Y Urade

Summary

Affiliation: Osaka Bioscience Institute
Country: Japan

Publications

  1. ncbi Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis
    Mitsuhiro Okano
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Rhinol 20:342-8. 2006
  2. ncbi Inhibition of prostaglandin D synthase suppresses muscular necrosis
    Ikuko Mohri
    Department of Molecular Behavioral Biology, Molecular Research Center for Child Mental Development, Osaka Bioscience Institute, Suita, Osaka, Japan
    Am J Pathol 174:1735-44. 2009
  3. ncbi Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide
    Jingshan Lu
    Department of Medical Chemistry, Kansai Medical University, Moriguchi, Japan
    Mol Pain 5:58. 2009
  4. ncbi Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase
    Y Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Biochim Biophys Acta 1482:259-71. 2000
  5. ncbi Sleep regulation in adenosine A2A receptor-deficient mice
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Neurology 61:S94-6. 2003
  6. ncbi Prostaglandin D2 and sleep regulation
    Y Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Biochim Biophys Acta 1436:606-15. 1999
  7. ncbi [Sleep and brain function]
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita
    No To Hattatsu 38:331-3. 2006
  8. ncbi [Structure and function of prostaglandin D synthase]
    Yoshihiro Urade
    Tanpakushitsu Kakusan Koso 53:217-26. 2008
  9. ncbi Prostaglandin D(2) and sleep/wake regulation
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4, Furuedai, Suita, Osaka 565 0874, Japan
    Sleep Med Rev 15:411-8. 2011
  10. ncbi Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids
    D Y Gerashchenko
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Invest Ophthalmol Vis Sci 39:198-203. 1998

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi Presence and characterization of prostaglandin D2-related molecules in nasal mucosa of patients with allergic rhinitis
    Mitsuhiro Okano
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Am J Rhinol 20:342-8. 2006
    ..We sought to determine the expression of synthases and receptors for PGD2 in human nasal mucosa. These expressions were compared between allergic and nonallergic patients...
  2. ncbi Inhibition of prostaglandin D synthase suppresses muscular necrosis
    Ikuko Mohri
    Department of Molecular Behavioral Biology, Molecular Research Center for Child Mental Development, Osaka Bioscience Institute, Suita, Osaka, Japan
    Am J Pathol 174:1735-44. 2009
    ..Our results show that HPGDS augments inflammation, which is followed by muscle injury. Furthermore, the inhibition of HPGDS ameliorates muscle necrosis even in cases of genetic muscular dystrophy...
  3. ncbi Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide
    Jingshan Lu
    Department of Medical Chemistry, Kansai Medical University, Moriguchi, Japan
    Mol Pain 5:58. 2009
    ..The "biotin-switch" method and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry were employed for identifying S-nitrosylated proteins...
  4. ncbi Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase
    Y Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Biochim Biophys Acta 1482:259-71. 2000
    ..Gene-knockout and transgenic mice for PGDS were generated and found to have abnormalities in the regulation of nociception and sleep...
  5. ncbi Sleep regulation in adenosine A2A receptor-deficient mice
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Neurology 61:S94-6. 2003
  6. ncbi Prostaglandin D2 and sleep regulation
    Y Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Biochim Biophys Acta 1436:606-15. 1999
    ....
  7. ncbi [Sleep and brain function]
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita
    No To Hattatsu 38:331-3. 2006
    ..The GABAergic inhibition of TMN is involved in non-REM sleep induction by PGD2 or adenosine A2A receptor-agonists. The neural network between VLPO and TMN is considered to play a key role in the regulation of vigilance states...
  8. ncbi [Structure and function of prostaglandin D synthase]
    Yoshihiro Urade
    Tanpakushitsu Kakusan Koso 53:217-26. 2008
  9. ncbi Prostaglandin D(2) and sleep/wake regulation
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4, Furuedai, Suita, Osaka 565 0874, Japan
    Sleep Med Rev 15:411-8. 2011
    ....
  10. ncbi Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids
    D Y Gerashchenko
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Invest Ophthalmol Vis Sci 39:198-203. 1998
    ..The authors have undertaken the localization of this unique enzyme within the tissues and spaces of the anterior segment of the eye...
