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Genomes and Genes | Hidenobu SoejimaSummaryAffiliation: Saga University Country: Japan Publications
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Publications
Epigenetic silencing of the MGMT gene in cancerHidenobu Soejima
Division of Molecular Biology and Genetics, Department of Molecular Sciences, Saga University, Japan
Biochem Cell Biol 83:429-37. 2005..In this review, we describe recent advances in understanding the silencing of MGMT and its role in carcinogenesis; epigenetic mechanisms; and clinical implications...- [Epigenetics-related diseases and analytic methods]Hidenobu Soejima
Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
Rinsho Byori 57:769-78. 2009..The great advance in epigenetic research, from basic to clinical, will bring significant benefits to human health and a broad range of life sciences... - The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG islandWei Zhao
Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501
J Biochem 137:431-40. 2005..The epigenetic mechanism leading to silent heterochromatin at the promoter CpG island may be the same in different types of cancer irrespective of the extent of DNA methylation... - Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancerHidenobu Soejima
Department of Biomolecular Sciences, Division of Molecular Biology and Genetics, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501 Japan
Oncogene 23:4380-8. 2004.... - Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cellsZhongming Zhang
Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
Cancer Lett 247:318-27. 2007..Our results suggest that RAR beta2 is silenced by either of the two key epigenetic pathways, DNA methylation or repressive histone modifications, depending on the individual cancer cells... - Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in miceZhongming Zhang
Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849 8501, Japan
Gene 366:77-86. 2006..These results suggest that this region is the imprinting control region of the Murr1/U2af1-rs1 locus in mouse... - Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancerTetsuji Nakagawachi
Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
Oncogene 22:8835-44. 2003..Furthermore, MeCP2 preferentially bound to the CpG-methylated island in the MGMT negative line. Given these results, we propose a model for gene silencing of MGMT that is dependent on the epigenetic state in cancer... - MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene productsShinya Yakabe
Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
Genes Genet Syst 83:199-208. 2008..These results suggest that in addition to the canonical gene repression function, MeCP2 can repress gene expression by binding to unmethylated DNA in particular genes in living cells... - Organotypic culture of human bone marrow adipose tissueKazuyoshi Uchihashi
Department of Pathology, Faculty of Medicine, Saga University, Saga, Japan
Pathol Int 60:259-67. 2010..The present novel method proved to be useful for the study of BMAT biology... - Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancersYasuo Koga
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
Ann Surg Oncol 12:354-63. 2005..The purpose of this study was to clarify how MGMT deficiency leads to a poor outcome in biliary tract cancer. Thus, we examined epigenetic (promoter methylation) and genetic (gene mutation) alterations in biliary tract cancer... - Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal alleleKeiichiro Joh
Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
J Biochem 146:771-4. 2009..These results strongly suggested that imprinting of Commd1 is generated by interference with paternal Commd1 transcription by the oppositely directed U2af1-rs1 transcription... - Japanese and North American/European patients with Beckwith-Wiedemann syndrome have different frequencies of some epigenetic and genetic alterationsKensaku Sasaki
Department of Biomolecular Sciences, Saga University, Saga, Japan
Eur J Hum Genet 15:1205-10. 2007..These results suggest that susceptibility to epigenetic and genetic alterations differs between the two groups... - Cisplatin represses transcriptional activity from the minimal promoter of the O6-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosoureaKen Sato
Department of Surgery, Saga University Faculty of Medicine, Nabeshima 5 1 1, Saga 849 8501, Japan
Oncol Rep 13:899-906. 2005..The 59 bp region in the MGMT promoter was crucial for repression by cisplatin. These results might form the basis of a chemotherapeutic strategy involving alkylating agents via prior cisplatin-induced biochemical modulation... - Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndromeKen Higashimoto
Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, Nabeshima, Saga, Japan
Am J Hum Genet 73:948-56. 2003.... - The mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 geneYoudong Wang
Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501, Japan
Mol Cell Biol 24:270-9. 2004.... - Primary palmar hyperhidrosis locus maps to 14q11.2-q13Ikuyo Higashimoto
Department of Anesthesiology, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan
Am J Med Genet A 140:567-72. 2006..This is the first report of systemic mapping of the PPH locus... - Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumorYuji Satoh
Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
J Biochem 133:303-8. 2003..beta-catenin mutated in only one WT without WT1 silencing, suggesting that the beta-catenin mutation was not associated with the reduction of WT1 expression... - Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouseKen Higashimoto
Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga, 849 8501, Japan
Genomics 80:575-84. 2002..It remains to be elucidated whether the gene is under the control of the KIP2/LIT1 subdomain or is regulated by a specific mechanism. Analysis of the precise genomic sequence around the region should help resolve this question... - A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cellsEmiko Sonoda
Department of Pathology and Biodefense, Faculty of Medicine, Saga University, Nabeshima 5 1 1, Saga 849 8501, Japan
Endocrinology 149:4794-8. 2008..This suggests that our method will open up a new way for studying both multiple cell types within adipose tissue and the cell-based mechanisms of obesity and metabolic syndrome... - Beckwith-Wiedemann syndrome with placental chorangioma due to H19-differentially methylated region hypermethylation: A case reportAiko Aoki
Department of Obstetrics and Gynecology, University of Toyama, Toyama Division of Molecular Genetics and Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, Japan
J Obstet Gynaecol Res 37:1872-6. 2011..This is the first report of BWS with placental tumor due to H19-differentially methylated region hypermethylation... - Imprinting centers, chromatin structure, and diseaseHidenobu Soejima
Division of Molecular Biology and Genetics, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
J Cell Biochem 95:226-33. 2005..ICs for both regions are subject to parent-specific epigenetic marking by covalent modification of DNA and histones. In this review, we summarize our current understanding of IC function and IC modification in these two regions... - Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal and gastric cancer cellsAyumi Satoh
First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
Oncogene 23:8876-86. 2004..It thus appears that CIITA methylation is a key mechanism that enables some gastrointestinal cancer cells to escape immune surveillance... - ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndromeTakahiro Arima
Department of Reproductive Physiology and Endocrinology, Medical Institute of Bioregulation, Kyusyu University 4546, Tsurumihara, Beppu, Oita 874 0838, Japan
Nucleic Acids Res 33:2650-60. 2005..Mutations in ZAC may, therefore, contribute to Beckwith-Wiedemann syndrome. Furthermore, we find changes in DNA methylation at the LIT1 putative imprinting control region in two patients with TNDB... - Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control regionHitomi Yatsuki
Department of Biochemistry, Saga Medical School, Saga, Saga 849-8501, Japan
Genome Res 12:1860-70. 2002..These data indicate that CGI8, called DMR-Lit1, is not only the region for gametic methylation but might also be the imprinting control region (ICR) of the subdomain... - A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21qYoichi Yamada
Division of Genome Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920-0934, Japan
Genome Res 14:247-66. 2004..Thus, the cell seems to have a broader repertoire of methylating CGIs than previously thought, and our approach may contribute to uncover novel modes of allelic methylation... - Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalitiesMasayuki Haruta
Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan
Genes Chromosomes Cancer 47:712-27. 2008..03) and CTNNB1 mutation (17/23; P = 0.03) more frequently than WTs with the deletion (2/13 and 4/13). Thus, three WT1 subtypes were correlated with certain genetic and clinicopathological characteristics... - MeCP2-dependent repression of an imprinted miR-184 released by depolarizationTasuku Nomura
Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
Hum Mol Genet 17:1192-9. 2008..The restricted release of MeCP2 from the paternal allele results in paternal allele-specific expression of miR-184. Our finding provides a clue to the link between the microRNA and DNA methylation pathways... - Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript AirYoko Yamasaki
Department of Human Genetics, Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
Hum Mol Genet 14:2511-20. 2005.... - A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: comparison with chromosome 21qYoichi Yamada
Department of Information and Systems Engineering, Faculty of Engineering, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
DNA Seq 17:300-6. 2006..Thus, methylation status of CGIs may substantially differ from one chromosome to another... - Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10Yoko Yamasaki-Ishizaki
Division of Functional Genomics, Center for Frontier Life Sciences, Nagasaki University, Sakamoto 1 12 4, Nagasaki 852 8523, Japan
Mol Cell Biol 27:732-42. 2007..Here, we propose a molecular model that gametic DNA methylation and chromatin remodeling by PcG proteins during cell differentiation cause tissue-specific imprinting in embryonic tissues... - Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancersSeiji Nakano
Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishimachi, Yonago, Tottori 683 8503, Japan
Cancer Sci 97:1147-54. 2006..Therefore, these findings suggest that LOI of LIT1 via epigenetic disruption plays an important role in colorectal carcinogenesis, but it is not necessarily associated with CDKN1C expression... - The human ASCL2 gene escaping genomic imprinting and its expression patternToshinobu Miyamoto
Department of Human Genetics, School of Medicine, Nagasaki University, Japan
J Assist Reprod Genet 19:240-4. 2002..In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting...