Research Topics
Genomes and Genes
| Masato KuboSummaryAffiliation: RIKEN Brain Science Institute Country: Japan Publications
| Collaborators
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Detail Information
Publications
[Th1/Th2 differentiation]Masato Kubo
Laboratory for Signal Network, RIKEN Research Center for Allergy and Immunology, RIKEN Yokohama Institute
Nippon Rinsho 63:355-63. 2005- Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, IgE, and eosinophiliaMasato Kubo
Laboratory for Signal Network, RIKEN Research Center for Allergy and Immunology RCAI, RIKEN Yokohama Institute, Suehiro cho 1 7 22, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
Curr Allergy Asthma Rep 6:32-9. 2006..In this article, we discuss the role of SOCS3 and SOCS5 proteins in atopic asthma and allergic conjunctivitis and explore the potential of SOCS proteins as targets for therapeutic strategies in allergic disorders... - Role of suppressor of cytokine signaling in ocular allergyMasato Kubo
Laboratory for Signal Network, RIKEN Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Tsurumi, Yokohama, Kanagawa, Japan
Curr Opin Allergy Clin Immunol 6:361-6. 2006..The goal of this article is to evaluate developments in the knowledge of suppressor of cytokine signaling (SOCS) protein ocular allergy and the potential of SOCS proteins as targets for therapeutic strategies... - Notch: filling a hole in T helper 2 cell differentiationMasato Kubo
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Suehiro cho 1 7 22, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
Immunity 27:3-5. 2007..In this issue of Immunity, Amsen et al. (2007) and Fang et al. (2007) propose a direct role for Notch signaling in the expression of GATA-3 transcription factor and T helper 2 cell differentiation... - The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cellsShinya Tanaka
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
Nat Immunol 12:77-85. 2011..Our results indicate that HS2 is the target of GATA-3 in regulating chromosomal modification of the Il4 locus and is independent of the Il5 and Il13 loci... - IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organsYoh Ichi Seki
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa, Japan
J Immunol 178:262-70. 2007..These results suggest that IL-7-mediated STAT5 activation is essential for long-term survival of naive CD4 cells after export from thymus, and that another SOCS1-sensitive cytokine is critical for short-term naive T cell survival... - Mina, an Il4 repressor, controls T helper type 2 biasMariko Okamoto
Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Japan
Nat Immunol 10:872-9. 2009..Our findings collectively provide mechanistic insight into an Il4-regulatory pathway that controls helper T cell differentiation and genetic variation in T(H)2 bias... - The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cellsYasutaka Motomura
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
Nat Immunol 12:450-9. 2011..Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells... - Regulation of the Il4 gene is independently controlled by proximal and distal 3' enhancers in mast cells and basophilsRyouji Yagi
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Suehiro cho 1 7 22, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
Mol Cell Biol 27:8087-97. 2007..The transcription of the Il4 gene in mast cells and basophils is independently regulated by CNS-2 and HS4 elements that may be critical for lineage-specific Il4 gene regulation in these cell types... - Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responsesShinya Tanaka
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Tsurumi, Yokohama, Kanagawa, Japan
J Immunol 183:7523-30. 2009..10 Rag(-/-) mice. These results demonstrate that a novel T cell subset, nTh17, facilitates the early phase of Ag-induced airway responses and host defenses against pathogen invasion before the establishment of acquired immunity... - The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cellsShinya Tanaka
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
Immunity 24:689-701. 2006.... - The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8alpha+ dendritic cell subsetJun Tsukada
Laboratory for Signal Network, Research Center for Allergy and Immunology RCAI, RIKEN Yokohama Institute, Suehiro cho 1 7 22, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
Int Immunol 17:1167-78. 2005..Therefore, SOCS1 expression during DC maturation plays a role in surveillance in controlling the aberrant expansion of abnormal DC subset to maintain homeostasis of immune system... - The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine modelAkemi Ozaki
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Kanagawa, Japan
J Immunol 175:5489-97. 2005..These results suggest that negative regulation of the Th2-mediated response by dominant-negative SOCS3 and SOCS5 could be a target for therapeutic intervention in allergic disease... - Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cellsShigeharu Fujita
Laboratory for Dendritic Cell Immunobiology, Rikagaku Kenkyusho RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
Blood 110:3793-803. 2007..Thus, immunotherapy with DC(regs) is a promising strategy for the treatment of cGVHD in alloBMT mediated through the induction of a dominant tolerance involving CD4(+)CD25(+)Foxp3(+) T(R) cells... - Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cellsAtsushi Hijikata
RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, Japan
Bioinformatics 23:2934-41. 2007..To address this, we constructed an open-access database that enabled us to cross-reference transcriptomic and proteomic data obtained from immune cells... - Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in miceMakoto Terada
Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
