Research Topics
Genomes and Genes
| M IzumiSummaryAffiliation: RIKEN Brain Science Institute Country: Japan Publications
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Detail Information
Publications
Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1M Izumi
Division of Radioisotope Technology, RIKEN The Institute of Physical and Chemical Research, Saitama, Japan
Biochim Biophys Acta 1492:341-52. 2000..These data indicate that E2F, GABP and Sp1 regulate the gene expression of this principal replication enzyme...- The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phaseM Izumi
Division of Radioisotope Technology, Cellular Physiology Laboratory, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama 351 0198, Japan
Nucleic Acids Res 28:4769-77. 2000..HsMcm10 also interacted with Orc2, Mcm2 and Mcm6 proteins in the yeast two-hybrid system. These results suggest that HsMcm10 may function in DNA replication through the interaction with Orc and Mcm2-7 complexes... - E2F regulates growth-dependent transcription of genes encoding both catalytic and regulatory subunits of mouse primaseN Nishikawa
Cellular Physiology Laboratory, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama 351 0198, Japan
Genes Cells 6:57-70. 2001..The promoter regions of the four subunits of mouse DNA polymerase d-primase complex share several common features. The coordinated transcription of all four subunits in response to growth stimulation appears to be controlled by E2F... - Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycleH Miyazawa
Cellular Physiology Laboratory, Institute of Physical and Chemical Research RIKEN, Wako, Saitama, Japan
J Biol Chem 268:8111-22. 1993..In growing mouse FM3A cells, the transcripts of the four subunits are present throughout the cell cycle and increase slightly prior to the S phase... - Cell cycle-dependent proteolysis and phosphorylation of human Mcm10M Izumi
Division of Radioisotope Technology, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama 351 0198, Japan
J Biol Chem 276:48526-31. 2001..It is further suggested that mammalian Mcm10 is involved in S phase progression, and not the formation of a prereplicative complex, as previously proposed from data on the S. cerevisiae protein... - Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunitT Mizuno
Institute of Physical and Chemical Research RIKEN, Saitama, Japan
J Cell Sci 109:2627-36. 1996..We present here first evidence for a novel role of p54 in the nuclear translocation process, and a piggy-back binding transport mechanism of mouse DNA primase... - Identification of a point mutation in the cDNA of the catalytic subunit of DNA polymerase alpha from a temperature-sensitive mouse FM3A cell lineM Izumi
Cellular Physiology Laboratory, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
J Biol Chem 269:7639-44. 1994..All revertant cell lines had a second point mutation adjacent to the first mutation site in tsFT20 cells... - Cellular responses to low dose heavy-ion exposure in human cellsS Morimoto
Division of Radioisotope Technology, Institute of Physical and Chemical Research (RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Radiat Prot Dosimetry 99:253-4. 2002..New detection methodology must be developed for identification of heavy-ion specific cellular responses... - Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytesM Funamoto
Department of Molecular Medicine, Osaka University Medical School, Osaka University, Suita Osaka 565 0871, Japan
J Biol Chem 275:10561-6. 2000..These data provide the first evidence that a STAT family protein functions as a regulator of angiogenic growth factors and suggest that gp130/STAT signaling in cardiac myocytes can control vessel growth during cardiac remodeling... - Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathwayM Izumi
Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka 565 0871, Japan
J Biol Chem 276:31133-41. 2001..Overall, our findings suggest that BMP-2 prevents apoptosis of myocytes by induction of Bcl-x(L) via a Smad1 pathway and might be a novel survival factor without any hypertrophic effect on myocytes... - Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutaseS Negoro
Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
Circulation 104:979-81. 2001..CONCLUSIONS: The activation of STAT3 induces a protective effect on H/R-induced cardiomyocyte damage, mainly by inducting MnSOD. The STAT3-mediated signal is proposed as a therapeutical target of ROS-induced cardiomyocyte injury... - Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12A Shiratori
Division of Human Genome Research and Gene Bank, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
Genomics 28:350-3. 1995..The PRIM1 gene was mapped to 1q44, and two PRIM2 loci (PRIM2A and PRIM2B) were detected at 6p11.1-p12 by fluorescence in situ hybridization using several genomic DNA probes...