Y F Sasaki

Summary

Country: Japan

Publications

  1. ncbi Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 388:33-44. 1997
  2. ncbi The comet assay with 8 mouse organs: results with 39 currently used food additives
    Yu F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16 1, Aomori 039 1192, Japan
    Mutat Res 519:103-19. 2002
  3. ncbi The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Hachinohe, Aomori, Japan
    Crit Rev Toxicol 30:629-799. 2000
  4. ncbi The alkaline single cell gel electrophoresis assay with mouse multiple organs: results with 30 aromatic amines evaluated by the IARC and U.S. NTP
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16 1, Hachinohe, Aomori 039 11, Japan
    Mutat Res 440:1-18. 1999
  5. ncbi Detection of in vivo genotoxicity of haloalkanes and haloalkenes carcinogenic to rodents by the alkaline single cell gel electrophoresis (comet) assay in multiple mouse organs
    Y F Sasaki
    Laboratory of Genotoxicity, Hachinohe National College of Technology, Tamonoki Uwanotai 16 1, Hachinohe, Aomori 039 11, Japan
    Mutat Res 419:13-20. 1998
  6. ncbi Organ-specific genotoxicity of the potent rodent colon carcinogen 1,2-dimethylhydrazine and three hydrazine derivatives: difference between intraperitoneal and oral administration
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 415:1-12. 1998
  7. ncbi Organ-specific genotoxicity of the potent rodent bladder carcinogens o-anisidine and p-cresidine
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 412:155-60. 1998
  8. ncbi In vivo genotoxicity of ortho-phenylphenol, biphenyl, and thiabendazole detected in multiple mouse organs by the alkaline single cell gel electrophoresis assay
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 395:189-98. 1997
  9. ncbi In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 395:57-73. 1997
  10. ncbi Detection of genotoxicity of polluted sea water using shellfish and the alkaline single-cell gel electrophoresis (SCE) assay: a preliminary study
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 393:133-9. 1997

Collaborators

Detail Information

Publications17

  1. ncbi Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 388:33-44. 1997
    ..We suggest that it may be possible to use the alkaline SCG assay using a homogenization technique to detect the genotoxicity of chemicals in vivo in their target organs...
  2. ncbi The comet assay with 8 mouse organs: results with 39 currently used food additives
    Yu F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16 1, Aomori 039 1192, Japan
    Mutat Res 519:103-19. 2002
    ..Based on these results, we believe that more extensive assessment of food additives in current use is warranted...
  3. ncbi The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Hachinohe, Aomori, Japan
    Crit Rev Toxicol 30:629-799. 2000
    ..In this review, we provide one recommendation for the in vivo comet assay protocol based on our own data...
  4. ncbi The alkaline single cell gel electrophoresis assay with mouse multiple organs: results with 30 aromatic amines evaluated by the IARC and U.S. NTP
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16 1, Hachinohe, Aomori 039 11, Japan
    Mutat Res 440:1-18. 1999
    ..These results suggest that the alkaline SCG assay can be usefully used to evaluate the in vivo genotoxicity of chemicals in multiple organs, providing for a good assessment of potential carcinogenicity...
  5. ncbi Detection of in vivo genotoxicity of haloalkanes and haloalkenes carcinogenic to rodents by the alkaline single cell gel electrophoresis (comet) assay in multiple mouse organs
    Y F Sasaki
    Laboratory of Genotoxicity, Hachinohe National College of Technology, Tamonoki Uwanotai 16 1, Hachinohe, Aomori 039 11, Japan
    Mutat Res 419:13-20. 1998
    ..We suggest that the alkaline SCG assay can be used in multiple organs to detect in vivo genotoxicity that is not expressed in bone marrow cells in mice given non-necrogenic doses of halocompounds...
  6. ncbi Organ-specific genotoxicity of the potent rodent colon carcinogen 1,2-dimethylhydrazine and three hydrazine derivatives: difference between intraperitoneal and oral administration
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 415:1-12. 1998
    ..p. treatment. HZ at 100 mg/kg yielded DNA damage in the stomach, liver, and lung when given i.p. and in the brain when p.o. Thus, the administration route is important when evaluating organ-specific genotoxicity in multiple organs...
  7. ncbi Organ-specific genotoxicity of the potent rodent bladder carcinogens o-anisidine and p-cresidine
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 412:155-60. 1998
    ..No significant effects were observed in any other organs. Our results suggest the importance of the urinary bladder as a sentinel organ for evaluating chemical genotoxicity in rodents...
  8. ncbi In vivo genotoxicity of ortho-phenylphenol, biphenyl, and thiabendazole detected in multiple mouse organs by the alkaline single cell gel electrophoresis assay
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 395:189-98. 1997
    ..The positive response to TBZ, an aneugen, supports the in vivo DNA-damaging action of TBZ...
  9. ncbi In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 395:57-73. 1997
    ..Our results suggest that the alkaline SCG assay applied to multiple organs is a good way to detect organ-specific genotoxicity of heterocyclic amines in mammals...
  10. ncbi Detection of genotoxicity of polluted sea water using shellfish and the alkaline single-cell gel electrophoresis (SCE) assay: a preliminary study
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 393:133-9. 1997
    ..These results suggested the utility of the alkaline SCG assay with shellfish gill cells for monitoring sea water genotoxicity...
  11. ncbi Detection of in vivo genotoxicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) by the alkaline single cell gel electrophoresis (Comet) assay in multiple mouse organs
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 393:47-53. 1997
    ....
  12. ncbi Simple detection of in vivo genotoxicity of pyrimethamine in rodents by the modified alkaline single-cell gel electrophoresis assay
    Y F Sasaki
    Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 392:251-9. 1997
    ..Genotoxicity in the spleen was only observed in mice. Our results suggest that the SCG technique, using isolated nuclei can be applied to rats and mice and that the optimal sampling time is different for different organs and species...
  13. ncbi Simple detection of chemical mutagens by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow)
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 391:215-31. 1997
    ....
  14. ncbi Detection of rodent liver carcinogen genotoxicity by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow)
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Aomori, Japan
    Mutat Res 391:201-14. 1997
    ..BHC, which is not genotoxic in in vitro tests, did not show any effects. We suggest that it may be possible to use the alkaline SCG assay to detect in vivo activity of chemicals whose genotoxicity is not expressed in bone marrow cells...
  15. ncbi Colon-specific genotoxicity of heterocyclic amines detected by the modified alkaline single cell gel electrophoresis assay of multiple mouse organs
    Y F Sasaki
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16 1, Hachinohe, Aomori 039 11, Japan
    Mutat Res 414:9-14. 1998
    ..In this study, five heterocyclic amines were injected intraperitoneally to avoid the consequences of ingestion. Thus, the extensive damage to colon DNA was concluded to be due, at least in part, to a systemic effect...
  16. ncbi A comparison of intraperitoneal and oral gavage administration in comet assay in mouse eight organs
    K Sekihashi
    Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16-1, Hachinohe, Aomori 039-1192, Japan
    Mutat Res 493:39-54. 2001
    ....
  17. ncbi Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards
    D J Tweats
    Centre for Molecular Genetics and Toxicology, University of Wales, Swansea, UK
    Mutat Res 627:78-91. 2007
    ..Regulatory implications of these findings are discussed and flow diagrams have been provided to aid in interpretation and decision-making when such changes in physiology are suspected...