:1084-91. 2002..Docosahexaenoic acid is thus a possible prophylactic means for preventing the learning deficiencies of Alzheimer's disease...- Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid ?-infused ratsMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, 693 8501, Japan
Food Funct 2:386-94. 2011..The present study suggests that long-term administration of TAK-085 is a possible therapeutic agent for protecting against Alzheimer's disease-induced learning deficiencies... - Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cellsMichio Hashimoto
Department of Environmental Physiology, Shimane University, Faculty of Medicine, Izumo, Japan
Prostaglandins Leukot Essent Fatty Acids 73:475-83. 2005..Therefore, decreases in PM fluidity, observed with age-dependent increased cholesterol and decreased USI, induce a decrease in 5'-ND activity, decrease extracellular adenosine levels, and might relate to hypertension in aged rats... - Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractionsMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
Biochim Biophys Acta 1738:91-8. 2005..These results suggest that DHA-induced protection of memory deficits in AD-model rats is related to the interactions of cholesterol, palmitic acid or stearic acid with A beta peptides in DIFs where DHA ameliorates these interactions... - Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidityMichio Hashimoto
Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane 693 8501, Japan
Mol Cell Biochem 293:1-8. 2006..These results suggest that DHA is a more potent membrane-fluidizer than EPA in withstanding cholesterol-induced decreases in platelet membrane fluidity and a stronger ameliorative modulator of platelet hyperaggregation... - Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidityMichio Hashimoto
Department of Environmental Physiology, Shimane University, Faculty of Medicine, Izumo, Japan
Clin Exp Pharmacol Physiol 33:934-9. 2006.... - The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid beta(1-40)Michio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
J Nutr Biochem 20:965-73. 2009..Amyloid beta (Abeta) peptide (1-40) can cause cognitive impairment... - Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model ratsMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan
J Neurochem 107:1634-46. 2008..DHA concentration-dependently reduced the levels of oligomeric amyloid species, suggesting that dietary DHA-induced suppression of in vivo Abeta(1-40) aggregation occurs through the inhibitory effect of DHA on oligomeric amyloid species... - Effects of docosahexaenoic acid on in vitro amyloid beta peptide 25-35 fibrillationMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Shimane, Japan
Biochim Biophys Acta 1791:289-96. 2009..These results suggest that DHA decreases the in vitro fibrillation of Abeta(25-35) by inhibiting the oligomeric amyloid species and, therefore, Abeta(25-35)-related neurotoxicity or behavioral impairment could be restrained by DHA... - Docosahexaenoic acid withstands the A?(25-35)-induced neurotoxicity in SH-SY5Y cellsMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
J Nutr Biochem 22:22-9. 2011..The level of A?(25-35)-induced lipid peroxide (LPO) was determined in the absence or presence of oligomer-specific antibody. Fatty acid profile was estimated by gas chromatography... - Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's diseaseMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Japan
J Pharmacol Sci 116:150-62. 2011..Therefore, it might be a useful therapeutic agent to prevent and/or delay cognitive impairment in mild cases of AD... - Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused ratsMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
J Nutr 135:549-55. 2005..DHA is thus a possible therapeutic agent for ameliorating learning deficiencies due to Alzheimer's disease... - Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat modelMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
Med Gas Res 1:26. 2011..abstract:.. - Green tea catechins prevent cognitive deficits caused by Abeta1-40 in ratsAbdul M Haque
Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo City, Shimane, 693 8501, Japan
J Nutr Biochem 19:619-26. 2008..Our results suggest that long-term administration of green tea catechins provides effective prophylactic benefits against Abeta-induced cognitive impairment by increasing antioxidative defenses... - Long-term administration of green tea catechins improves spatial cognition learning ability in ratsAbdul M Haque
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan
J Nutr 136:1043-7. 2006..We suggest that this improvement in spatial cognitive learning ability is due to the antioxidative activity of green tea catechins... - Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cellsShahdat Hossain
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan
J Neurochem 111:568-79. 2009..Taken together, these data suggest that by restraining Abeta(1-42) toxic tri/tetrameric oligomers, DHA may limit amyloidogenic neurodegenerative diseases, Alzheimer's disease... - Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampusYoko Tanabe