  11. ncbi Cloning and crystal structure of hematopoietic prostaglandin D synthase
    Y Kanaoka
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Cell 90:1085-95. 1997
    ..The unique 3-D architecture of the cleft leads to the putative substrate binding mode and its catalytic mechanism, responsible for the specific isomerization from PGH2 to PGD2...
  12. ncbi Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain
    C T Beuckmann
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Japan
    Neurochem Res 25:733-8. 2000
    ..8 min(-1) for GSTM2-2 and 1.5 mM and 130 min(-1) for GSTM3-3, respectively. GSTM2-2 and 3-3 may play crucial roles in temperature regulation, nociception, and sleep-wake regulation by producing PGE2 in the brain...
  13. ncbi Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep
    E Pinzar
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan Science and Technology Corporation, 6 2 4 Furuedai, Suita, 565 0874 Osaka, Japan
    Proc Natl Acad Sci U S A 97:4903-7. 2000
    ..Sleep, locomotion, and PGD(2) content were essentially unchanged in wild-type mice after tail clipping. The results with TG mice demonstrate the involvement of the PGDS gene in the regulation of NREM sleep...
  14. ncbi Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei
    B K Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Exp Med 192:1327-38. 2000
    ..The characterization of TbPGFS and its gene in T. brucei provides a basis for the molecular analysis of the role of parasite-derived PGF(2alpha) in the physiology of the parasite and the pathogenesis of African trypanosomiasis...
  15. ncbi Arousal effect of orexin A depends on activation of the histaminergic system
    Z L Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    Proc Natl Acad Sci U S A 98:9965-70. 2001
    ..These findings strongly indicate that the arousal effect of orexin A depends on the activation of histaminergic neurotransmission mediated by H1R...
  16. ncbi Dominant expression of rat prostanoid DP receptor mRNA in leptomeninges, inner segments of photoreceptor cells, iris epithelium, and ciliary processes
    D Gerashchenko
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Japan
    J Neurochem 71:937-45. 1998
    ....
  17. ncbi Mast cells contain spleen-type prostaglandin D synthetase
    Y Urade
    Department of Enzymes and Metabolism, Osaka Bioscience Institute, Japan
    J Biol Chem 265:371-5. 1990
    ..These findings indicate that prostaglandin D2 is produced by the spleen-type synthetase in mast cells of various tissues...
  18. ncbi Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase
    Y Kanaoka
    Department of Molecular Behavioral Biology, Osaka Bioscience, Institute, Osaka, Japan
    Eur J Biochem 267:3315-22. 2000
    ..0-21.5% identical to those of either H-PGDS. These findings suggest that the H-PGDS genes evolved from the same ancestral gene as the members of the sigma-class GST family...
  19. ncbi Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat
    C T Beuckmann
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Comp Neurol 428:62-78. 2000
    ..The localization of lipocalin-type prostaglandin D synthase in meningeal cells and its colocalization with COX-2 provide evidence for its function as a prostaglandin D(2)-producing enzyme...
  20. ncbi Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep
    O Hayaishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 5650874, Japan
    Arch Ital Biol 142:533-9. 2004
    ....
  21. ncbi Lipocalin-type prostaglandin D synthase (beta-trace) is upregulated in the alphaB-crystallin-positive oligodendrocytes and astrocytes in the chronic multiple sclerosis
    K Kagitani-Shimono
    Department of Developmental Medicine, Pediatrics, D-5 Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
    Neuropathol Appl Neurobiol 32:64-73. 2006
    ..Both L-PGDS-positive OLs and astrocytes expressed a stress protein, alphaB-crystallin. These results suggest that the upregulation of L-PGDS occurs in OLs and astrocytes as a stress reaction...
  22. ncbi Species-specific expression of microsomal prostaglandin E synthase-1 and cyclooxygenases in male monkey reproductive organs
    M Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, 6-2-4 Furuedai Suita, Osaka 565-0874, Japan
    Prostaglandins Leukot Essent Fatty Acids 71:233-40. 2004
    ..In monkeys, COX-1 was localized in epithelial cells of the epididymis and vas deferens, whereas COX-2 was dominantly found in epithelial cells of the seminal vesicles...
