Research Topics
| Masami SuganumaSummaryAffiliation: Saitama Cancer Center Country: Japan Publications
| Collaborators
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Detail Information
Publications
Translational research on TNF-alpha as an endogenous tumor promoter and green tea as cancer preventive in humansHirota Fujiki
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 23:3-30. 2005- [Mechanisms of action of tipa (TNF-alpha inducing protein), a new carcinogenic factor, released from H. pylori]Masami Suganuma
Saitama Cancer Center, Research Institute for Clinical Oncology
Nippon Rinsho 63:80-3. 2005 - Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pyloriTatsuro Watanabe
Saitama Cancer Center, Research Institute for Clinical Oncology, Kitaadachi gun, Saitama 362 0806, Japan
J Cancer Res Clin Oncol 136:911-21. 2010..To elucidate mechanism of action of Tipalpha, we studied a binding protein of Tipalpha in gastric epithelial cells... - New cancer treatment strategy using combination of green tea catechins and anticancer drugsMasami Suganuma
Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
Cancer Sci 102:317-23. 2011..Based on the evidence, we present a new concept: green tea catechins as synergists with anticancer drugs... - Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 geneMasami Suganuma
Research Institute of Clinical Oncology, Saitama Cancer Center, Saitama, Japan
Int J Cancer 119:33-40. 2006..These findings indicate that high upregulation of GADD153 is a key requirement for cancer prevention in combination with EGCG... - TNF-alpha-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cellsMasami Suganuma
Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan
Int J Cancer 123:117-22. 2008..Tip alpha is thus a new carcinogenic factor of H. pylori that can enter the nucleus through a specific binding molecule, and its mechanism of action is completely different from that of CagA... - New tumor necrosis factor-alpha-inducing protein released from Helicobacter pylori for gastric cancer progressionMasami Suganuma
Saitama Cancer Center, Ina Kitaadachi gun, 362 0806 Saitama, Japan
J Cancer Res Clin Oncol 131:305-13. 2005..To investigate the association between Helicobacter pylori infection and its inflammatory reaction in gastritis, gastric ulcer, and gastric cancer, a new tumor necrosis factor-alpha (TNF-alpha)-inducing protein of H. pylori was studied... - Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomachMasami Suganuma
Saitama Cancer Center, Research Institute for Clinical Oncology, Saitama 362 0806, Japan
J Biochem Mol Biol 39:1-8. 2006..Our recent finding showing that penicillin-binding proteins of other bacteria are weak homologues of Tipalpha is also discussed... - Nucleolin on the cell surface as a new molecular target for gastric cancer treatmentTatsuro Watanabe
Research Institute for Clinical Oncology, Saitama Cancer Center, Kitaadachigun, Saitama 362 0806, Japan
Biol Pharm Bull 33:796-803. 2010..All results indicate that nucleolin on the cell surface is a new and promising therapeutic target for treatment of gastric cancer... - Involvement of TNF-alpha changes in human cancer development, prevention and palliative careHirota Fujiki
Saitama Cancer Center, Ina, Kitaadachi gun, Saitama 362 0806, Japan
Mech Ageing Dev 123:1655-63. 2002.... - Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1Nobukazu Fujimoto
Saitama Cancer Center, Ina, Kitaadachi-gun 362-0806, Japan
Int J Oncol 20:1233-9. 2002.... - Helicobacter pylori-secreting protein Tipalpha is a potent inducer of chemokine gene expressions in stomach cancer cellsTakashi Kuzuhara
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
J Cancer Res Clin Oncol 133:287-96. 2007..pylori acts as a tumor promoter in stomach cancer development, and thus started to investigate whether Tipalpha is involved in induction of chemokine genes... - Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechinsTakashi Kuzuhara
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima, Japan
Mol Carcinog 46:640-5. 2007.... - Presence of a motif conserved between Helicobacter pylori TNF-alpha inducing protein (Tipalpha) and penicillin-binding proteinsTakashi Kuzuhara
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan
Biol Pharm Bull 28:2133-7. 2005..pylori. This finding suggests that Tipalpha and penicillin-binding proteins are derived from a common ancestral protein, and that Tipalpha gene may be transferred horizontally from Gram-positive bacteria to H. pylori... - New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifenHirota Fujiki
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
Mutat Res 523:119-25. 2003..Overall, our results indicate that, with the continuing spread of cancer chemoprevention as a fundamental medical strategy, both clinicians and researchers should take a closer look at herbal medicine... - Green tea: cancer preventive beverage and/or drugHirota Fujiki
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, 770 8514, Tokushima, Japan
Cancer Lett 188:9-13. 2002..An approach to develop green tea capsules as a cancer preventive drug in the US is discussed, aiming at taking full advantage of this cancer preventive beverage... - Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallateKosuke Dodo
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Bioorg Med Chem 16:7975-82. 2008..Upregulation of gadd-153, an ER-stress marker protein, was also observed. These results indicate that 6c induced apoptosis via the ER-stress-related pathway... - Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex bindersMasayuki Tera
Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei Tokyo 184-8588, Japan
Angew Chem Int Ed Engl 47:5557-60. 2008 - Generation of mouse monoclonal antibody against (-)-epigallocatechin gallateTakashi Kuzuhara
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
Biol Pharm Bull 31:816-9. 2008..The TG38 antibody is the first monoclonal antibody against EGCG and catechins, since it bound to four green tea catechins with a galloyl group... - Green tea catechin as a chemical chaperone in cancer preventionTakashi Kuzuhara
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
Cancer Lett 261:12-20. 2008..Since these conformations result in interaction with various types of molecules, we think that green tea catechin induces cancer preventive activity mediated through a chaperone-like property... - DNA and RNA as new binding targets of green tea catechinsTakashi Kuzuhara
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
J Biol Chem 281:17446-56. 2006..These findings reveal for the first time the link between catechins and polynucleotides and will intensify our understanding of the effects of catechins on DNA in terms of cancer prevention...