Proc Natl Acad Sci U S A 103:8816-21. 2006..il18-/-BALB/c mice similarly evaded SDS/SpA-induced AD. Thus, IL-18 might be important for the development of infection-associated AD by induction of IL-3 from super Th1 cells... - Role of endogenous inhibitors of cytokine signaling in allergic asthmaHiromasa Inoue
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Curr Med Chem 14:181-9. 2007..Here, we discuss the role of SOCS and SPRED proteins in allergic asthma and explore the potential of these proteins as targets for therapeutic strategies in allergic asthma... - Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga miceRyouji Yagi
Division of Immunobiology, Research Institute for Biological Sciences, Department of Applied Biological Science, Science University of Tokyo, Noda City, Chiba, Japan
J Immunol 168:2020-7. 2002..The skin microenvironment that favored IFN-gamma production tightly correlates with the skin disease in NC mice through the infiltration of eosinophils... - Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cellsKoji Tokoyoda
Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
Int Immunol 16:643-53. 2004..These findings indicate that the cAMP/PKA pathway transduces the critical activation signal to T(h)2 polarization by a CD3/CD28 co-stimulation signal and a PKA activating reagent... - Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expressionHiroaki Takatori
Department of Allergy and Clinical Immunology, Chiba University School of Medicine, Chiba City, Japan
J Immunol 174:4105-12. 2005..These results suggest that Stat5a forces the Th1/Th2 balance toward a Th2-type by preventing IL-12-induced Th1 cell differentiation through the induction of SOCS3... - Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiationYoh Ichi Seki
Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
Proc Natl Acad Sci U S A 99:13003-8. 2002..Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance... - Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsivenessHiromasa Inoue
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
J Exp Med 201:73-82. 2005..These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma... - SOCS proteins in T helper cell differentiation: implications for allergic disorders?Hiromasa Inoue
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Expert Rev Mol Med 6:1-11. 2004..Here, we discuss the role of SOCS proteins in Th-cell differentiation and explore the potential of SOCS proteins as targets for therapeutic strategies in allergic disorders... - [Role of SOCS/CIS/SSI molecules in Th1/Th2 differentiation and allergic immune disease]Masato Kubo
Tanpakushitsu Kakusan Koso 47:2279-85. 2002 - SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responsesYoh Ichi Seki
Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
Nat Med 9:1047-54. 2003..These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of T(H)2-mediated allergic immune disease, and suggest that SOCS-3 may be a new therapeutic target for the development of antiallergic drugs... - The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expressionOkiru Komine
Research Institute for Biological Sciences, Tokyo University of Science, Noda, Japan
J Exp Med 198:51-61. 2003..We conclude that Runx1 plays a novel role as a negative regulator of GATA3 expression, thereby inhibiting the Th2 cell differentiation... - The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cellsShin ichi Kano
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nat Immunol 9:34-41. 2008..Because both IL-12 and IL-23 bind to and transmit signals through IL-12Rbeta1, our data suggest that distinct thresholds of IL-12Rbeta1 expression are required for T(H)1 versus T(H)-17 differentiation... - Suppressors of cytokine signaling and immunityMasato Kubo
Department of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda 278-0022, Japan
Nat Immunol 4:1169-76. 2003..Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS... - Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 geneToshikatsu Hanada
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
J Immunol 174:4325-32. 2005..We propose that reduction of the SOCS1 gene expression in DCs leads to CD8alpha(+) DC-like phenotype which promotes Th1-type hyperresponses... - IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiationNoriyasu Seki
Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki, Noda City, Chiba, Japan
J Immunol 172:6158-66. 2004..In late stages of initial T cell activation, the chromatin structure of the IL-4 locus retains condensation state. These results demonstrate that IL-4-induced GATA-3 expression is time-restriction switch for Th2 differentiation... - SOCS proteins, cytokine signalling and immune regulationAkihiko Yoshimura
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Nat Rev Immunol 7:454-65. 2007..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function... - Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signalingKenji Tanigaki
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto, 606 8501, Japan
Immunity 20:611-22. 2004..Our data demonstrated that Notch/RBP-J signaling regulates gammadelta T cell generation and migration, alphabeta T cell maturation, terminal differentiation of CD4(+) T cells into Th1/Th2 cells, and activation of T cells... - ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signalingMasashi Watanabe
Division of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda, Chiba, Japan
J Immunol 174:1989-96. 2005..These observations led us to propose that the predominant effect of ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4R-mediated signaling... - Computer simulation of the role of SOCS family protein in helper T cell differentiationSatoshi Yamada
Faculty of Engineering, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan
Int Immunol 18:335-45. 2006..Our results demonstrate that models for the simulation of signaling network, such as our Th0 model, are useful tools for the in silico evaluation of novel drug candidates...