  23. ncbi Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix
    C T Beuckmann
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    J Neurosci 16:6119-24. 1996
    ..This enzyme is secreted from the RPE into IPM from which it is then taken up by photoreceptors. However, the nature of its ligand(s) is not known; they may be retinoids and/or docosahexanoic acid...
  24. ncbi Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1
    K Fujimori
    Department of Molecular Behavioral Biology and the Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 275:40511-6. 2000
    ....
  25. ncbi Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase
    C T Beuckmann
    Osaka Bioscience Institute, Suita, Japan
    Biochemistry 38:8006-13. 1999
    ..These results show that prostaglandin D synthase binds small lipophilic ligands with a specificity distinct from that of other lipocalins...
  26. ncbi Structural and functional significance of cysteine residues of glutathione-independent prostaglandin D synthase. Identification of Cys65 as an essential thiol
    Y Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan
    J Biol Chem 270:1422-8. 1995
    ....
  27. ncbi Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma
    Y Tokugawa
    Department of Obstetrics and Gynecology, Osaka University Medical School, Suita, Japan
    Biol Reprod 58:600-7. 1998
    ..Through immunohistochemistry, PGDS was localized in Leydig cells of the testis and in epithelial cells of the prostate and ductus epididymidis...
  28. ncbi Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:17949-54. 2006
    ..These results clearly show that the lipocalin-type PGDS/PGD2/DP1R system plays pivotal roles in the regulation of physiological sleep...
  29. ncbi Structural and mutational analysis of Trypanosoma brucei prostaglandin H2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases
    Kubata Bruno Kilunga
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 280:26371-82. 2005
    ..We also show Tyr52 acts as the general acid catalyst for 9,10-PQ reduction, and thus we not only elucidate the catalytic mechanism of a PGH2 reductase but also provide an insight into the catalytic specificity of AKRs...
  30. ncbi Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain
    Ikuko Mohri
    Department of Developmental Medicine Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
    Glia 42:263-74. 2003
    ....
  31. ncbi Brain oxidation is an initial process in sleep induction
    M Ikeda
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Neuroscience 130:1029-40. 2005
    ....
  32. ncbi Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives
    Osamu Hayaishi
    Osaka Bioscience Institute, Suita, Japan
    Neuroscientist 8:12-5. 2002
    ....
  33. ncbi Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid
    Takahisa Kanekiyo
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 104:6412-7. 2007
    ..Our findings may provide a diagnostic and therapeutic approach for AD...
  34. ncbi A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
    Bruno Kilunga Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Exp Med 196:1241-51. 2002
    ....
  35. ncbi Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice
    K Kuwamoto
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Invest Dermatol 114:241-6. 2000
    ..The induced production of PGE2 may be involved in the enhanced inflammation and immunosuppression caused by UV radiation in XPA-deficient mice and XP patients...
  36. ncbi Prostaglandins and adenosine in the regulation of sleep and wakefulness
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Opin Pharmacol 7:33-8. 2007
    ....
  37. ncbi Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme
    Daisuke Irikura
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 6 2 4 Furuedai, Suita, Osaka 565 0874
    J Biochem 133:29-32. 2003
    ..8, and c = 105.3 A. The selenomethionyl crystals obtained with citrate belong to orthorhombic space group C222(1) with lattice constants a = 45.5, b = 66.8, and c = 104.5 A. The native crystals diffracted beyond 2.1 A resolution...
  38. ncbi Mechanism of metal activation of human hematopoietic prostaglandin D synthase
    Tsuyoshi Inoue
    Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Struct Biol 10:291-6. 2003
    ..This effect explains a four-fold reduction in the K(m) of the enzyme for GSH. The structure provides insights into how Ca2+ or Mg2+ binding activates human hematopoietic PGD synthase...
  39. ncbi Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease
    Ikuko Mohri
    FrDepartment of Mental Health and Environmental Effects Research, The Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Neuropathol Exp Neurol 66:469-80. 2007
    ....
  40. ncbi Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase
    Kosuke Aritake
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4, Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 281:15277-86. 2006
    ....
  41. ncbi Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep
    Yo Oishi
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 105:19992-7. 2008
    ..These results indicate that endogenous adenosine in the TMN suppresses the histaminergic system via A(1)R to promote NREM sleep...
  42. ncbi [Sleep substances]
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita-city, Osaka 565-0874, Japan
    No To Shinkei 55:45-55. 2003
  43. ncbi Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice
    Yasushi Fujitani
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corp, Suita, Osaka, Japan
    J Immunol 168:443-9. 2002
    ..These results indicate that PGD(2) plays an important role in late phase allergic reactions in the pathophysiology of bronchial asthma...
  44. ncbi Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase
    Daisuke Irikura
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 284:7623-30. 2009
    ....
  45. ncbi Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 23:5975-83. 2003
    ..Furthermore, EP4 agonist perfusion into the TMN induced wakefulness. These findings indicate that PGE2 induces wakefulness through activation of the histaminergic system via EP4 receptors...
  46. ncbi Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence
    Y Urade
    Department of Enzymes and Metabolism, Osaka Bioscience Institute, Furuedai, Japan
    J Biol Chem 264:1041-5. 1989
    ..Fujimoto, N., Kaneko, T., Konishi, A., Mizuno, N., and Hayaishi, O. (1987) J. Biol. Chem. 262, 15132-15136) suggest that this enzyme is a membrane-associated protein...
  47. ncbi Prostaglandin production from arachidonic acid and evidence for a 9,11-endoperoxide prostaglandin H2 reductase in Leishmania
    Zakayi Kabututu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Int J Parasitol 32:1693-700. 2002
    ....
  48. ncbi Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 103:4687-92. 2006
    ....
  49. ncbi [Molecular mechanisms of insomnia]
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute
    Nihon Rinsho 67:1489-93. 2009
    ..These results indicate that the PGD2/ adenosine system plays a critical role in the regulation of physiological sleep...
  50. ncbi NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity
    Shigeru Shimamoto
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:31373-9. 2007
    ....
  51. ncbi Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury
    Hidetoshi Taniguchi
    Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Neurosci 27:4303-12. 2007
    ..In conclusion, it is probable that PGD2 protected the neonatal brain from hypoxic-ischemic injury mainly via DP1 receptors by preventing endothelial cell degeneration...
  52. ncbi Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Endocrinology 143:2410-9. 2002
    ..These results show that mPGES-1 is expressed coordinately with COX-1 and COX-2 and is involved in PGE(2) production in male genital organs...
  53. ncbi Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7
    Zakayi Kabututu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biochem 145:161-8. 2009
    ..2 and 18 mM, respectively). These data provide a molecular basis for investigating novel functional roles for AKR1B members and PGF(2alpha) as mediators of physiological and pathological processes in mammalian organisms...
  54. ncbi Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
    ..Thus, caffeine-induced wakefulness depends on adenosine A2A receptors...
  55. ncbi Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher
    Ikuko Mohri
    Department of Developmental Medicine Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Neurosci 26:4383-93. 2006
    ..These results suggest that PGD2 is the key neuroinflammatory molecule that heightens the pathological response to demyelination in twitcher mice...
  56. ncbi Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Gene 375:14-25. 2006
    ....
  57. ncbi De novo synthesis, uptake and proteolytic processing of lipocalin-type prostaglandin D synthase, beta-trace, in the kidneys
    Nanae Nagata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Japan
    FEBS J 276:7146-58. 2009
    ..These results suggest that L-PGDS is taken up by tubular cells and actively degraded within their lysosomes to produce the N-terminal-truncated form...
  58. ncbi Expression of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase mRNA in monkey ocular tissues and characterization of its recombinant enzyme
    Ko Fujimori
    Department of Molecular Behavioral Biology, Japan Science and Technology Corporation, Osaka Bioscience Institute, Furuedai, Suita, Osaka 565-0874, Japan
    J Biochem (Tokyo) 131:383-9. 2002
    ..These results indicate that PGF2a and the acid form of latanoprost are degraded to their 15-keto metabolites by NADP+-dependent PGDH localized in the monkey eye...
  59. ncbi Twenty-fifth anniversary of the discovery of somnogenic activity of prostaglandin D2: sleep research directed by Osamu Hayaishi
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    IUBMB Life 58:254-6. 2006
  60. ncbi Characterization of the unfolding process of lipocalin-type prostaglandin D synthase
    Takashi Inui
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation and Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 278:2845-52. 2003
    ..Therefore, L-PGDS is a unique protein whose enzyme activity and ligand-binding property are biphasically altered during the unfolding process by denaturants...
