Research Topics
Species | Atsushi WatanabeSummaryAffiliation: Nippon Medical School Country: Japan Publications
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Detail Information
Publications
Prevalence of c.1559delT in ALPL, a common mutation resulting in the perinatal (lethal) form of hypophosphatasia in Japanese and effects of the mutation on heterozygous carriersAtsushi Watanabe
Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan
J Hum Genet 56:166-8. 2011..Our results indicate that the only way to reliably detect whether individuals are pl-HPP carriers is to perform the ALPL mutation analysis...- Genetic aspects of the vascular type of Ehlers-Danlos syndrome (vEDS, EDSIV) in JapanAtsushi Watanabe
Division of Clinical Genetics, Nippon Medical School Main Hospital, Tokyo, Japan
Circ J 71:261-5. 2007..Affected individuals with vEDS are at risk of arterial rupture, aneurysm, and/or dissection; gastrointestinal perforation or rupture; and uterine rupture during pregnancy, which may lead to sudden death... - Prenatal genetic diagnosis of severe perinatal (lethal) hypophosphatasiaAtsushi Watanabe
Division of Clinical Genetics, Nippon Medical School Hospital
J Nihon Med Sch 74:65-9. 2007..As a result, prenatal genetic counseling for hypophosphatasia with collaboration between obstetricians and clinical genetics teams... - Vascular type of Ehlers-Danlos syndromeAtsushi Watanabe
Department of Molecular and Medical Genetics, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo, Japan
J Nihon Med Sch 75:254-61. 2008.... - Osteogenic and chondrogenic differentiation by adipose-derived stem cells harvested from GFP transgenic miceRei Ogawa
Department of Plastic and Reconstructive Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Toky 113-8603, Japan
Biochem Biophys Res Commun 313:871-7. 2004..Since this cell population can be easily identified through fluorescence microscopy, it may be an ideal source of ASCs for further experiments on stem cell biology and tissue engineering... - Expression of cochlin mRNA splice variants in the inner earKuwon Sekine
Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
Audiol Neurootol 15:88-96. 2010..The short mRNA was detected only in the inner ear, and this variant may provide a clue to understanding the formation and function of cochlin isoforms... - Expression of full-length Cochlin p63s is inner ear specificLishu Li
Department of Otorhinolaryngology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
Auris Nasus Larynx 32:219-23. 2005..These results will be central to understanding the function of Cochlin and its role in the pathophysiology of DFNA9... - Expression of cochlin in the vestibular organ of ratsTetsuo Ikezono
Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
ORL J Otorhinolaryngol Relat Spec 67:252-8. 2005..These findings support the theory that deposition of acidophilic substance in the inner ear caused by mutation of cochlin can induce a secondary retrograde dendritic degeneration of the vestibular nerves... - Transient cardiomyopathy in a patient with congenital contractural arachnodactyly (Beals syndrome)Tae Matsumoto
Department of Pediatrics, Nippon Medical School Graduate School of Medicine, Tokyo, Japan
J Nihon Med Sch 73:285-8. 2006..This is the first report of CCA with transient cardiomyopathy. We discuss the mechanism of the spontaneous improvement of cardiomyopathy in this case on the basis of expression of the responsible gene... - Chondrogenic and osteogenic differentiation of adipose-derived stem cells isolated from GFP transgenic miceRei Ogawa
Department of Plastic and Reconstructive Surgery, Nippon Medical School, Tokyo, Japan
J Nihon Med Sch 71:240-1. 2004..This cell population can be easily identified through fluorescence microscope, it should be an ideal source of ASCs for further experiments of stem cell biology and tissue engineering... - Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differencesRei Ogawa
Department of Plastic and Reconstructive Surgery, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo 113 8603, Japan
Biochem Biophys Res Commun 319:511-7. 2004..89 times greater than those harvested from male mice. This suggests that the adipogenic differentiation of ASCs is closely related to sex differences... - Identification of a novel Cochlin isoform in the perilymph: insights to Cochlin function and the pathogenesis of DFNA9Tetsuo Ikezono
Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
Biochem Biophys Res Commun 314:440-6. 2004..The pathogenesis of DFNA9 is not fully clarified as yet, and this novel perilymph-associated CTP isoform might provide mechanistic clues to how mutations in the COCH gene damage the inner ear function... - Cochlin-tomoprotein: a novel perilymph-specific protein and a potential marker for the diagnosis of perilymphatic fistulaTetsuo Ikezono
Department of Otorhinolaryngology, Nippon Medical School, Sendagi, Tokyo 113 8603, Japan
Audiol Neurootol 14:338-44. 2009..The aim of this study was to determine whether CTP, a novel perilymph-specific protein, could be used as a marker for the diagnosis of PLF... - The performance of Cochlin-tomoprotein detection test in the diagnosis of perilymphatic fistulaTetsuo Ikezono
Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan
Audiol Neurootol 15:168-74. 2010..To establish a definite diagnostic test for PLF using CTP as a biochemical marker, we examined the diagnostic performance of the CTP detection test... - A novel mutation screening system for Ehlers-Danlos Syndrome, vascular type by high-resolution melting curve analysis in combination with small amplicon genotyping using genomic DNABanyar Than Naing
Department of Biochemistry and Molecular Biology, Nippon Medical School, and Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan
Biochem Biophys Res Commun 405:368-72. 2011..A better understanding of the genotype-phenotype correlation in COL3A1 using this method will lead to improve in diagnosis and treatment... - Conservative management of hyperreactio luteinalis: a case reportTakashi Abe
Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Japan
