Research Topics
| Koji NagaoSummaryAffiliation: Saga University Country: Japan Publications
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Publications
Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signalingXiao Qian Hu
College of Food Science and Engineering, Ocean University of China, Qingdao, China
Lipids Health Dis 9:25. 2010..Therefore, the present study was undertaken to examine the effect of saponins extracted from sea cucumber (Pearsonothuria graeffei) on the preventive activity of fatty liver in rats...- Medium-chain fatty acids: functional lipids for the prevention and treatment of the metabolic syndromeKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Honjo 1, Saga 840 8502, Japan
Pharmacol Res 61:208-12. 2010..Additionally, several reports suggest that MCFAs/MCTs offer the therapeutic advantage of preserving insulin sensitivity in animal models and patients with type 2 diabetes... - Effect of leptin infusion on insulin sensitivity and lipid metabolism in diet-induced lipodystrophy model miceKoji Nagao
Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
Lipids Health Dis 7:8. 2008..All mice were fed normal or lipodystrophy model diets for 4 weeks and were infused intrapeneally 0 or 5 mug of leptin per day from third week of the feeding period for 1 week... - Bioactive lipids in metabolic syndromeKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Honjo 1, Saga 840 8502, Japan
Prog Lipid Res 47:127-46. 2008..In particular, the function of bioactive lipids as dietary adiponectin inducers (dietary insulin sensitizers) deserves attention with respect to alleviation of metabolic syndrome by dietary manipulation... - Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J miceYu-Ming Wang
Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan
J Nutr Sci Vitaminol (Tokyo) 51:440-4. 2005..These results show that short-term feeding of CLA does not induce adverse effect in C57BL/6J mice... - Isomer-specific anti-obese and hypolipidemic properties of conjugated linoleic acid in obese OLETF ratsYu-Ming Wang
Department of Applied Biological Sciences, Saga University, Japan
Biosci Biotechnol Biochem 70:355-62. 2006..We suppose that 10t,12c-CLA reveals hypolipidemic and anti-obese activity through the alteration of mRNA expressions in the liver and white adipose tissue... - Protective effects of fractional extracts from Panellus serotinus on non-alcoholic fatty liver disease in obese, diabetic db/db miceMasashi Inafuku
Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
Br J Nutr 107:639-46. 2012.... - Effect of dietary phosphatidylinositol on cholesterol metabolism in Zucker (fa/fa) ratsBungo Shirouchi
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
J Oleo Sci 58:111-5. 2009..Our study suggests that dietary PI normalizes cholesterol metabolism through the enhancement of fecal bile acid excretion in the metabolic syndrome model rats... - Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein 1 production in db/db miceKoji Nagao
Department of Applied Biochemistry and Food Science, Saga University, Saga, Japan
J Nutr Biochem 21:418-23. 2010..We speculate that the development and progression of NAFLD was prevented by the reduction of MCP1 production through the interference in the IKKbeta-NFkappaB signaling pathway in Mukitake-fed db/db mice... - Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive ratsNao Inoue
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan
Biochem Biophys Res Commun 323:679-84. 2004..We speculate that the antihypertensive effect of dietary CLA may be due to the increase of plasma adiponectin level and associated with the alleviation of membrane abnormality in SHRs... - Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N miceTeruyoshi Yanagita
Department of Applied Biological Sciences, Saga University, Saga 840 8502, Japan
J Agric Food Chem 53:9629-33. 2005..These results show that DHA supplementation to the CLA diet can attenuate CLA-induced fatty liver through the reduction of hepatic fatty acid synthesis without affecting adipocytokine production in C57BL/6N mice... - Effect of dietary omega 3 phosphatidylcholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima fatty ratsBungo Shirouchi
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
J Agric Food Chem 55:7170-6. 2007.... - Dietary phosphatidylcholine alleviates fatty liver induced by orotic acidYohanes Buang