  61. ncbi Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep
    Tetsuya Okada
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Biochem Biophys Res Commun 312:29-34. 2003
    ..These results demonstrate that the leptomeninges control the extracellular level of adenosine in the subarachnoid space by their high 5(')-nucleotidase and ADA activities and regulate non-rapid eye movement sleep...
  62. ncbi Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages
    Michael Lazarus
    Department of Molecular Behavioral Biology, Japan Science and Technology Corporation, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Arch Biochem Biophys 397:336-41. 2002
    ..Taken together, these results demonstrate that mPGES-1 is an efficient downstream enzyme for the production of PGE2 in the activated macrophages treated by lipopolysaccharide...
  63. ncbi Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 28:8462-9. 2008
    ..However, pretreatment of D(2)R KO mice with D(1)R antagonist completely abolished arousal effects of modafinil. These findings strongly indicate that dopaminergic D(1)R and D(2)R are essential for the wakefulness induced by modafinil...
  64. ncbi Drug delivery through a chronically implanted stomach catheter improves efficiency of evaluating wake-promoting components
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    J Neurosci Methods 175:58-63. 2008
    ..These results indicate that oral administration through a chronic stomach catheter is a useful way for evaluating wake-promoting components...
  65. ncbi Prostaglandin production from arachidonic acid and evidence for a 9,11-endoperoxide prostaglandin H2 reductase in Leishmania
    Zakayi Kabututu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan
    Int J Parasitol 33:221-8. 2003
    ....
  66. ncbi Induction of hematopoietic prostaglandin D synthase in hyalinated necrotic muscle fibers: its implication in grouped necrosis
    Takeshi Okinaga
    Department of Developmental Medicine (Pediatrics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Acta Neuropathol (Berl) 104:377-84. 2002
    ....
  67. ncbi Arterial pressure and heart rate increase during REM sleep in adenosine A2A-receptor knockout mice, but not in wild-type mice
    Mie Sakata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Neuropsychopharmacology 30:1856-60. 2005
    ..From these findings, it is likely that the adenosine A2AR is involved in autonomic regulation during REM sleep...
  68. ncbi [Functional analyses of lipocalin-type and hematopoietic prostaglandin D synthases]
    Yoshihiro Urade
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka, Japan
    Nippon Yakurigaku Zasshi 123:5-13. 2004
    ..H-PGDS-KO mice showed an allergic reaction weaker than that of the wild-type mice...
  69. ncbi Changes of lipocalin-type prostaglandin D synthase level during pregnancy
    Yasuhiko Shiki
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Obstet Gynaecol Res 30:65-70. 2004
    ..CONCLUSION: The measurement of L-PGDS in cervicovaginal fluid was useful in the detection of ROM during pregnancy...
  70. ncbi Cooperative activation of lipocalin-type prostaglandin D synthase gene expression by activator protein-2beta in proximal promoter and upstream stimulatory factor 1 within intron 4 in human brain-derived TE671 cells
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka, Japan
    Gene 397:143-52. 2007
    ..These results indicate that L-PGDS gene expression in TE671 cells was activated by USF1 through the aE-box within intron 4 and cooperatively by AP-2beta in the promoter in a cell-type-specific manner...
  71. ncbi Pharmacokinetics of recombinant human lipocalin-type prostaglandin D synthase/beta-trace in canine
    Weidong Li
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Neurosci Res 61:289-93. 2008
    ....
  72. ncbi A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 282:18458-66. 2007
    ..Liver X receptor-mediated up-regulation of L-PGDS through activation of SREBP-1c is a novel path-way to enhance adipocyte differentiation...
  73. ncbi Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx
    Ryo Kawata
    Department of Otolaryngology, Osaka Medical College, Osaka, Japan
    Acta Otolaryngol 126:627-32. 2006
    ..The COX-2-mPGES-PGE2 system may induce differentiation of cancer cells and prevent metastasis, thus improving the survival rate...
  74. ncbi Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells
    Ko Fujimori
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan
    J Biol Chem 280:18452-61. 2005
    ..These results reveal a novel transcriptional regulatory mechanism responsible for the high level expression of the human L-PGDS gene in TE671 cells...