J Nihon Med Sch 78:241-5. 2011..The present report describes case of HL in a woman with a normal singleton pregnancy in whom conservative management allowed the preservation of both ovaries... - Visualization of newly deposited tau in neurofibrillary tangles and neuropil threadsTomohiro Miyasaka
Department of Neuropathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
J Neuropathol Exp Neurol 64:665-74. 2005..Based on TM4-positive NFT counts and total NFT counts, we speculate that NFTs in the human hippocampus are produced at a constant rate irrespective of the disease stage... - Global diffuse distribution in the brain and efficient gene delivery to the dorsal root ganglia by intrathecal injection of adeno-associated viral vector serotype 1Naotaka Iwamoto
Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
J Gene Med 11:498-505. 2009..As an alternative approach, we examined the feasibility of intrathecal (IT) injection of adeno-associated viral vector serotype 1 (AAV1)... - Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy modelTsutomu Igarashi
Department of Biochemistry and Molecular Biology, Division of Gene Therapy, Research Center for Advanced Medical Technology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Gene Ther 10:219-26. 2003..These data suggest that the anti-angiogenic activity of angiostatin has therapeutic potential for the treatment of retinal neovascularization... - Bovine hepatocyte growth factor and its receptor c-Met: cDNA cloning and expression analysis in the mammary glandDaisuke Yamaji
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
Domest Anim Endocrinol 30:239-46. 2006..These results suggest pivotal roles of HGF and c-Met in the development of bovine mammary gland... - Interchromosomal duplication of major histocompatibility complex class I regions in rainbow trout (Oncorhynchus mykiss), a species with a presumably recent tetraploid ancestryTakashi Shiina
Department of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
Immunogenetics 56:878-93. 2005..The interchromosomal duplication and the homology levels are supportive of the tetraploid model... - Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in ratsShin ichi Satoh
First Laboratory for Pharmacology, Institute of Life Science Research, Asahi Kasei Corporation, 632-1, Mifuku, Ohito-cho, Tagata-gun, 410-2321, Japan
Life Sci 72:103-12. 2002..Inhibition of Rho-kinase is efficacious in preventing the ECG change and development of fibrosis induced by vasopressin in this model... - [Case of systemic mastocytosis with hemophagocytic syndrome]Atsushi Watanabe
Third Department of Internal Medicine, Akita University School of Medicine, Akita
Nippon Naika Gakkai Zasshi 92:874-6. 2003 - Cloning and characterization of the promoter region of the bovine membrane tethering protein p115 gene and its regulation in mammary epithelial cellsAtsushi Watanabe
Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Sapporo 062 0045, Japan
Biochim Biophys Acta 1629:60-72. 2003..Furthermore, the results suggested that p115 gene transcription is activated by E(2), by insulin, or by both in association with the stimulation of mammary epithelial cell proliferation... - Multidisciplinary treatment by pneumonectomy, PMX and CHDF in a case of pulmonary suppuration complicated with septic shockNoriyuki Takahashi
Department of Thoracic Surgery, Sapporo Medical University, Sapporo, Japan
Ann Thorac Cardiovasc Surg 9:319-22. 2003..Ann Thorac Cardiovasc Surg 2003; 9: 319-22).. - Mating communication systems of four Plusiinae species distributed in Japan: identification of the sex pheromones and field evaluationShin-Ichi Inomata
Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan
J Chem Ecol 31:1429-42. 2005..Using previously published chemical and biosynthetic data, together with the finding from this study, we propose a classification of the Plusiinae sex pheromones... - Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivoAtsushi Watanabe
Biomolecular Characterization Division, Characterization Center, RIKEN (The Institute of Physical and Chemical Research, Wako, Japan
J Neurochem 90:1302-11. 2004..Similar degradation products starting from the bulky residues next to asparaginyl residues were found in the smeared tau in vivo partially purified from the homogenates from Alzheimer's disease brains... - Complete nucleotide sequence of the Cryptomeria japonica D. Don. chloroplast genome and comparative chloroplast genomics: diversified genomic structure of coniferous speciesTomonori Hirao
Institute of Wood Technology, Akita Prefectural University, 11 1 Kaieisaka, Noshiro, Akita 016 0876, Japan
BMC Plant Biol 8:70. 2008.... - Effects of intramammary infusions of interleukin-8 on milk protein composition and induction of acute-phase protein in cows during mammary involutionAtsushi Watanabe
Hokkaido Research Station, National Institute of Animal Health, Sapporo 062 0045, Japan
Can J Vet Res 72:291-6. 2008..In the cows infused with 25 microg of rbIL-8, the rectal temperature and serum haptoglobin level were transiently elevated after the infusion, showing that intramammary infusion of rbIL-8 could elicit systemic inflammation... - Leptin inhibits hepatocyte growth factor-induced ductal morphogenesis of bovine mammary epithelial cellsDaisuke Yamaji
Laboratories of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
Jpn J Vet Res 54:183-9. 2007..These results suggest that stroma-derived factors intricately regulate mammary epithelial morphogenesis... - Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversityTakashi Shiina
Department of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Japan
Genetics 173:1555-70. 2006..This is most likely reminiscent of the fact that these hsSNV and hv1SNV have been selected in adaptation to the constantly evolving microbial antigenic repertoire... - CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXVTadafumi Hashimoto
Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033
EMBO J 21:1524-34. 2002..Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD...