Kanehisa Morimoto

..We also show that lymphocytes from habitual drinkers with the deficient ALDH2 enzyme had significantly higher frequencies of sister chromatid exchanges than those from ALDH2-proficient individuals...

..The changes in poor to good lifestyles through health education and learning were also shown to result in promotion of such health potentials...

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..To clarify whether the intake of fermented milk containing lactic acid bacteria restores NK cell activity in habitual smokers, we conducted a placebo-controlled double-blind test...

..This study examined the relationship between involuntary smoking and periodontitis progression and the effects of involuntary smoking on salivary inflammatory and microbiologic markers related to periodontitis...

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..The objective of this study was to examine the prospective association between smoking and periodontal disease progression and the effects of smoking on salivary biomarkers related to periodontitis...

..The mechanism of passive smoking in terms of development of periodontitis has not been investigated. This study examined the effect of passive smoking on salivary markers related to periodontitis...

..008). Multiple regression analysis indicated that smoking habits, polymorphisms of XRCC1 codons 194 and 399, and age were important variables affecting individuals basal DNA damage...

..These findings suggest that the effects of long-term stays in a spa resort are more beneficial for married women staying with their husbands than for either married men or women staying with female companions...

..Multiple regression analysis revealed that drinking frequency, smoking status, and ALDH2 polymorphisms significantly influence basal TM value, suggesting that these are important variables affecting individual basal DNA damage...

..In this study, we examined the effects of Mozart's music on spatial-reasoning ability by near-infrared spectroscopy (NIRS)...

..These results might reflect different acetaldehyde levels causing changes in the reactivity of the vascular smooth muscle and cerebral activity in the visual cortex...

..These findings suggest that levels of salivary cortisol may be affected by current circumstances and that levels of CgA may be affected by changes in comprehensive lifestyle...

..Thus, good health practices appear to be closely associated with good mental health status. However, to establish our results, larger study populations are required for further studies in various occupational fields...

..This suggests that, for these people, the long stay in the spa ameliorated stress. These findings are somewhat different from those of studies in which researchers have evaluated the effects of shorter-term leisure trips...

..In summary, the present result suggests that frequent alcohol drinking is significantly associated with a reduced electrophoretic DNA migration in peripheral blood leukocytes from ALDH2-deficient male Japanese subjects...

..Using shogi, a representative table game popular in Japan, to model a stress situation, we investigated the modulatory effects of player characteristics on changes in the levels of cortisol and testosterone in the saliva of the players...

..Moreover, we demonstrated the typical asymmetrical pattern of stress responses in upper temporal cortex areas, and suggested that happiness/sadness emotional processing might be related to stress reduction by music...

..Our results suggest that stress response is intimately linked with competition and could be used to determine which players are more capable of handing stress in a competitive environment...

..These findings suggest that, in addition to a stress relief effect, laughter can bring about feeling uplifted or fulfilled...

..We therefore investigated the associations between lifestyle factors and plasma adiponectin levels in general Japanese men...

..23, r = 0.995, P < 0.0001), these results suggest that levels of exposure to cigarette tar or nicotine (mg/day) would be a sensitive parameter in appreciation of genotoxicity of cigarette smoking in these male Japanese smokers...

..To further clarify the association of XRCC1 polymorphisms and cancer risks, additional studies are required from the perspectives of epidemiology and in vitro...

..13, p<0.05). Based on these findings, the ALDH2 genotypes seem to be associated with the severity of carotid atherosclerosis, potentially modifying the prevalence of atherosclerosis in Asians...

..We evaluated the stress relief effect of lavender aroma by measuring sensitive salivary endocrinological stress markers, cortisol and chromogranin A (CgA)...

..The aim of the present study was to show changes in salivary cortisol and chromogranin A/protein concentrations as stress markers during pregnancy and to clarify the effect of chronic stress on stress markers...

..On the other hand, plasma CgA did not show any obvious circadian rhythm. These findings suggest that salivary and plasma CgA has different routes of secretion...

..To determine the changes in salivary chromogranin A (CgA) levels upon awakening in response to of stress by investigating the relationship between salivary CgA levels and the stress response as assessed by GHQ-28 tests...

..Female workers with children may have different social backgrounds and different stressors according to their working hours and work status...

..To investigate the influence of individual patterns of personality and behavior on the change in mood status after a brief period of Tai Chi exercise...

..01). CONCLUSION: Poor lifestyles demonstrate a cumulative association with leukocyte DNA damage in these Japanese hard-metal workers...

..CONCLUSIONS: Even after adjusting for aspects of alcohol-related psychosocial factors, flushing reactions among Japanese university students were significantly related to drinking behavior in men but not in women...

..These findings suggest that the spa bathing has a moderate affect on the stress relief...

..To investigate the association among symptoms of sick building syndrome (SBS). Self-reported questionnaire and indoor environmental surveys of newly build dwellings in Japan were conducted...

..These findings suggest the potential of Tai Chi as a complementary and alternative therapy...

..On the other hand, B-cells showed the highest sensitivity to bleomycin...

..This study may provide a model that can be used to evaluate the functional significance of polymorphisms in DNA repair genes...

..Job demand was not significantly related to job performance. Our findings suggest that it is worthwhile to enhance employees' job control and provide a mutually supportive environment to ensure positive employee job performance...

..CONCLUSION: A significant association is suggested between enlarged-fold gastritis and gastric carcinoma...

..This study assesses the accuracy of the immediate blood separation method, a novel blood sampling strategy that enables blood analysis in any possible location...

..05-7.82] and 4.91 (95% CI; 1.80-13.35), respectively. CONCLUSION: These findings suggest that passive smoking classified in terms of salivary cotinine level may be an independent periodontitis risk indicator...

..2 +/- 8.7. CONCLUSION: These findings suggest that the CPDQ is a useful scale for rating cellular phone dependence...

..These findings suggest that test-tube sampling is more reliable than use of the Salivette system for measuring salivary adiponectin levels...

..Thus, this review may provide a reference of target cells sensitive to mutagens that will be useful for genetic biomonitoring of human populations...

..Alcohol intake does not significantly affect hemodynamic changes caused by visual stimulation in the visual cortex...

..The aim of our study was to examine the association of alcohol consumption and its genotoxic effect on hematopoietic stem cells in vivo...

..In order to explore the underlying mechanism, we investigated the effect of lifestyle on intracellular perforin, granulysin, and granzymes A/B in peripheral blood lymphocytes (PBL)...

..e., immediately before the tour). These findings suggest that even short periods of travel can bring about a reduction in di-stress and acquisition of eu-stress, experienced as feeling uplifted or fulfilled...

..Both smoking and obesity are independent risk indicators for periodontitis; moreover, these parameters exhibit a dose-response relationship with respect to periodontitis risk...

..Music therapy is widely used in the treatment of acute and chronic pain. Therefore, we investigated the effects of music therapy on pain and on salivary cortisol levels in patients undergoing screening colonoscopy...

..We also found that DDVP have a modest, but a significant inhibitory effect on the transcription of mRNA of perforin, granzyme A and granulysin...

..Also, it might be useful to observe the onset of mental disorders in work of less than 50 hours with the workers' perception of work time...

..No adverse effect was observed in either group. The study showed that administering AGE to patients with advanced cancer of the digestive system improved NK cell activity, but caused no improvement in QOL...

..Taken together, these data indicate that phytoncides significantly enhance human NK activity and this effect is at least partially mediated by induction of intracellular perforin, granzyme A, and granulysin...

..The effects of psychological job strain, especially discretion, must always be taken into account in examinations of working hours and health...