  75. ncbi Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells
    Ko Fujimori
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation and the Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 278:6018-26. 2003
    ..Moreover, the L-PGDS gene is a unique gene that is activated slowly by the NF-kappa B system...
  76. ncbi Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei
    B K Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Int J Parasitol 35:91-103. 2005
    ..This new anti-trypanosomal compound should be further studied to determine its efficacy and suitability as an anti-trypanosomal drug and may be used as a tool to define novel specific drug targets in BF trypanosomes...
  77. ncbi Characterization of a major secretory protein in the cane toad (Bufo marinus) choroid plexus as an amphibian lipocalin-type prostaglandin D synthase
    Daisuke Irikura
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biochem 141:173-80. 2007
    ..0 to 8.5. Our results suggest that the toad protein is a prototype of L-PGDS with a highly functional ligand-binding pocket and yet with a primitive catalytic pocket...
  78. ncbi Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep
    Akira Terao
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Neurochem 105:1480-98. 2008
    ..However, gene expression induced in the brain after PGD2 or CGS21680 treatment was distinct from that described during RS after SD and apparently involves glial cell gene activation and signaling pathways in neural-immune interactions...
  79. ncbi Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice
    Kousaku Ohinata
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan
    FEBS Lett 582:679-84. 2008
    ..The orexigenic activity of PGD(2) was also abolished by an antagonist for neuropeptide Y (NPY) Y(1) receptor. Taken together, PGD(2) may stimulate food intake through central DP(1) receptor coupled to the NPY system...
  80. ncbi Induction and function of lipocalin prostaglandin D synthase in host immunity
    Myungsoo Joo
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 179:2565-75. 2007
    ..Our study suggests a potential therapeutic usage of L-PGDS or PGD(2) against Pseudomonas pneumonia...
  81. ncbi Preparation, crystallization and preliminary crystallographic analysis of old yellow enzyme from Trypanosoma cruzi
    Shigeru Sugiyama
    Maruwa Foods Co Ltd, Tsutsui cho 170 1, Yamatokoriyama, Nara 639 1123, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:896-8. 2007
    ..The crystals were suitable for X-ray crystallographic studies and diffracted to 1.70 A resolution. A Patterson search method is in progress using the structure of OYE from Pseudomonas putida as a starting model...
  82. ncbi Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2)
    Tsuyoshi Tajima
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 326:493-501. 2008
    ....
  83. ncbi Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice
    Jae Man Park
    Division of Medical Genetics, Department of Pediatrics and Department of Pathology, Los Angeles Biomedical Research Institute, Harbor University of California Los Angeles Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
    Cancer Res 67:881-9. 2007
    ..Further studies will be needed to prove possible mechanisms, such as routing of PG production away from protumorigenic PGE(2) or inhibition of the nuclear factor-kappaB cascade by PGD(2) metabolites...
  84. ncbi Perineuronal oligodendrocytes protect against neuronal apoptosis through the production of lipocalin-type prostaglandin D synthase in a genetic demyelinating model
    Masako Taniike
    Department of Developmental Medicine Pediatrics, D 5 Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Neurosci 22:4885-96. 2002
    ..These lines of evidence suggest that L-PGDS is an anti-apoptotic molecule protecting neurons and OLs from apoptosis in the twitcher mouse. This is a novel example of OL-neuronal interaction...
  85. ncbi Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence
    Yoshihiro Urade
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita City, Osaka
    Prostaglandins Other Lipid Mediat 68:375-82. 2002
    ..Therefore, L-PGDS and H-PGDS are considered to be a novel example of functional convergence...
  86. ncbi Crystallization and preliminary X-ray crystallographic studies of Trypanosoma brucei prostaglandin F(2 alpha) synthase
    Yousuke Okano
    Department of Materials Chemistry, Graduate School of Engineering, Osaka University, Yamada-oka Suita, Osaka 565-0871, Japan
    J Biochem (Tokyo) 132:859-61. 2002
    ..The crystal belonged to a tetragonal space group, P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters of a = b = 112.3 A, and c = 140.0 A. Native data up to 2.6 A resolution were collected from the crystal using our home facility...