Department of Applied Biological Sciences, Saga University, Saga, Japan
Nutrition 21:867-73. 2005..CONCLUSIONS: Dietary PC appears to alleviate the OA-induced hepatic steatosis and hepatomegaly, mainly through the attenuation of hepatic TG synthesis and enhancement of fatty acid beta-oxidation in Sprague-Dawley rats... - Effect of Vaccinium ashei reade leaf extracts on lipid metabolism in obese OLETF ratsNao Inoue
Department of Applied Biochemistry and Food Science, Saga University, Japan
Biosci Biotechnol Biochem 75:2304-8. 2011..These results indicate that the BBL extracts, and especially FG and PA, exerted hypolipidemic effects on obese OLETF rats and suggest that an infusion of BBL can be useful as a dietary hypolipidemic component... - Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cellsNao Inoue
Department of Applied Biochemistry and Food Science, Saga University, Saga, Japan
J Oleo Sci 58:171-5. 2009..In the present study, LAME treatment increased apo A-1 secretion as compared with LA treatment in HepG2 cells. These results suggest that mentyl-esterification of fatty acids may be beneficial in anti-atherogenic dietary therapy... - Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) ratsKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan
J Nutr 135:9-13. 2005..We speculate that the enhanced level of liver adiponectin may prevent the development and progression of NAFLD in CLA-fed Zucker rats... - Physiological effects of dietary PIPS soybean-derived phospholipid in obese zucker (fa/fa) ratsBungo Shirouchi
Department of Applied Biochemistry and Food Science, Saga University, Japan
Biosci Biotechnol Biochem 74:2333-5. 2010..These effects were attributable to reduced lipogenesis and enhanced lipolysis in the liver. The results suggest that PIPS can be useful as a dietary component that would reduce the risk of lifestyle-related diseases... - Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db miceYumi Tsuruta
Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
Lipids Health Dis 10:202. 2011..In this study, we tested whether feeding a polyphenolic extract of lotus root to db/db mice protects them from hepatic steatosis... - Screening of soy protein-derived hypotriglyceridemic di-peptides in vitro and in vivoNao Inoue
Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
Lipids Health Dis 10:85. 2011..In the present study, we investigated the effects of soy protein-derived peptides on lipid metabolism, especially TG metabolism, in HepG2 cells and obese Otsuka Long-Evans Tokushima fatty (OLETF) rats... - The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF ratsKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga, Japan
Nutrition 19:652-6. 2003..CONCLUSIONS: These results demonstrated that the hypolipidemic effect and the enhancement of energy metabolism by CLA can be attributed to the effect of the 10t,12c-CLA isomer... - Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) ratsBungo Shirouchi
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
J Agric Food Chem 56:2375-9. 2008..This is the first report that dietary PI increases serum adiponectin level and prevents the development of NAFLD in a rat model of the metabolic syndrome... - Alleviation of fatty liver by alpha-linolenic acidYohanes Buang
Department of Applied Biological Sciences, Saga University, Saga, Japan
J Nutr Sci Vitaminol (Tokyo) 50:272-6. 2004..These results suggest that dietary alpha-LNA alleviates OA-induced hepatic TG accumulation through the attenuation of hepatic TG synthesis in rats... - Dietary conjugated linoleic acid lowered tumor necrosis factor-alpha content and altered expression of genes related to lipid metabolism and insulin sensitivity in the skeletal muscle of Zucker ratsNao Inoue
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan
J Agric Food Chem 54:7935-9. 2006..We suppose that the attenuated TNF-alpha accumulation in skeletal muscle may contribute to the alteration of expression of several genes and the alleviation of insulin resistance in CLA-fed Zucker rats... - Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF ratsBungo Shirouchi
Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
J Oleo Sci 59:299-305. 2010..In conclusion, results from the present study suggest that porpoise oil feeding prevents the development of fatty liver disease through the enhancement of lipoprotein secretion and increase of adiponectin production in obese rats... - The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cellsNao Inoue
