Hiroshi Sawada

Summary

Affiliation: Pharmaceutical Research Division
Country: Japan

Publications

  1. ncbi A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system
    Hiroshi Sawada
    Biomedical Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka 532 8686, Japan
    Toxicol Sci 83:282-92. 2005
  2. ncbi Improved toxicogenomic screening for drug-induced phospholipidosis using a multiplexed quantitative gene expression ArrayPlate assay
    Hiroshi Sawada
    Takeda Pharmaceutical Company Limited, Discovery Research Center, Pharmaceutical Research Division, 2 17 85 Juso Honmachi Yodogawa ku, Osaka 532 8686, Japan
    Toxicol In Vitro 20:1506-13. 2006
  3. ncbi Similar compounds searching system by using the gene expression microarray database
    Hiroyoshi Toyoshiba
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17 85 Jusohonmachi 2 Chome, Yodogawa ku, Osaka 532 8686, Japan toyoshiba
    Toxicol Lett 186:52-7. 2009
  4. ncbi Gene expression profiling of functional murine embryonic stem cell-derived cardiomyocytes and comparison with adult heart: profiling of murine ESC-derived cardiomyocytes
    Tadahiro Shinozawa
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan
    J Biomol Screen 14:239-45. 2009
  5. ncbi Molecular cloning and characterization of a cDNA encoding a novel cuticle protein in the silkworm, Bombyx mori
    Hiroshi Sawada
    Biological Laboratory, Center for Natural Science, Kitasato University, Kitasato 1 15 1, Sagamihara City, Kanagawa 228 8555, Japan
    Comp Biochem Physiol B Biochem Mol Biol 134:519-27. 2003
  6. ncbi Molecular properties and tissue distribution of 30K proteins as ommin-binding proteins from diapause eggs of the silkworm, Bombyx mori
    Hiroshi Sawada
    Laboratory of Biology, Department of General Studies, College of Humanities and Sciences, Nihon University, Sakurajosui 3 25 40, Tokyo, Japan
    Comp Biochem Physiol B Biochem Mol Biol 146:172-9. 2007

Detail Information

Publications6

  1. ncbi A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system
    Hiroshi Sawada
    Biomedical Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka 532 8686, Japan
    Toxicol Sci 83:282-92. 2005
    ..Furthermore, comprehensive gene expression analysis enabled us to identify biomarkers of this condition that we then used to develop a rapid and sensitive in vitro screening test for drug-induced phospholipidosis...
  2. ncbi Improved toxicogenomic screening for drug-induced phospholipidosis using a multiplexed quantitative gene expression ArrayPlate assay
    Hiroshi Sawada
    Takeda Pharmaceutical Company Limited, Discovery Research Center, Pharmaceutical Research Division, 2 17 85 Juso Honmachi Yodogawa ku, Osaka 532 8686, Japan
    Toxicol In Vitro 20:1506-13. 2006
    ..Thus, the in vitro screening assay for compound-induced phospholipidosis should be transferable from a PCR-based assay to the higher-throughput ArrayPlate-based method...
  3. ncbi Similar compounds searching system by using the gene expression microarray database
    Hiroyoshi Toyoshiba
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17 85 Jusohonmachi 2 Chome, Yodogawa ku, Osaka 532 8686, Japan toyoshiba
    Toxicol Lett 186:52-7. 2009
    ..Moreover, this method may be a powerful tool to understand the mechanisms by which biological systems respond to various chemical compounds and may also predict adverse effects of new compounds...
  4. ncbi Gene expression profiling of functional murine embryonic stem cell-derived cardiomyocytes and comparison with adult heart: profiling of murine ESC-derived cardiomyocytes
    Tadahiro Shinozawa
    Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan
    J Biomol Screen 14:239-45. 2009
    ..We conclude that EBs might be of use for the basic screening of drugs that might affect contractile function through ion channels...
  5. ncbi Molecular cloning and characterization of a cDNA encoding a novel cuticle protein in the silkworm, Bombyx mori
    Hiroshi Sawada
    Biological Laboratory, Center for Natural Science, Kitasato University, Kitasato 1 15 1, Sagamihara City, Kanagawa 228 8555, Japan
    Comp Biochem Physiol B Biochem Mol Biol 134:519-27. 2003
    ..We propose BMCPA may be a novel component of cuticle, and may play an important role in the integument of the larval silkworm...
  6. ncbi Molecular properties and tissue distribution of 30K proteins as ommin-binding proteins from diapause eggs of the silkworm, Bombyx mori
    Hiroshi Sawada
    Laboratory of Biology, Department of General Studies, College of Humanities and Sciences, Nihon University, Sakurajosui 3 25 40, Tokyo, Japan
    Comp Biochem Physiol B Biochem Mol Biol 146:172-9. 2007
    ..The 30K proteins as OMBP may play an important role in the transport and accumulation of tryptophan metabolites and ommochrome during the formation of serosa...