  87. ncbi Effect of phospholipase Cbeta4 lacking in thalamic neurons on electroencephalogram
    Miho Kameyama
    Department of Molecular Neurobiology, School of Human Sciences, Waseda University, 169 8555, Tokyo, Japan
    Biochem Biophys Res Commun 304:153-9. 2003
    ..Taken together, these results indicate that reduced PLCbeta4 activity in thalamic neurons may underlie high-cortical oscillation frequency...
  88. ncbi Hematopoietic prostaglandin D synthase
    Yoshihide Kanaoka
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Smith Building, Room 626C One Jimmy Fund Way, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 69:163-7. 2003
    ..In this review, we focus on the molecular biology of H-PGDS, the determination of its three-dimensional structure, characterization of the regulation of its gene expression, and information gleaned from transgenic animals...
  89. ncbi Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids
    Bruno L Diaz
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1397-404. 2002
    ..Thus, although exogenous prostanoids may contribute to amplification of the inflammatory response by augmenting PGD(2) generation and IL-6 secretion from mast cells, endogenous prostanoids do not play a role...
  90. ncbi An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats
    Zong-Yuan Hong
    School of Life Science, University of Science and Technology of China, Hefei, Anhui, China
    J Neurochem 92:1542-9. 2005
    ..These results suggest that the A(2A)R agonist induced sleep by inhibiting the histaminergic system through increasing GABA release in the tuberomammillary nucleus...
  91. ncbi Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice
    Louis Ragolia
    Vascular Biology Laboratory, Winthrop University Hospital, Mineola, New York 11501, USA
    J Biol Chem 280:29946-55. 2005
    ..We conclude that L-PGDS plays an important role regulating insulin sensitivity and atherosclerosis in type 2 diabetes and may represent a novel model of insulin resistance, atherosclerosis, and diabetic nephropathy...
  92. ncbi Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides
    Ikuko Mohri
    Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 97:641-51. 2006
    ..This suggests that L-PGDS may play a role in scavenging harmful lipophilic substrates in LSD...
  93. ncbi Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme
    Nahoko Uchiyama
    Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Antimicrob Agents Chemother 49:5123-6. 2005
    ..Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs...
  94. ncbi Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor
    Takahiro Satoh
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Immunol 177:2621-9. 2006
    ..These findings indicate that the PGD(2)-CRTH2 system plays a significant role in chronic allergic skin inflammation. CRTH2 may represent a novel therapeutic target for treatment of human allergic disorders, including atopic dermatitis...
  95. ncbi Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by MITF
    Kazuhisa Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Japan
    Biochem Biophys Res Commun 339:1098-106. 2006
    ..Thus, L-PGDS represents a newly identified melanocyte marker. MITF may modulate the production of prostaglandin D(2) by activating the L-PGDS gene in melanocytes...
  96. ncbi Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells
    Hideyuki Negoro
    Department of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Hypertens 20:1347-54. 2002
    ....
  97. ncbi Increased production of lipocalin-type prostaglandin D synthase in leptomeningeal cells through contact with astrocytes
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Neurosci Lett 423:133-7. 2007
    ..These results indicate that leptomeningeal cells enhance their L-PGDS production by a slow activation of L-PGDS gene expression through their contact with astrocytes...
  98. ncbi Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells
    Hideyuki Negoro
    Department of Medicine 2, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    Life Sci 78:22-9. 2005
    ..The results suggest that endogenous PGD(2) decreases VCAM-1 expression and VCAM-1 mRNA expression, probably through an intracrine mechanism...
  99. ncbi Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats
    Yilong Cui
    Molecular Imaging Research Program, Institute of Physical and Chemical Research RIKEN, Kobe, Hyogo, Japan
    J Neurosci Res 86:929-36. 2008
    ..A specific inhibitor of COX-2 completely arrested the increase in NREM sleep. These results indicate that up-regulated neuronal COX-2 would be involved in aberrant brain excitation-induced NREM sleep via production of PGs...
  100. ncbi Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus
    Mitsuhito Mase
    Department of Neurosurgery and Restorative Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8602, Japan
    Neurosci Res 47:455-9. 2003
    ..29+/-5.17, n=14, P<0.0001) and other dementia group (19.14+/-4.34, n=7, P=0.0003). Thus, PGDS level in CSF is a useful marker for the differential diagnosis of NPH from other diseases with dementia...