S Sasaki

..This unique 'Diagnostic Score' for the detection of choriocarcinoma plays an important role in initial management in our protocol...

..To evaluate the clinical usefulness of the "diagnostic score"for the detection of choriocarcinoma in persistent gestational trophoblastic disease without histologic findings...

..The patients must be followed up until their serial weekly serum human chorionic gonadotrophin (hCG) titre has fallen to an undetectable level...

..To evaluate the clinical usefulness of the Japanese Diagnostic Score to differentiate choriocarcinoma clinically without histologic findings from persistent gestational trophoblastic disease (GTD)...

..After careful evaluation, including measurement of hyperglycosylated hCG, we concluded that this case was not a quiescent GTD but recurrent GTD...

..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...

..50-3.34)]. Low BMI at age 20 years was substantially associated with an increased risk of breast cancer. In contrast, high recent BMI and subsequent BMI gain from age 20 were associated with increased risk of postmenopausal ER+PR+ tumors...

..Here, we investigated the association between alcohol consumption and lung cancer incidence...

..Herein, we investigate the association between body mass index (BMI) and kidney cancer risk in Japanese persons, a relatively lean population...

..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...

..15–3.66), respectively. In conclusion, cigarette smoking was confirmed as a risk factor for bladder cancer. Coffee and caffeine may be associated with an increased bladder cancer risk in never or former smokers among Japanese men...

..Although people with a history of diabetes may be at increased risk of cancer, extreme body mass index and metabolic factors in the aggregate had little impact on overall cancer risk in the Japanese population...

..The study aims to investigate the association between leisure-time physical activity and breast cancer risk in consideration of tumor estrogen-receptor/progesterone-receptor status...

..This finding indicates that ALT level is a good independent determinant of the need for intervention. Clinical application of these findings may help decrease HCC-associated mortality in hepatitis virus-endemic regions...

..10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response...

..Coffee consumption may be associated with a decreased risk of endometrial cancer...

..59). In contrast, no statistically significant association was found for rectal cancer. These findings suggest that late age at first birth is associated with a reduced risk of colon cancer in postmenopausal Japanese women...

..Women with hepatitis virus infection may be advised to abstain from isoflavone consumption. Further studies are warranted to confirm these findings...

..Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort...

..The risk was 3.86-fold higher (CI; 1.73-8.62) for genotype 1 than genotype 2. Our findings suggest that HCV viremia strongly influences the occurrence of hepatocellular carcinoma without titer-dependence...

..Finally, cruciferous vegetables deserve further investigation as foods possibly effective in the prevention of esophageal SCC...

..In conclusion, in this nested case-control study, concentrations of circulating total testosterone, free testosterone or SHBG were not strongly associated with a risk for total prostate cancer...

..Limited data are available with regard to longitudinal changes in body weight by food taste preference. Here, we examined the associations between taste preferences and weight change in adults for a large-scale cohort study in Japan...

..Self-reported diagnoses of cancer do not provide sufficient accuracy for the detection and classification of incident cancers. Our findings may be extrapolated to other Japanese populations...

..15). Excessive alcohol intake was associated with an increase in the risk of breast cancer in this population. There was no statistical evidence for effect modification...

..There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men...

..Our results suggest that coffee consumption may reduce the risk of liver cancer regardless of HCV and HBV infection status, whereas green tea may not reduce this risk..

..62 (1.15-2.29) and 1.53 (1.07-2.20), respectively. In conclusion, our results suggest that the intake of dairy products may be associated with an increased risk of prostate cancer...

..We investigated the association between major dietary patterns and depressive symptoms in Japanese...

..Our results suggest that intake of marine n-3 polyunsaturated fatty acids may be inversely related to the risk of cancer in the proximal site of the large bowel...

..However, because few published food values have considered cooking effect, allowing for cooking loss in the assessment of vitamin intake in Japan has been difficult...

..However, results of epidemiologic studies on this issue have been inconsistent. The objective of this study was to clarify the association between serum folate and homocysteine concentrations and depressive symptoms in Japanese adults...

..Our data do not support the hypothesis that plasma levels of p,p'-DDT, p,p'-DDE, HCB, and beta-HCH are associated with an overall increased risk of breast cancer among Japanese women...

..We sought to examine the association between education level and physical functional limitations among Japanese men and women, and whether that association was modified by gender and history of stroke...

..We prospectively examined the association between daily total physical activity level (METs/day) and subsequent risk of all-cause mortality and mortalities from cancer, heart disease, and cerebrovascular disease...

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..However, data from populations with high fish consumption are scarce...

..Here, we describe changes in the prevalences of overweight and obesity and calculated the incidence of these indices during a 10-year follow-up period for a large-scale cohort study in Japan...

