Research Topics
Genomes and Genes
| Jun ArugaSummaryAffiliation: RIKEN Brain Science Institute Country: Japan Publications
| Collaborators
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Detail Information
Publications
Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryoTakashi Inoue
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Dev Biol 306:669-84. 2007....- Zic1 regulates the patterning of vertebral arches in cooperation with Gli3J Aruga
Molecular Neurobiology Laboratory, Tsukuba Life Science Center, RIKEN, Tsukuba shi, Ibaraki, Japan
Mech Dev 89:141-50. 1999..The three genes may act synergistically in the development of the vertebral arches... - Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent tail) mutant miceJun Aruga
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Eur J Neurosci 20:2159-67. 2004..These findings may have some clinical implications in relation to disorders characterized by cerebellar dysgenesis, such as Joubert syndrome... - Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3Jun Aruga
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, 351 0198, Saitama, Japan
Gene Expr Patterns 3:727-33. 2003..The complementary expression of the two proteins in the dorsal thalamus persisted from E13.5 to the adult stage... - Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissueJun Aruga
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Gene 315:87-94. 2003..These results suggest that the human SLITRK genes are useful molecular indicators of brain tumor properties... - Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowthJun Aruga
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Mol Cell Neurosci 24:117-29. 2003..These results suggest that the Slitrk proteins are the neuronal components that control the neurite outgrowth... - The role of Zic genes in neural developmentJun Aruga
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
Mol Cell Neurosci 26:205-21. 2004..This association might be is a clue toward understanding of the multifunctional property of Zic proteins because Notch signaling also is implicated in the control of several developmental processes... - Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiationJun Aruga
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Saitama, Wako Shi, 351 0198, Japan
Dev Biol 244:329-41. 2002..Notch-mediated inhibition of neuronal differentiation is likely to act downstream of Zic genes since Notch1 is upregulated in Zic1-overexpressing spinal cords in both the mouse and the chick... - Zic2 controls cerebellar development in cooperation with Zic1Jun Aruga
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
J Neurosci 22:218-25. 2002..These results indicate that Zic1 and Zic2 may have very similar functions in the regulation of cerebellar development... - A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cordJ Aruga
Molecular Neurobiology Laboratory, Tsukuba Life Science Center, RIKEN Brain Science Institute, Tsukuba shi, 305 0074, Ibaraki, Japan
Brain Res Mol Brain Res 78:15-25. 2000..In these regions, there are sequences similar to the binding sequences for potential regulatory proteins... - Xenopus Zic4: conservation and diversification of expression profiles and protein function among the Xenopus Zic familyTakahiko J Fujimi
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
Dev Dyn 235:3379-86. 2006..These results indicate that the five Xenopus Zic genes cooperatively regulate both neural and neural crest development, despite significantly diverged expression profiles and functions... - Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteinsNaoko Morimura
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Gene 380:72-83. 2006..These results suggest that Lrfn proteins are neuronal components with a role in the developing or mature vertebrate nervous system... - Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouseJun Hoshino
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, 2 1 Hirosawa, Wako, Saitama 351 0918, Japan
Brain Res Mol Brain Res 120:57-64. 2003..In addition, Dorz1 expression was up-regulated in cultured cells overexpressing Zic1. These results suggest that Dorz1 expression is positively regulated by Zic1 during cerebellar development... - Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient miceKei Ichi Katayama
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
PLoS ONE 4:e7786. 2009..These results suggest that Slitrk6 promotes innervation and survival of inner ear sensory neurons by regulating the expression of trophic and/or tropic factors including neurotrophins from sensory epithelia... - Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic familyAkira Ishiguro
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Biochem Biophys Res Commun 324:302-7. 2004..The difference may be attributable to the dissimilarity of the N-terminal region between the Zic1/Zic2/Zic3 and Zic4/Zic5 proteins, since the binding of the Zic1/Zic2/Zic3 proteins to I-mfa occurs through their N-terminal regions... - Expression of ZIC family genes in meningiomas and other brain tumorsJun Aruga