Department of Environmental Physiology, Shimane University, Faculty of Medicine, Izumo, Japan
Clin Exp Pharmacol Physiol 31:700-3. 2004..These results suggest that the DHA-induced improvement in spatial cognition is associated with increased Fos expression in the CA1 hippocampus... - Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane orderHossain Shahdat
Department of Environmental Physiology, Shimane University School of Medicine, Izumo 693-8501, Japan
Life Sci 74:3009-24. 2004.... - Changes of noradrenaline-induced contractility and gene expression in aorta of rats acclimated to heat in two different modesGuang Hua Li
Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Japan
Eur J Appl Physiol 104:29-40. 2008..The phases of the day when such changes occurred appear to be closely related to the periods when the animals were previously subjected to heat... - Relationship between plasma and hippocampal lipid peroxidation in obese and hypertensive SHR/NDmcr-cp ratsMichio Hashimoto
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan
Clin Exp Pharmacol Physiol 31:S62-4. 2004..5. These results indicate that, in SHR-cp, lipid peroxidation in the hippocampus would not be affected even if plasma levels of fatty acids and lipid peroxide increased markedly, when ageing is not a predicative factor... - Contribution of the suprachiasmatic nucleus to the formation of a time memory for heat exposure in ratsMegumi Maruyama
Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, 693 8501 Japan
J Physiol Sci 57:107-14. 2007..These findings suggest that the SCN is crucial for establishing a time memory for heat stress, and it plays a minimal role in heat acclimation-induced changes in T(cor) in rats... - Proliferation of neuronal progenitor cells and neuronal differentiation in the hypothalamus are enhanced in heat-acclimated ratsKentaro Matsuzaki
Department of Environmental Physiology, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, 693 8501, Japan
Pflugers Arch 458:661-73. 2009.... - Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cellsToshiyuki Okui
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693 8501, Japan
Prostaglandins Leukot Essent Fatty Acids 85:163-9. 2011..These results suggest that CLA promotes neuronal differentiation by increasing, in part, the expression of Hes6 mRNA and by activating p21(cip1) and p27(kip1) to arrest cell cycle... - Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian workersAkiko Nogi
Department of Environmental and Preventive Medicine, Shimane University School of Medicine, Izumo City, Shimane, Japan
J Occup Health 49:205-16. 2007..In conclusion, an increase in n-3 PUFA was associated with HDL-C and TG in the Japanese and Mongolians, but these beneficial effects were not constant across the three Asian ethnic groups... - Alterations of calf venous and arterial compliance following acclimation to heat administered at a fixed daily time in humansMegumi Maruyama
Department of Environmental Physiology, School of Medicine, Shimane University, Izumo, 693-8501, Japan
Int J Biometeorol 50:269-74. 2006..The results presented suggest that repeated heat exposure in humans, for 4 h at a fixed time daily, increases the calf CV and the CSA particularly during the period when the subjects were previously exposed to heat... - Characterization of vasoconstrictor-induced relaxation in the cerebral basilar arteryBudbazar Enkhjargal
Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
Eur J Pharmacol 637:118-23. 2010.... - Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic ratsShahdat Hossain
Department of Physiology, Shimane Medical University, Shimane, Japan
Clin Exp Pharmacol Physiol 30:470-5. 2003..5. The present study suggests that 5% P. ostreatus supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition... - Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in AsiansKuninori Shiwaku
Department of Environmental and Preventive Medicine, Shimane University School of Medicine, Izumo, Japan
J Lipid Res 45:914-22. 2004..HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians... - Maternal dietary n-6/n-3 fatty acid ratio affects type 1 diabetes development in the offspring of non-obese diabetic miceYukiko Kagohashi
Department of Health and Nutrition, The University of Shimane, Matsue, Shimane, Japan
Congenit Anom (Kyoto) 50:212-20. 2010..The present findings suggest that n-6/n-3 ratio of the maternal diet during gestation and lactation rather than that of offspring after weaning strongly affects the development of overt diabetes in NOD mice... - Increased nitric oxide in proportion to the severity of heart failure in patients with dilated cardiomyopathy: close correlation of tumor necrosis factor-alpha with systemic and local production of nitric oxideTakashi Sugamori
The Fourth Department of Internal Medicine, Shimane Medical University, Izumo, Japan
Circ J 66:627-32. 2002..The findings indicate that the concentrations of NO and TNF-alpha in patients with CHF increase in proportion to the severity of heart failure, and that TNF-alpha plays a role in the enhanced systemic and local production of NO... - [Mechanism of improvement of spatial cognition with dietary docosahexaenoic acid]Michio Hashimoto
