Research Topics
| N ShinkaiSummaryAffiliation: Saitama Daiichi Pharmaceutical Co Country: Japan Publications
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Detail Information
Publications
Tocolytic effects of a long-acting beta2-adrenoceptor agonist, formoterol, in ratsN Shinkai
Research Department, Saitama Daiichi Pharmaceutical Co, Ltd, Kasukabe, Japan
J Pharm Pharmacol 52:1417-23. 2000..The results suggested that formoterol caused relaxation of uterine motility through production of cyclic adenosine monophosphate. Thus, formoterol may be useful as a treatment to counter premature delivery...
Tocolytic activity of formoterol against premature delivery in miceN Shinkai
Research Department, Saitama Daiichi Pharmaceutical Co Ltd, 8 1, Minamisakae cho, Kasukabe, Saitama 344 0057, Japan
J Pharm Pharmacol 54:1637-43. 2002..These findings strongly suggest that formoterol can suppress premature delivery mediated by its actions on IL-6 secretion...
Inhibitory effects of formoterol on lipopolysaccharide-induced premature delivery through modulation of proinflammatory cytokine production in miceN Shinkai
Research Department, Saitama Daiichi Pharmaceutical Co Ltd, 8 1 Minamisakae cho Kasukabe, Saitama 344 0067, Japan
Reproduction 125:199-203. 2003..These data indicate that formoterol exerts inhibitory effects on proinflammatory cytokine production, and these effects may play an important role in the prevention of premature delivery...
Tocolytic effects of formoterol are associated with local change in the progesterone/estradiol ratioNorihiro Shinkai
Daiichi Pharmaceutical Co Ltd, 8 1 Minamisakae cho, Kasukabe, Saitama 344 0067, Japan
Eur J Obstet Gynecol Reprod Biol 107:163-7. 2003..The aim of the study was to determine whether a beta(2)-adrenoceptor agonist, formoterol, inhibits premature delivery in connection with change in estradiol and progesterone concentrations in the amniotic fluid in ovariectomized rats...
Percutaneous penetration of felbinac after application of transdermal patches: relationship with pharmacological effects in ratsNorihiro Shinkai
Research Department, Saitama Daiichi Pharmaceutical Co, Ltd, 8 1 Minamisakae cho, Kasukabe, Saitama 344 0057 Japan
J Pharm Pharmacol 60:71-6. 2008..5% felbinac patches suppressed pain-associated behaviour induced by iodoacetate injection and plantar incision. These results suggested that the transdermal patch containing 3.5% felbinac may become a useful formulation...
Intra-articular penetration of ketoprofen and analgesic effects after topical patch application in ratsNorihiro Shinkai
Research and Development Department, Nipropatch Co, Ltd, 8 1, Minamisakae cho, Kasukabe, Saitama 344 0057, Japan
J Control Release 131:107-12. 2008..These results indicate that the transdermal ketoprofen patch is a useful formulation that can deliver the drug in sufficient amounts to inhibit prostaglandin E2 production in the skin and knee joint...
Formulation and evaluation of ethylene-vinyl acetate copolymer matrix patches containing formoterol fumarateIkuhiro Kakubari
Research Department, Saitama Daiichi Pharmaceutical Co, Ltd, Kasukabe, Saitama, Japan
Biol Pharm Bull 29:513-6. 2006..Thus an optimized matrix patch containing FF was prepared with potential advantages for control of asthma...
Automated analysis of fluvoxamine in rat plasma using a column-switching system and ion-pair high-performance liquid chromatographyShicheng Liu
Research Department, Saitama Daiichi Pharmaceutical Co, Ltd, 8 1, Minamisakae cho, Kasukabe, Saitama 344 0057, Japan
Biomed Chromatogr 22:1442-9. 2008..The analytical sensitivity and accuracy of this assay is suitable for characterization of the pharmacokinetics of orally-administered fluvoxamine in rats...
Comparison of poultice-type and tape-type patches containing ketoprofen on human skin irritationNaohisa Kawamura
Research Department, Saitama Daiichi Pharmaceutical Co, Ltd, 8-1 Minamisakae-cho Kasukabe, Saitama 344-0057, Japan
J Toxicol Sci 28:415-25. 2003..Finally, when a patch is applied to a region with little skin moisture, the amount of stripped stratum corneum may increase accordingly...