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
BMC Cancer 10:79. 2010..Although human ZIC genes are known to be molecular markers for medulloblastomas, their expression in meningioma has not been addressed to date... - Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligaseMiyuki Ogawa
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Genes Cells 13:397-409. 2008..These results suggest that Rines is a membrane-bound E3 ubiquitin ligase... - Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitorsTakashi Inoue
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
J Neurosci 27:5461-73. 2007..The functions of these genes may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon... - Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivativesTakashi Inoue
Laboratory for Developmental Neurobiology and Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Hirosawa, Wako Shi, Saitama 351 0198, Japan
Dev Biol 270:146-62. 2004..Based on both their similar expression pattern in mouse embryos and the malformations observed in Zic5-deficient mutant mice, human ZIC5 might be involved in the deletion syndrome... - Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephalyTakashi Inoue
Laboratory for Comparative Neurogenesis Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
J Neurosci 28:4712-25. 2008..These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly... - Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesisEmi Kinameri
Molecular Neuropathology Group, RIKEN Brain Science Institute, Wako, Saitama, Japan
PLoS ONE 3:e3859. 2008..In Drosophila we recently characterized Hamlet, a transcription factor that mediates Notch signalling and neural cell fate... - Conservation and diversification of Msx protein in metazoan evolutionHirokazu Takahashi
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
Mol Biol Evol 25:69-82. 2008..We speculate that selective loss of the conserved domains in Msx family proteins contributed to the diversification of animal body organization... - Myogenic repressor I-mfa interferes with the function of Zic family proteinsKiyomi Mizugishi
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute BSI, Wako Shi, Saitama 351 0198, Japan
Biochem Biophys Res Commun 320:233-40. 2004..These results suggest that the physical and functional interaction between Zic and I-mfa proteins can play a role in the vertebrate development... - Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/?-catenin signaling pathwayTakahiko J Fujimi
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Dev Biol 361:220-31. 2012..The findings in this report produce a novel system for fine-tuning of Wnt/?-catenin signaling... - An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene OpalinJun Aruga
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
J Neurochem 102:1533-47. 2007..These results suggest that LIF, cAMP signaling cascades and Myt1 play significant roles in the differentiation of oligodendrocytes through their action on the Opalin oligodendrocyte enhancer... - Dicyema Pax6 and Zic: tool-kit genes in a highly simplified bilaterianJun Aruga
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako 351 0198, Japan
BMC Evol Biol 7:201. 2007.... - Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in miceMotoko Maekawa
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Biochem Biophys Res Commun 402:431-7. 2010..These results demonstrate a gene-by-environment (GxE) interaction in eye development in mice. Furthermore, our molecular analysis suggested the potential roles of Pitx3 and Pax6 in the above interaction involving ARA... - Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiationJun Aruga
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, 351 0198, Japan
Neurochem Res 36:1286-92. 2011..Comprehensive understanding of the Zic family genes is therefore essential for the study of the neuroectodermal differentiation and stem cell biology... - Functional role of Zic2 phosphorylation in transcriptional regulationAkira Ishiguro
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
FEBS Lett 582:154-8. 2008..These data indicate that Zic2S200 is a target for phosphorylation by DNA-dependent protein kinase, regulating Zic2-mediated transcriptional activation... - Expression pattern of annelid Zic in embryonic development of the oligochaete Tubifex tubifexHirokazu Takahashi
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako, Japan
Dev Genes Evol 218:553-60. 2008..The Ttu-Zic expression profile in the early embryogenesis of T. tubifex may be homologous to those of evolutionarily distant animals... - Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophreniaNoriko Takashima
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
PLoS ONE 6:e22716. 2011..Although the pharmacobehavioral phenotype was not entirely characteristic of those of schizophrenia model animals, the impaired cognitive function may warrant the further study of LRRTM1 in relevance to schizophrenia... - A wide-range phylogenetic analysis of Zic proteins: implications for correlations between protein structure conservation and body plan complexityJun Aruga