Department of Physiology, Shimane Medical University, Izumo 693-8501, Japan
Nippon Yakurigaku Zasshi 120:54P-56P. 2002.... - Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model ratsKentaro Matsuzaki
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
Neurosci Lett 400:230-4. 2006..In the AD model rats, nobiletin showed protective effects on Abeta(1-40)-induced impairment of learning ability. These results suggest that nobiletin has the potential for becoming a novel lead compound for drug development for AD... - Characteristics of contractile activity in the renal artery of ovariectomized ratsBudbazar Enkhjargal
Division of Physiology, Department of Occupational Therapy, School of Nursing and Rehabilitation Sciences, Showa University, Japan
J Smooth Muscle Res 44:17-28. 2008..In conclusion, our results suggest that estrogen regulates contraction and relaxation in the renal artery via NO synthase activity and alteration of the Ca2+ transport systems... - Dysfunction of purinergic regulation of sympathetic neurotransmission in SHR/NDmcr-cp (SHR-cp) ratNaoko Tanaka
First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan
Clin Exp Pharmacol Physiol 31:S60-1. 2004..This P1 dysfunction may play a role in the sympathetic hyperinnervation in metabolic syndrome... - Effects of Hilsa ilisa fish oil on the atherogenic lipid profile and glycaemic status of streptozotocin-treated type 1 diabetic ratsIshtiaq Mahmud
Department of Food Science and Nutrition, College of Agricultural and Marine Sciences (CAMS, Sultan Qaboos University, Muscat, Oman
Clin Exp Pharmacol Physiol 31:76-81. 2004.... - [Safety management activities of Yokohama City University Hospital--safety management is the platform of quality improvement]Michio Hashimoto
Department of Medical Risk Management, Yokohama City University Hospital, Yokohama, Japan
Nippon Geka Gakkai Zasshi 104:35-9. 2003..The next step will be to expand these activities into a movement for hospital-wide quality improvement and establishing clinical governance... - Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layerNaoko Tanaka
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan
J Pharm Pharmacol 57:335-40. 2005..These results suggest that phosphorylation of the myosin light chain may play an important role in the purinergic regulation of macromolecular permeation through the vascular endothelium... - Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive ratsTohru Yamakuni
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Biochem Biophys Res Commun 298:793-7. 2002..It is also suggested that V-1 expression is increased by hypertension in DS rat atrium... - Measuring relative work values for home care nursing services in JapanYasuko Ogata
Department of Community Health Nursing, School of Nursing, Chiba University, Chiba shi, Japan
Nurs Res 53:145-53. 2004..To maintain the quality of services in home health nursing provided by Stations, reimbursement needs to account not only for the number of home visits, but also for the time and intensity of nursing services... - Effects of shrimp (Macrobracium rosenbergii)-derived chitosan on plasma lipid profile and liver lipid peroxide levels in normo- and hypercholesterolaemic ratsShahdat Hossain
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh
Clin Exp Pharmacol Physiol 34:170-6. 2007..Liver LPO levels were positively correlated with the TUFA/TSFA molar ratio. 6. The present study suggests that dietary CS decreases the atherogenic lipid profiles of both NC and HC rats and reduces the bodyweight gain of HC rats... - P2Y-receptor regulates size of endothelial cells in an intracellular Ca2+ dependent mannerNaoko Tanaka
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, 663-8179, Nishinomiya, Japan
Life Sci 72:1445-53. 2003..We concluded that the size of endothelial cells is regulated by P2Y receptors via intracelluar Ca(2+) derived from Ca(2+) stores... - ATP participates in the regulation of microvessel permeabilityNaoko Tanaka
First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki 882-8508, Japan
J Pharm Pharmacol 58:481-7. 2006..Such purinergic regulation of endothelial permeability may function in physiological and pathophysiological conditions... - [Diverse physiological and pharmacological functions of fatty acids]Harumi Okuyama
Nippon Yakurigaku Zasshi 131:259-67. 2008 - P2Y receptor-mediated enhancement of permeation requires Ca2+ signalling in vascular endothelial cellsNaoko Tanaka
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan
Clin Exp Pharmacol Physiol 30:649-52. 2003..4. These findings suggested that activation of the P2Y receptor enhances the passage of material in the endothelium, which is associated with Ca2+ signalling in endothelial cells... - [Safety issues in medical care: next step toward the safety standard]Michio Hashimoto
Nippon Naika Gakkai Zasshi 95:1813-7. 2006 - Traditional Japanese dietary basics: a solution for modern health issues?Kuninori Shiwaku
Lancet 363:1737-8. 2004