..We investigated the roles of the Akt pathway and apoptotic signals in (1) Madin-Darby canine kidney (MDCK) cells in a hyperosmotic condition in vitro and (2) in the inner medulla of dehydrated rat in vivo...

..Glucocorticoids are widely used for the treatment of glomerulonephritis, but the mechanism of cell cycle inhibition by glucocorticoids is poorly understood at a molecular level...

..Our findings suggest that those who have very low plasma levels of alpha-carotene and beta-carotene are at a higher risk of gastric cancer...

..We examined the association between dietary GI and GL as well as dietary fiber intake and overweight status in Japanese children and adolescents...

..The original FFQ and the shorter versions have sufficient validity and reproducibility to be used in epidemiologic studies...

..These results demonstrate that EPO gene transfer with the GeneSwitch system by in vivo electroporation is a useful procedure for efficient and drug-dependent regulated delivery of EPO...

..Recombinant Delta-1 significantly stimulated NRK-52E cell proliferation. Our study suggests that the Delta-1/Notch-2/Hes-1 signaling pathway may regulate the regeneration and proliferation of renal tubules during acute kidney injury...

..This study identified the cell types that express mCLC-6 and mCLC-7 in the mouse tissues, and the complementation assay suggested that mCLC-6 functions as an intracellular chloride channel...

..The supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) improves NAFLD. The aim of this study is to assess the cross-sectional association between dietary n-3 PUFAs and NAFLD in Japanese men and women...

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..The objective of this study was to evaluate the long-term effectiveness of combination therapy in children with IgA nephropathy showing diffuse mesangial proliferation...

..These data indicate that Liddle's syndrome should be considered even in patients without a family history of hypertension...

..The purpose of this study is to clarify the processes of care for patients undergoing mastectomy and postoperative radiotherapy in Japan...

..Leprosy has been stigmatized throughout history, and recent topics regarding the disease in Japan are also discussed...

..We investigated the association between plasma folate and the risk of colorectal cancer in a nested case-control study...

..These results suggest that CLC-K1 expression is one of the major determinants of the urine-concentrating capacity of the developing rat kidney...

..AQP7 and AQP8 proteins were detectable at 28 days post-partum. The results suggest that AQP7 and AQP8 appear in the testis in accordance with the maturation of germ cells, and are involved in spermatogenesis...

..Our results suggest that the PI3K-gamma-Akt pathway lessens apoptosis and plays a critical role in the maintenance of renal function in cisplatin-induced acute kidney injury...

..We examined misreporting of dietary intake against biomarkers and its relation with BMI in young Japanese women...

..Particular focus was placed on a history of cholelithiasis, body mass index (BMI), and their effect modification, and whether risk differs by cancer subsite, namely by gallbladder cancer and extrahepatic bile duct cancer...

..The present study was performed to evaluate whether the Patterns of Care Study (PCS) fulfills a role in monitoring the patterns of changes in clinical practices in Japan...

..To investigate the relationship between the common cold and vitamin C supplementation...

..Moderate to high alcohol consumption was positively associated with the incidence of diabetes in Japanese lean (BMI < or = 22 kg/m2) men...

..Most research on constipation has focused on dietary fiber intake. Here, we examined the intake of water and magnesium, nutrients possibly associated with constipation, as well as that of dietary fiber in relation to constipation...

..To discover possible risk factors for local-regional recurrence (LRR) following preoperative radiation therapy and curative surgery for head and neck squamous cell carcinoma (SCC) (stage II-IVB)...

..The outcomes of patients with localized or locally advanced prostate cancer treated with external-beam radiotherapy are not well known in Japan...

..We examined the relationship between the response to treatment and prognosis of patients with aggressive lymphoma...

..0093) were independently associated with psychological distress. These results suggest that work environment factors, particularly night duty, play important roles in modulating psychological distress among female doctors...

..The primary endpoint was compliance with the combined modality...

..Because mediastinal angioleiomyomas are very rare, they are difficult to diagnose preoperatively. However, we believe that CT and MRI can be of significant help in the differential diagnosis...

..In this study, the interim treatment outcomes of SEC patients, who had received radiation therapy following the standard radiotherapy methods, were investigated...

..Between the two national surveys, the Japanese Breast Cancer Society published its treatment guideline for BCT...

..Our results suggest that these alterations accumulate during the progression of IPMTs, reflecting results of analysis of allelic losses that showed a stepwise accumulation of genetic changes during progression...

..To present the results of a process survey on breast-conserving therapy (BCT) in Japan from 1995 to 1997...

..A multi-institutional clinical trial was conducted for localized lymphoma. This study evaluated whether a quality assurance (QA) program could clarify the source of variation in radiotherapy treatment between the institutions...