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako 351 0198, Japan
Genomics 87:783-92. 2006..The result indicates that the ancestral bilateralian Zic protein had already acquired an entire set of conserved domains, but that this was lost and diverged in the platyhelminthes, nematodes, and urochordates... - Upstream stimulatory factors, USF1 and USF2 are differentially expressed during Xenopus embryonic developmentTakahiko J Fujimi
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Gene Expr Patterns 8:376-81. 2008..USF1 was expressed in the notochord of the early neurula, but was lost at the stage... - Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetryTetsuya Kitaguchi
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan
Dev Growth Differ 44:55-61. 2002..Furthermore, activation of inducible type Xbra (Xbra-GR) induces Zic3 expression within 20 min. These results suggest that a role of Brachyury in L-R specification may be the direct regulation of Zic3 expression... - Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient miceYoshifumi Matsumoto
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Japan
PLoS ONE 6:e16497. 2011..Furthermore, the altered responses of Slitrk6-KO mice to the novel environment suggest a role of Slitrk6 in some cognitive functions... - Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domainMinoru Hatayama
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
Hum Mol Genet 17:3459-73. 2008..These results indicate that ZIC3 is imported into the cell nucleus by the Karyopherin (Importin) system and that the impaired nuclear localization by the ZF1 mutation is not due to a direct influence on the NLS... - ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase AAkira Ishiguro
Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
J Biol Chem 282:9983-95. 2007..Phosphorylation-dependent transformation of Zic2-containing molecular complexes may occur in transcriptional regulation... - Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactionsMinoru Hatayama
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
BMC Evol Biol 10:53. 2010..Because each tryptophan residue is located between the two cysteine residues of the C2H2 motif, we have named this structure the tandem CWCH2 (tCWCH2) motif... - IP3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryosMinoru Hatayama
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Biochem Biophys Res Commun 410:520-4. 2011..Examination of the gastrocoel roof plate revealed that the number of cilia was significantly reduced by IP(3) signal blocking. These results provide evidence that IP(3) signaling is involved in LR asymmetry formation in vertebrates... - Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophreniaKazuo Yamada
Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Proc Natl Acad Sci U S A 104:2815-20. 2007..These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene... - Comparative anatomy of marmoset and mouse cortex from genomic expressionHiromi Mashiko
Laboratory for Molecular Mechanisms of Thalamus Development, Support Unit for Animal Resources Development, Laboratory for Behavioral and Developmental Disorders, and Keio University Joint Research Laboratory, RIKEN Brain Science Institute, Wako, Saitama, Japan 351 0198, and Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 113 0021, Japan
J Neurosci 32:5039-53. 2012..Collectively, we propose that gene expression patterns in marmoset brain reveal important clues to the principles underlying the molecular evolution of cortical and cognitive expansion... - Gli protein nuclear localization signalMinoru Hatayama
Laboratory for Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
Vitam Horm 88:73-89. 2012..In addition, the Roadkill protein, a substrate recognition component of E3 ubiquitin ligase, competes with the Ci protein to interact with Importin ?3 resulting in inhibition of Ci protein nuclear import... - Zic2 patterns binocular vision by specifying the uncrossed retinal projectionEloisa Herrera
Department of Pathology and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Cell 114:545-57. 2003..These data provide evidence for transcriptional coding of axon pathfinding at the midline... - CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNAKumiko Sakai-Kato
Research Institute of Pharmaceutical Sciences, Musashino University, 1 1 20 Shinmachi, Nishitokyo shi, Tokyo, 202 8585, Japan
Biochim Biophys Acta 1784:1011-9. 2008..These results suggest that the alpha-helix structure is important for DNA binding and profoundly related to functional and structural diversity among the three families... - Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domainBrigitte Chhin
INSERM, Equipe de Recherche Methodologique ERM 0107, Bron, France
Hum Mutat 28:563-70. 2007..H286R showed diminished activities for both left-right axis disturbance and neural crest induction in Xenopus embryos. These results suggest that mutations in the first zinc finger of ZIC3 mildly affect several functions of the protein...