Department of Applied Biochemistry and Food Science, Saga University, Japan
Biosci Biotechnol Biochem 73:447-9. 2009..This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran... - Effects of Lotus Root (the Edible Rhizome of Nelumbo nucifera) on the Deveolopment of Non-Alcoholic Fatty Liver Disease in Obese Diabetic db/db MiceYumi Tsuruta
Department of Applied Biochemistry and Food Science, Saga University
Biosci Biotechnol Biochem 76:462-6. 2012..We speculate that the development and progression of NAFLD were prevented by suppressing the expression of lipogenic and inflammatory genes as a result of the higher serum adioponectin level in the Lotus diet-fed db/db mice... - Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cellsTeruyoshi Yanagita
Department of Applied Biochemistry and Food Science, Saga University, Saga 840 8502, Japan
Lipids Health Dis 7:38. 2008..The present study was undertaken to investigate the effect of taurine on apoB secretion and lipid metabolism in human liver model HepG2 cells... - Effect of Vaccinium ashei reade leaves on lipid metabolism in Otsuka Long-Evans Tokushima Fatty ratsKoji Nagao
Department of Applied Biochemistry and Food Science, Saga University, 1 Honjo, Saga 840 8502, Japan
Biosci Biotechnol Biochem 72:1619-22. 2008..The hypolipidemic effect might be attributable to a reduction of lipogenesis and enhancement of lipolysis in the liver. These results suggest the use of blueberry leaf as a dietary hypolipidemic component... - Functional lipids and the prevention of the metabolic syndromeTeruyoshi Yanagita
Saga University, Department of Applied Biochemistry and Food Science, Saga 840 8502, Japan
Asia Pac J Clin Nutr 17:189-91. 2008..Our study indicated that dietary PI lowered lipids in the plasma and liver by suppressing hepatic TAG synthesis... - Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) ratsKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan
Biochem Biophys Res Commun 310:562-6. 2003..We speculate that the increase alleviates hyperinsulinemia and prevents the onset of hypertension in CLA-fed ZDF rats... - Conjugated fatty acids in food and their health benefitsKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, 1 Honjo, Saga 840-8502, Japan
J Biosci Bioeng 100:152-7. 2005..More detailed evaluations of the physiological bioactivities of CFA isomers on lifestyle-related diseases in humans and animals will be of great interest in future studies... - The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cellsKeisuke Arao
Department of Applied Biological Sciences, Saga University, Honjyo-1, Saga 840-8502, Japan
Biosci Biotechnol Biochem 68:2643-5. 2004..The uptake of (14)C-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA... - The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty ratsKoji Nagao
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, 840-8502, Saga, Japan
Biochem Biophys Res Commun 306:134-8. 2003..We speculate that the antihypertensive effect of 10t,12c-CLA can be attributed to the lowered secretion of hypertensive adipocytokines from abdominal adipose tissues... - Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in ratsIkuo Ikeda
Laboratory of Food and Biomolecular Science, Department of Food Function and Health, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amemiyamachi, Aoba ku, Sendai 981 8555, Japan
Biochim Biophys Acta 1760:800-7. 2006..These observations suggest a possibility that campestenone has an ability to prevent coronary heart disease by improving obesity and abnormality of lipid metabolism... - Consumption of pork-liver protein hydrolysate reduces body fat in Otsuka Long-Evans Tokushima Fatty rats by suppressing hepatic lipogenesisMuneshige Shimizu
Research and Development Center, Nippon Meat Packers, Inc, Ibaraki, Japan
Biosci Biotechnol Biochem 70:112-8. 2006..In the LETO rats, growth and adipose tissue weight were unaffected by dietary treatment. The results suggest that PLH is a novel ingredient suppressing body fat in genetically obese rats by reducing lipogenesis... - Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in ratsIkuo Ikeda
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
Biosci Biotechnol Biochem 69:1049-53. 2005....