Research Topics
Genomes and Genes | Kiyoyuki OgataSummaryAffiliation: Nippon Medical School Country: Japan Publications
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Publications
Thrombopoietin and myelodysplastic syndromesK Ogata
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Int J Hematol 72:173-7. 2000..These findings may be of use when designing a clinical trial of TPO for MDS...- Diagnostic application of flow cytometric characteristics of CD34+ cells in low-grade myelodysplastic syndromesKiyoyuki Ogata
Division of Hematology, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8603, Japan
Blood 108:1037-44. 2006..Among LGw/oRS patients with chromosomal aberrations, patients with trisomy 8 or del20(q) had low FCM scores (P = .002). As a result, most LGw/oRS patients were identified based on high FCM score, chromosomal aberration, or both... - Clinical implications of blast immunophenotypes in myelodysplastic syndromesKiyoyuki Ogata
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Leuk Lymphoma 46:1269-74. 2005..Further studies of blast immunophenotypes will deepen our understanding of MDS and hopefully improve the clinical approach to these intractable disorders... - Identification and hematopoietic potential of CD45- clonal cells with very immature phenotype (CD45-CD34-CD38-Lin-) in patients with myelodysplastic syndromesKiyoyuki Ogata
Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Stem Cells 23:619-30. 2005..This newly identified cell population represents the most immature immunophenotype so far identified in the hematopoietic lineage and is involved in the malignant clone in MDS... - Association between phenotypic features of blasts and the blast percentage in bone marrow of patients with myelodysplastic syndromesKiyoyuki Ogata
Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Leuk Res 28:1171-5. 2004..The BM blast percentages where the blast immunophenotype changed were 5, 10, 20 and 25%. Blast immunophenotypes have the potential to provide a biological basis for and refine the present MDS classifications... - Diagnostic flow cytometry for low-grade myelodysplastic syndromesKiyoyuki Ogata
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Hematol Oncol 26:193-8. 2008..CD34+ cell-related parameters that are applicable for diagnosing low-grade MDS in many laboratories are introduced here... - [Myelodysplastic syndromes (preleukemic states)]Kiyoyuki Ogata
Division of Hematology, Department of Medicine, Nippon Medical School
J Nippon Med Sch 70:2-3. 2003 - Clinical significance of phenotypic features of blasts in patients with myelodysplastic syndromeKiyoyuki Ogata
Division of Hematology, Nippon Medical School, Kyoto, Japan
Blood 100:3887-96. 2002..Further, CD7 positivity of EBCs was an independent variable for a poor prognosis in MDS. These data represent new, valuable information regarding MDS... - Myelodysplastic syndromes: recent progress in diagnosis and understanding of their pathophysiologyKiyoyuki Ogata
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
J Nihon Med Sch 73:300-7. 2006..This review touches on some recent developments in the diagnosis and pathophysiology of MDS... - Diagnostic utility of flow cytometry in low-grade myelodysplastic syndromes: a prospective validation studyKiyoyuki Ogata
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Haematologica 94:1066-74. 2009..The diagnosis of myelodysplastic syndromes is not always straightforward when patients lack specific diagnostic markers, such as blast excess, karyotype abnormality, and ringed sideroblasts... - Association between natural killer cell activity and infection in immunologically normal elderly peopleK Ogata
Division of Haematology, Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Clin Exp Immunol 124:392-7. 2001..Our data indicate that low NK cell activity is associated with development of infections and death due to infection in immunologically normal elderly subjects with an impaired PS... - Reappraisal of the clinical significance of CD7 expression in association with cytogenetics in de novo acute myeloid leukaemiaK Ogata
Division of Haematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Br J Haematol 115:612-5. 2001..0001). CD7-positivity adversely affected the survival only in the cases with unfavourable cytogenetics (P < 0.03). We recommend that CD7 expression in AML be interpreted in association with the cytogenetics... - A simple centrifugation method for harvesting myeloblastsK Ogata
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Int J Hematol 74:272-6. 2001..0% before separation, 56.6% +/- 28.3% after separation) (n = 22). The enriched blasts were suitable for various analyses, eg, flow cytometry, immunocytochemistry, cytochemistry, fluorescence in situ hybridization, and gene analysis... - Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromesAsaka Kondo
Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
Blood 116:1124-31. 2010..B7-H1(+) MDS blasts have an intrinsic proliferative advantage and induce T-cell suppression, which may be associated with disease progression in MDS... - Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemiaHideto Tamura
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Clin Cancer Res 11:5708-17. 2005..The aim of this study was to examine whether leukemic cells of acute myeloid leukemia express functional B7 family molecules and, if so, whether such expression has any clinical significance... - Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantageTaishi Yamashita
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Clin Cancer Res 15:770-7. 2009..The aim of this study was to investigate whether functional B7.2 and B7-H2 molecules are expressed on myeloma cells and, if so, whether they are associated with pathophysiology in myeloma... - Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromesHideto Tamura
Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Leuk Res 34:986-90. 2010..Moreover, high values of anti-WT1 antibody were an independent predictor of longer survival. These data may justify therapeutic strategies targeting WT1 molecules in MDS... - Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromesChikako Satoh
Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Leuk Res 33:326-31. 2009..These findings might underlie the clinical aggressiveness in CD7+ MDS... - Flow cytometric parameters with little interexaminer variability for diagnosing low-grade myelodysplastic syndromesChikako Satoh
Division of Hematology, Department of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
Leuk Res 32:699-707. 2008..These parameters can be analyzed from one test tube for three-color FCM, and their analysis in combination can diagnose a certain percentage of low-grade MDS patients... - Increased apoptosis of circulating T cells in myelodysplastic syndromesYumiko Shioi
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Leuk Res 31:1641-8. 2007..Mechanisms other than the Fas-Fas ligand pathway may induce T cell apoptosis in MDS... - [Double balloon endoscopy as a useful tool for the diagnosis and treatment of four cases of primary small intestinal lymphoma]Hideto Tamura
Division of Hematology, Department of Medicine, Nippon Medical School
Rinsho Ketsueki 48:510-3. 2007..We conclude that DBE is useful in the management of PSIL. More PSIL cases must be analyzed to establish the optimal management of patients with this form of lymphoma... - Pure white cell aplasia: report of the first case associated with primary biliary cirrhosisHideto Tamura
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Int J Hematol 85:97-100. 2007..She died of infection, and the autopsy confirmed the diagnosis of PBC. In vitro investigations showed that factors inhibitory to normal CD34 cell-derived granulopoiesis were present in the patient's serum... - Characterization of blasts in clinical samples containing few blastsHideya Hyodo
Division of Hematology, Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Int J Hematol 77:376-82. 2003..The revealed blast characteristics were valuable for choosing appropriate therapy for the patients... - Disease progression mechanism in myelodysplastic syndromes: insight into the role of the microenvironmentMariko Ishibashi
Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
Leuk Res 35:1449-52. 2011..This causes B7-H1 molecule expression on MDS blasts, which generates a bifunctional signal inducing T-cell apoptosis and enhancing blast proliferation. The latter may provide more opportunity for developing secondary genetic changes... - Hypothesis: myeloid-restricted hematopoietic stem cells with self-renewal capacity may be the transformation site in acute myeloid leukemiaChikako Satoh
Third Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
Leuk Res 30:491-5. 2006..Based on these findings and re-evaluating the published data on AML stem cells, we hypothesize that MyHSCs may be the transformation site in AML. If so, therapy targeting leukemic MyHSCs but sparing PHSCs is worth investigating... - Immunology of B7-H1 and its roles in human diseasesHideto Tamura
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Int J Hematol 78:321-8. 2003..Precise manipulation of B7-H1 and its receptors may provide unique opportunities for designing new disease treatments... - Nationwide public-access defibrillation in JapanTetsuhisa Kitamura
Kyoto University Health Service, Kyoto, Japan
N Engl J Med 362:994-1004. 2010..It is unclear whether dissemination of automated external defibrillators (AEDs) in public places can improve the rate of survival among patients who have had an out-of-hospital cardiac arrest... - [Usefulness of a novel Blastretriever for harvesting blasts]K Ogata
Third Department of Internal Medicine, Nippon Medical School
Nippon Rinsho 59:2353-7. 2001..This new reagent should provide valuable information for the management and pathophysiology of hematologic malignancies... - CD20-positive T cell leukemia/lymphoma: case report and review of the literatureN Yokose
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
Ann Hematol 80:372-5. 2001..Hepatomegaly and/or splenomegaly were common features. Further cases must be evaluated to understand the clinical significance of the CD20 expression on the surface of T cell malignancies... - Phenotype and functional identity of GM-CSF-independent dendritic cells generated by long-term propagation of DC progenitor cells in bone marrow cells and skin Langerhans cellsH Katayama
Department of Research Surgery, National Research Center for Child Health and Development, Tokyo, Japan
Transplant Proc 37:17-9. 2005..A large population of DC generated by Flt3L/IL-6 from GM-CSF receptor-deficient mice by do not express NK1.1 (NKR-P1B and NKR-P1C). The profiles for BMC-derived DC were the same as for skin Langerhans cells... - Selective expansion of perforin-positive CD8+ T cells by immature dendritic cells infected with live Bacillus Calmette-Guérin mycobacteriaYasuko Tsunetsugu-Yokota
Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama-cho, Shinjuku-ku, Tokyo 162-8640, Japan
J Leukoc Biol 72:115-24. 2002.... - Flow cytometry in myelodysplastic syndromes: report from a working conferenceMichael R Loken
HematoLogics, Inc, Seattle, USA
Leuk Res 32:5-17. 2008..Clearly defined aberrancies on myeloid immature and maturing cells are now identified with possible impact on diagnosis, classification and prognostication in the near feature... - CD5-positive diffuse large B-cell lymphoma with an unusual phenotype: Cytoplasmic CD20 (+), surface CD20 (-)Norio Yokose
Leuk Lymphoma 47:1415-7. 2006 - Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignanciesOlga A Elisseeva
Department of Radiation Biology, Osaka University Medical School, Japan
Blood 99:3272-9. 2002..Our findings may provide new insight into the rationale for elicitation of cytotoxic T-cell responses against the WT1 protein in cancer immunotherapy using the WT1 vaccine... - Blastic natural killer cell lymphoma/leukemia (CD56-positive blastic tumor): prognostication and categorization according to anatomic sites of involvementRitsuro Suzuki
Division of Molecular Medicine, Aichi Cancer Center, Nagoya, Japan
Cancer 104:1022-31. 2005..Although further investigations are needed to settle a marker for distinction, the presence of cutaneous involvement is a useful prognostic factor... - On flow cytometry in myelodysplastic syndromes, with caveatsDenise A Wells
Leuk Res 32:209-10. 2008 - Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conferencePeter Valent
Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Leuk Res 31:727-36. 2007..Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials...